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PRJNA195909:zebrafish embryo and larva development
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Results for SPDEF
Z-value: 1.87
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Transcription factors associated with SPDEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | dr11_v1_chr6_-_54290227_54290227 | -0.80 | 1.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_3398383 Show fit | 3.47 |
ENSDART00000047865
|
si:dkey-46g23.2 |
|
| chr3_-_3413669 Show fit | 3.43 |
ENSDART00000113517
ENSDART00000179861 ENSDART00000115331 |
zgc:171446 |
|
| chr21_-_43636595 Show fit | 2.56 |
ENSDART00000151115
ENSDART00000151486 ENSDART00000151778 |
si:ch1073-263o8.2 |
|
| chr15_+_38299385 Show fit | 2.53 |
ENSDART00000142403
|
si:dkey-24p1.6 |
|
| chr8_+_23726708 Show fit | 2.42 |
ENSDART00000142395
|
makorin, ring finger protein, 4 |
|
| chr5_+_6854345 Show fit | 2.10 |
ENSDART00000066307
|
elaC ribonuclease Z 1 |
|
| chr15_+_38299563 Show fit | 2.06 |
ENSDART00000099375
|
si:dkey-24p1.6 |
|
| chr12_-_9468618 Show fit | 2.05 |
ENSDART00000152737
ENSDART00000091519 |
post-GPI attachment to proteins 3 |
|
| chr18_+_6638974 Show fit | 1.95 |
ENSDART00000162398
|
C2 calcium-dependent domain containing 5 |
|
| chr8_+_23726244 Show fit | 1.95 |
ENSDART00000132734
|
makorin, ring finger protein, 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.2 | 5.3 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.9 | 3.8 | GO:0042779 | tRNA 3'-trailer cleavage(GO:0042779) |
| 0.8 | 3.8 | GO:0010828 | positive regulation of glucose transport(GO:0010828) |
| 0.1 | 3.4 | GO:0032924 | activin receptor signaling pathway(GO:0032924) |
| 0.2 | 2.9 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 2.8 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.1 | 2.3 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.1 | 2.3 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 1.9 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.5 | 3.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.1 | 2.9 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 2.8 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 2.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 2.0 | GO:0000782 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784) |
| 0.1 | 1.9 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 1.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 1.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 1.5 | GO:0000243 | commitment complex(GO:0000243) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.3 | 3.8 | GO:0042781 | 3'-tRNA processing endoribonuclease activity(GO:0042781) |
| 0.0 | 3.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 3.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 3.4 | GO:0017002 | activin-activated receptor activity(GO:0017002) |
| 0.8 | 3.2 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.2 | 2.9 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 2.8 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.3 | 2.4 | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 2.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.3 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 1.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 1.0 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 1.0 | PID S1P S1P2 PATHWAY | S1P2 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 2.0 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 1.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 1.7 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 1.7 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.1 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 1.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 1.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |