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PRJEB1986: zebrafish developmental stages transcriptome

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Results for six4a+six4b

Z-value: 0.90

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Transcription factors associated with six4a+six4b

Gene Symbol Gene ID Gene Info
six4a
ENSDARG00000004695 SIX homeobox 4a
six4b
ENSDARG00000031983 SIX homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
six4bdr11_v1_chr20_+_20484827_20484827-0.901.2e-07Click!
six4adr11_v1_chr13_-_31647323_31647323-0.839.6e-06Click!

Activity profile of six4a+six4b motif

Sorted Z-values of six4a+six4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_28971002 4.63 ENSDART00000153159
si:rp71-1c10.11
si:rp71-1c10.11
chr2_+_10134345 3.76 ENSDART00000100725
ahsg2
alpha-2-HS-glycoprotein 2
chr5_+_37837245 3.60 ENSDART00000171617
epd
ependymin
chr8_-_25329967 3.10 ENSDART00000139682
eps8l3b
EPS8-like 3b
chr3_-_40955780 2.97 ENSDART00000130130
cyp3c3
cytochrome P450, family 3, subfamily c, polypeptide 3
chr5_+_13472234 2.51 ENSDART00000114069
ENSDART00000132406
cnnm4b
cyclin and CBS domain divalent metal cation transport mediator 4b
chr2_-_4797512 2.12 ENSDART00000160765
tnk2b
tyrosine kinase, non-receptor, 2b
chr11_+_40649412 2.11 ENSDART00000043016
ENSDART00000134560
slc45a1
solute carrier family 45, member 1
chr1_+_37752171 2.06 ENSDART00000183247
ENSDART00000189756
ENSDART00000139448
GALNTL6
si:ch211-15e22.3
chr16_-_13818061 2.01 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr2_-_30770736 1.94 ENSDART00000131230
rgs20
regulator of G protein signaling 20
chr2_+_50626476 1.84 ENSDART00000018150
neurod6b
neuronal differentiation 6b
chr23_+_45785563 1.70 ENSDART00000186027
CABZ01088036.1

chr14_-_2209742 1.67 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr1_+_55140970 1.66 ENSDART00000039807
mb
myoglobin
chr18_+_7264961 1.65 ENSDART00000188461
CABZ01015105.1

chr5_-_43071058 1.64 ENSDART00000165546
si:dkey-245n4.2
si:dkey-245n4.2
chr23_-_7125494 1.61 ENSDART00000111929
slco4a1
solute carrier organic anion transporter family, member 4A1
chr5_+_51079504 1.58 ENSDART00000097466
fam169aa
family with sequence similarity 169, member Aa
chr22_-_36774057 1.55 ENSDART00000125048
acy1
aminoacylase 1
chr7_-_41964877 1.55 ENSDART00000092351
ENSDART00000193395
ENSDART00000187947
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr2_+_29491314 1.55 ENSDART00000181774
dlgap1a
discs, large (Drosophila) homolog-associated protein 1a
chr7_+_58699900 1.48 ENSDART00000144009
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr5_-_5831037 1.42 ENSDART00000112856
zmp:0000000846
zmp:0000000846
chr17_+_37624704 1.41 ENSDART00000157001
tmem229b
transmembrane protein 229B
chr14_-_2318590 1.40 ENSDART00000192735
pcdh2ab8
protocadherin 2 alpha b 8
chr13_+_3954715 1.32 ENSDART00000182477
ENSDART00000192142
ENSDART00000190962
lrrc73
leucine rich repeat containing 73
chr19_+_31183495 1.31 ENSDART00000088618
meox2b
mesenchyme homeobox 2b
chr17_+_15882533 1.31 ENSDART00000164124
gabrr2a
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr17_-_31058900 1.30 ENSDART00000134998
ENSDART00000104307
ENSDART00000172721
eml1
echinoderm microtubule associated protein like 1
chr25_-_1235457 1.24 ENSDART00000093093
coro2bb
coronin, actin binding protein, 2Bb
chr7_-_73852594 1.20 ENSDART00000183194
zgc:165555
zgc:165555
chr2_+_38804223 1.17 ENSDART00000147939
carmil3
capping protein regulator and myosin 1 linker 3
chr1_-_6085750 1.17 ENSDART00000138891
si:ch1073-345a8.1
si:ch1073-345a8.1
chr25_-_17528994 1.12 ENSDART00000061712
si:dkey-44k1.5
si:dkey-44k1.5
chr1_-_7894255 1.10 ENSDART00000167126
ENSDART00000145460
radil
Ras association and DIL domains
chr17_-_13072334 1.10 ENSDART00000159598
CU469462.1

chr7_+_58699718 1.09 ENSDART00000049264
sdr16c5b
short chain dehydrogenase/reductase family 16C, member 5b
chr7_+_20656942 1.04 ENSDART00000100898
tnfsf12
TNF superfamily member 12
chr18_-_39188664 1.02 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr5_+_55221593 0.97 ENSDART00000073638
tmc2a
transmembrane channel-like 2a
chr7_-_32599669 0.93 ENSDART00000173752
kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr25_+_5604512 0.92 ENSDART00000042781
plxnb2b
plexin b2b
chr13_-_14269626 0.90 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr22_-_36774219 0.90 ENSDART00000056151
ENSDART00000168711
acy1
aminoacylase 1
chr6_+_40591149 0.86 ENSDART00000189060
ENSDART00000188298
frs3
fibroblast growth factor receptor substrate 3
chr2_-_11662851 0.84 ENSDART00000145108
zgc:110130
zgc:110130
chr4_-_22519516 0.84 ENSDART00000130409
ENSDART00000186258
ENSDART00000002851
ENSDART00000123801
kdm7aa
lysine (K)-specific demethylase 7Aa
chr7_-_60351537 0.83 ENSDART00000159875
plcb3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr7_-_58130703 0.82 ENSDART00000172082
ank2b
ankyrin 2b, neuronal
chr25_-_15214161 0.82 ENSDART00000031499
wt1a
wilms tumor 1a
chr22_+_19366866 0.81 ENSDART00000137301
si:dkey-21e2.12
si:dkey-21e2.12
chr16_+_50755133 0.80 ENSDART00000029283
IGLON5
zgc:110372
chr16_-_24561354 0.77 ENSDART00000193278
ENSDART00000126274
si:ch211-79k12.2
si:ch211-79k12.2
chr1_-_46632948 0.77 ENSDART00000148893
ENSDART00000053232
cdadc1
cytidine and dCMP deaminase domain containing 1
chr2_+_33335911 0.74 ENSDART00000126135
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr24_+_34089977 0.74 ENSDART00000157466
asb10
ankyrin repeat and SOCS box containing 10
chr21_-_43015383 0.72 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr2_-_30784198 0.71 ENSDART00000182523
ENSDART00000147355
rgs20
regulator of G protein signaling 20
chr8_+_49149907 0.70 ENSDART00000138746
snpha
syntaphilin a
chr7_+_18176162 0.69 ENSDART00000109171
rce1a
Ras converting CAAX endopeptidase 1a
chr20_+_22067337 0.69 ENSDART00000152636
clocka
clock circadian regulator a
chr24_-_26302375 0.68 ENSDART00000130696
cops9
COP9 signalosome subunit 9
chr5_-_57723929 0.67 ENSDART00000144237
gig2p
grass carp reovirus (GCRV)-induced gene 2p
chr18_+_27511976 0.66 ENSDART00000132017
ENSDART00000140781
tp53i11b
tumor protein p53 inducible protein 11b
chr14_-_7128980 0.64 ENSDART00000171311
si:ch73-43g23.1
si:ch73-43g23.1
chr8_+_35964482 0.64 ENSDART00000129357
ENSDART00000154953
glt1d1
glycosyltransferase 1 domain containing 1
chr6_-_35310224 0.63 ENSDART00000148997
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr4_-_14315855 0.63 ENSDART00000133325
nell2b
neural EGFL like 2b
chr19_+_770300 0.61 ENSDART00000062518
gstr
glutathione S-transferase rho
chr22_+_21317597 0.59 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr14_-_4043818 0.56 ENSDART00000179870
snx25
sorting nexin 25
chr20_+_34717403 0.55 ENSDART00000034252
pnocb
prepronociceptin b
chr21_+_34167178 0.52 ENSDART00000158308
trpc5b
transient receptor potential cation channel, subfamily C, member 5b
chr21_+_39365920 0.51 ENSDART00000140940
cluhb
clustered mitochondria (cluA/CLU1) homolog b
chr11_+_41560792 0.50 ENSDART00000127292
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr19_-_6983002 0.49 ENSDART00000104891
znf384l
zinc finger protein 384 like
chr8_+_14058646 0.48 ENSDART00000080852
ugt5e1
UDP glucuronosyltransferase 5 family, polypeptide E1
chr3_+_15773991 0.47 ENSDART00000089923
znf652
zinc finger protein 652
chr22_+_15310103 0.46 ENSDART00000145849
CU104797.1

chr18_-_26894732 0.46 ENSDART00000147735
ENSDART00000188938
BX470164.1
si:dkey-24l11.2

si:dkey-24l11.2
chr16_-_31756859 0.46 ENSDART00000149170
ENSDART00000126617
ENSDART00000182722
ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr3_+_12718100 0.44 ENSDART00000162343
ENSDART00000192425
cyp2k20
cytochrome P450, family 2, subfamily k, polypeptide 20
chr17_+_5768608 0.44 ENSDART00000157039
rp1l1a
retinitis pigmentosa 1-like 1a
chr1_-_58562129 0.44 ENSDART00000159070
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr4_-_77506362 0.43 ENSDART00000174387
ENSDART00000181181
CABZ01087415.1

chr3_-_56896702 0.43 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr20_+_33534038 0.42 ENSDART00000029206
kcnf1a
potassium voltage-gated channel, subfamily F, member 1a
chr12_-_4475890 0.39 ENSDART00000092492
si:ch211-173d10.1
si:ch211-173d10.1
chr19_-_15434813 0.39 ENSDART00000019843
ftr55
finTRIM family, member 55
chr18_-_12416019 0.39 ENSDART00000144799
si:ch211-1e14.1
si:ch211-1e14.1
chr2_-_32558795 0.38 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr12_+_31422557 0.37 ENSDART00000153179
zdhhc6
zinc finger, DHHC-type containing 6
chr12_-_18872927 0.36 ENSDART00000187717
shisa8b
shisa family member 8b
chr6_-_21678263 0.36 ENSDART00000038777
si:dkey-43k4.5
si:dkey-43k4.5
chr4_+_28355058 0.35 ENSDART00000150799
si:ch73-263o4.3
si:ch73-263o4.3
chr17_-_1407593 0.32 ENSDART00000157622
ENSDART00000159458
zbtb42
zinc finger and BTB domain containing 42
chr19_-_18626952 0.32 ENSDART00000168004
ENSDART00000162034
ENSDART00000165486
ENSDART00000167971
rps18
ribosomal protein S18
chr9_+_11034314 0.30 ENSDART00000032695
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr6_-_33129312 0.29 ENSDART00000156987
tspan1
tetraspanin 1
chr8_-_3346692 0.28 ENSDART00000057874
FUT9 (1 of many)
zgc:103510
chr10_-_39283883 0.28 ENSDART00000023831
cry5
cryptochrome circadian clock 5
chr3_+_311833 0.28 ENSDART00000187375
FP326649.2

chr16_+_11834516 0.27 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr11_+_1602916 0.26 ENSDART00000184434
ENSDART00000112597
ENSDART00000192165
si:dkey-40c23.2
si:dkey-40c23.3
si:dkey-40c23.2
si:dkey-40c23.3
chr1_-_45889820 0.25 ENSDART00000144735
pnpla6
patatin-like phospholipase domain containing 6
chr7_+_6480212 0.24 ENSDART00000173320
si:cabz01036022.1
si:cabz01036022.1
chr1_+_1941031 0.23 ENSDART00000110331
PTGFRN
si:ch211-132g1.7
chr7_+_13988075 0.22 ENSDART00000186812
furina
furin (paired basic amino acid cleaving enzyme) a
chr17_+_6217704 0.20 ENSDART00000129100
BX000363.1

chr11_+_583725 0.18 ENSDART00000189415
mkrn2os.2
MKRN2 opposite strand, tandem duplicate 2
chr23_-_10831995 0.18 ENSDART00000142533
pdzrn3a
PDZ domain containing RING finger 3a
chr20_-_5052786 0.16 ENSDART00000138818
ENSDART00000181655
ENSDART00000164274
arid1b
AT rich interactive domain 1B (SWI1-like)
chr18_+_19419120 0.15 ENSDART00000025107
map2k1
mitogen-activated protein kinase kinase 1
chr23_+_16469530 0.15 ENSDART00000132898
ntsr1
neurotensin receptor 1 (high affinity)
chr10_-_32610776 0.15 ENSDART00000017436
mogat2
monoacylglycerol O-acyltransferase 2
chr8_-_7474997 0.14 ENSDART00000146555
gata1b
GATA binding protein 1b
chr8_+_7801060 0.12 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr22_+_19220459 0.11 ENSDART00000163070
si:dkey-21e2.7
si:dkey-21e2.7
chr19_-_18626515 0.11 ENSDART00000160624
rps18
ribosomal protein S18
chr16_+_21242491 0.11 ENSDART00000145886
osbpl3b
oxysterol binding protein-like 3b
chr3_+_39099716 0.10 ENSDART00000083388
tmem98
transmembrane protein 98
chr1_-_58561963 0.08 ENSDART00000165040
slc27a1b
solute carrier family 27 (fatty acid transporter), member 1b
chr14_+_24042760 0.08 ENSDART00000106096
drd1a
dopamine receptor D1a
chr4_-_72468168 0.07 ENSDART00000182995
ENSDART00000174067
CR788316.1

chr3_+_1096831 0.07 ENSDART00000132817
si:ch1073-322p19.1
si:ch1073-322p19.1
chr3_-_39152478 0.05 ENSDART00000154550
si:dkeyp-57f11.2
si:dkeyp-57f11.2
chr2_+_30465102 0.05 ENSDART00000188404
neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr25_-_13201458 0.03 ENSDART00000192451
si:ch211-194m7.4
si:ch211-194m7.4
chr12_-_16524727 0.03 ENSDART00000166645
FO704724.1

chr7_+_38770167 0.02 ENSDART00000190827
arhgap1
Rho GTPase activating protein 1
chr8_+_23485079 0.02 ENSDART00000026316
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr15_+_11683114 0.01 ENSDART00000168233
si:dkey-31c13.1
si:dkey-31c13.1
chr21_+_40232910 0.00 ENSDART00000075915
or115-11
odorant receptor, family F, subfamily 115, member 11
chr13_+_4883377 0.00 ENSDART00000181530
ENSDART00000092521
micu1
mitochondrial calcium uptake 1

Network of associatons between targets according to the STRING database.

First level regulatory network of six4a+six4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 0.7 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 2.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 0.7 GO:2000434 regulation of protein neddylation(GO:2000434)
0.2 1.5 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.2 0.8 GO:0061032 visceral serous pericardium development(GO:0061032) glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.2 0.7 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 0.8 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.8 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.7 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 1.3 GO:0036368 cone photoresponse recovery(GO:0036368)
0.1 1.0 GO:0060004 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.1 0.5 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 1.5 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.4 GO:0006565 L-serine catabolic process(GO:0006565)
0.1 1.7 GO:0014823 response to activity(GO:0014823)
0.1 1.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.7 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.4 GO:0050957 equilibrioception(GO:0050957)
0.1 0.4 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.8 GO:0043114 regulation of vascular permeability(GO:0043114) regulation of calcium ion import(GO:0090279)
0.0 0.5 GO:0098900 regulation of action potential(GO:0098900)
0.0 0.9 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 3.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.4 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 1.0 GO:0009648 photoperiodism(GO:0009648)
0.0 3.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.2 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.2 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 1.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 1.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.1 GO:0042311 vasodilation(GO:0042311)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 3.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.2 GO:0035060 brahma complex(GO:0035060)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.3 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.5 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590) dendritic spine membrane(GO:0032591)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.5 GO:0043679 axon terminus(GO:0043679)
0.0 0.7 GO:0030426 growth cone(GO:0030426)
0.0 3.6 GO:0005764 lysosome(GO:0005764)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 2.4 GO:0004046 aminoacylase activity(GO:0004046)
0.2 0.8 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.6 GO:0043295 glutathione binding(GO:0043295)
0.1 2.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.7 GO:0070888 E-box binding(GO:0070888)
0.1 3.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.3 GO:0003913 DNA photolyase activity(GO:0003913)
0.1 1.1 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.9 GO:0031420 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.1 1.7 GO:0005344 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.1 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.4 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 1.0 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.1 1.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.7 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 3.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.5 GO:0031628 opioid receptor binding(GO:0031628)
0.0 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.1 GO:0051020 GTPase binding(GO:0051020)
0.0 1.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.0 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.8 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 2.6 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.6 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 2.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.9 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels