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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tfap2e

Z-value: 0.44

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Transcription factors associated with tfap2e

Gene Symbol Gene ID Gene Info
tfap2e
ENSDARG00000008861 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2edr11_v1_chr19_-_47456787_474567870.233.5e-01Click!

Activity profile of tfap2e motif

Sorted Z-values of tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_26704829 0.74 ENSDART00000078563
neurog1
neurogenin 1
chr3_-_55328548 0.43 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr23_+_27778670 0.36 ENSDART00000053863
kmt2d
lysine (K)-specific methyltransferase 2D
chr23_-_27647769 0.32 ENSDART00000059974
wnt10b
wingless-type MMTV integration site family, member 10b
chr3_-_54607166 0.32 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr9_+_32358514 0.31 ENSDART00000144608
plcl1
phospholipase C like 1
chr17_+_34186632 0.31 ENSDART00000014306
mpp5a
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr19_+_1184878 0.28 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr7_-_23563092 0.28 ENSDART00000132275
gpr185b
G protein-coupled receptor 185 b
chr6_-_39313027 0.28 ENSDART00000012644
krt4
keratin 4
chr11_-_26180714 0.27 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr19_-_30510930 0.27 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr11_+_31323746 0.27 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr21_-_39058490 0.26 ENSDART00000114885
aldh3a2b
aldehyde dehydrogenase 3 family, member A2b
chr10_-_5135788 0.26 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr5_-_14509137 0.25 ENSDART00000180742
si:ch211-244o22.2
si:ch211-244o22.2
chr19_+_2835240 0.24 ENSDART00000190838
CDCP1
CUB domain containing protein 1
chr19_-_31707892 0.23 ENSDART00000088427
ripor2
RHO family interacting cell polarization regulator 2
chr10_+_5135842 0.23 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr24_+_42074143 0.23 ENSDART00000170514
top1mt
DNA topoisomerase I mitochondrial
chr15_+_44929497 0.22 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr14_-_33821515 0.21 ENSDART00000173218
vimr2
vimentin-related 2
chr25_+_36405021 0.21 ENSDART00000152801
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr7_-_51476276 0.20 ENSDART00000082464
nhsl2
NHS-like 2
chr12_+_19036380 0.20 ENSDART00000153086
ENSDART00000181060
kctd17
potassium channel tetramerization domain containing 17
chr24_+_21346796 0.20 ENSDART00000126519
shisa2b
shisa family member 2b
chr5_+_46424437 0.20 ENSDART00000186511
vcana
versican a
chr7_+_32693890 0.20 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr16_-_39859119 0.19 ENSDART00000138388
rbms3
RNA binding motif, single stranded interacting protein
chr19_-_10395683 0.19 ENSDART00000109488
zgc:194578
zgc:194578
chr6_-_10320676 0.19 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr13_+_16342926 0.18 ENSDART00000105496
ENSDART00000124710
dlg5a
discs, large homolog 5a (Drosophila)
chr25_+_5249513 0.18 ENSDART00000126814
CABZ01039863.1

chr16_-_46393154 0.17 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr1_+_33328857 0.17 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr8_-_11004726 0.16 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr16_-_5143124 0.16 ENSDART00000131876
ENSDART00000060630
ttk
ttk protein kinase
chr14_+_39258569 0.16 ENSDART00000103298
diaph2
diaphanous-related formin 2
chr17_-_15149192 0.15 ENSDART00000180511
ENSDART00000103405
gch1
GTP cyclohydrolase 1
chr4_+_32649955 0.15 ENSDART00000135750
znf1042
zinc finger protein 1042
chr11_+_14333441 0.15 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr10_-_2526526 0.15 ENSDART00000191726
ENSDART00000192767
CU856539.1

chr5_+_63302660 0.13 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr18_+_34478959 0.12 ENSDART00000059394
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr11_+_31324335 0.12 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr12_+_43585527 0.12 ENSDART00000161590
clrn3
clarin 3
chr25_+_11281970 0.11 ENSDART00000180094
AKAP13
si:dkey-187e18.1
chr9_+_32978302 0.11 ENSDART00000007630
nhlh2
nescient helix loop helix 2
chr4_+_26972862 0.11 ENSDART00000011519
ENSDART00000138830
slc6a1l
solute carrier family 6 (neurotransmitter transporter, GABA), member 1, like
chr2_+_27010439 0.10 ENSDART00000030547
cdh7a
cadherin 7a
chr23_+_2760573 0.10 ENSDART00000129719
top1
DNA topoisomerase I
chr2_+_1988036 0.10 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr20_-_20312789 0.10 ENSDART00000114779
si:ch211-212g7.6
si:ch211-212g7.6
chr21_-_21089781 0.10 ENSDART00000144361
ank1b
ankyrin 1, erythrocytic b
chr1_-_30457062 0.10 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr21_+_39941559 0.10 ENSDART00000189718
ENSDART00000160875
ENSDART00000135235
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr25_-_19574146 0.10 ENSDART00000156811
si:ch211-59o9.10
si:ch211-59o9.10
chr20_-_15089738 0.09 ENSDART00000164552
si:dkey-239i20.2
si:dkey-239i20.2
chr4_-_1914228 0.09 ENSDART00000087835
ano6
anoctamin 6
chr4_+_77966055 0.09 ENSDART00000174203
ENSDART00000130100
ENSDART00000080665
ENSDART00000174317
ENSDART00000190123
zgc:113921
zgc:113921
chr3_-_8160457 0.09 ENSDART00000183379
si:ch211-51i16.1
si:ch211-51i16.1
chr23_-_18668836 0.09 ENSDART00000138792
ENSDART00000051182
arhgap4b
Rho GTPase activating protein 4b
chr7_-_15252540 0.09 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
si:dkey-172h23.2
chr18_-_47103131 0.09 ENSDART00000188553
CABZ01039304.1

chr3_-_49163683 0.08 ENSDART00000166146
dnajb1a
DnaJ (Hsp40) homolog, subfamily B, member 1a
chr11_+_1657221 0.08 ENSDART00000164394
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr2_+_24199073 0.08 ENSDART00000144110
map4l
microtubule associated protein 4 like
chr21_-_32680638 0.08 ENSDART00000147203
adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr20_-_2725930 0.06 ENSDART00000081643
akirin2
akirin 2
chr16_-_29458806 0.06 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr23_-_9965148 0.06 ENSDART00000137308
plxnb1a
plexin b1a
chr2_+_17508323 0.05 ENSDART00000169703
pimr199
Pim proto-oncogene, serine/threonine kinase, related 199
chr22_+_15633013 0.05 ENSDART00000188095
ENSDART00000048763
CABZ01090041.1

chr14_-_31465905 0.05 ENSDART00000173108
gpc3
glypican 3
chr18_+_34181655 0.05 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr11_-_28050559 0.05 ENSDART00000136859
ece1
endothelin converting enzyme 1
chr19_+_32979331 0.05 ENSDART00000078066
spire1a
spire-type actin nucleation factor 1a
chr24_-_6898302 0.04 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr6_-_25369295 0.04 ENSDART00000191475
PKN2 (1 of many)
zgc:153916
chr5_+_27267186 0.04 ENSDART00000182238
ENSDART00000087857
unc5db
unc-5 netrin receptor Db
chr5_-_38451082 0.04 ENSDART00000136428
chrne
cholinergic receptor, nicotinic, epsilon
chr2_-_22927581 0.04 ENSDART00000109515
myo7bb
myosin VIIBb
chr1_-_53476758 0.03 ENSDART00000074221
b3gnt2a
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2a
chr5_-_62801879 0.03 ENSDART00000191749
adora2b
adenosine A2b receptor
chr11_+_30253968 0.03 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr13_+_24279021 0.03 ENSDART00000058629
acta1b
actin, alpha 1b, skeletal muscle
chr2_+_17556177 0.02 ENSDART00000074113
pimr197
Pim proto-oncogene, serine/threonine kinase, related 197
chr24_-_21903588 0.02 ENSDART00000180991
spata13
spermatogenesis associated 13
chr9_-_2892045 0.01 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr5_+_25736979 0.01 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr6_-_49873020 0.01 ENSDART00000148511
gnas
GNAS complex locus
chr5_-_62801724 0.00 ENSDART00000144469
adora2b
adenosine A2b receptor
chr2_+_36616830 0.00 ENSDART00000169547
ENSDART00000098417
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr24_-_21903360 0.00 ENSDART00000091252
spata13
spermatogenesis associated 13
chr22_+_110158 0.00 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr7_-_2116512 0.00 ENSDART00000098148
si:cabz01007802.1
si:cabz01007802.1

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0048909 dorsal spinal cord development(GO:0021516) anterior lateral line nerve development(GO:0048909)
0.1 0.2 GO:1990869 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.1 0.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.2 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.2 GO:0003093 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.1 0.3 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.2 GO:1902102 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.0 0.4 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.3 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.1 GO:1902260 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.2 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.2 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0070888 E-box binding(GO:0070888)
0.1 0.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.3 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC