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PRJEB1986: zebrafish developmental stages transcriptome

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Results for tcf21

Z-value: 0.76

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Transcription factors associated with tcf21

Gene Symbol Gene ID Gene Info
ENSDARG00000036869 transcription factor 21
ENSDARG00000111209 transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tcf21dr11_v1_chr23_-_31555696_315556960.282.5e-01Click!

Activity profile of tcf21 motif

Sorted Z-values of tcf21 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_13256415 4.31 ENSDART00000144542
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like
chr9_-_22122590 4.25 ENSDART00000108748
ENSDART00000174614
crystallin, gamma M2d9
chr8_-_25247284 4.03 ENSDART00000132697
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr19_+_9174166 3.32 ENSDART00000104637
ENSDART00000150968
si:ch211-81a5.8
chr21_+_39185761 3.24 ENSDART00000075992
ENSDART00000140644
crystallin, beta A1b
chr21_+_39185461 2.92 ENSDART00000178419
crystallin, beta A1b
chr15_+_20403084 2.77 ENSDART00000141388
ENSDART00000152734
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr10_+_21576909 2.44 ENSDART00000168604
ENSDART00000166533
protocadherin 1 alpha 3
chr9_+_13714379 2.38 ENSDART00000017593
ENSDART00000145503
transmembrane protein 237a
chr6_+_13742899 2.37 ENSDART00000104722
cyclin-dependent kinase 5, regulatory subunit 2a (p39)
chr11_+_29975830 2.25 ENSDART00000148929
si:ch73-226l13.2
chr1_-_22691182 2.12 ENSDART00000076766
fibroblast growth factor binding protein 2b
chr25_-_19655820 2.03 ENSDART00000149585
ENSDART00000104353
ATPase plasma membrane Ca2+ transporting 1b
chr21_-_43952958 2.03 ENSDART00000039571
calcium/calmodulin-dependent protein kinase II alpha
chr11_-_11266882 1.99 ENSDART00000020256
lengsin, lens protein with glutamine synthetase domain
chr1_-_14258409 1.98 ENSDART00000079359
phosphodiesterase 5A, cGMP-specific, a
chr6_-_39344259 1.86 ENSDART00000104074
zgc:158846
chr25_-_20258508 1.75 ENSDART00000133860
ENSDART00000006840
ENSDART00000173434
dynamin 1-like
chr10_-_24362775 1.75 ENSDART00000182104
phosphatidylinositol transfer protein, alpha b
chr8_+_39724138 1.72 ENSDART00000009323
phospholipase A2, group IB (pancreas)
chr23_+_29908348 1.67 ENSDART00000186622
ENSDART00000150174
si:ch73-236e11.2
chr5_-_24238733 1.65 ENSDART00000138170
phospholipid scramblase 3a
chr8_-_44004135 1.54 ENSDART00000136269
RIMS binding protein 2
chr24_-_26383978 1.51 ENSDART00000031426
SKI-like proto-oncogene b
chr22_+_1049367 1.50 ENSDART00000065380
calcium/calmodulin-dependent protein kinase IGa
chr4_+_7508316 1.49 ENSDART00000170924
ENSDART00000170933
ENSDART00000164985
ENSDART00000167571
ENSDART00000158843
ENSDART00000158999
troponin T2e, cardiac
chr11_+_21910343 1.48 ENSDART00000161485
forkhead box P4
chr3_+_56876280 1.47 ENSDART00000154197
amnion associated transmembrane protein
chr9_-_49531762 1.46 ENSDART00000121875
xin actin binding repeat containing 2b
chr2_+_6734108 1.45 ENSDART00000112227
bone morphogenetic protein/retinoic acid inducible neural-specific 3b
chr11_-_183328 1.43 ENSDART00000168562
advillin
chr8_-_43997538 1.40 ENSDART00000186449
RIMS binding protein 2
chr5_+_37068223 1.39 ENSDART00000164279
si:dkeyp-110c7.4
chr14_+_32837914 1.33 ENSDART00000158888
arrestin 3b, retinal (X-arrestin)
chr7_+_34231782 1.32 ENSDART00000173547
lactase-like a
chr5_+_28830643 1.32 ENSDART00000051448
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr24_+_37361111 1.31 ENSDART00000078771
si:ch211-183d21.3
chr18_+_39028417 1.29 ENSDART00000148428
myosin VAa
chr24_-_29906904 1.27 ENSDART00000178791

chr15_-_16098531 1.26 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr23_+_44307996 1.26 ENSDART00000042430
discs, large homolog 4b (Drosophila)
chr6_+_112579 1.26 ENSDART00000034505
adaptor-related protein complex 1, mu 2 subunit
chr23_+_20563779 1.24 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr7_+_26224211 1.23 ENSDART00000173999
VGF nerve growth factor inducible
chr13_-_40499296 1.22 ENSDART00000158338
Danio rerio cyclin and CBS domain divalent metal cation transport mediator 1 (cnnm1), mRNA.
chr18_+_907266 1.18 ENSDART00000171729
pyruvate kinase M1/2a
chr24_+_22056386 1.16 ENSDART00000132390
ankyrin repeat domain 33ba
chr24_-_35707552 1.13 ENSDART00000165199
microtubule-associated protein, RP/EB family, member 2
chr15_-_10455438 1.11 ENSDART00000158958
ENSDART00000192971
ENSDART00000162133
ENSDART00000185071
ENSDART00000192444
ENSDART00000165668
ENSDART00000175825
teneurin transmembrane protein 4
chr20_-_26551210 1.10 ENSDART00000077715
si:dkey-25e12.3
chr19_+_43669122 1.05 ENSDART00000139151
si:ch211-193k19.1
chr5_+_28849155 1.04 ENSDART00000079090
zgc:174259
chr5_-_30079434 1.04 ENSDART00000133981
beta-carotene oxygenase 2a
chr10_+_10738880 1.03 ENSDART00000004181
solute carrier family 27 (fatty acid transporter), member 4
chr25_+_3326885 1.03 ENSDART00000104866
lactate dehydrogenase Bb
chr7_+_10610791 1.01 ENSDART00000166064
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr8_+_25247245 1.00 ENSDART00000045798
adenosine monophosphate deaminase 2b
chr19_-_2085027 0.98 ENSDART00000063615
sorting nexin 13
chr15_-_47115787 0.98 ENSDART00000192601

chr3_+_29714775 0.97 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr11_+_24819624 0.97 ENSDART00000155514
lysine (K)-specific demethylase 5Ba
chr23_-_16692312 0.96 ENSDART00000046784
FK506 binding protein 1Ab
chr8_+_14792830 0.96 ENSDART00000139972
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr4_-_75175407 0.96 ENSDART00000180125

chr20_+_42668875 0.95 ENSDART00000048890
solute carrier family 22 (organic cation transporter), member 2
chr16_-_22004402 0.95 ENSDART00000145100
ENSDART00000188217
ENSDART00000180083
si:dkey-71b5.7
chr7_-_44672095 0.95 ENSDART00000073745
CKLF-like MARVEL transmembrane domain containing 4
chr3_+_22935183 0.95 ENSDART00000157378
histone deacetylase 5
chr20_+_46560258 0.94 ENSDART00000122115
si:ch211-153j24.3
chr7_-_24047316 0.94 ENSDART00000184799
dehydrogenase/reductase (SDR family) member 4
chr21_-_16632808 0.94 ENSDART00000172645
unc-5 netrin receptor Da
chr21_-_293146 0.93 ENSDART00000157781
plasminogen receptor, C-terminal lysine transmembrane protein
chr6_+_37752781 0.92 ENSDART00000154364
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr24_-_31123365 0.92 ENSDART00000182947
transmembrane protein 56a
chr4_-_815871 0.91 ENSDART00000067455
dihydropyrimidinase-like 5b
chr20_+_18163355 0.89 ENSDART00000011287
aquaporin 4
chr4_+_53246788 0.88 ENSDART00000184708
ENSDART00000169256
si:dkey-250k10.1
chr14_+_21783229 0.88 ENSDART00000170784
ankyrin repeat domain 13 family, member D
chr21_+_27382893 0.87 ENSDART00000005682
actinin alpha 3a
chr21_-_41617372 0.85 ENSDART00000187171

chr18_-_399554 0.84 ENSDART00000164374
ENSDART00000186311
ENSDART00000181816
ENSDART00000181892
si:ch211-79l17.1
chr6_+_58915889 0.84 ENSDART00000083628
DNA-damage-inducible transcript 3
chr17_-_14726824 0.83 ENSDART00000162947
si:ch73-305o9.3
chr13_+_23677949 0.83 ENSDART00000144215
pecanex-like 2 (Drosophila)
chr19_-_32804535 0.83 ENSDART00000175613
ENSDART00000052098
5'-nucleotidase, cytosolic IAa
chr9_-_35155089 0.81 ENSDART00000077901
amyloid beta (A4) precursor protein b
chr10_+_24445698 0.81 ENSDART00000146370
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr25_-_32869794 0.78 ENSDART00000162784
transmembrane protein 266
chr18_-_7948188 0.78 ENSDART00000091805
SH3 and multiple ankyrin repeat domains 3a
chr16_+_27957808 0.77 ENSDART00000133696
zinc finger protein 804B
chr21_+_19418563 0.76 ENSDART00000181113
ENSDART00000080110
alpha-methylacyl-CoA racemase
chr6_+_28054639 0.76 ENSDART00000187478
ENSDART00000189194
si:ch73-194h10.2
chr6_-_35032792 0.76 ENSDART00000168256
discoidin domain receptor tyrosine kinase 2a
chr8_-_6943155 0.76 ENSDART00000139545
ENSDART00000033294
WD repeat domain 13
chr22_-_10470663 0.75 ENSDART00000143352
osteomodulin
chr13_+_2442841 0.75 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
ARFGEF family member 3
chr13_+_1575276 0.74 ENSDART00000165987
dystonin
chr14_-_46832825 0.74 ENSDART00000149571
LIM domain binding 2a
chr16_+_47428721 0.73 ENSDART00000180597
ENSDART00000032309
solute carrier family 25 (mitochondrial folate carrier), member 32b
chr5_+_28848870 0.73 ENSDART00000149563
zgc:174259
chr23_+_23183449 0.73 ENSDART00000132296
kelch-like family member 17
chr21_-_22635245 0.72 ENSDART00000115224
ENSDART00000101782
nectin cell adhesion molecule 1a
chr7_-_24046999 0.71 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dehydrogenase/reductase (SDR family) member 4
chr13_-_280827 0.71 ENSDART00000144819
solute carrier family 30 (zinc transporter), member 6
chr17_-_19828505 0.71 ENSDART00000154745
formin 2a
chr2_+_243778 0.70 ENSDART00000182262

chr12_+_2660733 0.70 ENSDART00000152235
interphotoreceptor retinoid-binding protein like
chr5_-_57480660 0.69 ENSDART00000147875
ENSDART00000142776
si:ch211-202f5.2
chr7_+_17096281 0.68 ENSDART00000035558
HIV-1 Tat interactive protein 2
chr8_-_44868020 0.68 ENSDART00000142712
calcium channel, voltage-dependent, L type, alpha 1F subunit a
chr21_+_8427059 0.68 ENSDART00000143151
DENN/MADD domain containing 1A
chr3_-_28075756 0.68 ENSDART00000122037
RNA binding fox-1 homolog 1
chr19_-_24758109 0.68 ENSDART00000161016
si:dkey-154b15.1
chr22_+_24157807 0.67 ENSDART00000159165
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr3_-_34724879 0.66 ENSDART00000177021
thyroid hormone receptor alpha a
chr1_+_25801648 0.65 ENSDART00000129471
guanylate cyclase 1 soluble subunit beta 1
chr5_-_38428217 0.63 ENSDART00000191902
phospholipase D2
chr8_-_1838315 0.63 ENSDART00000114476
ENSDART00000140077
phosphatidylinositol 4-kinase, catalytic, alpha b
chr10_-_34741738 0.62 ENSDART00000163072
doublecortin-like kinase 1a
chr2_-_34483597 0.62 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr14_+_21783400 0.62 ENSDART00000164023
ankyrin repeat domain 13 family, member D
chr8_+_40080728 0.62 ENSDART00000111506
leucine rich repeat containing 75Ba
chr21_-_36571804 0.62 ENSDART00000138129
WW and C2 domain containing 1
chr13_+_2625150 0.60 ENSDART00000164177
phospholipid phosphatase 4
chr2_+_37480669 0.60 ENSDART00000029801
signal peptide peptidase-like 2
chr15_+_29276508 0.59 ENSDART00000170537
ENSDART00000126559
RAP1 GTPase activating protein 2a
chr3_+_4266289 0.59 ENSDART00000101636
si:dkey-73p2.1
chr15_+_28096152 0.58 ENSDART00000100293
ENSDART00000140092
crystallin, beta B1, like 3
chr3_+_14571813 0.58 ENSDART00000146728
ENSDART00000171731
zinc finger protein 653
chr18_-_10995410 0.58 ENSDART00000136751
tetraspanin 33b
chr25_-_36044583 0.58 ENSDART00000073432
retinoblastoma-like 2 (p130)
chr7_+_6969909 0.57 ENSDART00000189886
actinin alpha 3b
chr8_+_36500061 0.57 ENSDART00000185840
solute carrier family 7, member 4
chr17_-_51195651 0.56 ENSDART00000191205
ENSDART00000088185
papilin a, proteoglycan-like sulfated glycoprotein
chr8_+_53563949 0.55 ENSDART00000190022
ENSDART00000190927

chr14_+_12110020 0.55 ENSDART00000192462
potassium channel tetramerisation domain containing 12b
chr18_+_23218980 0.55 ENSDART00000185014
myocyte enhancer factor 2aa
chr6_-_40098641 0.54 ENSDART00000017402
inositol hexakisphosphate kinase 2b
chr14_+_12109535 0.54 ENSDART00000054620
ENSDART00000121913
potassium channel tetramerisation domain containing 12b
chr10_-_7892192 0.53 ENSDART00000145480
smoothelin a
chr5_+_67448664 0.53 ENSDART00000105731
si:dkey-251i10.1
chr8_+_30456161 0.53 ENSDART00000085894
phosphoglucomutase 5
chr13_+_24584401 0.53 ENSDART00000057599
fucose mutarotase
chr14_+_9287683 0.52 ENSDART00000122485
moesin b
chr21_-_12749501 0.51 ENSDART00000179724

chr15_+_42599501 0.51 ENSDART00000177646
glutamate receptor, ionotropic, kainate 1b
chr8_-_14151051 0.51 ENSDART00000090427
si:dkey-6n6.1
chr13_+_21601149 0.51 ENSDART00000179369
SH2 domain containing 4Ba
chr23_+_25879320 0.50 ENSDART00000124963
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr11_+_77526 0.50 ENSDART00000193521

chr24_+_38155830 0.50 ENSDART00000152019
si:ch211-234p6.5
chr10_-_35321625 0.49 ENSDART00000131268
rhomboid domain containing 2
chr7_-_66864756 0.48 ENSDART00000184462
ENSDART00000189424
adenosine monophosphate deaminase 3a
chr3_+_23654233 0.48 ENSDART00000078428
homeobox B13a
chr6_+_23931236 0.48 ENSDART00000166079
growth arrest and DNA-damage-inducible, alpha, b
chr15_+_9072821 0.47 ENSDART00000154463
si:dkey-202g17.3
chr2_-_52455525 0.47 ENSDART00000160768
ENSDART00000002241
chico
chr5_+_28857969 0.47 ENSDART00000149850
si:ch211-186e20.2
chr14_+_146857 0.46 ENSDART00000122521

chr7_-_6357952 0.46 ENSDART00000173197
zgc:165555
chr16_+_11151699 0.46 ENSDART00000140674
capicua transcriptional repressor b
chr17_+_8323348 0.45 ENSDART00000169900
CDC42 binding protein kinase alpha (DMPK-like) a
chr5_+_19165949 0.44 ENSDART00000140710
unc-13 homolog Ba (C. elegans)
chr24_-_11905911 0.44 ENSDART00000033621
transmembrane 9 superfamily member 1
chr3_-_19495814 0.44 ENSDART00000162248

chr3_-_2623176 0.43 ENSDART00000179792
ENSDART00000123512
si:dkey-217f16.6
chr7_+_7048245 0.42 ENSDART00000001649
actinin alpha 3b
chr5_+_28830388 0.42 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr13_+_2448251 0.41 ENSDART00000188361
ARFGEF family member 3
chr16_-_42750295 0.41 ENSDART00000176570
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr19_+_43119698 0.41 ENSDART00000167847
ENSDART00000186962
ENSDART00000187305
eukaryotic translation elongation factor 1 alpha 1, like 1
chr1_-_8012476 0.40 ENSDART00000177051

chr13_-_37619159 0.40 ENSDART00000186348
zgc:152791
chr6_+_27339962 0.40 ENSDART00000193726
kelch-like family member 30
chr1_+_52560549 0.39 ENSDART00000167514
ATP-binding cassette, sub-family A (ABC1), member 1A
chr10_+_23520952 0.39 ENSDART00000125317
zmp:0000000937
chr9_-_39624173 0.39 ENSDART00000180106
ENSDART00000126766
erb-b2 receptor tyrosine kinase 4b
chr10_-_20065149 0.37 ENSDART00000182603

chr21_-_4755943 0.36 ENSDART00000137404
calmodulin regulated spectrin-associated protein 1a
chr3_+_58379450 0.36 ENSDART00000155759
short chain dehydrogenase/reductase family 42E, member 2
chr5_+_28858345 0.35 ENSDART00000111180
si:ch211-186e20.2
chr23_-_31346319 0.35 ENSDART00000008401
ENSDART00000138106
pleckstrin homology domain interacting protein
chr5_+_1911814 0.35 ENSDART00000172233
si:ch73-55i23.1
chr9_-_44983666 0.35 ENSDART00000149704
integrin, beta 2
chr15_-_25365319 0.34 ENSDART00000152651
clustered mitochondria (cluA/CLU1) homolog a
chr22_-_906757 0.34 ENSDART00000193182

chr16_-_31451720 0.33 ENSDART00000146886
casein kinase 2, alpha 1 polypeptide
chr23_-_18057553 0.33 ENSDART00000173102
ENSDART00000058742
zgc:92287
chr18_+_8901846 0.33 ENSDART00000132109
ENSDART00000144247
si:dkey-5i3.5
chr15_-_23647078 0.33 ENSDART00000059366
creatine kinase, muscle b
chr7_-_40578733 0.33 ENSDART00000173926
ENSDART00000010035
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr11_-_18604542 0.32 ENSDART00000171183
zinc finger, MYND-type containing 8
chr2_-_49997055 0.32 ENSDART00000140294
si:ch211-106n13.3
chr17_+_8292892 0.32 ENSDART00000125728
si:ch211-236p5.3
chr4_-_4834347 0.32 ENSDART00000141803
cytochrome c oxidase assembly factor 6
chr18_+_14277003 0.32 ENSDART00000006628
zgc:173742
chr24_-_28333029 0.32 ENSDART00000149015
ENSDART00000129174
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr21_-_2248239 0.31 ENSDART00000169448
si:ch73-299h12.1
chr6_-_39218609 0.31 ENSDART00000133305
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr15_-_727479 0.30 ENSDART00000157279
si:dkey-7i4.21

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.4 1.3 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.4 4.0 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.3 1.7 GO:1903146 regulation of mitophagy(GO:1903146)
0.3 1.0 GO:0010657 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.3 1.0 GO:0015695 organic cation transport(GO:0015695)
0.3 1.8 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 0.7 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.2 1.7 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 0.9 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.2 1.1 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 0.8 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.2 2.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 1.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.7 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 1.0 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 2.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.5 GO:0015859 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 1.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 1.7 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 1.0 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.8 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.1 1.5 GO:0032264 IMP salvage(GO:0032264)
0.1 0.9 GO:0006833 water transport(GO:0006833)
0.1 0.4 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.5 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331) positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1 0.6 GO:0032475 otolith formation(GO:0032475)
0.1 0.9 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.4 GO:0016081 synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.1 9.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 0.9 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.7 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.1 0.3 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.1 0.8 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 3.3 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 1.0 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 1.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 2.4 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.9 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 1.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 4.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.7 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 1.4 GO:0051014 actin filament severing(GO:0051014)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.2 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 2.0 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.6 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 8.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 1.5 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.4 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 2.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 2.0 GO:0003146 heart jogging(GO:0003146)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.3 GO:0010888 negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888)
0.0 0.7 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 1.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.4 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 1.2 GO:0006096 glycolytic process(GO:0006096)
0.0 1.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.9 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.6 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.3 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.1 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.7 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 1.8 GO:0060027 convergent extension involved in gastrulation(GO:0060027)
0.0 2.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.3 GO:0006090 pyruvate metabolic process(GO:0006090)
0.0 0.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.8 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.7 GO:0045010 actin nucleation(GO:0045010)
0.0 0.0 GO:0009447 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.0 1.3 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 2.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 4.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 4.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 1.9 GO:0045095 keratin filament(GO:0045095)
0.2 0.6 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 3.3 GO:0043195 terminal bouton(GO:0043195)
0.1 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.7 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.3 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 2.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.8 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.4 GO:1990752 microtubule minus-end(GO:0036449) microtubule end(GO:1990752)
0.0 1.5 GO:0005861 troponin complex(GO:0005861)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.4 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.5 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 1.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.8 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.4 GO:0042641 actomyosin(GO:0042641)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.3 4.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 0.7 GO:0008517 folic acid transporter activity(GO:0008517)
0.2 1.0 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 1.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.2 2.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 2.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 2.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.5 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 1.5 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.5 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 11.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.5 GO:0070052 collagen V binding(GO:0070052)
0.1 1.0 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 3.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.8 GO:0035255 GKAP/Homer scaffold activity(GO:0030160) ionotropic glutamate receptor binding(GO:0035255)
0.1 1.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.9 GO:0015250 water channel activity(GO:0015250)
0.1 4.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.0 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.8 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 0.9 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.6 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.8 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 2.1 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.0 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.1 0.4 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.9 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.6 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 0.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 5.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.5 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 2.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 3.3 GO:0019905 syntaxin binding(GO:0019905)
0.0 2.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.7 GO:0005501 retinoid binding(GO:0005501) isoprenoid binding(GO:0019840)
0.0 0.4 GO:0030507 spectrin binding(GO:0030507)
0.0 3.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 1.5 GO:0046332 SMAD binding(GO:0046332)
0.0 1.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.1 GO:0019838 growth factor binding(GO:0019838)
0.0 0.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 2.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 2.0 GO:0005125 cytokine activity(GO:0005125)
0.0 0.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.3 GO:0016208 AMP binding(GO:0016208)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 0.6 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 0.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 1.7 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.3 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.3 0.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 0.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 3.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.3 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.0 0.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1