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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tcf7l1a+tcf7l1b+tcf7l2

Z-value: 1.37

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Transcription factors associated with tcf7l1a+tcf7l1b+tcf7l2

Gene Symbol Gene ID Gene Info
ENSDARG00000004415 transcription factor 7 like 2
ENSDARG00000007369 transcription factor 7 like 1b
ENSDARG00000038159 transcription factor 7 like 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tcf7l2dr11_v1_chr12_-_31103187_311033160.893.2e-07Click!
tcf7l1adr11_v1_chr10_-_42297889_42297889-0.862.4e-06Click!
tcf7l1bdr11_v1_chr8_-_52143109_52143109-0.512.7e-02Click!

Activity profile of tcf7l1a+tcf7l1b+tcf7l2 motif

Sorted Z-values of tcf7l1a+tcf7l1b+tcf7l2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_6109861 6.69 ENSDART00000185154
Purkinje cell protein 4
chr16_+_52512025 5.46 ENSDART00000056095
fatty acid binding protein 10a, liver basic
chr7_+_39446247 5.14 ENSDART00000033610
ENSDART00000099015
troponin T type 3b (skeletal, fast)
chr13_+_3252950 4.70 ENSDART00000020671
peripherin 2b (retinal degeneration, slow)
chr12_+_5129245 4.50 ENSDART00000169073
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr17_-_20897407 4.19 ENSDART00000149481
ankyrin 3b
chr25_-_30429607 4.07 ENSDART00000162429
ENSDART00000176535
si:ch211-93f2.1
chr22_-_282498 3.93 ENSDART00000182766

chr20_+_35484070 3.92 ENSDART00000026234
ENSDART00000141675
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
chr25_+_14092871 3.81 ENSDART00000067239
guanylate cyclase activator 1g
chr22_-_263117 3.67 ENSDART00000158134
zgc:66156
chr17_+_27176243 3.66 ENSDART00000162527
si:ch211-160f23.7
chr15_-_12545683 3.65 ENSDART00000162807
sodium channel, voltage-gated, type II, beta
chr11_+_41135055 3.58 ENSDART00000173252
calmodulin binding transcription activator 1
chr13_+_27073901 3.53 ENSDART00000146227
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr5_+_37068223 3.43 ENSDART00000164279
si:dkeyp-110c7.4
chr15_+_30158652 3.41 ENSDART00000190682
nemo-like kinase, type 2
chr14_+_22172047 3.40 ENSDART00000114750
ENSDART00000148259
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr23_-_39784368 3.23 ENSDART00000110282
si:ch211-286f9.2
chr12_+_40905427 3.22 ENSDART00000170526
ENSDART00000185771
ENSDART00000193945
cadherin 18
chr8_-_25329967 3.10 ENSDART00000139682
EPS8-like 3b
chr16_-_383664 3.06 ENSDART00000051693
iroquois homeobox 4a
chr9_-_9992697 3.04 ENSDART00000123415
UDP glucuronosyltransferase 1 family a, b
chr20_+_30445971 2.99 ENSDART00000153150
myelin transcription factor 1-like, a
chr21_-_37889727 2.97 ENSDART00000163612
ENSDART00000180958
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr20_+_43083745 2.90 ENSDART00000139014
ENSDART00000153438
monooxygenase, DBH-like 1, like
chr3_-_30861177 2.82 ENSDART00000154811
SH3 and multiple ankyrin repeat domains 1
chr22_-_237651 2.82 ENSDART00000075210
zgc:66156
chr22_-_294700 2.81 ENSDART00000189179

chr25_+_7229046 2.80 ENSDART00000149965
ENSDART00000041820
leucine rich repeat and Ig domain containing 1a
chr9_-_9998087 2.79 ENSDART00000124423
UDP glucuronosyltransferase 1 family a, b
chr5_-_18474486 2.76 ENSDART00000090580
si:dkey-215k6.1
chr5_+_15992655 2.71 ENSDART00000182148
zinc and ring finger 3
chr20_-_40451115 2.56 ENSDART00000075092
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr12_-_31103187 2.56 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
transcription factor 7 like 2
chr15_-_2188332 2.52 ENSDART00000138941
ENSDART00000009564
short stature homeobox 2
chr24_-_5932982 2.52 ENSDART00000138412
ENSDART00000135124
ENSDART00000007373
acyl-CoA binding domain containing 5a
chr17_-_20897250 2.52 ENSDART00000088106
ankyrin 3b
chr7_+_27977065 2.40 ENSDART00000089574
tubby bipartite transcription factor
chr2_-_30784502 2.39 ENSDART00000056735
regulator of G protein signaling 20
chr13_-_23264724 2.37 ENSDART00000051886
si:dkey-103j14.5
chr20_+_34455645 2.34 ENSDART00000135789
methyltransferase like 11B
chr8_-_18899427 2.21 ENSDART00000079840
RAR-related orphan receptor C a
chr13_+_28702104 2.18 ENSDART00000135481
si:ch211-67n3.9
chr18_+_10907999 2.16 ENSDART00000133555
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr6_-_57938043 2.16 ENSDART00000171073
TOX high mobility group box family member 2
chr12_+_35203091 2.14 ENSDART00000153022
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b
chr3_-_33573252 2.10 ENSDART00000191339
ENSDART00000184612
ENSDART00000187232
ENSDART00000190671

chr2_+_9822319 2.10 ENSDART00000144078
ENSDART00000144371
annexin A13, like
chr7_-_30087048 2.08 ENSDART00000112743
neuromedin Bb
chr8_+_17009199 2.07 ENSDART00000139452
phosphodiesterase 4D, cAMP-specific
chr25_-_19395476 2.06 ENSDART00000182622
microtubule-associated protein 1Ab
chr10_-_39011514 2.06 ENSDART00000075123
Purkinje cell protein 4a
chr19_-_44801918 2.06 ENSDART00000108507
si:ch211-233f16.1
chr23_+_16620801 2.05 ENSDART00000189859
ENSDART00000184578
syntaphilin b
chr17_-_8638713 2.05 ENSDART00000148971
C-terminal binding protein 2a
chr12_+_6214041 2.02 ENSDART00000179759
protein kinase, cGMP-dependent, type Ib
chr1_-_29045426 2.01 ENSDART00000019770
glycoprotein M6Ba
chr6_-_15604157 1.96 ENSDART00000141597
leucine rich repeat (in FLII) interacting protein 1b
chr24_+_32411753 1.95 ENSDART00000058530
neuronal differentiation 6a
chr4_+_10366532 1.87 ENSDART00000189901
potassium voltage-gated channel, Shal-related subfamily, member 2
chr23_-_20764227 1.86 ENSDART00000089750
zinc finger protein 362b
chr7_+_34492744 1.85 ENSDART00000109635
ENSDART00000173844
calmodulin-like 4a
chr2_+_2503396 1.81 ENSDART00000168418
corticotropin releasing hormone receptor 2
chr20_+_43942278 1.81 ENSDART00000100571
chloride intracellular channel 5b
chr24_-_1985007 1.79 ENSDART00000189870
par-3 family cell polarity regulator
chr2_+_7192966 1.79 ENSDART00000142735
si:ch211-13f8.1
chr12_-_6880694 1.78 ENSDART00000171846
protocadherin-related 15b
chr2_-_34483597 1.77 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr15_-_43768776 1.77 ENSDART00000170398
glutamate receptor, metabotropic 5b
chr4_-_17409533 1.77 ENSDART00000011943
phenylalanine hydroxylase
chr25_+_26921480 1.77 ENSDART00000155949
glutamate receptor, metabotropic 8b
chr17_-_26507289 1.75 ENSDART00000155616
coiled-coil serine-rich protein 2a
chr1_-_19233890 1.75 ENSDART00000127145
protein tyrosine phosphatase, receptor type, D, b
chr7_-_71486162 1.75 ENSDART00000045253
aconitase 1, soluble
chr2_-_43083749 1.75 ENSDART00000084303
ENSDART00000145494
potassium voltage-gated channel, KQT-like subfamily, member 3
chr20_+_41549200 1.72 ENSDART00000135715
family with sequence similarity 184, member A
chr15_-_163586 1.71 ENSDART00000163597
septin-4
chr24_+_15897717 1.69 ENSDART00000105956
neuropilin (NRP) and tolloid (TLL)-like 1, like
chr1_+_23161369 1.69 ENSDART00000162827
si:dkey-92j12.5
chr8_+_14778292 1.68 ENSDART00000089971
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr4_+_7391110 1.68 ENSDART00000160708
ENSDART00000187823
troponin I4a
chr6_-_15603675 1.68 ENSDART00000143502
leucine rich repeat (in FLII) interacting protein 1b
chr2_-_30784198 1.68 ENSDART00000182523
ENSDART00000147355
regulator of G protein signaling 20
chr13_+_28701233 1.66 ENSDART00000135931
si:ch211-67n3.9
chr12_-_33706726 1.65 ENSDART00000153135
myosin XVB
chr24_-_32408404 1.65 ENSDART00000144157
si:ch211-56a11.2
chr5_+_26728115 1.63 ENSDART00000098545
transmembrane protein 150Aa
chr1_+_32528097 1.63 ENSDART00000128317
neuroligin 4a
chr2_-_30734098 1.62 ENSDART00000133769
retinitis pigmentosa 1 (autosomal dominant)
chr24_+_11105786 1.59 ENSDART00000175182
prolactin releasing hormone 2
chr2_+_30379650 1.59 ENSDART00000129542
cysteine-rich secretory protein LCCL domain containing 1b
chr19_+_42469058 1.58 ENSDART00000076915
si:dkey-166k12.1
chr9_+_28693592 1.54 ENSDART00000110198
zgc:162780
chr7_+_27976448 1.53 ENSDART00000181026
tubby bipartite transcription factor
chr6_-_40429411 1.52 ENSDART00000156005
ENSDART00000156357
si:dkey-28n18.9
chr1_-_8428736 1.52 ENSDART00000138435
ENSDART00000121823
synaptogyrin 3b
chr13_-_18835254 1.48 ENSDART00000147579
ENSDART00000146795
leucine zipper, putative tumor suppressor 2a
chr22_-_21150845 1.45 ENSDART00000027345
transmembrane protein 59-like
chr9_-_35155089 1.45 ENSDART00000077901
amyloid beta (A4) precursor protein b
chr17_+_26611929 1.44 ENSDART00000166450
ENSDART00000087023
tetratricopeptide repeat domain 7B
chr8_-_22739757 1.44 ENSDART00000182167
ENSDART00000171891
IQ motif and Sec7 domain 2a
chr4_+_69619 1.43 ENSDART00000164425
MANSC domain containing 1
chr12_-_31457301 1.41 ENSDART00000043887
ENSDART00000148603
acyl-CoA synthetase long chain family member 5
chr16_+_17389116 1.41 ENSDART00000103750
ENSDART00000173448
family with sequence similarity 131, member Bb
chr21_-_40782393 1.40 ENSDART00000075808
amyloid beta (A4) precursor protein-binding, family B, member 3
chr23_+_37579107 1.40 ENSDART00000169376
pleckstrin homology domain containing, family G (with RhoGef domain) member 5b
chr16_+_16933002 1.39 ENSDART00000173163
myosin, heavy chain 14, non-muscle
chr21_-_25522906 1.38 ENSDART00000110923
connector enhancer of kinase suppressor of Ras 2b
chr6_-_53143667 1.37 ENSDART00000079694
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr19_-_8732037 1.34 ENSDART00000138971
si:ch211-39a7.1
chr8_-_34051548 1.32 ENSDART00000105204
pre-B-cell leukemia homeobox 3b
chr15_-_30714130 1.31 ENSDART00000156914
ENSDART00000154714
musashi RNA-binding protein 2b
chr12_-_31995840 1.31 ENSDART00000112881
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr19_-_6134802 1.31 ENSDART00000140051
capicua transcriptional repressor a
chr12_+_10115964 1.30 ENSDART00000152369
si:dkeyp-118b1.2
chr7_+_19762595 1.30 ENSDART00000130347
si:dkey-9k7.3
chr20_+_25597527 1.25 ENSDART00000130242
cytochrome P450, family 2, subfamily J, polypeptide 20
chr16_+_39146696 1.24 ENSDART00000121756
ENSDART00000084381
syntabulin (syntaxin-interacting)
chr11_+_34522554 1.23 ENSDART00000109833
zinc finger, matrin-type 3
chr21_+_26612777 1.21 ENSDART00000142667
estrogen-related receptor alpha
chr18_-_46380471 1.20 ENSDART00000144444
ENSDART00000086772
solute carrier family 19 (thiamine transporter), member 3b
chr24_-_6546479 1.19 ENSDART00000160538
Rho GTPase activating protein 21a
chr20_+_36234335 1.19 ENSDART00000193484
ENSDART00000181664
cornichon family AMPA receptor auxiliary protein 3
chr13_-_31829786 1.18 ENSDART00000138667
SERTA domain containing 4
chr20_-_9436521 1.17 ENSDART00000133000
zgc:101840
chr6_+_3282809 1.17 ENSDART00000187444
ENSDART00000187407
ENSDART00000191883
lysine (K)-specific demethylase 4A, genome duplicate a
chr21_-_25722834 1.16 ENSDART00000101208
abhydrolase domain containing 11
chr3_-_19091024 1.16 ENSDART00000188485
ENSDART00000110554
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr18_+_45796096 1.16 ENSDART00000087070
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr15_-_31588162 1.15 ENSDART00000153598
heat shock 105/110 protein 1
chr16_+_39159752 1.14 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr22_+_3045495 1.10 ENSDART00000164061

chr7_-_42206720 1.10 ENSDART00000110907
integrin alpha FG-GAP repeat containing 1
chr9_+_10014817 1.09 ENSDART00000132065
neurexophilin 2a
chr13_+_4505232 1.08 ENSDART00000007500
ENSDART00000161684
phosphodiesterase 10A
chr7_-_9674073 1.07 ENSDART00000187902
leucine-rich repeat kinase 1
chr4_-_77432218 1.06 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr6_-_7208119 1.06 ENSDART00000105148
ENSDART00000185846
heparan sulfate 6-O-sulfotransferase 3a
chr3_+_15773991 1.05 ENSDART00000089923
zinc finger protein 652
chr18_+_36806545 1.05 ENSDART00000098958
tetratricopeptide repeat domain 9B
chr8_+_36803415 1.03 ENSDART00000111680
IQ motif and Sec7 domain 2b
chr6_-_26559921 1.03 ENSDART00000104532
SRY (sex determining region Y)-box 14
chr20_+_39283849 1.01 ENSDART00000002481
ENSDART00000146683
scavenger receptor class A, member 3
chr1_-_42779075 1.00 ENSDART00000133917
leucine rich repeat transmembrane neuronal 1
chr20_+_28266892 0.99 ENSDART00000103330
ChaC, cation transport regulator homolog 1 (E. coli)
chr24_-_24848612 0.96 ENSDART00000190941
corticotropin releasing hormone b
chr3_+_55288200 0.96 ENSDART00000157002
ENSDART00000155600
si:dkey-114l24.2
chr8_-_4097722 0.95 ENSDART00000135006
cut-like homeobox 2b
chr9_+_10014514 0.95 ENSDART00000185590
neurexophilin 2a
chr19_-_32600138 0.95 ENSDART00000052101
zgc:91944
chr12_+_32323098 0.94 ENSDART00000188722
si:ch211-277e21.2
chr8_-_50346246 0.93 ENSDART00000025008
stanniocalcin 1
chr6_-_53144336 0.92 ENSDART00000154429
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr2_-_42396592 0.92 ENSDART00000127136
solute carrier organic anion transporter family member 5A1b
chr4_-_6459863 0.88 ENSDART00000138367
forkhead box P2
chr20_+_22666548 0.88 ENSDART00000147520
ligand of numb-protein X 1
chr18_+_16330720 0.87 ENSDART00000080638
neurotensin
chr25_-_19395156 0.86 ENSDART00000155335
microtubule-associated protein 1Ab
chr14_+_30910114 0.86 ENSDART00000187166
ENSDART00000078187
forkhead box O4
chr5_+_44190974 0.84 ENSDART00000182634
ENSDART00000190626
si:dkey-84j12.1
chr21_-_28439596 0.84 ENSDART00000089980
ENSDART00000132844
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr13_+_4505079 0.83 ENSDART00000144312
phosphodiesterase 10A
chr10_+_11309814 0.83 ENSDART00000145673
si:ch211-126i22.5
chr15_+_24691088 0.82 ENSDART00000110618
si:dkey-151p21.7
chr16_+_34493987 0.81 ENSDART00000138374
si:ch211-255i3.4
chr7_+_42206847 0.80 ENSDART00000149250
phosphorylase kinase, beta
chr6_+_58915889 0.80 ENSDART00000083628
DNA-damage-inducible transcript 3
chr15_+_28106498 0.78 ENSDART00000041707
unc-119 homolog a (C. elegans)
chr16_+_19014886 0.76 ENSDART00000079298
si:ch211-254p10.2
chr19_-_10043142 0.75 ENSDART00000193016
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
chr9_-_14055959 0.74 ENSDART00000146675
fer-1-like family member 6
chr3_-_41715690 0.73 ENSDART00000184703

chr15_+_22722684 0.73 ENSDART00000156760
glutamate receptor, ionotropic, kainate 4
chr3_-_41292275 0.71 ENSDART00000144088
sidekick cell adhesion molecule 1a
chr15_+_1705167 0.70 ENSDART00000081940
otolin 1b
chr13_-_24906307 0.70 ENSDART00000148191
ENSDART00000189810
K(lysine) acetyltransferase 6B
chr5_-_8096232 0.69 ENSDART00000158447
nipped-B homolog a (Drosophila)
chr9_+_3055566 0.69 ENSDART00000189906
ENSDART00000175891
ENSDART00000093021
protein phosphatase 1 regulatory subunit 9A-like A
chr7_+_56651759 0.69 ENSDART00000073600
potassium voltage-gated channel, subfamily G, member 4b
chr13_-_2112450 0.68 ENSDART00000189343
family with sequence similarity 83, member B
chr17_+_3379673 0.67 ENSDART00000176354
syntrophin, gamma 2
chr4_-_2036620 0.66 ENSDART00000150490
si:dkey-97m3.1
chr13_-_31441042 0.66 ENSDART00000076571
reticulon 1a
chr11_+_34523132 0.66 ENSDART00000192257
zinc finger, matrin-type 3
chr8_-_34052019 0.63 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pre-B-cell leukemia homeobox 3b
chr9_+_3087889 0.63 ENSDART00000146148
protein phosphatase 1 regulatory subunit 9A-like A
chr5_-_27867657 0.63 ENSDART00000112495
transcriptional and immune response regulator a
chr4_+_9836465 0.61 ENSDART00000004879
heat shock protein 90, beta (grp94), member 1
chr19_-_32487469 0.61 ENSDART00000050130
guanosine monophosphate reductase
chr6_-_13498745 0.61 ENSDART00000027684
ENSDART00000189438
myosin light chain kinase b
chr5_-_28149767 0.61 ENSDART00000051515
zgc:110329
chr1_-_26023678 0.60 ENSDART00000054202
si:ch211-145b13.5
chr17_-_24714837 0.60 ENSDART00000154871
si:ch211-15d5.11
chr21_-_25522510 0.59 ENSDART00000162711
connector enhancer of kinase suppressor of Ras 2b
chr3_-_41292569 0.59 ENSDART00000111856
sidekick cell adhesion molecule 1a
chr23_-_29824146 0.58 ENSDART00000020616
zgc:194189
chr9_-_12034444 0.57 ENSDART00000038651
zinc finger protein 804A
chr11_-_18604317 0.55 ENSDART00000182081
zinc finger, MYND-type containing 8
chr20_+_36730049 0.55 ENSDART00000045948
nuclear receptor coactivator 1

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7l1a+tcf7l1b+tcf7l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.7 0.7 GO:0055057 neuroblast division(GO:0055057)
0.7 2.7 GO:0032801 receptor catabolic process(GO:0032801)
0.7 2.0 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792)
0.6 2.6 GO:0010226 response to lithium ion(GO:0010226)
0.6 2.4 GO:0060074 synapse maturation(GO:0060074)
0.6 2.4 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.6 1.8 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.5 3.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.5 2.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.5 1.4 GO:0010747 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) regulation of organic acid transport(GO:0032890) positive regulation of organic acid transport(GO:0032892) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transport(GO:1903793) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.4 1.7 GO:0010039 response to iron ion(GO:0010039)
0.4 1.3 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.4 2.5 GO:0030242 pexophagy(GO:0030242)
0.4 2.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.4 1.9 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
0.3 5.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 1.0 GO:0035902 response to immobilization stress(GO:0035902)
0.3 2.1 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.2 2.3 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.2 5.1 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.2 0.8 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 2.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 1.5 GO:0051013 microtubule severing(GO:0051013)
0.2 0.5 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.2 1.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 1.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.7 GO:0090579 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 3.2 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 1.8 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 4.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 2.1 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.1 0.5 GO:0060092 inhibitory postsynaptic potential(GO:0060080) regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 0.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 1.2 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 2.9 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 0.8 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 2.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.6 GO:0035889 otolith tethering(GO:0035889)
0.1 0.8 GO:1900186 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 1.0 GO:0010955 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.1 1.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:0035092 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.3 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1 3.9 GO:0061512 protein localization to cilium(GO:0061512)
0.1 0.2 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.4 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.5 GO:0042554 superoxide anion generation(GO:0042554)
0.1 0.3 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 1.7 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.1 3.4 GO:0030901 midbrain development(GO:0030901)
0.1 2.8 GO:0031103 axon regeneration(GO:0031103)
0.1 3.9 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.1 4.8 GO:0042461 photoreceptor cell development(GO:0042461)
0.1 1.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 1.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 2.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.3 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.3 GO:0015846 polyamine transport(GO:0015846) putrescine biosynthetic process from ornithine(GO:0033387) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.4 GO:0051928 positive regulation of calcium ion transport(GO:0051928)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 1.6 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.6 GO:0045471 response to ethanol(GO:0045471)
0.0 1.4 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.3 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 1.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.9 GO:0010842 retina layer formation(GO:0010842)
0.0 0.9 GO:0051180 vitamin transport(GO:0051180)
0.0 2.5 GO:0008016 regulation of heart contraction(GO:0008016)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.4 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 2.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 2.1 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.6 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 0.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 5.2 GO:0034765 regulation of ion transmembrane transport(GO:0034765)
0.0 5.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.2 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 4.7 GO:0007601 visual perception(GO:0007601)
0.0 1.8 GO:0007098 centrosome cycle(GO:0007098)
0.0 1.9 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 0.7 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0 2.1 GO:1990778 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 1.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.7 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 1.1 GO:0044042 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 0.2 GO:0048512 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 1.7 GO:0043194 axon initial segment(GO:0043194)
0.2 3.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 0.6 GO:1902560 GMP reductase complex(GO:1902560)
0.2 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.2 6.8 GO:0005861 troponin complex(GO:0005861)
0.2 3.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.7 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 1.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 3.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.8 GO:0032420 stereocilium(GO:0032420)
0.1 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.2 GO:0016459 myosin complex(GO:0016459)
0.1 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 1.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.8 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 1.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.5 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 6.6 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.3 GO:0005844 polysome(GO:0005844)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.5 GO:0030496 midbody(GO:0030496)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.4 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.7 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.2 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 1.1 GO:0005930 axoneme(GO:0005930)
0.0 3.9 GO:0005929 cilium(GO:0005929)
0.0 0.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.3 GO:0014069 postsynaptic density(GO:0014069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.5 GO:0032052 bile acid binding(GO:0032052)
0.8 2.3 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.6 1.7 GO:0003994 aconitate hydratase activity(GO:0003994)
0.5 2.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.5 3.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.5 2.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.5 5.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.4 1.3 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.4 3.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.4 1.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 2.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 1.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 2.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.3 2.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.3 1.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.3 1.8 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.3 1.8 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.2 1.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.6 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.2 1.8 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 1.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 6.6 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.2 3.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 3.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 2.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.5 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
0.1 4.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 5.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.2 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.1 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.1 0.7 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 3.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 2.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 3.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.9 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.5 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 2.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.2 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.1 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 2.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.5 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.8 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.3 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.5 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 2.2 GO:0071949 FAD binding(GO:0071949)
0.0 0.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.5 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 7.5 GO:0003774 motor activity(GO:0003774)
0.0 3.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 4.3 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 1.7 GO:0051287 NAD binding(GO:0051287)
0.0 3.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 1.0 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.9 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.5 PID CONE PATHWAY Visual signal transduction: Cones
0.1 3.1 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.9 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 1.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 4.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 0.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 0.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.9 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling