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PRJEB1986: zebrafish developmental stages transcriptome

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Results for vsx1_shox_shox2_uncx4.1_lhx2a

Z-value: 0.89

Motif logo

Transcription factors associated with vsx1_shox_shox2_uncx4.1_lhx2a

Gene Symbol Gene ID Gene Info
ENSDARG00000056292 visual system homeobox 1 homolog, chx10-like
ENSDARG00000109766 visual system homeobox 1 homolog, chx10-like
ENSDARG00000025891 short stature homeobox
ENSDARG00000075713 short stature homeobox 2
ENSDARG00000037760 Unc4.1 homeobox (C. elegans)
ENSDARG00000037964 LIM homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
vsx1dr11_v1_chr17_-_21066075_21066105-0.512.6e-02Click!
uncx4.1dr11_v1_chr1_+_9290103_92901030.455.5e-02Click!
shox2dr11_v1_chr15_-_2188332_2188422-0.418.2e-02Click!
shoxdr11_v1_chr9_+_34641237_34641237-0.321.9e-01Click!
lhx2adr11_v1_chr21_-_8420830_84208300.194.3e-01Click!

Activity profile of vsx1_shox_shox2_uncx4.1_lhx2a motif

Sorted Z-values of vsx1_shox_shox2_uncx4.1_lhx2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_26596794 3.61 ENSDART00000134685
ENSDART00000056787
zgc:113691
chr4_+_306036 2.67 ENSDART00000103659
mesogenin 1
chr22_+_18315490 2.49 ENSDART00000160413
GATA zinc finger domain containing 2Ab
chr2_+_20793982 2.40 ENSDART00000014785
proteoglycan 4a
chr13_+_22295905 2.00 ENSDART00000180133
ENSDART00000181125
ubiquitin specific peptidase 54a
chr5_-_12219572 1.96 ENSDART00000167834
nitric oxide synthase 1 (neuronal)
chr12_-_35830625 1.94 ENSDART00000180028

chr19_+_15440841 1.91 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr2_-_30668580 1.80 ENSDART00000087270
catenin (cadherin-associated protein), delta 2b
chr9_-_20372977 1.72 ENSDART00000113418
immunoglobulin superfamily, member 3
chr23_-_17003533 1.71 ENSDART00000080545
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr17_-_16422654 1.61 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr18_-_33979693 1.60 ENSDART00000021215
si:ch211-203b20.7
chr2_-_55298075 1.55 ENSDART00000186404
ENSDART00000149062
RAB8A, member RAS oncogene family
chr15_-_4528326 1.53 ENSDART00000158122
ENSDART00000155619
ENSDART00000128602
transcription factor Dp-2
chr19_+_15441022 1.53 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr16_-_16761164 1.52 ENSDART00000135872
si:dkey-27n14.1
chr16_+_29509133 1.50 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr24_+_19415124 1.49 ENSDART00000186931
sulfatase 1
chr2_+_41526904 1.49 ENSDART00000127520
activin A receptor, type 1 like
chr25_+_14507567 1.46 ENSDART00000015681
developing brain homeobox 1b
chr6_-_43283122 1.46 ENSDART00000186022
FERM domain containing 4Ba
chr9_+_25776971 1.40 ENSDART00000146011
zinc finger E-box binding homeobox 2a
chr22_+_16535575 1.40 ENSDART00000083063
T-cell acute lymphocytic leukemia 1
chr15_+_34988148 1.36 ENSDART00000076269
coiled-coil domain containing 105
chr5_+_60590796 1.35 ENSDART00000159859
transmembrane protein 132E
chr8_-_50888806 1.30 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr15_+_17258246 1.25 ENSDART00000101707
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr20_-_9095105 1.17 ENSDART00000140792
OMA1 zinc metallopeptidase
chr16_+_28994709 1.12 ENSDART00000088023
gon-4-like (C. elegans)
chr8_+_21353878 1.09 ENSDART00000056420
aminolevulinate, delta-, synthase 2
chr18_+_24921587 1.07 ENSDART00000191345
repulsive guidance molecule family member a
chr15_-_16177603 1.05 ENSDART00000156352
si:ch211-259g3.4
chr6_-_40922971 1.04 ENSDART00000155363
SFI1 centrin binding protein
chr2_-_7246848 1.02 ENSDART00000146434
zgc:153115
chr20_-_22476255 1.02 ENSDART00000103510
platelet-derived growth factor receptor, alpha polypeptide
chr4_-_56954002 0.98 ENSDART00000160934
si:dkey-269o24.1
chr6_+_41191482 0.98 ENSDART00000000877
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr10_+_6884627 0.96 ENSDART00000125262
ENSDART00000121729
ENSDART00000105384
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr2_-_38363017 0.95 ENSDART00000088026
protein arginine methyltransferase 5
chr23_-_33709964 0.94 ENSDART00000143333
ENSDART00000130338
POU class 6 homeobox 1
chr15_+_1796313 0.94 ENSDART00000126253
family with sequence similarity 124B
chr4_-_9891874 0.92 ENSDART00000067193
adrenomedullin 2a
chr23_+_38251864 0.91 ENSDART00000183498
ENSDART00000129593
zinc finger protein 217
chr11_+_33818179 0.91 ENSDART00000109418
speckle-type POZ protein-like b
chr5_+_66433287 0.90 ENSDART00000170757
kinetochore associated 1
chr20_-_48485354 0.88 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr18_-_2433011 0.87 ENSDART00000181922
ENSDART00000193276

chr8_+_23355484 0.86 ENSDART00000085361
ENSDART00000125729
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr20_-_23426339 0.86 ENSDART00000004625
zygote arrest 1
chr24_-_6078222 0.85 ENSDART00000146830
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr11_-_35171162 0.85 ENSDART00000017393
TRAF-interacting protein
chr2_-_38206034 0.84 ENSDART00000144518
ENSDART00000137395
apoptotic chromatin condensation inducer 1a
chr13_+_27232848 0.84 ENSDART00000138043
Ras and Rab interactor 2
chr3_-_16719244 0.83 ENSDART00000055859
polymerase (DNA directed), delta 1, catalytic subunit
chr17_-_31659670 0.83 ENSDART00000030448
visual system homeobox 2
chr25_-_20378721 0.82 ENSDART00000181707
potassium channel tetramerization domain containing 15a
chr21_-_37973819 0.82 ENSDART00000133405
ripply transcriptional repressor 1
chr11_+_18873113 0.80 ENSDART00000103969
ENSDART00000103968
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr18_-_15551360 0.80 ENSDART00000159915
ENSDART00000172690
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr1_+_10318089 0.80 ENSDART00000029774
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr6_+_39232245 0.79 ENSDART00000187351
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr16_+_25116827 0.79 ENSDART00000163244
si:ch211-261d7.6
chr23_+_39695827 0.79 ENSDART00000113893
ENSDART00000186679
transmembrane and coiled-coil domains 4
chr13_-_31017960 0.78 ENSDART00000145287
WDFY family member 4
chr18_-_25568994 0.78 ENSDART00000133029
si:ch211-13k12.2
chr5_-_30481263 0.78 ENSDART00000086734
pleckstrin homology-like domain, family B, member 1a
chr6_-_8311044 0.78 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr14_-_22113600 0.77 ENSDART00000113752
si:dkey-6i22.5
chr23_-_31913231 0.76 ENSDART00000146852
ENSDART00000085054
mitochondrial fission regulator 2
chr24_-_25144441 0.76 ENSDART00000152104
pleckstrin homology-like domain, family B, member 2b
chr20_-_28642061 0.76 ENSDART00000135513
regulator of G protein signaling 6
chr1_-_5455498 0.76 ENSDART00000040368
ENSDART00000114035
motor neuron and pancreas homeobox 2b
chr13_-_31008275 0.76 ENSDART00000139394
WDFY family member 4
chr17_-_49438873 0.75 ENSDART00000004424
zinc finger protein 292a
chr14_+_45406299 0.75 ENSDART00000173142
ENSDART00000112377
microtubule-associated protein 1 light chain 3 gamma, like
chr6_-_43616936 0.74 ENSDART00000149301
forkhead box P1b
chr3_-_26183699 0.74 ENSDART00000147517
ENSDART00000140731
si:ch211-11k18.4
chr19_+_2631565 0.74 ENSDART00000171487
family with sequence similarity 126, member A
chr1_+_21731382 0.73 ENSDART00000054395
paired box 5
chr3_-_21094437 0.73 ENSDART00000153739
ENSDART00000109790
nemo-like kinase, type 1
chr1_-_55248496 0.73 ENSDART00000098615
nanos homolog 3
chr18_+_17827149 0.70 ENSDART00000190237
ENSDART00000189345
si:ch211-216l23.1
chr17_+_21295132 0.69 ENSDART00000103845
enolase family member 4
chr1_+_34696503 0.69 ENSDART00000186106

chr8_-_23612462 0.69 ENSDART00000025024
solute carrier family 38, member 5b
chr3_-_23643751 0.68 ENSDART00000078425
ENSDART00000140264
even-skipped-like1
chr9_-_35633827 0.68 ENSDART00000077745
zona pellucida glycoprotein 2, like 1
chr17_+_16046314 0.67 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr10_+_16584382 0.66 ENSDART00000112039

chr23_-_18130264 0.66 ENSDART00000016976
nuclear casein kinase and cyclin-dependent kinase substrate 1b
chr19_+_22062202 0.66 ENSDART00000100181
spalt-like transcription factor 3b
chr8_+_11425048 0.65 ENSDART00000018739
tight junction protein 2b (zona occludens 2)
chr5_-_25733745 0.65 ENSDART00000051566
zgc:101016
chr15_-_2493771 0.65 ENSDART00000184906
sialidase 4
chr19_-_19871211 0.65 ENSDART00000170980
even-skipped homeobox 1
chr23_+_11285662 0.65 ENSDART00000111028
cell adhesion molecule L1-like a
chr13_+_30903816 0.64 ENSDART00000191727
excision repair cross-complementation group 6
chr21_-_40676224 0.64 ENSDART00000162623
aristaless related homeobox b
chr13_+_38817871 0.64 ENSDART00000187708
collagen, type XIX, alpha 1
chr5_+_68807170 0.64 ENSDART00000017849
hairy and enhancer of split related-7
chr6_-_12172424 0.63 ENSDART00000109344
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr4_+_31405646 0.63 ENSDART00000128732
si:rp71-5o12.3
chr23_-_31913069 0.63 ENSDART00000135526
mitochondrial fission regulator 2
chr2_+_33326522 0.63 ENSDART00000056655
Kruppel-like factor 17
chr7_+_24023653 0.63 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr21_+_25802190 0.62 ENSDART00000128987
neurofibromin 2b (merlin)
chr21_+_34088110 0.62 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr18_+_19456648 0.62 ENSDART00000079695
zwilch kinetochore protein
chr24_-_40860603 0.62 ENSDART00000188032

chr21_-_18648861 0.61 ENSDART00000112113
si:dkey-112m2.1
chr4_+_13586689 0.61 ENSDART00000067161
ENSDART00000138201
transportin 3
chr12_-_43664682 0.60 ENSDART00000159423
forkhead box i1
chr24_+_9412450 0.60 ENSDART00000132724
si:ch211-285f17.1
chr5_-_14326959 0.60 ENSDART00000137355
tet methylcytosine dioxygenase 3
chr19_-_30510259 0.60 ENSDART00000135128
ENSDART00000186169
ENSDART00000182974
ENSDART00000187797
BCL2 associated athanogene 6, like
chr8_+_17168114 0.59 ENSDART00000183901
centromere protein H
chr6_+_40922572 0.59 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr3_-_30488063 0.58 ENSDART00000055393
ENSDART00000151367
mediator complex subunit 25
chr10_-_21362320 0.58 ENSDART00000189789
avidin
chr9_-_32753535 0.58 ENSDART00000060006
oligodendrocyte lineage transcription factor 2
chr2_+_4146606 0.57 ENSDART00000171170
mindbomb E3 ubiquitin protein ligase 1
chr3_-_46811611 0.57 ENSDART00000134092
ELAV like neuron-specific RNA binding protein 3
chr24_-_34680956 0.57 ENSDART00000171009
catenin (cadherin-associated protein), alpha 1
chr11_-_29563437 0.57 ENSDART00000163958
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr19_-_19379084 0.57 ENSDART00000165206
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b
chr25_+_35891342 0.56 ENSDART00000147093
LSM14A mRNA processing body assembly factor a
chr2_+_6253246 0.56 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr24_-_2450597 0.56 ENSDART00000188080
ENSDART00000093331
ras responsive element binding protein 1a
chr17_+_21964472 0.56 ENSDART00000063704
ENSDART00000188904
cysteine-rich protein 3
chr17_+_24821627 0.55 ENSDART00000112389
WD repeat domain 43
chr17_+_12865746 0.55 ENSDART00000157083
Ral GTPase activating protein, alpha subunit 1 (catalytic)
chr12_-_33972798 0.55 ENSDART00000105545
ADP-ribosylation factor-like 3
chr2_-_38284648 0.55 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr10_-_21362071 0.55 ENSDART00000125167
avidin
chr16_+_54209504 0.55 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr20_+_539852 0.55 ENSDART00000185994
dermatan sulfate epimerase
chr5_-_41307550 0.55 ENSDART00000143446
natriuretic peptide receptor 3
chr19_+_19786117 0.54 ENSDART00000167757
ENSDART00000163546
homeobox A1a
chr3_+_18807006 0.53 ENSDART00000180091
transportin 2 (importin 3, karyopherin beta 2b)
chr15_+_27384798 0.52 ENSDART00000164887
T-box 4
chr2_+_4146299 0.52 ENSDART00000173418
mindbomb E3 ubiquitin protein ligase 1
chr4_+_11723852 0.52 ENSDART00000028820
muskelin 1, intracellular mediator containing kelch motifs
chr4_+_9400012 0.51 ENSDART00000191960
transmembrane and tetratricopeptide repeat containing 1
chr10_+_17714866 0.51 ENSDART00000039969
solute carrier family 20 (phosphate transporter), member 1b
chr23_-_29553430 0.51 ENSDART00000157773
ENSDART00000126384
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr24_+_1023839 0.51 ENSDART00000082526
zgc:111976
chr5_+_38900249 0.51 ENSDART00000097856
Fraser extracellular matrix complex subunit 1
chr3_+_32365811 0.50 ENSDART00000155967
adaptor-related protein complex 2, alpha 1 subunit
chr17_-_41798856 0.50 ENSDART00000156031
ENSDART00000192801
ENSDART00000180172
ENSDART00000084745
ENSDART00000175577
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr7_+_29167744 0.49 ENSDART00000076345
solute carrier family 38, member 8b
chr10_+_43039947 0.49 ENSDART00000193434
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr6_-_8392104 0.48 ENSDART00000081561
ENSDART00000181178
interleukin enhancer binding factor 3a
chr7_+_25221757 0.48 ENSDART00000173551
exocyst complex component 6B
chr3_+_26244353 0.48 ENSDART00000103733
ATPase family, AAA domain containing 5a
chr23_-_29553691 0.48 ENSDART00000053804
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr10_+_17371356 0.47 ENSDART00000122663
signal peptide peptidase 3
chr15_-_20024205 0.47 ENSDART00000161379
autism susceptibility candidate 2b
chr17_-_2690083 0.47 ENSDART00000135374
protein tyrosine phosphatase, non-receptor type 21
chr1_-_36152131 0.47 ENSDART00000182113
ENSDART00000182904
zinc finger protein 827
chr7_-_31759602 0.47 ENSDART00000113467
immunoglobulin superfamily, DCC subclass, member 4
chr17_+_23298928 0.47 ENSDART00000153652
zgc:165461
chr1_+_30100257 0.47 ENSDART00000134311
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr10_-_33297864 0.47 ENSDART00000163360
PR/SET domain 15
chr7_-_31759394 0.46 ENSDART00000193040
immunoglobulin superfamily, DCC subclass, member 4
chr21_+_30746348 0.45 ENSDART00000050172
transient receptor potential cation channel, subfamily C, member 2b
chr14_-_33945692 0.45 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr3_-_58798815 0.45 ENSDART00000082920
si:ch73-281f12.4
chr10_+_17235370 0.45 ENSDART00000038780
signal peptide peptidase 3
chr17_-_10122204 0.44 ENSDART00000160751

chr9_+_24008879 0.44 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
melanophilin b
chr7_-_30174882 0.44 ENSDART00000110409
FERM domain containing 5
chr21_+_15592426 0.44 ENSDART00000138207
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr2_-_28085884 0.44 ENSDART00000131506
cadherin 6
chr11_-_36341028 0.43 ENSDART00000146093
sortilin 1a
chr17_+_1496107 0.43 ENSDART00000187804

chr3_-_26787430 0.43 ENSDART00000087047
RAB40c, member RAS oncogene family
chr14_+_35428152 0.43 ENSDART00000172597
synaptotagmin-like 4
chr9_+_7732714 0.43 ENSDART00000145853
si:ch1073-349o24.2
chr21_-_37194365 0.42 ENSDART00000100286
fibroblast growth factor receptor 4
chr1_-_40102836 0.42 ENSDART00000147317
ciliary neurotrophic factor
chr9_+_38457806 0.42 ENSDART00000142512
minichromosome maintenance complex component 3 associated protein
chr9_+_38372216 0.42 ENSDART00000141895
phospholipase C, delta 4b
chr9_+_25568839 0.41 ENSDART00000177342
zinc finger E-box binding homeobox 2a
chr8_-_37249813 0.41 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
RNA binding motif protein 39b
chr14_+_22113331 0.41 ENSDART00000109759
thioredoxin-related transmembrane protein 2a
chr8_-_15129573 0.41 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr5_-_68333081 0.41 ENSDART00000168786
linker histone H1M
chr14_+_34971554 0.41 ENSDART00000184271
ring finger protein 145a
chr22_+_5176255 0.41 ENSDART00000092647
ceramide synthase 1
chr22_-_8725768 0.40 ENSDART00000189873
ENSDART00000181819
si:ch73-27e22.1
si:ch73-27e22.8
chr11_+_24820542 0.40 ENSDART00000135443
lysine (K)-specific demethylase 5Ba
chr8_-_15292197 0.40 ENSDART00000140867
spermatogenesis associated 6
chr19_+_21362553 0.40 ENSDART00000122002
teashirt zinc finger homeobox 1
chr17_+_16046132 0.40 ENSDART00000155005
si:ch73-204p21.2
chr21_-_25801956 0.40 ENSDART00000101219
methyltransferase like 27
chr13_+_22476742 0.40 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
LIM domain binding 3a
chr5_+_6954162 0.39 ENSDART00000086666
sperm-tail PG-rich repeat containing 2
chr23_-_1017605 0.39 ENSDART00000138290
cadherin 26, tandem duplicate 1
chr10_+_16092671 0.39 ENSDART00000182761
ENSDART00000154835
multiple EGF-like-domains 10

Network of associatons between targets according to the STRING database.

First level regulatory network of vsx1_shox_shox2_uncx4.1_lhx2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0048340 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.7 2.0 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.5 1.4 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.4 2.2 GO:0000012 single strand break repair(GO:0000012)
0.4 1.6 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.4 1.5 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.4 1.1 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408) spinal cord association neuron specification(GO:0021519)
0.3 1.7 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.3 1.8 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.2 1.2 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.2 0.9 GO:0034969 histone arginine methylation(GO:0034969)
0.2 1.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 0.6 GO:0048785 hatching gland development(GO:0048785)
0.2 0.8 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.2 1.0 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.2 2.2 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.2 0.8 GO:0015871 choline transport(GO:0015871)
0.2 1.5 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.2 0.7 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.2 0.7 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.2 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 0.6 GO:0048890 epidermal cell fate specification(GO:0009957) lateral line ganglion development(GO:0048890)
0.1 1.2 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.6 GO:0021742 abducens nucleus development(GO:0021742)
0.1 0.4 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1 0.6 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1 0.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.5 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.1 0.9 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.1 0.3 GO:0060898 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.3 GO:0033512 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 0.7 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.7 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.1 0.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.2 GO:0030910 olfactory placode formation(GO:0030910)
0.1 0.7 GO:0060114 reflex(GO:0060004) vestibular reflex(GO:0060005) vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.1 1.3 GO:2000344 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:0010990 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.4 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.1 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.4 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.1 0.7 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.6 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395)
0.1 1.1 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 1.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.2 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.1 0.3 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 1.0 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.1 0.2 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.1 1.0 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 0.2 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.1 0.6 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 0.3 GO:2000742 regulation of anterior head development(GO:2000742)
0.1 1.3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 1.5 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 0.1 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.8 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.6 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.6 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.2 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508)
0.0 1.0 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.3 GO:0033687 osteoblast proliferation(GO:0033687)
0.0 0.1 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.1 GO:0007414 axonal defasciculation(GO:0007414)
0.0 0.1 GO:0090219 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.2 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0009595 detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581)
0.0 0.1 GO:0043584 nose development(GO:0043584)
0.0 0.2 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.0 0.1 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.1 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.1 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.0 1.5 GO:0021515 cell differentiation in spinal cord(GO:0021515)
0.0 0.1 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 0.2 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.2 GO:0098773 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.0 0.1 GO:0051645 Golgi localization(GO:0051645)
0.0 0.2 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.3 GO:1901099 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.6 GO:0060021 palate development(GO:0060021)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.5 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0032042 mitochondrial DNA replication(GO:0006264) mitochondrial DNA metabolic process(GO:0032042)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.1 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 1.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.0 0.2 GO:0045738 negative regulation of DNA repair(GO:0045738) negative regulation of double-strand break repair(GO:2000780)
0.0 0.5 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.0 0.2 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0070285 pigment cell development(GO:0070285)
0.0 0.7 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 0.1 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 1.4 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.1 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 1.4 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.1 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.0 0.4 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.5 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.2 GO:0060030 dorsal convergence(GO:0060030)
0.0 0.1 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.5 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.8 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 1.8 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.0 GO:0031645 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.0 0.1 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.5 GO:0050768 negative regulation of neurogenesis(GO:0050768) negative regulation of nervous system development(GO:0051961)
0.0 0.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0031057 negative regulation of histone modification(GO:0031057)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 1.8 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.8 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.7 GO:0007602 phototransduction(GO:0007602)
0.0 0.2 GO:0031297 replication fork processing(GO:0031297)
0.0 1.0 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.6 GO:0001894 tissue homeostasis(GO:0001894)
0.0 0.4 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.0 0.4 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.6 GO:0001570 vasculogenesis(GO:0001570)
0.0 1.1 GO:0001756 somitogenesis(GO:0001756)
0.0 0.1 GO:0034505 tooth mineralization(GO:0034505)
0.0 1.6 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.5 GO:0018198 peptidyl-cysteine modification(GO:0018198)
0.0 0.4 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.1 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.2 GO:0036294 cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.0 0.9 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.2 GO:0048769 sarcomerogenesis(GO:0048769)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0070724 BMP receptor complex(GO:0070724)
0.2 0.9 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 0.6 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.2 0.8 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.2 0.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 2.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.7 GO:0071818 BAT3 complex(GO:0071818)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.4 GO:0070390 transcription export complex 2(GO:0070390)
0.1 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.4 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.3 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 1.8 GO:0045180 basal cortex(GO:0045180)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.5 GO:0030897 HOPS complex(GO:0030897)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.1 1.7 GO:0043186 P granule(GO:0043186)
0.0 0.1 GO:0097189 apoptotic body(GO:0097189)
0.0 0.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0070187 telosome(GO:0070187)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 2.1 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0035101 FACT complex(GO:0035101)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 3.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.3 GO:0005795 Golgi stack(GO:0005795)
0.0 3.1 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.4 1.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 0.9 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 2.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 1.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.2 1.1 GO:0009374 biotin binding(GO:0009374)
0.2 2.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 0.8 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 0.5 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 1.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.1 1.0 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 1.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.5 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.3 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.4 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.1 1.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.4 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.3 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 1.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.8 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.2 GO:0045545 syndecan binding(GO:0045545)
0.1 0.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.6 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.2 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.0 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.2 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 1.1 GO:0051020 GTPase binding(GO:0051020)
0.0 3.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.2 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 1.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.9 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.1 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 1.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0016918 retinal binding(GO:0016918)
0.0 0.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.4 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0060182 apelin receptor activity(GO:0060182)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 2.0 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.0 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.0 1.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0071558 histone demethylase activity (H4-K20 specific)(GO:0035575) histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.0 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.4 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0017022 myosin binding(GO:0017022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 3.2 PID E2F PATHWAY E2F transcription factor network
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.5 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID P73PATHWAY p73 transcription factor network
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.8 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.6 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 0.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME BASE EXCISION REPAIR Genes involved in Base Excision Repair
0.0 0.9 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 2.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways