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PRJEB1986: zebrafish developmental stages transcriptome

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Results for vsx2

Z-value: 0.29

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Transcription factors associated with vsx2

Gene Symbol Gene ID Gene Info
ENSDARG00000005574 visual system homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
vsx2dr11_v1_chr17_-_31659670_31659670-0.302.1e-01Click!

Activity profile of vsx2 motif

Sorted Z-values of vsx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_-_13085242 0.66 ENSDART00000044504
zgc:109965
chr16_+_31804590 0.56 ENSDART00000167321
wingless-type MMTV integration site family, member 4b
chr3_-_43356082 0.49 ENSDART00000171213
UNC homeobox
chr20_-_9436521 0.46 ENSDART00000133000
zgc:101840
chr16_+_46111849 0.34 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr6_+_28208973 0.33 ENSDART00000171216
ENSDART00000171377
ENSDART00000167389
ENSDART00000166988
si:ch73-14h10.2
chr4_+_21129752 0.31 ENSDART00000169764
synaptotagmin Ia
chr21_+_6751760 0.30 ENSDART00000135914
olfactomedin 1b
chr22_-_20011476 0.30 ENSDART00000093312
ENSDART00000093310
cugbp, Elav-like family member 5a
chr24_+_35881124 0.29 ENSDART00000143015
kelch-like family member 14
chr21_+_6751405 0.29 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr2_-_35566938 0.28 ENSDART00000029006
ENSDART00000077178
ENSDART00000125298
tenascin N
chr23_+_28731379 0.27 ENSDART00000047378
cortistatin
chr5_-_16996482 0.26 ENSDART00000144501
polypeptide N-acetylgalactosaminyltransferase 9
chr2_-_16216568 0.24 ENSDART00000173758
Rho guanine nucleotide exchange factor (GEF) 4
chr12_+_20352400 0.22 ENSDART00000066383
hemoglobin, alpha embryonic 5
chr20_+_37294112 0.22 ENSDART00000076293
ENSDART00000140450
connexin 23
chr15_-_9272328 0.22 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr13_+_19322686 0.20 ENSDART00000058036
empty spiracles homeobox 2
chr21_+_28958471 0.19 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr7_+_36898850 0.19 ENSDART00000113342
TOX high mobility group box family member 3
chr11_-_3865472 0.18 ENSDART00000161426
GATA binding protein 2a
chr2_-_15324837 0.18 ENSDART00000015655
trans-2,3-enoyl-CoA reductase-like 2b
chr1_+_9290103 0.18 ENSDART00000055009
Unc4.1 homeobox (C. elegans)
chr9_+_50001746 0.18 ENSDART00000058892
solute carrier family 38, member 11
chr24_-_21923930 0.17 ENSDART00000131944
transgelin 3b
chr21_-_37790727 0.17 ENSDART00000162907
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr20_+_35382482 0.15 ENSDART00000135284
visinin-like 1a
chr14_+_23717165 0.15 ENSDART00000006373
Nedd4 family interacting protein 1
chr17_+_31185276 0.14 ENSDART00000062887
dispatched homolog 2 (Drosophila)
chr21_+_25231160 0.14 ENSDART00000063089
ENSDART00000139127
guanine nucleotide binding protein (G protein), gamma 8
chr12_-_19862912 0.14 ENSDART00000145788
shisa family member 9a
chr3_-_46817499 0.14 ENSDART00000013717
ELAV like neuron-specific RNA binding protein 3
chr13_-_42560662 0.13 ENSDART00000124898

chr5_-_64831207 0.12 ENSDART00000144816
limb and CNS expressed 1
chr18_-_1185772 0.12 ENSDART00000143245
neuroplastin b
chr14_-_7207961 0.11 ENSDART00000167994
ENSDART00000166532
storkhead box 2b
chr15_-_16098531 0.11 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr21_+_33172526 0.11 ENSDART00000183532
ADP-ribosylation factor-like 3, like 1
chr11_-_29768054 0.11 ENSDART00000079117
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr20_-_37813863 0.10 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr1_+_55755304 0.10 ENSDART00000144983
trans-2,3-enoyl-CoA reductase b
chr24_-_25004553 0.10 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr20_+_29209615 0.10 ENSDART00000062350
katanin p80 subunit B-like 1
chr14_+_25817628 0.10 ENSDART00000047680
glycine receptor, alpha 1
chr20_+_29209767 0.09 ENSDART00000141252
katanin p80 subunit B-like 1
chr18_+_14529005 0.09 ENSDART00000186379
potassium voltage-gated channel, subfamily G, member 4a
chr6_-_32726848 0.09 ENSDART00000155294
zinc finger CCCH-type containing 3
chr23_-_19230627 0.08 ENSDART00000007122
guanylate cyclase activator 1B
chr9_+_11532025 0.08 ENSDART00000109037
cyclin-dependent kinase 5, regulatory subunit 2b (p39)
chr24_-_23320223 0.07 ENSDART00000135846
zinc finger homeobox 4
chr17_+_3379673 0.07 ENSDART00000176354
syntrophin, gamma 2
chr11_+_18873619 0.07 ENSDART00000176141
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr14_+_23874062 0.06 ENSDART00000172149
SH3 domain containing ring finger 2
chr21_+_32820175 0.06 ENSDART00000076903
adrenergic, alpha-2D-, receptor b
chr20_+_29209926 0.06 ENSDART00000152949
ENSDART00000153016
katanin p80 subunit B-like 1
chr25_+_11456696 0.06 ENSDART00000171408
si:ch73-141f14.1
chr23_+_28582865 0.05 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr24_+_1023839 0.05 ENSDART00000082526
zgc:111976
chr12_-_35095414 0.05 ENSDART00000153229
si:dkey-21e13.3
chr19_+_22062202 0.05 ENSDART00000100181
spalt-like transcription factor 3b
chr9_-_5263947 0.04 ENSDART00000088342
cytohesin 1 interacting protein
chr20_-_20270191 0.04 ENSDART00000009356
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr19_-_5265155 0.03 ENSDART00000145003
perforin 1.3
chr3_-_46811611 0.03 ENSDART00000134092
ELAV like neuron-specific RNA binding protein 3
chr24_+_39518774 0.03 ENSDART00000132939
defective in cullin neddylation 1 domain containing 3
chr3_+_17537352 0.03 ENSDART00000104549
hypocretin (orexin) neuropeptide precursor
chr23_-_24195519 0.03 ENSDART00000112370
ENSDART00000180377
anoctamin 11
chr5_-_27438812 0.03 ENSDART00000078755
dopamine receptor D7
chr5_-_48268049 0.03 ENSDART00000187454
myocyte enhancer factor 2cb
chr11_+_18873113 0.02 ENSDART00000103969
ENSDART00000103968
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr6_-_39198912 0.02 ENSDART00000077938
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr6_-_39199070 0.02 ENSDART00000131793
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr8_+_18588551 0.02 ENSDART00000177476
ENSDART00000063539
proline rich Gla (G-carboxyglutamic acid) 1
chr1_-_17715493 0.02 ENSDART00000133027
si:dkey-256e7.8
chr14_+_21820034 0.02 ENSDART00000122739
C-terminal binding protein 1
chr8_-_23776399 0.01 ENSDART00000114800
si:ch211-163l21.4
chr20_-_46362606 0.01 ENSDART00000153087
BCL2 modifying factor 2
chr22_+_9003090 0.01 ENSDART00000106414
ribonuclease/angiogenin inhibitor 1
chr6_-_8264751 0.01 ENSDART00000091628
coiled-coil domain containing 151
chr5_-_28109416 0.01 ENSDART00000042002
si:ch211-48m9.1
chr4_+_11464255 0.01 ENSDART00000008584
GDP dissociation inhibitor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of vsx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.1 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.2 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.6 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:1902387 ceramide transporter activity(GO:0035620) ceramide 1-phosphate binding(GO:1902387) ceramide 1-phosphate transporter activity(GO:1902388)
0.0 0.2 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events