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PRJEB1986: zebrafish developmental stages transcriptome

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Results for stat3

Z-value: 0.56

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Transcription factors associated with stat3

Gene Symbol Gene ID Gene Info
ENSDARG00000022712 signal transducer and activator of transcription 3 (acute-phase response factor)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
stat3dr11_v1_chr3_+_17030665_17030704-0.761.8e-04Click!

Activity profile of stat3 motif

Sorted Z-values of stat3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_16595177 2.68 ENSDART00000133962
si:dkey-239j18.2
chr12_-_16941319 2.58 ENSDART00000109968
zgc:174855
chr12_+_16949391 2.26 ENSDART00000152635
zgc:174153
chr19_+_10846182 1.53 ENSDART00000168479
apolipoprotein A-IV a
chr13_+_33651416 1.45 ENSDART00000180221

chr13_+_14976108 1.41 ENSDART00000011520
notochord homeobox
chr19_-_47782916 1.35 ENSDART00000063337
cell division cycle associated 8
chr23_+_42414652 1.34 ENSDART00000171119
cytochrome P450, family 2, subfamily AA, polypeptide 9
chr19_-_47782586 1.27 ENSDART00000177126
cell division cycle associated 8
chr21_-_34844059 1.14 ENSDART00000136402
zgc:56585
chr21_-_34844316 1.12 ENSDART00000029708
zgc:56585
chr19_+_15443540 1.09 ENSDART00000193355
lin-28 homolog A (C. elegans)
chr2_+_13710439 1.04 ENSDART00000155712
EBNA1 binding protein 2
chr21_+_20901505 1.04 ENSDART00000132741
complement component 7b
chr14_-_32744464 1.00 ENSDART00000075617
SRY (sex determining region Y)-box 3
chr24_+_31361407 0.99 ENSDART00000162668
cAMP responsive element modulator b
chr15_+_24737599 0.97 ENSDART00000078024
v-crk avian sarcoma virus CT10 oncogene homolog
chr13_-_49819027 0.96 ENSDART00000067824
beta-1,3-N-acetylgalactosaminyltransferase 2
chr21_+_8341774 0.94 ENSDART00000129749
ENSDART00000055325
ENSDART00000133804
proteasome subunit beta 7
chr5_-_23619911 0.92 ENSDART00000020004
myotubularin related protein 2
chr19_+_15443063 0.92 ENSDART00000151732
lin-28 homolog A (C. elegans)
chr19_+_15443353 0.90 ENSDART00000135923
lin-28 homolog A (C. elegans)
chr19_+_10845953 0.89 ENSDART00000157589
apolipoprotein A-IV a
chr7_+_41313568 0.89 ENSDART00000016660
zgc:165532
chr21_+_43328685 0.85 ENSDART00000109620
ENSDART00000139668
septin 8a
chr7_+_38809241 0.84 ENSDART00000190979
harbinger transposase derived 1
chr11_+_12720171 0.81 ENSDART00000135761
ENSDART00000122812
adaptor-related protein complex 1, sigma 2 subunit
chr2_+_26288301 0.80 ENSDART00000017668
polypyrimidine tract binding protein 1a
chr18_-_26797723 0.79 ENSDART00000008013
SEC11 homolog A, signal peptidase complex subunit
chr25_-_24240797 0.76 ENSDART00000132790
SPT2 chromatin protein domain containing 1
chr4_+_47257854 0.74 ENSDART00000173868
crestin
chr5_+_24179307 0.73 ENSDART00000051552
mannose-P-dolichol utilization defect 1a
chr17_-_10838434 0.71 ENSDART00000064597
lectin, galactoside binding soluble 3b
chr13_+_39532050 0.69 ENSDART00000019379
MARVEL domain containing 1
chr10_-_20105553 0.69 ENSDART00000184502
polysaccharide biosynthesis domain containing 1
chr17_+_16046314 0.67 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr19_+_10937932 0.67 ENSDART00000168968
si:ch73-347e22.8
chr7_+_22313533 0.67 ENSDART00000123457
si:dkey-11f12.2
chr18_-_14860435 0.66 ENSDART00000018502
mitogen-activated protein kinase 12a
chr9_-_43644261 0.66 ENSDART00000023684
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr7_-_22790630 0.65 ENSDART00000173496
si:ch211-15b10.6
chr10_+_13209580 0.65 ENSDART00000000887
ENSDART00000136932
Ras association (RalGDS/AF-6) domain family 6
chr2_-_37837472 0.64 ENSDART00000165347
methyltransferase like 17
chr14_+_11457500 0.64 ENSDART00000169202
si:ch211-153b23.5
chr12_-_34435604 0.64 ENSDART00000115088
baculoviral IAP repeat containing 5a
chr15_-_3282220 0.63 ENSDART00000092942
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15a
chr4_-_1818315 0.62 ENSDART00000067433
ubiquitin-conjugating enzyme E2Nb
chr17_+_10318071 0.62 ENSDART00000161844
forkhead box A1
chr3_-_35541378 0.62 ENSDART00000183075
ENSDART00000022147
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1b
chr10_-_3332362 0.59 ENSDART00000007577
ENSDART00000055140
torsin family 4, member Aa
chr2_-_37896646 0.59 ENSDART00000075931
hexose-binding lectin 1
chr5_+_28271412 0.59 ENSDART00000031727
vesicle-associated membrane protein 8 (endobrevin)
chr3_+_19665319 0.59 ENSDART00000007857
ENSDART00000193509
methyltransferase like 2A
chr7_-_28696556 0.59 ENSDART00000148822
adhesion G protein-coupled receptor G1
chr6_+_55357188 0.59 ENSDART00000158219
phospholipid transfer protein
chr15_-_1485086 0.59 ENSDART00000191651
si:dkeyp-97b10.3
chr23_-_5783421 0.57 ENSDART00000131521
ENSDART00000019455
cysteine and glycine-rich protein 1a
chr13_-_12021566 0.57 ENSDART00000125430
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr18_-_19004247 0.57 ENSDART00000135800
integrator complex subunit 14
chr17_+_16046132 0.57 ENSDART00000155005
si:ch73-204p21.2
chr22_-_834106 0.57 ENSDART00000105873
cryptochrome circadian clock 4
chr19_+_43359075 0.56 ENSDART00000148287
ENSDART00000149856
ENSDART00000188236
ENSDART00000136695
ENSDART00000193859
Yes-related kinase
chr6_+_43015916 0.56 ENSDART00000064888
T cell leukemia translocation altered
chr1_-_26398361 0.56 ENSDART00000160183
pyrophosphatase (inorganic) 2
chr16_-_31718013 0.55 ENSDART00000190716
retinol binding protein 1a, cellular
chr19_+_47783137 0.55 ENSDART00000024777
ENSDART00000158979
c19h1orf109 homolog (H. sapiens)
chr5_+_25765522 0.55 ENSDART00000133217
transmembrane protein 2
chr15_-_23475051 0.55 ENSDART00000152460
NLR family member X1
chr5_+_65040228 0.55 ENSDART00000164278
peptidase (mitochondrial processing) alpha
chr3_+_40289418 0.54 ENSDART00000017304
cleavage and polyadenylation specific factor 4
chr16_-_22930925 0.54 ENSDART00000133819
si:dkey-246i14.3
chr15_-_1484795 0.54 ENSDART00000129356
si:dkeyp-97b10.3
chr2_+_37837249 0.53 ENSDART00000113337
poly (ADP-ribose) polymerase 2
chr5_+_15819651 0.53 ENSDART00000081230
ENSDART00000186969
ENSDART00000134206
heat shock protein b8
chr2_-_47431205 0.52 ENSDART00000014350
ENSDART00000038828
paired box 3a
chr16_+_42772678 0.52 ENSDART00000155575
si:ch211-135n15.2
chr15_+_40188076 0.52 ENSDART00000063779
EF-hand domain family, member D1
chr23_-_33558161 0.52 ENSDART00000018301
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr6_-_7726849 0.52 ENSDART00000151511
solute carrier family 25, member 38b
chr9_+_40825065 0.52 ENSDART00000137673
si:dkey-95p16.2
chr1_-_59313465 0.51 ENSDART00000158067
ENSDART00000159419
thioredoxin domain containing 11
chr21_+_19834072 0.49 ENSDART00000147555
coiled-coil domain containing 80 like 2
chr8_+_32755688 0.49 ENSDART00000137897
hemicentin 2
chr18_-_3166726 0.49 ENSDART00000165002
aquaporin 11
chr2_+_4402765 0.48 ENSDART00000159525
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b
chr5_+_36895860 0.48 ENSDART00000134493
serine/arginine-rich splicing factor 7a
chr7_-_22941472 0.47 ENSDART00000190334
TNF superfamily member 10, like
chr2_-_37837056 0.47 ENSDART00000158179
ENSDART00000160317
ENSDART00000171409
methyltransferase like 17
chr2_+_10766744 0.46 ENSDART00000015379
growth factor independent 1A transcription repressor a
chr20_+_35433192 0.46 ENSDART00000017485
splicing factor 3b, subunit 6
chr18_+_37219140 0.46 ENSDART00000088247
glutaminyl-peptide cyclotransferase-like a
chr23_-_10175898 0.46 ENSDART00000146185
keratin 5
chr23_+_5524247 0.46 ENSDART00000189679
ENSDART00000083622
TEA domain family member 3 a
chr20_-_23440955 0.46 ENSDART00000153386
solute carrier family 10, member 4
chr6_+_36821621 0.45 ENSDART00000104157
transmembrane protein 45a
chr1_-_17711636 0.45 ENSDART00000148322
ENSDART00000122670
ufm1-specific peptidase 2
chr20_+_27087539 0.45 ENSDART00000062094
transmembrane protein 251
chr2_+_20967673 0.45 ENSDART00000057174
actin related protein 2/3 complex, subunit 5A
chr3_+_18050667 0.44 ENSDART00000035531
methyltransferase like 26
chr16_-_31717851 0.44 ENSDART00000169109
retinol binding protein 1a, cellular
chr13_+_22719789 0.43 ENSDART00000057672
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr8_-_14609284 0.43 ENSDART00000146175
centrosomal protein 350
chr6_-_34220641 0.42 ENSDART00000102391
doublesex and mab-3 related transcription factor 2b
chr2_+_44972720 0.42 ENSDART00000075146
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr8_+_29749017 0.41 ENSDART00000185144
mitogen-activated protein kinase 4
chr16_+_48631412 0.41 ENSDART00000154273
pre-B-cell leukemia homeobox 2
chr2_+_17181777 0.41 ENSDART00000112063
prostaglandin E receptor 4 (subtype EP4) c
chr21_+_35215810 0.41 ENSDART00000135256
ubiquitin domain containing 2
chr24_+_16149251 0.41 ENSDART00000188289
si:dkey-118j18.2
chr16_+_31922065 0.40 ENSDART00000131661
ENSDART00000144194
ENSDART00000145510
ribosomal protein S9
chr16_+_31921812 0.40 ENSDART00000176928
ENSDART00000193733
ribosomal protein S9
chr13_+_25549425 0.40 ENSDART00000087553
ENSDART00000169199
SEC23 interacting protein
chr24_+_37406535 0.40 ENSDART00000138264
si:ch211-183d21.1
chr22_-_9861531 0.39 ENSDART00000193197
si:dkey-253d23.2
chr24_+_16149514 0.38 ENSDART00000152087
si:dkey-118j18.2
chr23_+_30736895 0.38 ENSDART00000042944
additional sex combs like transcriptional regulator 1
chr23_-_19715799 0.38 ENSDART00000142072
ENSDART00000032744
ENSDART00000131860
ribosomal protein L10
chr9_-_12659140 0.38 ENSDART00000058565
PTTG1 interacting protein b
chr14_-_6987649 0.37 ENSDART00000060990
eukaryotic translation initiation factor 4E binding protein 3, like
chr20_-_5400395 0.37 ENSDART00000168103
SNW domain containing 1
chr13_-_25548733 0.37 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
minichromosome maintenance complex binding protein
chr6_-_35106425 0.37 ENSDART00000165139
nitric oxide synthase 1 (neuronal) adaptor protein a
chr2_+_41526904 0.36 ENSDART00000127520
activin A receptor, type 1 like
chr16_-_32006737 0.36 ENSDART00000184813
ENSDART00000179827
glutathione S-transferase kappa 4
chr18_+_18982077 0.36 ENSDART00000006300
3-hydroxyacyl-CoA dehydratase 3
chr11_-_287670 0.36 ENSDART00000035737
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr3_-_6709938 0.35 ENSDART00000172196
autophagy related 4D, cysteine peptidase b
chr6_-_40573221 0.35 ENSDART00000157203
ENSDART00000154951
translocase of outer mitochondrial membrane 6 homolog (yeast)
chr6_+_13232934 0.34 ENSDART00000089725
INO80 complex subunit Db
chr11_+_16040517 0.33 ENSDART00000111284
angiotensin II receptor-associated protein
chr9_+_20853894 0.33 ENSDART00000003648
WD repeat domain 3
chr1_+_32341734 0.32 ENSDART00000135078
pseudouridine 5'-phosphatase
chr4_-_72356954 0.32 ENSDART00000127023
si:cabz01071909.2
chr14_+_11395383 0.32 ENSDART00000106657
glyoxalase domain containing 5
chr25_-_28587896 0.32 ENSDART00000111908
si:dkeyp-67e1.6
chr14_+_7932973 0.32 ENSDART00000109941
CXXC finger protein 5b
chr3_+_59899452 0.31 ENSDART00000064311
Rho GDP dissociation inhibitor (GDI) alpha
chr13_+_6092135 0.31 ENSDART00000162738
family with sequence similarity 120B
chr24_+_13635108 0.31 ENSDART00000183008
transient receptor potential cation channel, subfamily A, member 1b
chr19_-_30420602 0.31 ENSDART00000144121
protein phosphatase 1, regulatory subunit 10
chr11_-_20956309 0.30 ENSDART00000188659

chr8_-_30979494 0.30 ENSDART00000138959
si:ch211-251j10.3
chr1_+_29741843 0.30 ENSDART00000136066
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr5_+_29820266 0.30 ENSDART00000146331
ENSDART00000098315
F11 receptor, tandem duplicate 2
chr6_+_40573365 0.30 ENSDART00000004075
ubiquinol-cytochrome c reductase complex assembly factor 2
chr20_+_32497260 0.30 ENSDART00000145175
ENSDART00000132921
si:ch73-257c13.2
chr21_+_39673157 0.30 ENSDART00000100240
mitochondrial rRNA methyltransferase 3b
chr3_+_1219344 0.30 ENSDART00000161945
ribosomal RNA processing 7 homolog A
chr5_+_67835595 0.30 ENSDART00000159386
si:ch211-271b14.1
chr18_-_15373620 0.30 ENSDART00000031752
regulatory factor X, 4
chr1_+_51827046 0.30 ENSDART00000052992
DAN domain family, member 5
chr22_+_10713713 0.29 ENSDART00000122349
hippocampus abundant transcript 1b
chr4_+_3455665 0.29 ENSDART00000058277
zinc finger protein 800b
chr9_-_20853439 0.29 ENSDART00000028247
ENSDART00000133321
ganglioside induced differentiation associated protein 2
chr17_+_34206167 0.29 ENSDART00000136167
membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5)
chr3_+_4502066 0.29 ENSDART00000088610
RAN GTPase activating protein 1a
chr18_+_44631789 0.29 ENSDART00000144271
BRD4 interacting chromatin remodeling complex associated protein
chr16_-_15387459 0.29 ENSDART00000053754
hyaluronan synthase 2
chr19_+_5418006 0.28 ENSDART00000132874
eukaryotic translation initiation factor 1B
chr21_-_5879897 0.28 ENSDART00000184034
ribosomal protein L35
chr14_-_21661015 0.28 ENSDART00000189403
ENSDART00000172442
ENSDART00000181913
lysine (K)-specific demethylase 3B
chr9_+_26103814 0.28 ENSDART00000026011
ephrin-B2a
chr11_-_17964525 0.28 ENSDART00000018948
cytokine inducible SH2-containing protein b
chr6_+_37655078 0.28 ENSDART00000122199
ENSDART00000065127
cytoplasmic FMR1 interacting protein 1
chr5_+_26213874 0.27 ENSDART00000193816
ENSDART00000098514
occludin b
chr14_-_24101897 0.27 ENSDART00000143695
cytoplasmic polyadenylation element binding protein 4a
chr22_+_9239831 0.26 ENSDART00000133720
si:ch211-250k18.5
chr18_+_6054816 0.26 ENSDART00000113668
si:ch73-386h18.1
chr21_-_43457554 0.26 ENSDART00000085039
serine/threonine protein kinase 26
chr1_+_5402476 0.26 ENSDART00000040204
tubulin, alpha 8 like 2
chr6_+_33897624 0.25 ENSDART00000166706
coiled-coil domain containing 17
chr4_+_29206813 0.25 ENSDART00000131893
si:dkey-23a23.1
chr8_-_26033176 0.25 ENSDART00000184533

chr20_-_3997531 0.25 ENSDART00000092217
tetratricopeptide repeat domain 13
chr20_-_20932760 0.25 ENSDART00000152415
ENSDART00000039907
BTB (POZ) domain containing 6b
chr4_+_76306625 0.25 ENSDART00000193823
ENSDART00000180622
si:ch73-389k6.1
chr7_-_29043075 0.25 ENSDART00000052342
THAP domain containing 11
chr4_-_4592287 0.25 ENSDART00000155287
Ras association (RalGDS/AF-6) domain family member 3
chr22_+_11153590 0.24 ENSDART00000188207
BCL6 corepressor
chr1_-_11616295 0.24 ENSDART00000188891
si:dkey-26i13.5
chr18_+_22217489 0.23 ENSDART00000165464
RHO family interacting cell polarization regulator 1
chr16_-_19254323 0.23 ENSDART00000138744
dynein, axonemal, heavy chain 11
chr16_+_25343934 0.23 ENSDART00000109710
zinc finger and AT hook domain containing
chr18_+_14684115 0.23 ENSDART00000108469
spermatogenesis associated 2-like
chr17_+_40989973 0.23 ENSDART00000160049
mitochondrial ribosomal protein L33
chr6_-_3998199 0.23 ENSDART00000059212
unc-50 homolog (C. elegans)
chr23_+_25995727 0.23 ENSDART00000137123
WNT1 inducible signaling pathway protein 2
chr1_+_19535144 0.23 ENSDART00000103089
si:dkey-245p14.4
chr18_+_20225961 0.22 ENSDART00000045679
transducin-like enhancer of split 3a
chr6_-_12296170 0.22 ENSDART00000155685
plakophilin 4
chr12_+_17042754 0.22 ENSDART00000066439
cholesterol 25-hydroxylase
chr8_-_17997845 0.22 ENSDART00000121660
acyl-CoA thioesterase 11b
chr25_+_15933411 0.22 ENSDART00000191581
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr24_-_26485098 0.22 ENSDART00000135496
ENSDART00000009609
ENSDART00000133782
ENSDART00000141029
ENSDART00000113739
eukaryotic translation initiation factor 5A
chr4_+_57580303 0.22 ENSDART00000166492
ENSDART00000103025
ENSDART00000170786
interleukin 17 receptor A1b
interleukin 17 receptor A2
chr5_+_36895545 0.21 ENSDART00000135776
ENSDART00000147561
ENSDART00000133842
ENSDART00000051185
ENSDART00000141984
ENSDART00000136301
ENSDART00000142388
serine/arginine-rich splicing factor 7a
chr4_-_41269844 0.21 ENSDART00000186177

chr21_+_25777425 0.21 ENSDART00000021620
claudin d
chr20_-_19858936 0.21 ENSDART00000161579
protein tyrosine kinase 2 beta, b
chr6_+_22679610 0.21 ENSDART00000102701
zmp:0000000634

Network of associatons between targets according to the STRING database.

First level regulatory network of stat3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0048327 axial mesodermal cell differentiation(GO:0048321) axial mesodermal cell fate commitment(GO:0048322) axial mesodermal cell fate specification(GO:0048327) axial mesoderm structural organization(GO:0048331) mesoderm structural organization(GO:0048338)
0.3 0.8 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.2 0.6 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.2 0.8 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.2 0.8 GO:0060467 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
0.2 0.6 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.2 0.5 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.2 0.5 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.2 0.6 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.1 0.9 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.1 0.7 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1 0.4 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.1 0.5 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 0.3 GO:0065001 specification of axis polarity(GO:0065001)
0.1 0.6 GO:0070254 mucus secretion(GO:0070254)
0.1 0.6 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 0.3 GO:0003097 renal water homeostasis(GO:0003091) renal water transport(GO:0003097) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.4 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.4 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.4 GO:0010039 response to iron ion(GO:0010039)
0.1 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.4 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.1 0.2 GO:0007635 chemosensory behavior(GO:0007635) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 0.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.5 GO:0090497 mesenchymal cell migration(GO:0090497)
0.1 0.3 GO:0099563 modification of synaptic structure(GO:0099563)
0.1 0.5 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 1.5 GO:0006949 syncytium formation by plasma membrane fusion(GO:0000768) syncytium formation(GO:0006949)
0.0 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.5 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.5 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.0 0.5 GO:0050936 xanthophore differentiation(GO:0050936)
0.0 0.3 GO:0002931 response to ischemia(GO:0002931)
0.0 0.3 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.0 0.1 GO:0001774 microglial cell activation(GO:0001774)
0.0 1.0 GO:0019835 cytolysis(GO:0019835)
0.0 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.0 1.2 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.2 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.6 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 1.5 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 1.0 GO:0043049 otic placode formation(GO:0043049)
0.0 0.1 GO:0002727 response to tumor cell(GO:0002347) natural killer cell cytokine production(GO:0002370) immune response to tumor cell(GO:0002418) natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.1 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
0.0 1.0 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.1 GO:0042546 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 2.6 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.0 0.3 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.6 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0072020 proximal straight tubule development(GO:0072020)
0.0 0.4 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.0 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.0 0.1 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0 0.2 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.4 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 1.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 2.6 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.4 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.2 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.6 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 0.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.5 GO:0035329 hippo signaling(GO:0035329)
0.0 0.4 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0032366 intracellular sterol transport(GO:0032366)
0.0 0.4 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.5 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:1901099 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 7.4 GO:0051603 proteolysis involved in cellular protein catabolic process(GO:0051603)
0.0 0.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.6 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.2 1.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.3 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.1 0.6 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 0.7 GO:0001772 immunological synapse(GO:0001772)
0.1 1.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.4 GO:0070724 BMP receptor complex(GO:0070724)
0.1 1.0 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.4 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 1.0 GO:0034399 preribosome, large subunit precursor(GO:0030687) nuclear periphery(GO:0034399)
0.0 0.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.9 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 7.4 GO:0005764 lysosome(GO:0005764)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.8 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686) U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.3 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.5 GO:0008305 integrin complex(GO:0008305)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0000035 acyl binding(GO:0000035)
0.2 0.8 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 0.6 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 0.6 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.1 0.7 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.1 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.4 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.1 0.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.0 GO:0016918 retinal binding(GO:0016918)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.4 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.6 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 7.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.5 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.2 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.1 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 1.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.0 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.6 GO:0042805 actinin binding(GO:0042805)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.8 GO:0019843 rRNA binding(GO:0019843)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 0.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import