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PRJEB1986: zebrafish developmental stages transcriptome

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Results for thraa+thrab

Z-value: 1.05

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Transcription factors associated with thraa+thrab

Gene Symbol Gene ID Gene Info
ENSDARG00000000151 thyroid hormone receptor alpha a
ENSDARG00000052654 thyroid hormone receptor alpha b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
thrabdr11_v1_chr12_-_21834611_218346110.615.1e-03Click!
thraadr11_v1_chr3_-_34717882_347178820.561.2e-02Click!

Activity profile of thraa+thrab motif

Sorted Z-values of thraa+thrab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_39185761 8.45 ENSDART00000075992
ENSDART00000140644
crystallin, beta A1b
chr6_-_13783604 6.20 ENSDART00000149536
ENSDART00000041269
ENSDART00000150102
crystallin, beta A2a
chr9_-_22129788 5.64 ENSDART00000124272
ENSDART00000175417
crystallin, gamma M2d8
chr9_-_22245572 4.73 ENSDART00000114943
crystallin, gamma M2d4
chr9_-_22272181 4.73 ENSDART00000113174
crystallin, gamma M2d7
chr9_-_22135576 4.72 ENSDART00000101902
crystallin, gamma M2d8
chr21_+_39185461 4.62 ENSDART00000178419
crystallin, beta A1b
chr12_-_30841679 4.53 ENSDART00000105594
crystallin, gamma MX
chr9_-_22147567 4.04 ENSDART00000110941
crystallin, gamma M2d14
chr10_-_44027391 4.00 ENSDART00000145404
crystallin, beta B1
chr23_-_4855122 3.99 ENSDART00000133701
solute carrier family 6 (neurotransmitter transporter), member 1a
chr9_-_22299412 3.78 ENSDART00000139101
crystallin, gamma M2d21
chr20_+_30490682 3.65 ENSDART00000184871
myelin transcription factor 1-like, a
chr9_-_22205682 3.58 ENSDART00000101869
crystallin, gamma M2d12
chr9_-_22240052 3.49 ENSDART00000111109
crystallin, gamma M2d9
chr1_+_29096881 3.33 ENSDART00000075539
crystallin, alpha A
chr5_-_26118855 2.56 ENSDART00000009028
elastase 3 like
chr4_-_16853464 2.54 ENSDART00000125743
ENSDART00000164570
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a
chr5_-_29643381 2.40 ENSDART00000034849
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr11_-_44543082 2.34 ENSDART00000099568
G protein-coupled receptor 137Bb
chr11_+_25477643 2.25 ENSDART00000065941
opsin 1 (cone pigments), long-wave-sensitive, 1
chr20_+_5564042 2.24 ENSDART00000090934
ENSDART00000127050
neurexin 3b
chr19_+_10341738 1.97 ENSDART00000128721
recoverin 3
chr1_-_58975098 1.89 ENSDART00000189899

chr4_-_1360495 1.89 ENSDART00000164623
pleiotrophin
chr1_-_59176949 1.88 ENSDART00000128742

chr10_-_30785501 1.87 ENSDART00000020054
opioid binding protein/cell adhesion molecule-like
chr25_-_244263 1.79 ENSDART00000190224

chr16_+_5774977 1.77 ENSDART00000134202
cholecystokinin a
chr25_-_5740334 1.71 ENSDART00000169622
ENSDART00000168720

chr12_+_34896956 1.71 ENSDART00000055415
peripherin 2a (retinal degeneration, slow)
chr5_+_15350954 1.64 ENSDART00000140990
ENSDART00000137287
ENSDART00000061653
phosphatidylethanolamine binding protein 1
chr3_+_13440900 1.63 ENSDART00000143715
si:dkey-117i10.1
chr5_-_23277385 1.63 ENSDART00000134982
proteolipid protein 1b
chr8_+_36339470 1.60 ENSDART00000191250

chr5_-_23277939 1.57 ENSDART00000003514
proteolipid protein 1b
chr2_-_32643738 1.56 ENSDART00000112452
si:dkeyp-73d8.9
chr21_-_41870029 1.51 ENSDART00000182035
endonuclease, polyU-specific 2
chr13_+_22249636 1.49 ENSDART00000108472
ENSDART00000173123
synaptopodin 2-like a
chr9_-_49493305 1.47 ENSDART00000148707
ENSDART00000148561
xin actin binding repeat containing 2b
chr15_+_28096152 1.42 ENSDART00000100293
ENSDART00000140092
crystallin, beta B1, like 3
chr6_+_29305190 1.42 ENSDART00000078647
si:ch211-201h21.5
chr18_+_36037223 1.40 ENSDART00000144410
transmembrane protein 91
chr24_-_39610585 1.40 ENSDART00000066506
cytochrome c oxidase subunit VIb polypeptide 1
chr9_-_22892838 1.39 ENSDART00000143888
nebulin
chr1_-_22512063 1.38 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr11_+_42730639 1.37 ENSDART00000165297
zgc:194981
chr8_-_46894362 1.34 ENSDART00000111124
acyl-CoA thioesterase 7
chr23_-_7826849 1.32 ENSDART00000157612
myelin transcription factor 1b
chr19_-_47456787 1.31 ENSDART00000168792
transcription factor AP-2 epsilon
chr4_+_26496489 1.26 ENSDART00000160652
IQ motif and Sec7 domain 3a
chr19_-_6988837 1.24 ENSDART00000145741
ENSDART00000167640
zinc finger protein 384 like
chr7_-_30082931 1.23 ENSDART00000075600
tetraspanin 3b
chr9_-_22023061 1.23 ENSDART00000101952
crystallin, gamma M2c
chr14_+_36738069 1.21 ENSDART00000105590
tryptophan 2,3-dioxygenase a
chr11_+_45421761 1.20 ENSDART00000167347
HRAS-like suppressor
chr15_-_33896159 1.17 ENSDART00000159791
myelin associated glycoprotein
chr12_+_1286642 1.16 ENSDART00000157467
phosphatidylethanolamine N-methyltransferase
chr2_+_42191592 1.16 ENSDART00000144716
caveolae associated protein 4a
chr16_-_13612650 1.13 ENSDART00000080372
D site albumin promoter binding protein b
chr19_-_103289 1.12 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr20_-_26001288 1.12 ENSDART00000136518
ENSDART00000063177
calpain 3b
chr5_-_58840971 1.09 ENSDART00000050932
transmembrane protein 136b
chr6_-_29305132 1.09 ENSDART00000132456
basic, immunoglobulin-like variable motif containing
chr1_-_30039331 1.07 ENSDART00000086935
ENSDART00000143800
zgc:153256
chr24_+_39137001 1.05 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
TBC1 domain family, member 24
chr23_-_3703569 1.04 ENSDART00000143731
protein kinase C and casein kinase substrate in neurons 1a
chr11_+_30960743 1.02 ENSDART00000149597
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr15_-_28095532 1.01 ENSDART00000191490
crystallin, beta A1a
chr7_-_2129076 1.00 ENSDART00000182385
si:cabz01007807.1
chr19_+_1184878 0.99 ENSDART00000163539
scratch family zinc finger 1a
chr12_-_3133483 0.98 ENSDART00000015092
collagen, type I, alpha 1b
chr16_-_17175731 0.98 ENSDART00000183057
opsin 9
chr15_+_47386939 0.97 ENSDART00000128224

chr17_-_15149192 0.97 ENSDART00000180511
ENSDART00000103405
GTP cyclohydrolase 1
chr3_+_12710350 0.97 ENSDART00000157959
cytochrome P450, family 2, subfamily K, polypeptide 18
chr1_-_31505144 0.96 ENSDART00000087115
regulating synaptic membrane exocytosis 1b
chr10_+_7563755 0.96 ENSDART00000165877
purine-rich element binding protein G
chr21_+_45387903 0.95 ENSDART00000186253
ENSDART00000075432
jade family PHD finger 2
chr7_+_29133321 0.93 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr12_+_27589607 0.92 ENSDART00000066288
spermatogenesis associated 20
chr12_-_47782623 0.88 ENSDART00000115742
selenoprotein U1b
chr7_-_11638126 0.87 ENSDART00000125827
si:dkey-15b23.3
chr18_+_3530769 0.86 ENSDART00000163469
si:ch73-338a16.3
chr6_-_27139396 0.86 ENSDART00000055848
zgc:103559
chr6_-_49873020 0.85 ENSDART00000148511
GNAS complex locus
chr13_-_16257848 0.85 ENSDART00000079745
zgc:110045
chr9_-_202805 0.83 ENSDART00000182260

chr1_+_54626491 0.83 ENSDART00000136063
si:ch211-202h22.9
chr17_-_51829310 0.82 ENSDART00000154544
numb homolog (Drosophila)
chr10_+_22782522 0.82 ENSDART00000079498
ENSDART00000145558
si:ch211-237l4.6
chr13_-_29424454 0.82 ENSDART00000026765
solute carrier family 18 (vesicular acetylcholine transporter), member 3a
chr20_-_25669813 0.82 ENSDART00000153118
si:dkeyp-117h8.2
chr20_+_42761881 0.81 ENSDART00000113625
Pim proto-oncogene, serine/threonine kinase, related 113
chr10_-_39153959 0.81 ENSDART00000150193
ENSDART00000111362
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr19_-_32804535 0.81 ENSDART00000175613
ENSDART00000052098
5'-nucleotidase, cytosolic IAa
chr24_+_26036395 0.81 ENSDART00000143485
tyrosine kinase, non-receptor, 2a
chr3_+_7808459 0.80 ENSDART00000162374
hook microtubule-tethering protein 2
chr1_+_58094551 0.79 ENSDART00000146316
si:ch211-114l13.1
chr19_-_42045372 0.78 ENSDART00000144275
trio Rho guanine nucleotide exchange factor a
chr5_-_67661102 0.77 ENSDART00000013605
zinc finger and BTB domain containing 20
chr23_-_11870962 0.76 ENSDART00000143481
si:dkey-178k16.1
chr2_-_127945 0.76 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr2_-_4797512 0.76 ENSDART00000160765
tyrosine kinase, non-receptor, 2b
chr6_-_60031693 0.75 ENSDART00000160275

chr2_+_6181383 0.75 ENSDART00000153307
si:ch73-344o19.1
chr6_-_33707278 0.75 ENSDART00000188103
microtubule associated serine/threonine kinase 2
chr1_+_54673846 0.74 ENSDART00000145018
G protein-coupled receptor, class C, group 5, member Bb
chr3_-_37681824 0.74 ENSDART00000185858
G patch domain containing 8
chr1_-_38813679 0.73 ENSDART00000148917
ankyrin repeat and SOCS box containing 5b
chr18_+_8340886 0.73 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr17_+_3124129 0.73 ENSDART00000155323
zgc:136872
chr21_-_10446405 0.72 ENSDART00000167948
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr16_+_50289916 0.72 ENSDART00000168861
ENSDART00000167332
hepcidin antimicrobial peptide
chr5_+_60928576 0.72 ENSDART00000131041
double C2-like domains, beta
chr22_-_29336268 0.71 ENSDART00000132776
ENSDART00000186351
ENSDART00000121599
platelet-derived growth factor beta polypeptide a
chr4_-_2162688 0.71 ENSDART00000148900
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr2_+_29610114 0.71 ENSDART00000131271
discs, large (Drosophila) homolog-associated protein 1a
chr13_+_23677949 0.70 ENSDART00000144215
pecanex-like 2 (Drosophila)
chr7_-_72435159 0.70 ENSDART00000173060
rabphilin 3A homolog (mouse), b
chr1_+_57311901 0.70 ENSDART00000149397
mycbp associated protein
chr17_+_389218 0.69 ENSDART00000162898
si:rp71-62i8.1
chr2_-_34483597 0.69 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr11_-_40742424 0.69 ENSDART00000173399
ENSDART00000021369
taste receptor, type 1, member 3
chr4_+_17280868 0.69 ENSDART00000145349
branched chain amino-acid transaminase 1, cytosolic
chr18_+_25546227 0.68 ENSDART00000085824
peroxisomal biogenesis factor 11 alpha
chr16_-_8120203 0.68 ENSDART00000193430
SNF related kinase a
chr18_-_37007294 0.68 ENSDART00000088309
mitogen-activated protein kinase kinase kinase 10
chr6_+_39279104 0.68 ENSDART00000023686
ankyrin repeat domain 33Ab
chr20_+_54738210 0.67 ENSDART00000151399
p21 protein (Cdc42/Rac)-activated kinase 7
chr4_+_75314247 0.67 ENSDART00000162365

chr23_+_6232895 0.67 ENSDART00000139795
synaptotagmin IIa
chr10_+_7564106 0.67 ENSDART00000159042
purine-rich element binding protein G
chr11_+_6819050 0.67 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr14_-_7128980 0.66 ENSDART00000171311
si:ch73-43g23.1
chr11_-_34147205 0.65 ENSDART00000173216
ATPase 13A3
chr14_+_2095394 0.65 ENSDART00000186847

chr3_+_58379450 0.65 ENSDART00000155759
short chain dehydrogenase/reductase family 42E, member 2
chr18_-_37007061 0.64 ENSDART00000136432
mitogen-activated protein kinase kinase kinase 10
chr21_+_170038 0.63 ENSDART00000157614
kelch-like family member 8
chr1_-_46343999 0.63 ENSDART00000145117
ENSDART00000193233
ATPase phospholipid transporting 11A
chr8_-_4097722 0.62 ENSDART00000135006
cut-like homeobox 2b
chr25_+_27937585 0.62 ENSDART00000151994
Ca++-dependent secretion activator 2
chr8_-_7391721 0.61 ENSDART00000149836
LHFPL tetraspan subfamily member 4b
chr20_+_42780162 0.61 ENSDART00000127069
Pim proto-oncogene, serine/threonine kinase, related 213
chr10_-_44341288 0.61 ENSDART00000166131
zinc finger, SWIM-type containing 6
chr19_-_6631900 0.61 ENSDART00000144571
poliovirus receptor-related 2 like
chr21_+_26612777 0.60 ENSDART00000142667
estrogen-related receptor alpha
chr12_+_7491690 0.59 ENSDART00000152564
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr22_-_18022416 0.59 ENSDART00000141563
neurocan b
chr25_-_19420949 0.58 ENSDART00000181338
microtubule-associated protein 1Ab
chr3_-_36612877 0.57 ENSDART00000167164
si:dkeyp-72e1.7
chr19_-_82504 0.57 ENSDART00000027864
ENSDART00000160560
heterogeneous nuclear ribonucleoprotein R
chr10_-_39154594 0.56 ENSDART00000148825
solute carrier family 37 (glucose-6-phosphate transporter), member 4b
chr11_-_11471857 0.55 ENSDART00000030103
keratin 94
chr17_-_2386569 0.54 ENSDART00000121614
phospholipase C beta 2
chr21_-_45728069 0.54 ENSDART00000185101

chr9_-_19699728 0.54 ENSDART00000166780
si:ch211-141e20.2
chr17_+_15845765 0.54 ENSDART00000130881
ENSDART00000074936
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr25_+_37443194 0.54 ENSDART00000163178
ENSDART00000190262
solute carrier family 10, member 3
chr1_+_2112726 0.53 ENSDART00000131714
ENSDART00000138396
muscleblind-like splicing regulator 2
chr3_+_29600917 0.53 ENSDART00000048867
somatostatin receptor 3
chr15_+_1199407 0.53 ENSDART00000163827
major facilitator superfamily domain containing 1
chr16_+_22618620 0.53 ENSDART00000185728
ENSDART00000041625
cholinergic receptor, nicotinic, beta 2b
chr19_+_3849378 0.53 ENSDART00000166218
ENSDART00000159228
organic solute carrier partner 1a
chr8_+_53269657 0.51 ENSDART00000184212
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr6_-_9563534 0.51 ENSDART00000184765
mitogen-activated protein kinase kinase kinase 2
chr5_-_67629263 0.50 ENSDART00000133753
zinc finger and BTB domain containing 20
chr8_+_25913787 0.49 ENSDART00000190257
ENSDART00000062515
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H
chr6_+_22068589 0.49 ENSDART00000151205
aldehyde dehydrogenase 1 family, member L1
chr7_-_51528661 0.49 ENSDART00000174263
NHS-like 2
chr16_+_53526135 0.49 ENSDART00000083558
sphingomyelin phosphodiesterase 5
chr15_-_5157572 0.49 ENSDART00000174192
odorant receptor, family E, subfamily 128, member 10
chr25_-_21085661 0.49 ENSDART00000099355
proline rich 5a (renal)
chr13_+_51869025 0.48 ENSDART00000187066

chr8_-_2434282 0.47 ENSDART00000137262
ENSDART00000134044
voltage-dependent anion channel 3
chr21_+_11248448 0.46 ENSDART00000142431
AT-rich interaction domain 6
chr18_-_26785861 0.46 ENSDART00000098361
neuromedin Ba
chr2_-_58142854 0.46 ENSDART00000169909

chr3_-_19495814 0.46 ENSDART00000162248

chr11_-_25213651 0.45 ENSDART00000097316
ENSDART00000152186
myosin, heavy chain 7B, cardiac muscle, beta a
chr16_-_5844881 0.45 ENSDART00000085678
trafficking protein, kinesin binding 1a
chr14_+_11946395 0.45 ENSDART00000193290
FERM and PDZ domain containing 3
chr7_+_31871830 0.45 ENSDART00000139899
myosin binding protein C, cardiac
chr11_-_22997506 0.44 ENSDART00000167817
ATPase plasma membrane Ca2+ transporting 2
chr18_+_45542981 0.44 ENSDART00000140357
kinesin family member C3
chr18_+_48943875 0.42 ENSDART00000076803

chr11_-_16093018 0.42 ENSDART00000139309
ENSDART00000139819
si:dkey-205k8.5
chr19_+_19600297 0.42 ENSDART00000160134
ENSDART00000183493
3-hydroxyisobutyrate dehydrogenase a
chr6_+_103361 0.41 ENSDART00000151899
low density lipoprotein receptor b
chr23_-_20010579 0.41 ENSDART00000089999
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr8_-_25980694 0.40 ENSDART00000135456
si:dkey-72l14.3
chr2_-_53481912 0.40 ENSDART00000189610
hydroxysteroid (11-beta) dehydrogenase 1-like b
chr16_-_44649053 0.40 ENSDART00000184807

chr5_-_9580837 0.39 ENSDART00000102236
SH2B adaptor protein 3
chr5_+_36439405 0.39 ENSDART00000102973
ectodysplasin A
chr2_+_36015049 0.38 ENSDART00000158276
laminin, gamma 2
chr15_-_41807371 0.38 ENSDART00000156819
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36b
chr1_+_57187794 0.38 ENSDART00000152485
si:dkey-27j5.9
chr17_-_29213710 0.37 ENSDART00000076481
EH-domain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of thraa+thrab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.5 64.5 GO:0002088 lens development in camera-type eye(GO:0002088)
0.4 1.1 GO:0097264 self proteolysis(GO:0097264)
0.3 1.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.3 0.9 GO:0000256 allantoin catabolic process(GO:0000256) purine nucleobase catabolic process(GO:0006145)
0.3 1.1 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.3 0.8 GO:0042908 xenobiotic transport(GO:0042908)
0.2 1.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 1.4 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.2 0.7 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 2.0 GO:0036368 cone photoresponse recovery(GO:0036368)
0.2 0.7 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.9 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.2 0.5 GO:0009397 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.2 3.2 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.2 1.2 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.2 0.8 GO:0032615 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1 0.6 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 1.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.3 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.1 2.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.4 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.5 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.1 0.7 GO:0016559 peroxisome fission(GO:0016559)
0.1 2.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 2.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.9 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 0.7 GO:0032570 response to progesterone(GO:0032570)
0.1 0.4 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 0.3 GO:0033605 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.1 0.3 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.7 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.3 GO:0072314 visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.1 0.5 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.8 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 0.2 GO:0060688 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 1.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.4 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.8 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 2.3 GO:0009648 photoperiodism(GO:0009648)
0.1 0.3 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 0.8 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.1 1.3 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.1 0.4 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.7 GO:0050909 sensory perception of taste(GO:0050909)
0.1 0.5 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.3 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.0 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.6 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 1.0 GO:0097320 membrane tubulation(GO:0097320)
0.0 1.6 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 1.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.5 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.7 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.7 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 1.7 GO:0007586 digestion(GO:0007586)
0.0 0.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 4.0 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.0 0.4 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 1.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 1.4 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.6 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 1.0 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.1 GO:0060055 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 1.0 GO:0007602 phototransduction(GO:0007602)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.7 GO:0007601 visual perception(GO:0007601)
0.0 0.2 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.5 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.8 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) dopamine transport(GO:0015872)
0.0 0.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.1 GO:0033273 response to vitamin(GO:0033273)
0.0 0.2 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0035094 response to nicotine(GO:0035094)
0.0 0.1 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.4 GO:0042476 odontogenesis(GO:0042476)
0.0 0.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.7 GO:0045010 actin nucleation(GO:0045010)
0.0 0.4 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:0033151 V(D)J recombination(GO:0033151)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0043209 myelin sheath(GO:0043209)
0.2 2.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.7 GO:0070062 extracellular exosome(GO:0070062)
0.1 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 2.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.3 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.0 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
0.0 0.1 GO:0097519 DNA recombinase complex(GO:0097519)
0.0 1.2 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 3.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.6 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 4.9 GO:0030424 axon(GO:0030424)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 2.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.5 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 64.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.4 1.8 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 4.0 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.2 1.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.9 GO:0050897 cobalt ion binding(GO:0050897)
0.2 3.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 1.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 0.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 0.7 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 2.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.5 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 1.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.4 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 2.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.7 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.4 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 0.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.0 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.6 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.1 0.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 2.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.8 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 3.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.5 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.8 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 0.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.2 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 2.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.0 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.7 GO:0030552 cAMP binding(GO:0030552)
0.0 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:1990238 double-stranded DNA endodeoxyribonuclease activity(GO:1990238)
0.0 0.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.4 GO:0030546 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0042285 xylosyltransferase activity(GO:0042285)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.6 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.9 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.7 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis