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PRJEB1986: zebrafish developmental stages transcriptome

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Results for twist1a+twist1b+twist3

Z-value: 0.36

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Transcription factors associated with twist1a+twist1b+twist3

Gene Symbol Gene ID Gene Info
twist3
ENSDARG00000019646 twist3
twist1a
ENSDARG00000030402 twist family bHLH transcription factor 1a
twist1b
ENSDARG00000076010 twist family bHLH transcription factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
twist1bdr11_v1_chr16_+_19732543_19732543-0.502.8e-02Click!
twist1adr11_v1_chr19_-_2231146_22311880.445.8e-02Click!
twist3dr11_v1_chr23_+_2669_2669-0.409.1e-02Click!

Activity profile of twist1a+twist1b+twist3 motif

Sorted Z-values of twist1a+twist1b+twist3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_46216703 0.40 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr21_-_43666420 0.37 ENSDART00000139008
ENSDART00000183996
ENSDART00000183395
si:dkey-229d11.3
si:dkey-229d11.5
si:dkey-229d11.3
si:dkey-229d11.5
chr14_-_31087830 0.35 ENSDART00000002250
hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr12_-_11294979 0.35 ENSDART00000148850
get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr5_-_32505109 0.35 ENSDART00000188219
ntmt1
N-terminal Xaa-Pro-Lys N-methyltransferase 1
chr20_+_36623807 0.33 ENSDART00000149171
ENSDART00000062895
srp9
signal recognition particle 9
chr17_+_1360192 0.33 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr23_-_21471022 0.33 ENSDART00000104206
her4.2
hairy-related 4, tandem duplicate 2
chr13_-_12602920 0.31 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr20_-_2134620 0.31 ENSDART00000064375
tmem244
transmembrane protein 244
chr20_-_22193190 0.30 ENSDART00000047624
tmem165
transmembrane protein 165
chr6_-_55423220 0.29 ENSDART00000158929
ctsa
cathepsin A
chr13_-_31296358 0.27 ENSDART00000030946
prdm8
PR domain containing 8
chr22_-_5752009 0.24 ENSDART00000190052
bcdin3d
BCDIN3 domain containing
chr5_+_53482597 0.24 ENSDART00000180333
BX323994.1

chr13_+_25486608 0.23 ENSDART00000057689
bag3
BCL2 associated athanogene 3
chr22_-_26251563 0.23 ENSDART00000060888
ENSDART00000142821
ccdc130
coiled-coil domain containing 130
chr11_-_34232906 0.23 ENSDART00000162150
lsg1
large 60S subunit nuclear export GTPase 1
chr6_-_10728921 0.22 ENSDART00000151484
sp3b
Sp3b transcription factor
chr13_-_9119867 0.22 ENSDART00000137255
si:dkey-112g5.15
si:dkey-112g5.15
chr4_+_77973876 0.22 ENSDART00000057423
terfa
telomeric repeat binding factor a
chr6_-_10728057 0.20 ENSDART00000002247
sp3b
Sp3b transcription factor
chr5_-_11809404 0.20 ENSDART00000132564
nf2a
neurofibromin 2a (merlin)
chr18_-_35842554 0.19 ENSDART00000088488
opa3
optic atrophy 3
chr2_-_10896745 0.19 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr13_-_36579086 0.18 ENSDART00000146671
lgals3a
lectin, galactoside binding soluble 3a
chr15_-_1590858 0.17 ENSDART00000081875
nnr
nanor
chr17_-_40876680 0.15 ENSDART00000127200
supt7l
SPT7-like STAGA complex gamma subunit
chr23_-_36313431 0.15 ENSDART00000125860
nfe2
nuclear factor, erythroid 2
chr7_+_4671483 0.15 ENSDART00000111390
si:ch211-225k7.6
si:ch211-225k7.6
chr24_+_39660124 0.14 ENSDART00000066500
stub1
STIP1 homology and U-Box containing protein 1
chr3_+_58472305 0.14 ENSDART00000154122
si:ch211-165g14.1
si:ch211-165g14.1
chr4_+_33830944 0.13 ENSDART00000170238
znf1026
zinc finger protein 1026
chr8_+_247163 0.13 ENSDART00000122378
cep120
centrosomal protein 120
chr23_+_2914577 0.13 ENSDART00000184897
DHX35
zgc:158828
chr10_+_40737540 0.11 ENSDART00000125577
taar19a
trace amine associated receptor 19a
chr7_+_17485782 0.11 ENSDART00000098083
CU179759.1
Danio rerio novel immune-type receptor 1d (nitr1d), mRNA.
chr3_+_24190207 0.11 ENSDART00000034762
prr15la
proline rich 15-like a
chr18_+_33100606 0.10 ENSDART00000003907
si:ch211-229c8.13
si:ch211-229c8.13
chr6_+_42693114 0.10 ENSDART00000154353
si:ch211-207d10.2
si:ch211-207d10.2
chr3_+_59411956 0.10 ENSDART00000166982
sec14l1
SEC14-like lipid binding 1
chr21_-_5879897 0.10 ENSDART00000184034
rpl35
ribosomal protein L35
chr6_-_16981321 0.10 ENSDART00000154585
pimr29
Pim proto-oncogene, serine/threonine kinase, related 29
chr6_+_16982613 0.10 ENSDART00000156104
pimr8
Pim proto-oncogene, serine/threonine kinase, related 8
chr20_-_46046758 0.09 ENSDART00000127455
taar12j
trace amine associated receptor 12j
chr4_-_71177920 0.09 ENSDART00000158287
si:dkey-193i10.1
si:dkey-193i10.1
chr12_-_44180132 0.09 ENSDART00000165998
si:ch73-329n5.1
si:ch73-329n5.1
chr24_-_25184553 0.08 ENSDART00000166917
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr5_-_65159258 0.08 ENSDART00000160429
sh2d3cb
SH2 domain containing 3Cb
chr16_-_21047872 0.08 ENSDART00000131582
cbx3b
chromobox homolog 3b
chr8_-_14067517 0.07 ENSDART00000140948
dedd
death effector domain containing
chr15_-_46736432 0.07 ENSDART00000124567
ilkap
integrin-linked kinase-associated serine/threonine phosphatase
chr18_+_45666489 0.07 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_+_45925150 0.06 ENSDART00000074689
eif5b
eukaryotic translation initiation factor 5B
chr3_+_49021079 0.06 ENSDART00000162012
zgc:163083
zgc:163083
chr21_-_35419486 0.06 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr4_-_17725008 0.06 ENSDART00000016658
chpt1
choline phosphotransferase 1
chr4_-_36476889 0.04 ENSDART00000163956
si:ch211-263l8.1
si:ch211-263l8.1
chr16_-_31791165 0.04 ENSDART00000148389
chd4b
chromodomain helicase DNA binding protein 4b
chr9_-_40014339 0.04 ENSDART00000166918
IKZF2
si:zfos-1425h8.1
chr14_+_18785727 0.04 ENSDART00000184452
si:ch211-111e20.1
si:ch211-111e20.1
chr23_-_44574059 0.03 ENSDART00000123007
si:ch73-160p18.3
si:ch73-160p18.3
chr18_+_7345417 0.03 ENSDART00000041429
glipr1b
GLI pathogenesis-related 1b
chr25_+_25438322 0.03 ENSDART00000150364
LRRC56
si:ch211-103e16.5
chr6_+_18142623 0.02 ENSDART00000169431
ENSDART00000158841
si:dkey-237i9.8
si:dkey-237i9.8
chr3_+_16663373 0.01 ENSDART00000100961
zgc:55558
zgc:55558
chr5_-_15321451 0.01 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr15_-_766015 0.01 ENSDART00000190648
si:dkey-7i4.15
si:dkey-7i4.15
chr21_-_35325466 0.00 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr18_-_21859019 0.00 ENSDART00000100885
nrn1la
neuritin 1-like a

Network of associatons between targets according to the STRING database.

First level regulatory network of twist1a+twist1b+twist3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.1 0.3 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.1 0.4 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 0.2 GO:0010664 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 0.2 GO:1903798 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.1 0.2 GO:0032208 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.0 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.1 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.4 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.3 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.2 GO:0033750 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0015030 Cajal body(GO:0015030)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.1 0.4 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.3 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.2 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis