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PRJEB1986: zebrafish developmental stages transcriptome

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Results for zfhx3+zfhx3a+zfhx4

Z-value: 0.53

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Transcription factors associated with zfhx3+zfhx3a+zfhx4

Gene Symbol Gene ID Gene Info
zfhx3a
ENSDARG00000073944 si_ch73-386h18.1
zfhx4
ENSDARG00000075542 zinc finger homeobox 4
zfhx3
ENSDARG00000103057 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
zfhx3dr11_v1_chr7_-_68373495_683734950.341.5e-01Click!
zfhx4dr11_v1_chr24_-_23320223_233202230.302.2e-01Click!
si:ch73-386h18.1dr11_v1_chr18_+_6054816_6054816-0.126.2e-01Click!

Activity profile of zfhx3+zfhx3a+zfhx4 motif

Sorted Z-values of zfhx3+zfhx3a+zfhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_30620625 2.70 ENSDART00000098273
tcnl
transcobalamin like
chr4_+_18804317 2.56 ENSDART00000101043
slc26a3.2
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr20_-_40754794 1.85 ENSDART00000187251
cx32.3
connexin 32.3
chr22_+_20720808 1.83 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr22_-_294700 1.49 ENSDART00000189179
CABZ01079179.1

chr20_-_40755614 1.40 ENSDART00000061247
cx32.3
connexin 32.3
chr20_-_40750953 1.05 ENSDART00000061256
cx28.9
connexin 28.9
chr5_-_44829719 1.04 ENSDART00000019104
fbp2
fructose-1,6-bisphosphatase 2
chr5_-_65158203 0.98 ENSDART00000171656
sh2d3cb
SH2 domain containing 3Cb
chr1_-_14233815 0.96 ENSDART00000044896
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr3_+_40170216 0.95 ENSDART00000011568
syngr3a
synaptogyrin 3a
chr3_-_28120092 0.94 ENSDART00000151143
rbfox1
RNA binding fox-1 homolog 1
chr5_+_28797771 0.93 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
si:ch211-186e20.7
chr8_-_18042089 0.93 ENSDART00000132596
dio1
iodothyronine deiodinase 1
chr23_+_20689255 0.92 ENSDART00000182420
usp21
ubiquitin specific peptidase 21
chr13_+_27314795 0.90 ENSDART00000128726
eef1a1a
eukaryotic translation elongation factor 1 alpha 1a
chr6_+_30456788 0.90 ENSDART00000121492
FP236735.1

chr20_+_31076488 0.89 ENSDART00000136255
ENSDART00000008840
otofa
otoferlin a
chr7_+_20587506 0.85 ENSDART00000172416
ENSDART00000170633
si:dkey-19b23.7
si:dkey-19b23.7
chr3_+_50312422 0.83 ENSDART00000157689
gas7a
growth arrest-specific 7a
chr1_-_14234076 0.82 ENSDART00000040049
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr5_+_9382301 0.82 ENSDART00000124017
ugt2a7
UDP glucuronosyltransferase 2 family, polypeptide A7
chr18_-_16181952 0.82 ENSDART00000157824
slc6a15
solute carrier family 6 (neutral amino acid transporter), member 15
chr18_+_15644559 0.81 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr5_+_28848870 0.79 ENSDART00000149563
zgc:174259
zgc:174259
chr5_+_28830643 0.79 ENSDART00000051448
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_+_9310259 0.77 ENSDART00000186158
ENSDART00000190329
NPAS3
neuronal PAS domain protein 3
chr25_-_35599887 0.76 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr16_-_46645396 0.74 ENSDART00000131485
tmem176l.2
transmembrane protein 176l.2
chr21_+_9689103 0.70 ENSDART00000165132
mapk10
mitogen-activated protein kinase 10
chr16_-_44127307 0.70 ENSDART00000104583
ENSDART00000151936
ENSDART00000058685
ENSDART00000190830
zfpm2a
zinc finger protein, FOG family member 2a
chr25_+_24291156 0.69 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr5_+_28830388 0.68 ENSDART00000149150
serpina7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr21_-_13123176 0.68 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr22_-_38480186 0.67 ENSDART00000171704
soul4
heme-binding protein soul4
chr6_-_40058686 0.67 ENSDART00000103240
uroc1
urocanate hydratase 1
chr23_+_13375359 0.66 ENSDART00000151947
ZNF512B
si:dkey-256k13.2
chr17_-_30975707 0.65 ENSDART00000138346
evla
Enah/Vasp-like a
chr25_+_28679672 0.64 ENSDART00000139965
ENSDART00000134072
cnot2
CCR4-NOT transcription complex, subunit 2
chr1_-_15797663 0.62 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr11_+_29770966 0.62 ENSDART00000088624
ENSDART00000124471
rpgrb
retinitis pigmentosa GTPase regulator b
chr23_+_45200481 0.61 ENSDART00000004357
ENSDART00000111126
ENSDART00000193560
ENSDART00000190476
psip1b
PC4 and SFRS1 interacting protein 1b
chr5_+_28849155 0.60 ENSDART00000079090
zgc:174259
zgc:174259
chr8_+_10339869 0.58 ENSDART00000132253
tbc1d22b
TBC1 domain family, member 22B
chr8_-_20230559 0.57 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr3_+_29714775 0.56 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr17_+_8212477 0.55 ENSDART00000064665
slc18b1
solute carrier family 18, subfamily B, member 1
chr6_-_48473694 0.54 ENSDART00000154237
ppm1j
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr22_-_34551568 0.50 ENSDART00000148147
rnf123
ring finger protein 123
chr19_+_14573998 0.49 ENSDART00000022076
fam46bb
family with sequence similarity 46, member Bb
chr17_+_2162916 0.49 ENSDART00000103775
pak6a
p21 protein (Cdc42/Rac)-activated kinase 6a
chr10_+_42423318 0.48 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr13_+_45524475 0.48 ENSDART00000074567
ENSDART00000019113
maco1b
macoilin 1b
chr25_-_16818380 0.46 ENSDART00000155401
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr1_+_45085194 0.46 ENSDART00000193863
si:ch211-151p13.8
si:ch211-151p13.8
chr24_-_21470766 0.45 ENSDART00000178121
atp8a2
ATPase phospholipid transporting 8A2
chr7_-_4296771 0.45 ENSDART00000128855
cbln11
cerebellin 11
chr9_+_45227028 0.43 ENSDART00000185579
adarb1b
adenosine deaminase, RNA-specific, B1b
chr20_-_38617766 0.40 ENSDART00000050474
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr3_-_34084387 0.39 ENSDART00000155365
ighv4-3
immunoglobulin heavy variable 4-3
chr23_-_41965557 0.38 ENSDART00000144183
slc1a7b
solute carrier family 1 (glutamate transporter), member 7b
chr14_-_7207961 0.37 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr24_+_14713776 0.37 ENSDART00000134475
gdap1
ganglioside induced differentiation associated protein 1
chr11_+_23760470 0.36 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
nfasca
neurofascin homolog (chicken) a
chr8_-_25569920 0.34 ENSDART00000136869
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr10_-_11261565 0.34 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr25_-_16818195 0.33 ENSDART00000185215
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr3_-_30388525 0.32 ENSDART00000183790
lrrc4ba
leucine rich repeat containing 4Ba
chr17_-_7371564 0.32 ENSDART00000060336
rab32b
RAB32b, member RAS oncogene family
chr5_+_28858345 0.32 ENSDART00000111180
si:ch211-186e20.2
si:ch211-186e20.2
chr10_-_42131408 0.32 ENSDART00000076693
stambpa
STAM binding protein a
chr3_-_20040636 0.31 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr4_-_22338906 0.30 ENSDART00000131402
golgb1
golgin B1
chr2_-_30784198 0.30 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr6_-_32349153 0.29 ENSDART00000140004
angptl3
angiopoietin-like 3
chr8_+_1839695 0.28 ENSDART00000148254
ENSDART00000143473
snap29
synaptosomal-associated protein 29
chr5_+_4054704 0.27 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr7_+_4194306 0.25 ENSDART00000190454
si:dkey-28d5.5
si:dkey-28d5.5
chr18_+_29950233 0.25 ENSDART00000146431
atmin
ATM interactor
chr4_+_9669717 0.24 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr4_-_5302866 0.22 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr12_+_47081783 0.21 ENSDART00000158568
mtr
5-methyltetrahydrofolate-homocysteine methyltransferase
chr20_+_27298783 0.20 ENSDART00000013861
ppp4r4
protein phosphatase 4, regulatory subunit 4
chr17_-_51893123 0.19 ENSDART00000103350
ENSDART00000017329
numb
numb homolog (Drosophila)
chr15_+_28685625 0.19 ENSDART00000188797
ENSDART00000166036
nova2
neuro-oncological ventral antigen 2
chr15_-_17868870 0.19 ENSDART00000170950
atf5b
activating transcription factor 5b
chr17_+_31914877 0.19 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr21_-_20765338 0.19 ENSDART00000135940
ghrb
growth hormone receptor b
chr3_-_34337969 0.19 ENSDART00000151634
tnrc6c1
trinucleotide repeat containing 6C1
chr11_-_2838699 0.18 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr10_+_8690936 0.18 ENSDART00000144218
si:dkey-27b3.4
si:dkey-27b3.4
chr3_-_5228137 0.17 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr13_+_31205439 0.16 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr14_+_2487672 0.15 ENSDART00000170629
ENSDART00000123063
fgf18a
fibroblast growth factor 18a
chr2_+_29249561 0.14 ENSDART00000099157
cdh18a
cadherin 18, type 2a
chr19_+_3056450 0.13 ENSDART00000141324
ENSDART00000082353
hsf1
heat shock transcription factor 1
chr21_+_13150937 0.13 ENSDART00000102251
sptan1
spectrin alpha, non-erythrocytic 1
chr20_+_36629173 0.12 ENSDART00000161241
ephx1
epoxide hydrolase 1, microsomal (xenobiotic)
chr9_+_21151138 0.12 ENSDART00000133903
hao2
hydroxyacid oxidase 2 (long chain)
chr14_+_8594367 0.12 ENSDART00000037749
stx5a
syntaxin 5A
chr2_+_29249204 0.12 ENSDART00000168957
cdh18a
cadherin 18, type 2a
chr17_-_30975978 0.11 ENSDART00000051697
evla
Enah/Vasp-like a
chr15_-_3534705 0.11 ENSDART00000158150
cog6
component of oligomeric golgi complex 6
chr18_+_2228737 0.10 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr16_-_31351419 0.10 ENSDART00000178298
ENSDART00000018091
mroh1
maestro heat-like repeat family member 1
chr7_-_38658411 0.09 ENSDART00000109463
ENSDART00000017155
npsn
nephrosin
chr9_+_12444494 0.07 ENSDART00000102430
tmem41aa
transmembrane protein 41aa
chr16_+_28383758 0.07 ENSDART00000059038
ENSDART00000141061
itga8
integrin, alpha 8
chr8_-_25074319 0.05 ENSDART00000134190
sort1b
sortilin 1b
chr24_-_26328721 0.04 ENSDART00000125468
apodb
apolipoprotein Db
chr10_+_11261576 0.03 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr22_+_19220459 0.03 ENSDART00000163070
si:dkey-21e2.7
si:dkey-21e2.7
chr5_+_13385837 0.02 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr2_+_55984788 0.02 ENSDART00000183599
nmrk2
nicotinamide riboside kinase 2
chr20_+_41756996 0.01 ENSDART00000186393
fam184a
family with sequence similarity 184, member A
chr6_+_20647155 0.01 ENSDART00000193477
slc19a1
solute carrier family 19 (folate transporter), member 1
chr12_+_30788912 0.00 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr12_-_18578218 0.00 ENSDART00000125803
zdhhc4
zinc finger, DHHC-type containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of zfhx3+zfhx3a+zfhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.2 0.7 GO:0043606 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.2 0.8 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.9 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 2.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.5 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 0.4 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.3 GO:0055091 phospholipid homeostasis(GO:0055091)
0.1 0.9 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 0.6 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 0.6 GO:0046548 retinal rod cell development(GO:0046548)
0.1 0.8 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 4.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.0 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.9 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.4 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.3 GO:0048730 epidermis morphogenesis(GO:0048730)
0.0 0.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.8 GO:0051289 protein homotetramerization(GO:0051289)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.9 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.3 GO:0032438 melanosome organization(GO:0032438)
0.0 0.2 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.2 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.7 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 0.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.7 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 2.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.8 GO:0032052 bile acid binding(GO:0032052)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.1 0.9 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.7 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.1 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
0.0 0.4 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 1.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 4.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins