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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tfap2a+tfap2c

Z-value: 0.61

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Transcription factors associated with tfap2a+tfap2c

Gene Symbol Gene ID Gene Info
tfap2c
ENSDARG00000040606 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
tfap2a
ENSDARG00000059279 transcription factor AP-2 alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2cdr11_v1_chr6_+_56147812_561478120.916.2e-08Click!
tfap2adr11_v1_chr24_-_8730913_87310390.634.0e-03Click!

Activity profile of tfap2a+tfap2c motif

Sorted Z-values of tfap2a+tfap2c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_46424437 1.72 ENSDART00000186511
vcana
versican a
chr23_-_27152866 1.46 ENSDART00000141305
si:dkey-157g16.6
si:dkey-157g16.6
chr11_+_14333441 1.36 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr3_-_55328548 1.13 ENSDART00000082944
dock6
dedicator of cytokinesis 6
chr24_-_21903588 1.04 ENSDART00000180991
spata13
spermatogenesis associated 13
chr23_-_27647769 1.02 ENSDART00000059974
wnt10b
wingless-type MMTV integration site family, member 10b
chr3_+_26244353 1.01 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr24_-_21903360 1.00 ENSDART00000091252
spata13
spermatogenesis associated 13
chr7_+_32693890 0.97 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr3_-_54607166 0.95 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr11_+_31323746 0.92 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr11_+_14321113 0.90 ENSDART00000039822
ENSDART00000137347
ENSDART00000132997
ptbp1b
polypyrimidine tract binding protein 1b
chr20_-_2725594 0.90 ENSDART00000152120
akirin2
akirin 2
chr16_-_5143124 0.87 ENSDART00000131876
ENSDART00000060630
ttk
ttk protein kinase
chr25_+_5249513 0.86 ENSDART00000126814
CABZ01039863.1

chr5_+_63302660 0.83 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr20_-_2725930 0.82 ENSDART00000081643
akirin2
akirin 2
chr3_-_26805455 0.81 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr24_-_37272116 0.81 ENSDART00000022999
ube2ib
ubiquitin-conjugating enzyme E2Ib
chr11_+_31324335 0.78 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr14_+_14806851 0.77 ENSDART00000169235
fhdc2
FH2 domain containing 2
chr8_+_48942470 0.73 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr23_-_9965148 0.71 ENSDART00000137308
plxnb1a
plexin b1a
chr2_+_27010439 0.71 ENSDART00000030547
cdh7a
cadherin 7a
chr8_+_48943009 0.65 ENSDART00000180763
rer1
retention in endoplasmic reticulum sorting receptor 1
chr7_-_34265481 0.64 ENSDART00000173596
si:ch211-98n17.5
si:ch211-98n17.5
chr3_-_26244256 0.63 ENSDART00000103741
ppp4ca
protein phosphatase 4, catalytic subunit a
chr3_-_35865040 0.63 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr1_+_33328857 0.61 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr2_+_1988036 0.58 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr18_-_15551360 0.55 ENSDART00000159915
ENSDART00000172690
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr23_-_21215520 0.55 ENSDART00000143206
megf6a
multiple EGF-like-domains 6a
chr4_-_21466480 0.54 ENSDART00000139962
pawr
PRKC, apoptosis, WT1, regulator
chr19_-_5369486 0.53 ENSDART00000105004
krt17
keratin 17
chr1_+_58990121 0.52 ENSDART00000171654
CABZ01083166.1

chr10_-_5135788 0.51 ENSDART00000108587
ENSDART00000138537
sec31a
SEC31 homolog A, COPII coat complex component
chr20_-_34292607 0.48 ENSDART00000144705
hmcn1
hemicentin 1
chr10_-_8032885 0.47 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr5_-_62801879 0.43 ENSDART00000191749
adora2b
adenosine A2b receptor
chr22_+_30839702 0.43 ENSDART00000139849
ENSDART00000135775
si:dkey-49n23.3
si:dkey-49n23.3
chr5_+_25736979 0.42 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr25_+_36405021 0.40 ENSDART00000152801
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr25_-_20378721 0.39 ENSDART00000181707
kctd15a
potassium channel tetramerization domain containing 15a
chr1_+_26467071 0.38 ENSDART00000112329
ENSDART00000159318
ENSDART00000193833
ENSDART00000011809
uso1
USO1 vesicle transport factor
chr18_+_34181655 0.38 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr1_+_27977297 0.38 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr5_+_61799629 0.36 ENSDART00000113508
hnrnpul1l
heterogeneous nuclear ribonucleoprotein U-like 1 like
chr5_-_62801724 0.32 ENSDART00000144469
adora2b
adenosine A2b receptor
chr8_-_11004726 0.32 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr3_+_3454610 0.31 ENSDART00000024900
zgc:165453
zgc:165453
chr20_-_15089738 0.31 ENSDART00000164552
si:dkey-239i20.2
si:dkey-239i20.2
chr4_-_16345227 0.28 ENSDART00000079521
kera
keratocan
chr20_-_34292285 0.28 ENSDART00000020389
hmcn1
hemicentin 1
chr13_-_36566260 0.27 ENSDART00000030133
synj2bp
synaptojanin 2 binding protein
chr8_-_13211527 0.24 ENSDART00000090541
si:ch73-61d6.3
si:ch73-61d6.3
chr20_+_4157815 0.24 ENSDART00000113132
gnpat
glyceronephosphate O-acyltransferase
chr24_+_21346796 0.23 ENSDART00000126519
shisa2b
shisa family member 2b
chr11_-_8782871 0.22 ENSDART00000158546
si:ch211-51h4.2
si:ch211-51h4.2
chr18_-_31969939 0.22 ENSDART00000171516
olfcs1
olfactory receptor C family, s1
chr19_-_30510930 0.21 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr11_-_28050559 0.20 ENSDART00000136859
ece1
endothelin converting enzyme 1
chr13_-_28674422 0.17 ENSDART00000122754
ENSDART00000057574
nt5c2a
5'-nucleotidase, cytosolic IIa
chr15_+_618081 0.17 ENSDART00000181518
si:ch211-210b2.1
si:ch211-210b2.1
chr5_+_21100356 0.17 ENSDART00000051586
hs3st1l2
heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2
chr7_-_15252540 0.16 ENSDART00000173072
ENSDART00000125258
si:dkey-172h23.2
si:dkey-172h23.2
chr16_-_29458806 0.15 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr2_-_43635777 0.13 ENSDART00000148633
itgb1b.1
integrin, beta 1b.1
chr15_+_44929497 0.13 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr8_+_48858132 0.13 ENSDART00000124737
ENSDART00000079644
tp73
tumor protein p73
chr24_+_31374324 0.13 ENSDART00000172335
ENSDART00000163162
cpne3
copine III
chr3_+_36160979 0.12 ENSDART00000038525
si:ch211-234h8.7
si:ch211-234h8.7
chr9_-_98982 0.12 ENSDART00000147882
lims2
LIM and senescent cell antigen-like domains 2
chr5_-_38451082 0.12 ENSDART00000136428
chrne
cholinergic receptor, nicotinic, epsilon
chr4_-_68853063 0.10 ENSDART00000162386
si:dkey-264f17.1
si:dkey-264f17.1
chr15_+_6459847 0.10 ENSDART00000157250
ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr14_+_14806692 0.10 ENSDART00000193050
fhdc2
FH2 domain containing 2
chr8_-_4789034 0.08 ENSDART00000082256
ciao1
cytosolic iron-sulfur assembly component 1
chr16_+_26601364 0.07 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr1_+_16548733 0.04 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr8_-_26792912 0.04 ENSDART00000139787
kazna
kazrin, periplakin interacting protein a
chr16_-_46393154 0.03 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr5_+_6672870 0.02 ENSDART00000126598
pxna
paxillin a
chr11_-_26180714 0.01 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr20_-_20312789 0.00 ENSDART00000114779
si:ch211-212g7.6
si:ch211-212g7.6

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2a+tfap2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0003093 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.3 0.9 GO:1901994 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.2 0.8 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.2 1.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 1.0 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.4 GO:0048211 Golgi vesicle docking(GO:0048211)
0.1 0.2 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 0.7 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.1 0.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 1.0 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.3 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.4 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.7 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.5 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.4 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.5 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 0.7 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.8 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.4 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.7 GO:0045089 positive regulation of innate immune response(GO:0045089)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.8 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 1.0 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 2.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.4 GO:0060037 pharyngeal system development(GO:0060037)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 1.4 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0051117 ATPase binding(GO:0051117)
0.0 0.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 3.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 1.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.8 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA