ISMARA results: sp8a+sp8b_sp4_rsl1d1+sp3a

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PRJEB1986: zebrafish developmental stages transcriptome

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Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 2.05

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Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Gene Symbol	Gene ID	Gene Info
sp8a NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000011870	sp8 transcription factor a
sp8b NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000056666	sp8 transcription factor b
sp4 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000005186	sp4 transcription factor
sp3a NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000001549	sp3a transcription factor
rsl1d1 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000005846	Sp5 transcription factor b
klf4 NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000079922	Kruppel-like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sp8a	dr11_v1_chr19_-_2317558_2317558	-0.89	2.5e-07	Click!
sp4	dr11_v1_chr19_+_2364552_2364552	-0.78	9.0e-05	Click!
sp8b	dr11_v1_chr16_+_19537073_19537073	-0.66	2.1e-03	Click!
sp3a	dr11_v1_chr9_+_2762270_2762415	0.64	3.1e-03	Click!
FO704755.1	dr11_v1_chr6_+_3730843_3730843	-0.53	2.1e-02	Click!
klf4	dr11_v1_chr21_-_435466_435466	0.33	1.6e-01	Click!

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_58221163 Show fit	12.59	ENSDART00000157939	FO704813.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr16_+_53455638 Show fit	12.26	ENSDART00000045792 ENSDART00000154189	rbm24b NCBI UniProt ZFIN ENSEMBL Google Show fit	RNA binding motif protein 24b
chr3_-_62380146 Show fit	9.05	ENSDART00000155853	gprc5ba NCBI UniProt ZFIN ENSEMBL Google Show fit	G protein-coupled receptor, class C, group 5, member Ba
chr5_+_67812062 Show fit	8.36	ENSDART00000158611	zgc:175280 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:175280
chr17_+_27456804 Show fit	8.21	ENSDART00000017756 ENSDART00000181461 ENSDART00000180178	ctsl.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	cathepsin L.1
chr5_-_50992690 Show fit	8.16	ENSDART00000149553 ENSDART00000097460 ENSDART00000192021	hmgcra NCBI UniProt ZFIN ENSEMBL Google Show fit	3-hydroxy-3-methylglutaryl-CoA reductase a
chr2_+_413370 Show fit	7.44	ENSDART00000122138	mylk4a NCBI UniProt ZFIN ENSEMBL Google Show fit	myosin light chain kinase family, member 4a
chr3_+_5575313 Show fit	7.16	ENSDART00000134693 ENSDART00000101807	si:ch211-106h11.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-106h11.3
chr5_-_69482891 Show fit	6.88	ENSDART00000109487	CABZ01032476.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr1_+_54677173 Show fit	6.78	ENSDART00000114705	gprc5bb NCBI UniProt ZFIN ENSEMBL Google Show fit	G protein-coupled receptor, class C, group 5, member Bb
chr3_+_19299309 Show fit	6.06	ENSDART00000046297 ENSDART00000146955	ldlra NCBI UniProt ZFIN ENSEMBL Google Show fit	low density lipoprotein receptor a
chr11_-_4235811 Show fit	5.86	ENSDART00000121716	si:ch211-236d3.4 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-236d3.4
chr22_+_37874691 Show fit	5.73	ENSDART00000028565	ahsg1 NCBI UniProt ZFIN ENSEMBL Google Show fit	alpha-2-HS-glycoprotein 1
chr10_+_1668106 Show fit	5.46	ENSDART00000142278	sgsm1b NCBI UniProt ZFIN ENSEMBL Google Show fit	small G protein signaling modulator 1b
chr6_-_607063 Show fit	5.41	ENSDART00000189900	lgals2b NCBI UniProt ZFIN ENSEMBL Google Show fit	lectin, galactoside-binding, soluble, 2b
chr11_+_1796426 Show fit	5.39	ENSDART00000173330	lrp1aa NCBI UniProt ZFIN ENSEMBL Google Show fit	low density lipoprotein receptor-related protein 1Aa
chr9_+_42095220 Show fit	5.32	ENSDART00000148317 ENSDART00000134431	pcbp3 NCBI UniProt ZFIN ENSEMBL Google Show fit	poly(rC) binding protein 3
chr21_-_39670375 Show fit	5.20	ENSDART00000151567	sgk494b NCBI UniProt ZFIN ENSEMBL Google Show fit	uncharacterized serine/threonine-protein kinase SgK494b
chr10_-_22831611 Show fit	4.98	ENSDART00000160115	per1a NCBI UniProt ZFIN ENSEMBL Google Show fit	period circadian clock 1a
chr5_-_13086616 Show fit	4.89	ENSDART00000051664	ypel1 NCBI UniProt ZFIN ENSEMBL Google Show fit	yippee-like 1
chr18_-_40684756 Show fit	4.88	ENSDART00000113799 ENSDART00000139042	si:ch211-132b12.7 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-132b12.7
chr8_+_1187928 Show fit	4.81	ENSDART00000127252	slc35d2 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr8_+_23213320 Show fit	4.65	ENSDART00000032996 ENSDART00000137536	ppdpfa NCBI UniProt ZFIN ENSEMBL Google Show fit	pancreatic progenitor cell differentiation and proliferation factor a
chr10_+_439692 Show fit	4.56	ENSDART00000147740	zdhhc8a NCBI UniProt ZFIN ENSEMBL Google Show fit	zinc finger, DHHC-type containing 8a
chr8_-_410728 Show fit	4.48	ENSDART00000151255	trim36 NCBI UniProt ZFIN ENSEMBL Google Show fit	tripartite motif containing 36
chr9_-_11263228 Show fit	4.41	ENSDART00000113847	chpfa NCBI UniProt ZFIN ENSEMBL Google Show fit	chondroitin polymerizing factor a
chr11_+_6819050 Show fit	4.40	ENSDART00000104289	rab3ab NCBI UniProt ZFIN ENSEMBL Google Show fit	RAB3A, member RAS oncogene family, b
chr5_-_1047222 Show fit	4.40	ENSDART00000181112	mbd2 NCBI UniProt ZFIN ENSEMBL Google Show fit	methyl-CpG binding domain protein 2
chr10_+_1638876 Show fit	4.39	ENSDART00000184484 ENSDART00000060946 ENSDART00000181251	sgsm1b NCBI UniProt ZFIN ENSEMBL Google Show fit	small G protein signaling modulator 1b
chr6_-_16406210 Show fit	4.25	ENSDART00000012023	faimb NCBI UniProt ZFIN ENSEMBL Google Show fit	Fas apoptotic inhibitory molecule b
chr8_+_1082100 Show fit	4.22	ENSDART00000149276	lzts3b NCBI UniProt ZFIN ENSEMBL Google Show fit	leucine zipper, putative tumor suppressor family member 3b
chr7_-_6592142 Show fit	4.21	ENSDART00000160137	kcnj10a NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium inwardly-rectifying channel, subfamily J, member 10a
chr25_+_35375848 Show fit	4.16	ENSDART00000155721	ano3 NCBI UniProt ZFIN ENSEMBL Google Show fit	anoctamin 3
chr24_-_14712427 Show fit	4.15	ENSDART00000176316	jph1a NCBI UniProt ZFIN ENSEMBL Google Show fit	junctophilin 1a
chr18_-_8312848 Show fit	4.13	ENSDART00000092033	mapk8ip2 NCBI UniProt ZFIN ENSEMBL Google Show fit	mitogen-activated protein kinase 8 interacting protein 2
chr10_+_5135842 Show fit	4.11	ENSDART00000132627 ENSDART00000162434	zgc:113274 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:113274
chr1_-_59176949 Show fit	4.07	ENSDART00000128742	CABZ01118678.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr5_-_46273938 Show fit	3.99	ENSDART00000080033	si:ch211-130m23.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-130m23.3
chr20_+_13175379 Show fit	3.98	ENSDART00000025644	ppp2r5a NCBI UniProt ZFIN ENSEMBL Google Show fit	protein phosphatase 2, regulatory subunit B', alpha isoform
chr18_-_8313686 Show fit	3.88	ENSDART00000182187	mapk8ip2 NCBI UniProt ZFIN ENSEMBL Google Show fit	mitogen-activated protein kinase 8 interacting protein 2
chr23_-_41762797 Show fit	3.87	ENSDART00000186564	stk35 NCBI UniProt ZFIN ENSEMBL Google Show fit	serine/threonine kinase 35
chr22_-_6562618 Show fit	3.86	ENSDART00000106100	zgc:171490 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:171490
chr7_+_67325933 Show fit	3.82	ENSDART00000170575 ENSDART00000183342	nfat5b NCBI UniProt ZFIN ENSEMBL Google Show fit	nuclear factor of activated T cells 5b
chr1_+_9004719 Show fit	3.77	ENSDART00000006211 ENSDART00000137211	prkcba NCBI UniProt ZFIN ENSEMBL Google Show fit	protein kinase C, beta a
chr2_+_7192966 Show fit	3.77	ENSDART00000142735	si:ch211-13f8.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-13f8.1
chr19_+_9305964 Show fit	3.67	ENSDART00000136241	si:ch73-15n24.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-15n24.1
chr2_+_24177190 Show fit	3.64	ENSDART00000099546	map4l NCBI UniProt ZFIN ENSEMBL Google Show fit	microtubule associated protein 4 like
chr18_+_507835 Show fit	3.63	ENSDART00000189701	nedd4a NCBI UniProt ZFIN ENSEMBL Google Show fit	neural precursor cell expressed, developmentally down-regulated 4a
chr3_+_49074008 Show fit	3.58	ENSDART00000168864	zgc:112146 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:112146
chr16_-_20707742 Show fit	3.57	ENSDART00000103630	creb5b NCBI UniProt ZFIN ENSEMBL Google Show fit	cAMP responsive element binding protein 5b
chr3_+_11568523 Show fit	3.57	ENSDART00000179668	CABZ01087224.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr23_-_30960506 Show fit	3.55	ENSDART00000142661	osbpl2a NCBI UniProt ZFIN ENSEMBL Google Show fit	oxysterol binding protein-like 2a
chr3_+_7617353 Show fit	3.41	ENSDART00000165551	zgc:109949 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:109949
chr5_+_4332220 Show fit	3.41	ENSDART00000051699	sat1a.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	spermidine/spermine N1-acetyltransferase 1a, duplicate 1
chr15_+_24388782 Show fit	3.38	ENSDART00000191661 ENSDART00000179995 ENSDART00000111226	sez6b NCBI UniProt ZFIN ENSEMBL Google Show fit	seizure related 6 homolog b
chr17_-_4318393 Show fit	3.34	ENSDART00000167995 ENSDART00000153824	napba NCBI UniProt ZFIN ENSEMBL Google Show fit	N-ethylmaleimide-sensitive factor attachment protein, beta a
chr22_-_607812 Show fit	3.32	ENSDART00000145983	cdkn1a NCBI UniProt ZFIN ENSEMBL Google Show fit	cyclin-dependent kinase inhibitor 1A
chr25_+_37443194 Show fit	3.32	ENSDART00000163178 ENSDART00000190262	slc10a3 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 10, member 3
chr5_-_12031174 Show fit	3.32	ENSDART00000159896	castor1 NCBI UniProt ZFIN ENSEMBL Google Show fit	cytosolic arginine sensor for mTORC1 subunit 1
chr16_-_6821927 Show fit	3.29	ENSDART00000149070 ENSDART00000149570	mbpb NCBI UniProt ZFIN ENSEMBL Google Show fit	myelin basic protein b
chr21_+_1382078 Show fit	3.27	ENSDART00000188463	TCF4 NCBI UniProt ZFIN ENSEMBL Google Show fit	transcription factor 4
chr6_+_34511886 Show fit	3.27	ENSDART00000179450	lrp8 NCBI UniProt ZFIN ENSEMBL Google Show fit	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr24_-_31439841 Show fit	3.26	ENSDART00000169952	cngb3.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	cyclic nucleotide gated channel beta 3, tandem duplicate 2
chr13_-_18691041 Show fit	3.24	ENSDART00000057867	sfxn3 NCBI UniProt ZFIN ENSEMBL Google Show fit	sideroflexin 3
chr5_-_68022631 Show fit	3.17	ENSDART00000143199	wasf3a NCBI UniProt ZFIN ENSEMBL Google Show fit	WAS protein family, member 3a
chr3_-_11624694 Show fit	3.12	ENSDART00000127157	hlfa NCBI UniProt ZFIN ENSEMBL Google Show fit	hepatic leukemia factor a
chr6_+_40661703 Show fit	3.11	ENSDART00000142492	eno1b NCBI UniProt ZFIN ENSEMBL Google Show fit	enolase 1b, (alpha)
chr11_-_103136 Show fit	3.09	ENSDART00000173308 ENSDART00000162982	elmo2 NCBI UniProt ZFIN ENSEMBL Google Show fit	engulfment and cell motility 2
chr6_-_7776612 Show fit	3.08	ENSDART00000190269	myh9a NCBI UniProt ZFIN ENSEMBL Google Show fit	myosin, heavy chain 9a, non-muscle
chr13_+_1100197 Show fit	3.06	ENSDART00000139560	ppp3r1a NCBI UniProt ZFIN ENSEMBL Google Show fit	protein phosphatase 3, regulatory subunit B, alpha a
chr10_+_41668483 Show fit	3.05	ENSDART00000127073	lrrc75bb NCBI UniProt ZFIN ENSEMBL Google Show fit	leucine rich repeat containing 75Bb
chr15_-_30816370 Show fit	3.02	ENSDART00000142982 ENSDART00000050649 ENSDART00000136901 ENSDART00000100194	msi2b NCBI UniProt ZFIN ENSEMBL Google Show fit	musashi RNA-binding protein 2b
chr21_-_43398122 Show fit	2.98	ENSDART00000050533	ccni2 NCBI UniProt ZFIN ENSEMBL Google Show fit	cyclin I family, member 2
chr23_-_41762956 Show fit	2.97	ENSDART00000128302	stk35 NCBI UniProt ZFIN ENSEMBL Google Show fit	serine/threonine kinase 35
chr23_+_14590767 Show fit	2.97	ENSDART00000143675	si:rp71-79p20.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:rp71-79p20.2
chr22_-_6801876 Show fit	2.95	ENSDART00000135726	si:ch1073-188e1.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch1073-188e1.1
chr15_-_43164591 Show fit	2.93	ENSDART00000171305	ap1s3a NCBI UniProt ZFIN ENSEMBL Google Show fit	adaptor-related protein complex 1, sigma 3 subunit, a
chr19_+_1606185 Show fit	2.93	ENSDART00000092183	lrrc3b NCBI UniProt ZFIN ENSEMBL Google Show fit	leucine rich repeat containing 3B
chr23_+_45822935 Show fit	2.91	ENSDART00000161892	vdra NCBI UniProt ZFIN ENSEMBL Google Show fit	vitamin D receptor a
chr23_+_28693278 Show fit	2.87	ENSDART00000078148	smc1a NCBI UniProt ZFIN ENSEMBL Google Show fit	structural maintenance of chromosomes 1A
chr21_-_43079161 Show fit	2.87	ENSDART00000144151	jakmip2 NCBI UniProt ZFIN ENSEMBL Google Show fit	janus kinase and microtubule interacting protein 2
chr2_-_48966431 Show fit	2.86	ENSDART00000147948	kcnj9 NCBI UniProt ZFIN ENSEMBL Google Show fit	potassium inwardly-rectifying channel, subfamily J, member 9
chr3_-_16227683 Show fit	2.84	ENSDART00000111707	cacnb1 NCBI UniProt ZFIN ENSEMBL Google Show fit	calcium channel, voltage-dependent, beta 1 subunit
chr20_-_25518488 Show fit	2.84	ENSDART00000186993	cyp2n13 NCBI UniProt ZFIN ENSEMBL Google Show fit	cytochrome P450, family 2, subfamily N, polypeptide 13
chr4_+_57093908 Show fit	2.81	ENSDART00000170198	si:ch211-238e22.5 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-238e22.5
chr25_+_24250247 Show fit	2.81	ENSDART00000064646	tmem86a NCBI UniProt ZFIN ENSEMBL Google Show fit	transmembrane protein 86A
chr3_+_11548516 Show fit	2.80	ENSDART00000059117	mmd NCBI UniProt ZFIN ENSEMBL Google Show fit	monocyte to macrophage differentiation-associated
chr2_-_34555945 Show fit	2.80	ENSDART00000056671	brinp2 NCBI UniProt ZFIN ENSEMBL Google Show fit	bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr19_+_47299212 Show fit	2.76	ENSDART00000158262	tpmt.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	thiopurine S-methyltransferase, tandem duplicate 1
chr15_-_47956388 Show fit	2.75	ENSDART00000116506	si:ch1073-111c8.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch1073-111c8.3
chr20_+_42565049 Show fit	2.75	ENSDART00000061101	igf2r NCBI UniProt ZFIN ENSEMBL Google Show fit	insulin-like growth factor 2 receptor
chr9_-_54001502 Show fit	2.74	ENSDART00000085253	mid1 NCBI UniProt ZFIN ENSEMBL Google Show fit	midline 1
chr2_+_38924975 Show fit	2.74	ENSDART00000109219	rem2 NCBI UniProt ZFIN ENSEMBL Google Show fit	RAS (RAD and GEM)-like GTP binding 2
chr5_-_8483457 Show fit	2.71	ENSDART00000171886 ENSDART00000159477 ENSDART00000157423	lifra NCBI UniProt ZFIN ENSEMBL Google Show fit	leukemia inhibitory factor receptor alpha a
chr25_+_4541211 Show fit	2.71	ENSDART00000129978	pnpla2 NCBI UniProt ZFIN ENSEMBL Google Show fit	patatin-like phospholipase domain containing 2
chr8_+_53051701 Show fit	2.69	ENSDART00000131514	nadka NCBI UniProt ZFIN ENSEMBL Google Show fit	NAD kinase a
chr8_-_4100365 Show fit	2.65	ENSDART00000142846	cux2b NCBI UniProt ZFIN ENSEMBL Google Show fit	cut-like homeobox 2b
chr8_-_53490376 Show fit	2.65	ENSDART00000158789	chdh NCBI UniProt ZFIN ENSEMBL Google Show fit	choline dehydrogenase
chr21_+_45386033 Show fit	2.64	ENSDART00000151773	jade2 NCBI UniProt ZFIN ENSEMBL Google Show fit	jade family PHD finger 2
chr11_+_39959039 Show fit	2.64	ENSDART00000024304	per3 NCBI UniProt ZFIN ENSEMBL Google Show fit	period circadian clock 3
chr24_-_14711597 Show fit	2.63	ENSDART00000131830	jph1a NCBI UniProt ZFIN ENSEMBL Google Show fit	junctophilin 1a
chr5_+_11812089 Show fit	2.61	ENSDART00000111359	fbxo21 NCBI UniProt ZFIN ENSEMBL Google Show fit	F-box protein 21
chr25_-_19655820 Show fit	2.60	ENSDART00000149585 ENSDART00000104353	atp2b1b NCBI UniProt ZFIN ENSEMBL Google Show fit	ATPase plasma membrane Ca2+ transporting 1b
chr19_-_15397946 Show fit	2.60	ENSDART00000143480	hivep3a NCBI UniProt ZFIN ENSEMBL Google Show fit	human immunodeficiency virus type I enhancer binding protein 3a
chr23_+_14590483 Show fit	2.59	ENSDART00000088359 ENSDART00000184868	si:rp71-79p20.2 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:rp71-79p20.2
chr6_+_47424518 Show fit	2.59	ENSDART00000165939	si:ch211-286o17.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-286o17.1
chr8_+_52637507 Show fit	2.59	ENSDART00000163830	si:dkey-90l8.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-90l8.3
chr8_+_7740004 Show fit	2.56	ENSDART00000170184 ENSDART00000187811	fgd1 NCBI UniProt ZFIN ENSEMBL Google Show fit	FYVE, RhoGEF and PH domain containing 1
chr20_+_46741074 Show fit	2.54	ENSDART00000145294	si:ch211-57i17.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-57i17.1
chr10_-_41352502 Show fit	2.54	ENSDART00000052971 ENSDART00000128156	rab11fip1b NCBI UniProt ZFIN ENSEMBL Google Show fit	RAB11 family interacting protein 1 (class I) b
chr7_-_24520866 Show fit	2.52	ENSDART00000077039	faah2b NCBI UniProt ZFIN ENSEMBL Google Show fit	fatty acid amide hydrolase 2b
chr19_-_27858033 Show fit	2.49	ENSDART00000103898 ENSDART00000144884	srd5a1 NCBI UniProt ZFIN ENSEMBL Google Show fit	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr2_-_37478418 Show fit	2.48	ENSDART00000146103	dapk3 NCBI UniProt ZFIN ENSEMBL Google Show fit	death-associated protein kinase 3
chr6_-_60104628 Show fit	2.48	ENSDART00000057463 ENSDART00000169188	pmepa1 NCBI UniProt ZFIN ENSEMBL Google Show fit	prostate transmembrane protein, androgen induced 1
chr13_+_47821524 Show fit	2.44	ENSDART00000109978	zc3h6 NCBI UniProt ZFIN ENSEMBL Google Show fit	zinc finger CCCH-type containing 6
chr10_+_4875262 Show fit	2.42	ENSDART00000165942	palm2 NCBI UniProt ZFIN ENSEMBL Google Show fit	paralemmin 2
chr6_-_52156427 Show fit	2.41	ENSDART00000082821	rims4 NCBI UniProt ZFIN ENSEMBL Google Show fit	regulating synaptic membrane exocytosis 4
chr15_+_47418565 Show fit	2.41	ENSDART00000155709	clpb NCBI UniProt ZFIN ENSEMBL Google Show fit	ClpB homolog, mitochondrial AAA ATPase chaperonin
chr4_-_22519516 Show fit	2.41	ENSDART00000130409 ENSDART00000186258 ENSDART00000002851 ENSDART00000123801	kdm7aa NCBI UniProt ZFIN ENSEMBL Google Show fit	lysine (K)-specific demethylase 7Aa
chr8_+_6954984 Show fit	2.40	ENSDART00000145610	si:ch211-255g12.6 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-255g12.6
chr2_-_48153945 Show fit	2.40	ENSDART00000146553	pfkpb NCBI UniProt ZFIN ENSEMBL Google Show fit	phosphofructokinase, platelet b
chr20_-_1635922 Show fit	2.40	ENSDART00000181502	CR846082.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr8_+_2656231 Show fit	2.39	ENSDART00000160833	fam102aa NCBI UniProt ZFIN ENSEMBL Google Show fit	family with sequence similarity 102, member Aa
chr19_-_6193448 Show fit	2.37	ENSDART00000151405	erf NCBI UniProt ZFIN ENSEMBL Google Show fit	Ets2 repressor factor
chr2_+_48073972 Show fit	2.36	ENSDART00000186442	klf6b NCBI UniProt ZFIN ENSEMBL Google Show fit	Kruppel-like factor 6b
chr14_+_22172047 Show fit	2.35	ENSDART00000114750 ENSDART00000148259	gabrb2 NCBI UniProt ZFIN ENSEMBL Google Show fit	gamma-aminobutyric acid (GABA) A receptor, beta 2
chr1_+_7189856 Show fit	2.29	ENSDART00000092114	si:ch73-383l1.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch73-383l1.1
chr3_+_59117136 Show fit	2.27	ENSDART00000182745	MGAT5B NCBI UniProt ZFIN ENSEMBL Google Show fit	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr24_-_38644937 Show fit	2.25	ENSDART00000170194	slc6a16b NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 6, member 16b
chr25_-_20268027 Show fit	2.23	ENSDART00000138763	dnajb9a NCBI UniProt ZFIN ENSEMBL Google Show fit	DnaJ (Hsp40) homolog, subfamily B, member 9a
chr22_-_29336268 Show fit	2.23	ENSDART00000132776 ENSDART00000186351 ENSDART00000121599	pdgfba NCBI UniProt ZFIN ENSEMBL Google Show fit	platelet-derived growth factor beta polypeptide a
chr21_+_8427059 Show fit	2.22	ENSDART00000143151	dennd1a NCBI UniProt ZFIN ENSEMBL Google Show fit	DENN/MADD domain containing 1A
chr24_-_29777413 Show fit	2.22	ENSDART00000087724	wu:fj05g07 NCBI UniProt ZFIN ENSEMBL Google Show fit	wu:fj05g07
chr21_-_39058490 Show fit	2.21	ENSDART00000114885	aldh3a2b NCBI UniProt ZFIN ENSEMBL Google Show fit	aldehyde dehydrogenase 3 family, member A2b
chr8_+_8166285 Show fit	2.20	ENSDART00000147940	plxnb3 NCBI UniProt ZFIN ENSEMBL Google Show fit	plexin B3
chr5_+_6617401 Show fit	2.19	ENSDART00000060532	zgc:110796 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:110796
chr10_+_16501699 Show fit	2.19	ENSDART00000121864	slc27a6 NCBI UniProt ZFIN ENSEMBL Google Show fit	solute carrier family 27 (fatty acid transporter), member 6
chr6_-_39006449 Show fit	2.18	ENSDART00000150885	vdrb NCBI UniProt ZFIN ENSEMBL Google Show fit	vitamin D receptor b
chr18_-_6803424 Show fit	2.17	ENSDART00000142647	si:dkey-266m15.5 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-266m15.5
chr20_-_51917771 Show fit	2.14	ENSDART00000147240	dusp10 NCBI UniProt ZFIN ENSEMBL Google Show fit	dual specificity phosphatase 10
chr7_-_12596727 Show fit	2.14	ENSDART00000186413	adamtsl3 NCBI UniProt ZFIN ENSEMBL Google Show fit	ADAMTS-like 3
chr10_+_41765616 Show fit	2.14	ENSDART00000170682	rnf34b NCBI UniProt ZFIN ENSEMBL Google Show fit	ring finger protein 34b
chr5_-_38506981 Show fit	2.14	ENSDART00000097822	atp1b2b NCBI UniProt ZFIN ENSEMBL Google Show fit	ATPase Na+/K+ transporting subunit beta 2b
chr5_-_33274943 Show fit	2.13	ENSDART00000143435 ENSDART00000145222 ENSDART00000004797	kyat1 NCBI UniProt ZFIN ENSEMBL Google Show fit	kynurenine aminotransferase 1
chr23_-_452365 Show fit	2.13	ENSDART00000146776	tspan2b NCBI UniProt ZFIN ENSEMBL Google Show fit	tetraspanin 2b
chr10_-_32524035 Show fit	2.12	ENSDART00000137608	dgat2 NCBI UniProt ZFIN ENSEMBL Google Show fit	diacylglycerol O-acyltransferase 2
chr7_-_38698583 Show fit	2.12	ENSDART00000173900 ENSDART00000126737	cd59 NCBI UniProt ZFIN ENSEMBL Google Show fit	CD59 molecule (CD59 blood group)
chr8_+_51958968 Show fit	2.12	ENSDART00000139509 ENSDART00000186544	gna14a NCBI UniProt ZFIN ENSEMBL Google Show fit	guanine nucleotide binding protein (G protein), alpha 14a
chr9_-_10145795 Show fit	2.11	ENSDART00000004745 ENSDART00000143295	hnmt NCBI UniProt ZFIN ENSEMBL Google Show fit	histamine N-methyltransferase
chr2_+_52232630 Show fit	2.10	ENSDART00000006216	plpp2a NCBI UniProt ZFIN ENSEMBL Google Show fit	phospholipid phosphatase 2a
chr17_+_51764310 Show fit	2.09	ENSDART00000157171	si:ch211-168d23.3 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:ch211-168d23.3
chr19_+_233143 Show fit	2.08	ENSDART00000175273	syngap1a NCBI UniProt ZFIN ENSEMBL Google Show fit	synaptic Ras GTPase activating protein 1a
chr14_-_962171 Show fit	2.08	ENSDART00000010773	acsl1b NCBI UniProt ZFIN ENSEMBL Google Show fit	acyl-CoA synthetase long chain family member 1b
chr22_-_38459316 Show fit	2.08	ENSDART00000149683 ENSDART00000098461	ptk7a NCBI UniProt ZFIN ENSEMBL Google Show fit	protein tyrosine kinase 7a
chr2_+_24177006 Show fit	2.07	ENSDART00000132582	map4l NCBI UniProt ZFIN ENSEMBL Google Show fit	microtubule associated protein 4 like
chr17_+_389218 Show fit	2.07	ENSDART00000162898	si:rp71-62i8.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:rp71-62i8.1
chr9_-_48397702 Show fit	2.06	ENSDART00000147169	zgc:172182 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:172182
chr6_-_58828398 Show fit	2.05	ENSDART00000090634	kif5ab NCBI UniProt ZFIN ENSEMBL Google Show fit	kinesin family member 5A, b
chr9_-_7655243 Show fit	2.05	ENSDART00000102706	dnajb2 NCBI UniProt ZFIN ENSEMBL Google Show fit	DnaJ (Hsp40) homolog, subfamily B, member 2
chr19_+_342094 Show fit	2.02	ENSDART00000151013 ENSDART00000187622	ensaa NCBI UniProt ZFIN ENSEMBL Google Show fit	endosulfine alpha a
chr1_-_12109216 Show fit	2.00	ENSDART00000079930	mttp NCBI UniProt ZFIN ENSEMBL Google Show fit	microsomal triglyceride transfer protein
chr7_+_1579510 Show fit	2.00	ENSDART00000190525	supt16h NCBI UniProt ZFIN ENSEMBL Google Show fit	SPT16 homolog, facilitates chromatin remodeling subunit
chr11_-_38083397 Show fit	1.97	ENSDART00000086516 ENSDART00000184033	klhdc8a NCBI UniProt ZFIN ENSEMBL Google Show fit	kelch domain containing 8A
chr18_-_47662696 Show fit	1.96	ENSDART00000184260	CABZ01073963.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr21_+_43253538 Show fit	1.94	ENSDART00000179940 ENSDART00000164806 ENSDART00000147026	shroom1 NCBI UniProt ZFIN ENSEMBL Google Show fit	shroom family member 1
chr10_+_32683089 Show fit	1.94	ENSDART00000063551	ppm1e NCBI UniProt ZFIN ENSEMBL Google Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr9_-_54840124 Show fit	1.92	ENSDART00000137214 ENSDART00000085693	gpm6bb NCBI UniProt ZFIN ENSEMBL Google Show fit	glycoprotein M6Bb
chr19_+_1097393 Show fit	1.91	ENSDART00000168218	CABZ01111953.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr22_-_16275236 Show fit	1.90	ENSDART00000149051	cdc14ab NCBI UniProt ZFIN ENSEMBL Google Show fit	cell division cycle 14Ab
chr22_-_27136451 Show fit	1.90	ENSDART00000153589	si:dkey-16m19.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-16m19.1
chr13_-_45795722 Show fit	1.89	ENSDART00000141779	fndc5a NCBI UniProt ZFIN ENSEMBL Google Show fit	fibronectin type III domain containing 5a
chr1_-_55196103 Show fit	1.89	ENSDART00000140153	mri1 NCBI UniProt ZFIN ENSEMBL Google Show fit	methylthioribose-1-phosphate isomerase 1
chr15_-_9593532 Show fit	1.87	ENSDART00000169912	gab2 NCBI UniProt ZFIN ENSEMBL Google Show fit	GRB2-associated binding protein 2
chr21_-_40880317 Show fit	1.86	ENSDART00000100054 ENSDART00000137696	elnb NCBI UniProt ZFIN ENSEMBL Google Show fit	elastin b
chr10_+_45148005 Show fit	1.85	ENSDART00000182501	ogdhb NCBI UniProt ZFIN ENSEMBL Google Show fit	oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr10_-_32524771 Show fit	1.84	ENSDART00000066793	dgat2 NCBI UniProt ZFIN ENSEMBL Google Show fit	diacylglycerol O-acyltransferase 2
chr3_+_472158 Show fit	1.84	ENSDART00000134971	zgc:194659 NCBI UniProt ZFIN ENSEMBL Google Show fit	zgc:194659
chr9_+_993477 Show fit	1.84	ENSDART00000182045	CABZ01066921.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr8_+_8532407 Show fit	1.84	ENSDART00000169276 ENSDART00000138993	grm6a NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamate receptor, metabotropic 6a
chr15_+_20543770 Show fit	1.84	ENSDART00000092357	sgsm2 NCBI UniProt ZFIN ENSEMBL Google Show fit	small G protein signaling modulator 2
chr25_+_19149241 Show fit	1.84	ENSDART00000184982 ENSDART00000067324	mfge8b NCBI UniProt ZFIN ENSEMBL Google Show fit	milk fat globule-EGF factor 8 protein b
chr13_+_33688474 Show fit	1.83	ENSDART00000161465	CABZ01087953.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr2_-_48826707 Show fit	1.82	ENSDART00000134711	svilb NCBI UniProt ZFIN ENSEMBL Google Show fit	supervillin b
chr22_+_883678 Show fit	1.82	ENSDART00000140588	stk38b NCBI UniProt ZFIN ENSEMBL Google Show fit	serine/threonine kinase 38b
chr7_-_2163361 Show fit	1.81	ENSDART00000173654	si:cabz01007812.1 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:cabz01007812.1
chr14_-_2933185 Show fit	1.80	ENSDART00000161677 ENSDART00000162446 ENSDART00000109378	si:dkey-201i24.6 NCBI UniProt ZFIN ENSEMBL Google Show fit	si:dkey-201i24.6
chr20_-_53366137 Show fit	1.80	ENSDART00000146001	wasf1 NCBI UniProt ZFIN ENSEMBL Google Show fit	WAS protein family, member 1
chr19_+_43119698 Show fit	1.79	ENSDART00000167847 ENSDART00000186962 ENSDART00000187305	eef1a1l1 NCBI UniProt ZFIN ENSEMBL Google Show fit	eukaryotic translation elongation factor 1 alpha 1, like 1
chr21_-_32436679 Show fit	1.79	ENSDART00000076974	gfpt2 NCBI UniProt ZFIN ENSEMBL Google Show fit	glutamine-fructose-6-phosphate transaminase 2
chr19_-_46088429 Show fit	1.76	ENSDART00000161385	ptdss1b NCBI UniProt ZFIN ENSEMBL Google Show fit	phosphatidylserine synthase 1b
chr10_+_45148167 Show fit	1.76	ENSDART00000172621	ogdhb NCBI UniProt ZFIN ENSEMBL Google Show fit	oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
chr1_+_2222363 Show fit	1.76	ENSDART00000058877	rap2ab NCBI UniProt ZFIN ENSEMBL Google Show fit	RAP2A, member of RAS oncogene family b
chr24_-_36238054 Show fit	1.75	ENSDART00000155725	tmem241 NCBI UniProt ZFIN ENSEMBL Google Show fit	transmembrane protein 241
chr24_+_3307857 Show fit	1.75	ENSDART00000106527	gyg1b NCBI UniProt ZFIN ENSEMBL Google Show fit	glycogenin 1b
chr18_+_3634652 Show fit	1.73	ENSDART00000159913	lrch3 NCBI UniProt ZFIN ENSEMBL Google Show fit	leucine-rich repeats and calponin homology (CH) domain containing 3
chr3_+_26019426 Show fit	1.72	ENSDART00000135389 ENSDART00000182411	foxred2 NCBI UniProt ZFIN ENSEMBL Google Show fit	FAD-dependent oxidoreductase domain containing 2
chr24_-_20599781 Show fit	1.72	ENSDART00000179664 ENSDART00000141823	zbtb47b NCBI UniProt ZFIN ENSEMBL Google Show fit	zinc finger and BTB domain containing 47b
chr3_+_31925067 Show fit	1.72	ENSDART00000127330 ENSDART00000055279	snrnp70 NCBI UniProt ZFIN ENSEMBL Google Show fit	small nuclear ribonucleoprotein 70 (U1)
chr22_-_26558166 Show fit	1.71	ENSDART00000111125	glis2a NCBI UniProt ZFIN ENSEMBL Google Show fit	GLIS family zinc finger 2a
chr10_+_41765944 Show fit	1.70	ENSDART00000171484	rnf34b NCBI UniProt ZFIN ENSEMBL Google Show fit	ring finger protein 34b

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.2	12.7	GO:0003228	atrial cardiac muscle tissue development(GO:0003228)
1.7	5.2	GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
1.3	7.5	GO:0097638	L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
1.2	4.9	GO:0042754	negative regulation of circadian rhythm(GO:0042754)
1.1	3.4	GO:0019284	L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
1.0	6.1	GO:0032367	intracellular cholesterol transport(GO:0032367)
1.0	4.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
1.0	1.9	GO:1903792	negative regulation of anion transport(GO:1903792)
0.9	2.7	GO:0044321	leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.9	2.6	GO:0019695	choline metabolic process(GO:0019695)
0.9	3.4	GO:0006598	polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
0.8	3.3	GO:0010807	regulation of synaptic vesicle priming(GO:0010807)
0.7	8.1	GO:1902042	regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.7	2.1	GO:0001692	histamine metabolic process(GO:0001692)
0.7	2.7	GO:0010898	regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.6	3.1	GO:0061439	renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.6	4.2	GO:0036268	swimming(GO:0036268)
0.5	3.8	GO:0098971	dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.5	1.5	GO:1901232	regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.5	4.6	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.5	9.1	GO:0015936	coenzyme A metabolic process(GO:0015936)
0.5	2.4	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.5	2.8	GO:0003272	endocardial cushion formation(GO:0003272)
0.5	7.0	GO:0061001	regulation of dendritic spine morphogenesis(GO:0061001)
0.4	1.3	GO:0099552	trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.4	1.3	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.4	1.7	GO:0003242	growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.4	3.3	GO:0051673	membrane disruption in other organism(GO:0051673)
0.4	4.0	GO:0061588	calcium activated phospholipid scrambling(GO:0061588)
0.4	2.4	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.4	3.1	GO:0032889	regulation of vacuole fusion, non-autophagic(GO:0032889)
0.4	7.8	GO:0009649	entrainment of circadian clock(GO:0009649)
0.4	2.5	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.4	1.8	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.3	2.4	GO:0006741	NADP biosynthetic process(GO:0006741)
0.3	1.4	GO:0070317	G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.3	4.9	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.3	1.6	GO:0036371	protein localization to T-tubule(GO:0036371)
0.3	1.3	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.3	2.3	GO:0098815	postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.3	0.9	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.3	2.5	GO:0001579	medium-chain fatty acid transport(GO:0001579)
0.3	1.6	GO:0039689	viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.3	1.8	GO:1902047	polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.3	2.8	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.3	6.4	GO:0031952	regulation of protein autophosphorylation(GO:0031952)
0.3	4.5	GO:2000601	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3	3.0	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.3	4.7	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.3	0.9	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.3	0.9	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.3	0.9	GO:0071361	cellular response to ethanol(GO:0071361)
0.3	4.6	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.3	0.8	GO:0039531	RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.3	1.7	GO:0016572	histone phosphorylation(GO:0016572)
0.3	1.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.3	2.4	GO:0043981	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.3	1.9	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.3	2.1	GO:2000095	cerebrospinal fluid circulation(GO:0090660) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.3	1.0	GO:0055107	Golgi to secretory granule transport(GO:0055107)
0.2	0.2	GO:1903538	meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.2	3.3	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.2	2.6	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.2	0.7	GO:0090435	protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.2	1.2	GO:0051148	smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.2	1.6	GO:1905097	regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2	0.9	GO:0070255	regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.2	1.1	GO:0051792	medium-chain fatty acid biosynthetic process(GO:0051792)
0.2	4.6	GO:0098508	endothelial to hematopoietic transition(GO:0098508)
0.2	3.2	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.2	1.7	GO:0006543	glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.2	0.6	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.2	1.6	GO:0042135	neurotransmitter catabolic process(GO:0042135)
0.2	0.6	GO:0045830	response to protozoan(GO:0001562) TRIF-dependent toll-like receptor signaling pathway(GO:0035666) defense response to protozoan(GO:0042832) regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.2	0.8	GO:0046900	tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2	1.0	GO:1903146	regulation of mitophagy(GO:1903146)
0.2	3.7	GO:0036376	cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.2	1.8	GO:0032486	Rap protein signal transduction(GO:0032486)
0.2	1.6	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.2	1.4	GO:0002931	response to ischemia(GO:0002931)
0.2	0.6	GO:0034036	sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2	1.1	GO:0010269	response to selenium ion(GO:0010269)
0.2	0.9	GO:0030299	intestinal cholesterol absorption(GO:0030299)
0.2	2.0	GO:0034605	cellular response to heat(GO:0034605)
0.2	0.2	GO:0072020	proximal straight tubule development(GO:0072020)
0.2	2.8	GO:2000300	regulation of synaptic vesicle exocytosis(GO:2000300)
0.2	2.2	GO:0070189	kynurenine metabolic process(GO:0070189)
0.2	1.2	GO:0097340	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.2	0.9	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.2	0.5	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2	1.6	GO:0044206	pyrimidine-containing compound salvage(GO:0008655) pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.2	0.2	GO:0051580	regulation of neurotransmitter uptake(GO:0051580)
0.2	0.5	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.2	1.3	GO:0045338	farnesyl diphosphate metabolic process(GO:0045338)
0.2	1.3	GO:0032309	icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.2	0.8	GO:0097272	ammonia homeostasis(GO:0097272)
0.2	1.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2	3.6	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2	0.5	GO:0097688	AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.2	1.2	GO:0030859	polarized epithelial cell differentiation(GO:0030859)
0.2	0.9	GO:0006572	tyrosine catabolic process(GO:0006572)
0.2	0.9	GO:0099525	synaptic vesicle docking(GO:0016081) presynaptic dense core granule exocytosis(GO:0099525)
0.2	0.6	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.2	0.9	GO:0031507	heterochromatin assembly(GO:0031507)
0.2	3.3	GO:0010165	response to X-ray(GO:0010165)
0.2	1.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.7	GO:0051659	maintenance of mitochondrion location(GO:0051659)
0.1	1.2	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.1	1.9	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	3.0	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1	0.4	GO:0035992	tendon formation(GO:0035992)
0.1	1.1	GO:0097476	spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1	1.2	GO:0045923	negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888) positive regulation of fatty acid metabolic process(GO:0045923)
0.1	1.3	GO:0050819	negative regulation of coagulation(GO:0050819)
0.1	1.3	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.1	1.7	GO:0019433	triglyceride catabolic process(GO:0019433)
0.1	1.6	GO:0045670	regulation of osteoclast differentiation(GO:0045670)
0.1	2.7	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.1	0.4	GO:0034214	protein hexamerization(GO:0034214)
0.1	0.5	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.1	2.0	GO:0021772	olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.1	0.5	GO:0052746	inositol phosphorylation(GO:0052746)
0.1	4.9	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.1	1.1	GO:0006561	proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1	0.5	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.1	0.8	GO:0035306	positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.1	6.5	GO:0046328	regulation of JNK cascade(GO:0046328)
0.1	0.8	GO:0045604	regulation of epidermal cell differentiation(GO:0045604)
0.1	0.5	GO:0034505	tooth mineralization(GO:0034505)
0.1	0.3	GO:0032290	peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.1	3.8	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.1	0.4	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.6	GO:0042542	response to hydrogen peroxide(GO:0042542)
0.1	1.0	GO:0015886	heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1	0.7	GO:1902868	positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1	0.2	GO:0045921	positive regulation of exocytosis(GO:0045921)
0.1	3.0	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1	2.2	GO:1902807	negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1	0.2	GO:0035676	anterior lateral line neuromast hair cell development(GO:0035676)
0.1	1.6	GO:0006000	fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	1.1	GO:0006611	protein export from nucleus(GO:0006611)
0.1	0.5	GO:0010754	negative regulation of cGMP-mediated signaling(GO:0010754)
0.1	0.7	GO:1901021	activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	1.5	GO:0006228	UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1	1.1	GO:0050909	sensory perception of taste(GO:0050909)
0.1	0.5	GO:0008592	regulation of Toll signaling pathway(GO:0008592)
0.1	0.2	GO:0045601	positive regulation of epithelial cell differentiation(GO:0030858) regulation of endothelial cell differentiation(GO:0045601)
0.1	0.1	GO:0032366	intracellular sterol transport(GO:0032366)
0.1	1.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1	1.0	GO:0097009	energy homeostasis(GO:0097009)
0.1	11.6	GO:0090630	activation of GTPase activity(GO:0090630)
0.1	2.0	GO:0050829	defense response to Gram-negative bacterium(GO:0050829)
0.1	2.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	0.5	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1	0.3	GO:0048909	anterior lateral line nerve development(GO:0048909) anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.1	0.4	GO:0055071	manganese ion homeostasis(GO:0055071)
0.1	2.8	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1	3.0	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1	1.3	GO:0051899	membrane depolarization(GO:0051899)
0.1	0.2	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1	0.9	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1	0.3	GO:0009251	polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1	0.6	GO:0048745	smooth muscle tissue development(GO:0048745)
0.1	0.8	GO:0055117	regulation of cardiac muscle contraction(GO:0055117)
0.1	2.9	GO:0051966	regulation of synaptic transmission, glutamatergic(GO:0051966)
0.1	1.2	GO:0016486	peptide hormone processing(GO:0016486)
0.1	0.3	GO:2000767	positive regulation of cytoplasmic translation(GO:2000767)
0.1	0.8	GO:0036368	cone photoresponse recovery(GO:0036368)
0.1	2.0	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.1	0.7	GO:0007220	Notch receptor processing(GO:0007220)
0.1	0.3	GO:0036149	phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1	1.4	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1	1.0	GO:0032094	response to food(GO:0032094)
0.1	0.3	GO:2000677	histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.1	1.0	GO:0009303	rRNA transcription(GO:0009303)
0.1	1.8	GO:0031114	regulation of microtubule depolymerization(GO:0031114)
0.1	0.4	GO:0070650	actin filament bundle distribution(GO:0070650)
0.1	0.5	GO:0051013	microtubule severing(GO:0051013)
0.1	0.2	GO:1903644	regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.1	0.4	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1	1.0	GO:0008053	mitochondrial fusion(GO:0008053)
0.1	0.3	GO:0042491	auditory receptor cell differentiation(GO:0042491)
0.1	0.3	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.1	0.3	GO:0061551	trigeminal ganglion development(GO:0061551)
0.1	5.4	GO:0051017	actin filament bundle assembly(GO:0051017)
0.1	0.5	GO:0043363	nucleate erythrocyte differentiation(GO:0043363)
0.1	0.5	GO:0046959	nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1	3.0	GO:0035304	regulation of protein dephosphorylation(GO:0035304)
0.1	0.3	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.1	1.4	GO:0043652	engulfment of apoptotic cell(GO:0043652)
0.1	0.5	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.1	2.9	GO:0042737	drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1	2.6	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.1	0.8	GO:0032264	IMP salvage(GO:0032264)
0.1	0.1	GO:0098773	skin epidermis development(GO:0098773)
0.1	0.2	GO:0038093	Fc receptor signaling pathway(GO:0038093)
0.1	0.2	GO:0032801	receptor catabolic process(GO:0032801)
0.1	1.2	GO:0006828	manganese ion transport(GO:0006828)
0.1	0.3	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.1	1.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.4	GO:0038026	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.1	0.4	GO:0070572	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.1	0.9	GO:0016082	synaptic vesicle priming(GO:0016082)
0.1	0.2	GO:0052576	carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.1	0.5	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1	1.8	GO:0046847	filopodium assembly(GO:0046847)
0.1	0.4	GO:0050890	cognition(GO:0050890)
0.1	2.5	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1	1.9	GO:0007041	lysosomal transport(GO:0007041)
0.1	0.2	GO:0046654	tetrahydrofolate biosynthetic process(GO:0046654)
0.0	0.2	GO:0014909	smooth muscle cell migration(GO:0014909)
0.0	0.8	GO:0097581	lamellipodium organization(GO:0097581)
0.0	0.4	GO:0034394	protein localization to cell surface(GO:0034394)
0.0	0.2	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	1.0	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.4	GO:2001222	regulation of neuron migration(GO:2001222)
0.0	0.2	GO:2000725	regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.0	0.6	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:1904983	transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.0	0.3	GO:0030534	adult behavior(GO:0030534)
0.0	0.9	GO:0010675	regulation of cellular carbohydrate metabolic process(GO:0010675) regulation of glucose metabolic process(GO:0010906)
0.0	5.2	GO:0021782	glial cell development(GO:0021782)
0.0	0.9	GO:0015908	fatty acid transport(GO:0015908)
0.0	0.4	GO:0038171	cannabinoid signaling pathway(GO:0038171)
0.0	0.7	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.6	GO:0044154	histone H3-K14 acetylation(GO:0044154)
0.0	0.5	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.5	GO:0097105	presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.0	0.3	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.2	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	2.6	GO:1902668	negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0	0.4	GO:1990402	embryonic liver development(GO:1990402)
0.0	0.5	GO:0006094	gluconeogenesis(GO:0006094)
0.0	0.4	GO:0035372	protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0	0.4	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.3	GO:0071467	cellular response to pH(GO:0071467)
0.0	0.1	GO:0002320	lymphoid progenitor cell differentiation(GO:0002320)
0.0	0.4	GO:0002154	thyroid hormone mediated signaling pathway(GO:0002154)
0.0	0.1	GO:0006864	pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0	2.1	GO:0060119	inner ear receptor cell development(GO:0060119)
0.0	0.9	GO:0014059	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0	0.2	GO:0071691	cardiac muscle thin filament assembly(GO:0071691)
0.0	3.8	GO:0006865	amino acid transport(GO:0006865)
0.0	0.4	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.5	GO:0045667	regulation of osteoblast differentiation(GO:0045667)
0.0	0.9	GO:0060319	primitive erythrocyte differentiation(GO:0060319)
0.0	2.7	GO:0006694	steroid biosynthetic process(GO:0006694)
0.0	0.3	GO:0021694	cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.5	GO:0019226	transmission of nerve impulse(GO:0019226)
0.0	0.4	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.3	GO:0034198	cellular response to amino acid starvation(GO:0034198)
0.0	2.1	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.0	0.6	GO:0007040	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0	0.6	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0	0.5	GO:0033555	multicellular organismal response to stress(GO:0033555)
0.0	0.5	GO:0035860	esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.9	GO:0019432	triglyceride biosynthetic process(GO:0019432) neutral lipid biosynthetic process(GO:0046460) acylglycerol biosynthetic process(GO:0046463)
0.0	0.6	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.2	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.2	GO:0032732	positive regulation of interleukin-1 production(GO:0032732)
0.0	0.3	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0	0.9	GO:0051014	actin filament severing(GO:0051014)
0.0	0.2	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	1.7	GO:0045055	regulated exocytosis(GO:0045055)
0.0	1.0	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.9	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.4	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.0	0.6	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	3.4	GO:0051260	protein homooligomerization(GO:0051260)
0.0	0.3	GO:1904071	presynaptic active zone assembly(GO:1904071)
0.0	0.2	GO:0032218	riboflavin transport(GO:0032218)
0.0	0.1	GO:2000812	positive regulation of protein depolymerization(GO:1901881) regulation of barbed-end actin filament capping(GO:2000812)
0.0	0.6	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.5	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.3	GO:0046620	regulation of organ growth(GO:0046620)
0.0	0.8	GO:0046785	microtubule polymerization(GO:0046785)
0.0	0.4	GO:0006112	glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) energy reserve metabolic process(GO:0006112) glucan metabolic process(GO:0044042)
0.0	0.2	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0	2.0	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.4	GO:0007254	JNK cascade(GO:0007254)
0.0	0.9	GO:0014065	phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0	1.2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0	0.3	GO:0048769	sarcomerogenesis(GO:0048769)
0.0	0.1	GO:0015864	uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0	0.7	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.0	0.8	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.3	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	3.3	GO:0051321	meiotic cell cycle(GO:0051321)
0.0	1.6	GO:0006352	DNA-templated transcription, initiation(GO:0006352)
0.0	0.2	GO:0046473	phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0	0.0	GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0	0.3	GO:1990126	retrograde transport, endosome to plasma membrane(GO:1990126)
0.0	0.2	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.9	GO:0030042	actin filament depolymerization(GO:0030042)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.6	GO:0003140	determination of left/right asymmetry in lateral mesoderm(GO:0003140)
0.0	0.8	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	3.6	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.0	0.3	GO:0001539	cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0	0.4	GO:0001878	response to yeast(GO:0001878)
0.0	0.3	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0	0.5	GO:0006801	superoxide metabolic process(GO:0006801)
0.0	0.4	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.0	1.3	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0	0.2	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	1.0	GO:0051607	defense response to virus(GO:0051607)
0.0	0.5	GO:0043406	positive regulation of MAP kinase activity(GO:0043406)
0.0	0.1	GO:0008105	asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0	0.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.1	GO:0006559	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.5	GO:0045332	phospholipid translocation(GO:0045332)
0.0	0.4	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.3	GO:0030183	B cell differentiation(GO:0030183)
0.0	0.5	GO:0006289	nucleotide-excision repair(GO:0006289)
0.0	0.4	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.2	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.0	0.2	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.3	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0	0.3	GO:0036297	interstrand cross-link repair(GO:0036297)
0.0	0.8	GO:0006414	translational elongation(GO:0006414)
0.0	2.7	GO:0007601	visual perception(GO:0007601)
0.0	0.1	GO:0019859	thymine catabolic process(GO:0006210) valine catabolic process(GO:0006574) thymine metabolic process(GO:0019859)
0.0	0.2	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.2	GO:0061647	histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0	0.2	GO:0006555	methionine metabolic process(GO:0006555)
0.0	0.1	GO:0010002	cardioblast differentiation(GO:0010002)
0.0	0.1	GO:2000765	regulation of cytoplasmic translation(GO:2000765)
0.0	0.6	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0	0.2	GO:0007631	feeding behavior(GO:0007631)
0.0	0.8	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.0	0.1	GO:0006797	polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0	0.1	GO:0009154	purine ribonucleotide catabolic process(GO:0009154)
0.0	0.3	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	15.5	GO:0070062	extracellular exosome(GO:0070062)
1.4	6.8	GO:0030314	junctional membrane complex(GO:0030314)
0.8	3.3	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.4	3.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.4	5.6	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.3	3.4	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.3	1.9	GO:1902636	kinociliary basal body(GO:1902636)
0.3	3.3	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.3	1.7	GO:0033181	plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.3	2.9	GO:0098894	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.3	4.1	GO:0031209	SCAR complex(GO:0031209)
0.2	4.3	GO:0043209	myelin sheath(GO:0043209)
0.2	1.9	GO:0061700	GATOR2 complex(GO:0061700)
0.2	2.7	GO:0030893	meiotic cohesin complex(GO:0030893)
0.2	2.4	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.2	0.6	GO:0032998	Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.2	0.6	GO:0033268	node of Ranvier(GO:0033268)
0.2	3.8	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2	1.4	GO:0030315	T-tubule(GO:0030315)
0.2	8.3	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2	0.7	GO:0044611	nuclear pore inner ring(GO:0044611)
0.2	0.5	GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.2	0.5	GO:0060077	inhibitory synapse(GO:0060077)
0.1	1.0	GO:0043194	axon initial segment(GO:0043194)
0.1	0.6	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.1	3.0	GO:0002116	semaphorin receptor complex(GO:0002116)
0.1	0.4	GO:0031166	integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1	2.8	GO:0009925	basal plasma membrane(GO:0009925)
0.1	1.8	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.8	GO:0001650	fibrillar center(GO:0001650)
0.1	4.0	GO:0098831	presynaptic active zone cytoplasmic component(GO:0098831)
0.1	1.2	GO:0035101	FACT complex(GO:0035101)
0.1	3.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	5.9	GO:0042641	actomyosin(GO:0042641)
0.1	1.4	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	5.0	GO:0098839	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1	1.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	2.9	GO:0005844	polysome(GO:0005844)
0.1	5.7	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	0.7	GO:0070765	gamma-secretase complex(GO:0070765)
0.1	1.0	GO:0031045	dense core granule(GO:0031045)
0.1	0.3	GO:0098890	extrinsic component of postsynaptic membrane(GO:0098890)
0.1	0.3	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1	0.6	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1	10.4	GO:0014069	postsynaptic density(GO:0014069)
0.1	6.5	GO:0005871	kinesin complex(GO:0005871)
0.1	1.3	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	1.3	GO:0005801	cis-Golgi network(GO:0005801)
0.1	3.6	GO:0005811	lipid particle(GO:0005811)
0.1	0.2	GO:0072380	TRC complex(GO:0072380)
0.1	1.5	GO:0005685	U1 snRNP(GO:0005685)
0.1	0.4	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1	0.7	GO:0044295	axonal growth cone(GO:0044295)
0.1	2.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.1	6.7	GO:0016459	myosin complex(GO:0016459)
0.1	5.9	GO:0043025	neuronal cell body(GO:0043025)
0.1	0.9	GO:0034706	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1	1.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	1.0	GO:0044666	MLL3/4 complex(GO:0044666)
0.1	1.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	1.6	GO:0000421	autophagosome membrane(GO:0000421)
0.0	1.3	GO:0031941	filamentous actin(GO:0031941)
0.0	1.4	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.5	GO:0017119	Golgi transport complex(GO:0017119)
0.0	2.6	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.4	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	1.9	GO:0008305	integrin complex(GO:0008305)
0.0	2.3	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	4.9	GO:0016324	apical plasma membrane(GO:0016324)
0.0	0.3	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	14.9	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.5	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.3	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.4	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	2.0	GO:0031201	SNARE complex(GO:0031201)
0.0	0.6	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.7	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.7	GO:0031430	M band(GO:0031430)
0.0	0.9	GO:0098978	glutamatergic synapse(GO:0098978)
0.0	0.1	GO:0005854	nascent polypeptide-associated complex(GO:0005854)
0.0	0.1	GO:0098553	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	4.3	GO:0008021	synaptic vesicle(GO:0008021)
0.0	1.0	GO:0005581	collagen trimer(GO:0005581)
0.0	1.3	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0	2.0	GO:0034703	cation channel complex(GO:0034703)
0.0	1.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.2	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.4	GO:0005921	gap junction(GO:0005921)
0.0	2.6	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.0	0.1	GO:0043073	germ cell nucleus(GO:0043073)
0.0	0.4	GO:0016528	sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.0	1.5	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.0	1.0	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	4.8	GO:0005764	lysosome(GO:0005764)
0.0	1.3	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0	0.3	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.0	1.9	GO:0000786	nucleosome(GO:0000786)
0.0	0.2	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	0.3	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	1.3	GO:0000123	histone acetyltransferase complex(GO:0000123)
0.0	0.3	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.4	GO:0046930	pore complex(GO:0046930)
0.0	0.9	GO:0030117	membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0	0.5	GO:0042383	sarcolemma(GO:0042383)
0.0	0.3	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.0	0.4	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.5	GO:0005795	Golgi stack(GO:0005795)
0.0	0.2	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.2	GO:0045277	respiratory chain complex IV(GO:0045277)
0.0	0.3	GO:0035861	site of double-strand break(GO:0035861)
0.0	2.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.1	GO:0000243	commitment complex(GO:0000243)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	6.1	GO:0030228	lipoprotein particle receptor activity(GO:0030228)
1.4	4.2	GO:0008119	thiopurine S-methyltransferase activity(GO:0008119)
1.2	4.8	GO:0005461	UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
1.1	3.3	GO:0034618	arginine binding(GO:0034618)
1.1	7.5	GO:0015189	L-lysine transmembrane transporter activity(GO:0015189)
1.0	5.1	GO:0070644	vitamin D response element binding(GO:0070644)
1.0	7.6	GO:0001222	transcription corepressor binding(GO:0001222)
0.9	4.5	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.7	2.7	GO:0004925	prolactin receptor activity(GO:0004925)
0.6	2.4	GO:0035671	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.6	2.4	GO:0035575	histone demethylase activity (H4-K20 specific)(GO:0035575)
0.6	5.8	GO:0016936	galactoside binding(GO:0016936)
0.6	7.4	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.6	3.3	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.6	3.3	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.5	3.2	GO:0022889	serine transmembrane transporter activity(GO:0022889)
0.5	2.1	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.5	4.7	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.5	2.0	GO:1904121	phosphatidylethanolamine transporter activity(GO:1904121)
0.5	2.5	GO:0070412	R-SMAD binding(GO:0070412)
0.5	4.4	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.5	3.4	GO:0019809	spermidine binding(GO:0019809)
0.5	3.6	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.4	1.3	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.4	1.3	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.4	0.4	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.4	4.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.4	3.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.4	2.7	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4	5.7	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.4	1.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4	10.8	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.4	4.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.4	1.8	GO:0070004	cysteine-type exopeptidase activity(GO:0070004)
0.4	2.8	GO:0016803	ether hydrolase activity(GO:0016803)
0.3	1.7	GO:0008131	primary amine oxidase activity(GO:0008131)
0.3	2.3	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.3	2.9	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3	1.8	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.3	2.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3	16.7	GO:0019209	kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.3	0.9	GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.3	3.7	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3	1.1	GO:0004478	methionine adenosyltransferase activity(GO:0004478)
0.3	1.8	GO:0001642	group III metabotropic glutamate receptor activity(GO:0001642)
0.3	1.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3	1.3	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.3	3.6	GO:0008327	methyl-CpG binding(GO:0008327)
0.2	2.2	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.2	1.0	GO:0031781	type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.2	2.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.2	3.0	GO:0005222	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.2	0.7	GO:0004904	interferon receptor activity(GO:0004904)
0.2	2.9	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.2	2.2	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2	1.1	GO:0015288	porin activity(GO:0015288)
0.2	2.4	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.2	1.1	GO:0098639	C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2	6.3	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.2	1.7	GO:0030619	U1 snRNA binding(GO:0030619)
0.2	1.1	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2	3.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.2	0.6	GO:0019767	immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
0.2	1.0	GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.2	2.4	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.2	0.6	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.2	1.2	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2	0.6	GO:0004779	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2	2.1	GO:0047676	arachidonate-CoA ligase activity(GO:0047676)
0.2	3.6	GO:0072542	phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.2	1.7	GO:0004359	glutaminase activity(GO:0004359)
0.2	0.5	GO:0031779	melanocortin receptor binding(GO:0031779)
0.2	0.9	GO:0035173	histone kinase activity(GO:0035173)
0.2	1.3	GO:0099530	G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.2	3.2	GO:0035497	cAMP response element binding(GO:0035497)
0.2	4.8	GO:0015248	sterol transporter activity(GO:0015248)
0.2	1.2	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2	0.5	GO:1990174	phosphodiesterase decapping endonuclease activity(GO:1990174)
0.2	3.5	GO:0001671	ATPase activator activity(GO:0001671)
0.2	0.5	GO:0004736	pyruvate carboxylase activity(GO:0004736)
0.2	1.2	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2	6.0	GO:0003951	NAD+ kinase activity(GO:0003951)
0.2	1.1	GO:0000254	C-4 methylsterol oxidase activity(GO:0000254)
0.2	1.2	GO:0033878	hormone-sensitive lipase activity(GO:0033878)
0.1	0.6	GO:0003989	acetyl-CoA carboxylase activity(GO:0003989)
0.1	1.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.1	1.2	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1	4.3	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.1	0.4	GO:1990715	mRNA CDS binding(GO:1990715)
0.1	1.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.1	0.6	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.1	3.9	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.1	1.4	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	0.4	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.1	3.6	GO:0004697	protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1	0.5	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.1	4.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	0.5	GO:0017020	myosin phosphatase regulator activity(GO:0017020)
0.1	1.8	GO:0030506	ankyrin binding(GO:0030506)
0.1	0.5	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1	0.6	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	1.9	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1	2.8	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	1.6	GO:0008443	phosphofructokinase activity(GO:0008443)
0.1	0.9	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1	0.4	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	1.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.3	GO:0035613	RNA stem-loop binding(GO:0035613)
0.1	1.0	GO:0015924	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1	0.5	GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1	0.9	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1	0.4	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1	0.5	GO:0004645	phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1	0.9	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.1	2.6	GO:0005246	calcium channel regulator activity(GO:0005246)
0.1	0.3	GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145)
0.1	0.4	GO:0015369	calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.1	0.4	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.4	GO:0043734	oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.1	1.0	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	1.7	GO:0004190	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1	0.5	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	0.5	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	0.3	GO:0004968	gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1	0.9	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.1	0.7	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	2.6	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.3	GO:0070513	death domain binding(GO:0070513)
0.1	1.0	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.1	0.6	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.1	2.0	GO:0004806	triglyceride lipase activity(GO:0004806)
0.1	0.2	GO:0001160	transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1	1.4	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.3	GO:0019215	intermediate filament binding(GO:0019215)
0.1	0.2	GO:0051499	D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.1	0.3	GO:0031151	histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.1	0.6	GO:0004096	catalase activity(GO:0004096)
0.1	7.1	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.1	0.3	GO:0038131	neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.1	1.2	GO:0005080	protein kinase C binding(GO:0005080)
0.1	2.2	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1	0.4	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.1	0.6	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.1	1.7	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1	2.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.1	0.4	GO:0033781	cholesterol 24-hydroxylase activity(GO:0033781)
0.1	0.9	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1	0.7	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	0.3	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.1	1.3	GO:0004623	phospholipase A2 activity(GO:0004623)
0.1	4.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.1	0.3	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1	0.3	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1	0.3	GO:0004126	cytidine deaminase activity(GO:0004126)
0.1	0.8	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	4.5	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.1	3.0	GO:0044325	ion channel binding(GO:0044325)
0.1	1.5	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.1	0.5	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	0.9	GO:0016208	AMP binding(GO:0016208)
0.1	1.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.1	0.3	GO:0016361	activin receptor activity, type I(GO:0016361)
0.1	1.5	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	0.3	GO:0044736	acid-sensing ion channel activity(GO:0044736)
0.1	0.5	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.2	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	1.0	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0	0.7	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	4.6	GO:0019905	syntaxin binding(GO:0019905)
0.0	0.2	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.6	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	2.5	GO:0050661	NADP binding(GO:0050661)
0.0	0.5	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	15.1	GO:0008017	microtubule binding(GO:0008017)
0.0	0.2	GO:0008459	chondroitin 6-sulfotransferase activity(GO:0008459)
0.0	0.3	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.6	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.2	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.0	0.7	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.2	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.0	0.2	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	2.6	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.6	GO:0010484	H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0	0.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0015218	pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0	0.4	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.6	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0004997	thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0	0.2	GO:0016519	gastric inhibitory peptide receptor activity(GO:0016519)
0.0	1.0	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	1.5	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	1.9	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	1.7	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	1.9	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.4	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.2	GO:0043295	glutathione binding(GO:0043295)
0.0	0.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.2	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.9	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.2	GO:0030116	glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.0	0.5	GO:2001069	glycogen binding(GO:2001069)
0.0	0.2	GO:0031841	neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.0	0.1	GO:0004422	hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0	0.3	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.6	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.4	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.7	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.4	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.7	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	0.4	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	1.1	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.2	GO:0032217	riboflavin transporter activity(GO:0032217)
0.0	0.4	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0072571	ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.0	0.5	GO:0008242	omega peptidase activity(GO:0008242)
0.0	1.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.5	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.6	GO:0008483	transaminase activity(GO:0008483)
0.0	1.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.7	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.5	GO:0004659	prenyltransferase activity(GO:0004659)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.5	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	1.1	GO:0019902	phosphatase binding(GO:0019902)
0.0	0.9	GO:0019003	GDP binding(GO:0019003)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	1.8	GO:0016763	transferase activity, transferring pentosyl groups(GO:0016763)
0.0	0.1	GO:0004061	arylformamidase activity(GO:0004061)
0.0	8.0	GO:0005096	GTPase activator activity(GO:0005096)
0.0	1.3	GO:1901981	phosphatidylinositol phosphate binding(GO:1901981)
0.0	0.1	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.0	0.1	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	2.1	GO:0003774	motor activity(GO:0003774)
0.0	0.2	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	1.1	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.5	GO:0042287	MHC protein binding(GO:0042287)
0.0	0.2	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.6	GO:0003823	antigen binding(GO:0003823)
0.0	0.3	GO:0016289	CoA hydrolase activity(GO:0016289)
0.0	0.2	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.3	GO:0098882	structural constituent of presynaptic active zone(GO:0098882)
0.0	0.1	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0	2.0	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.2	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.3	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0022829	wide pore channel activity(GO:0022829)
0.0	0.2	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.3	GO:0008308	voltage-gated anion channel activity(GO:0008308)
0.0	0.3	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.2	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0	0.1	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0	0.6	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.0	0.4	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.2	GO:0031682	G-protein gamma-subunit binding(GO:0031682)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0004309	exopolyphosphatase activity(GO:0004309)
0.0	0.4	GO:0043022	ribosome binding(GO:0043022)
0.0	0.7	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	3.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	1.6	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	2.9	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	3.6	PID REELIN PATHWAY	Reelin signaling pathway
0.2	0.8	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.2	3.2	ST ADRENERGIC	Adrenergic Pathway
0.1	0.7	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	1.9	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	1.7	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	2.7	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	1.7	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	1.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	1.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	1.6	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	0.3	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	1.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	2.3	PID ATM PATHWAY	ATM pathway
0.1	2.0	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	0.5	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	0.3	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	3.6	PID BCR 5PATHWAY	BCR signaling pathway
0.1	1.9	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	1.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	3.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	1.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	0.4	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	0.3	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	0.5	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	0.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	1.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	2.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	2.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	0.5	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.3	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	0.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	2.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.4	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	7.6	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.3	4.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	1.3	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.3	2.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.3	7.0	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3	2.5	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.2	2.5	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.2	1.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	3.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	2.0	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	2.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	1.6	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	2.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	0.6	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.2	0.6	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	5.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	1.1	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	1.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	2.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	2.4	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	4.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	2.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	2.5	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	1.9	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	1.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	2.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	1.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	0.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	0.8	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	0.5	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	0.9	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.1	1.9	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.1	2.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	3.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	0.8	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1	1.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	0.3	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.1	0.3	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.1	0.8	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	1.7	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1	0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	3.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	1.0	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.1	0.7	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.1	0.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	1.5	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	0.3	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.1	1.9	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.7	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.1	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.6	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME PI3K EVENTS IN ERBB4 SIGNALING	Genes involved in PI3K events in ERBB4 signaling
0.0	0.3	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.5	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.7	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.5	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.5	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	1.4	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	1.1	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.0	0.1	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.5	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.2	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.7	REACTOME ION CHANNEL TRANSPORT	Genes involved in Ion channel transport
0.0	0.2	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.2	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters

Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 2.05

Motif logo

Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Activity-expression correlation:

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: