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PRJEB1986: zebrafish developmental stages transcriptome

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Results for prox1a+prox2+prox3

Z-value: 0.31

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Transcription factors associated with prox1a+prox2+prox3

Gene Symbol Gene ID Gene Info
prox2
ENSDARG00000041952 prospero homeobox 2
prox1a
ENSDARG00000055158 prospero homeobox 1a
prox3
ENSDARG00000088810 prospero homeobox 3
prox3
ENSDARG00000113014 prospero homeobox 3
prox2
ENSDARG00000117137 prospero homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prox1adr11_v1_chr17_-_32865788_32865788-0.597.5e-03Click!
prox1bdr11_v1_chr7_-_19940473_19940473-0.493.1e-02Click!
prox2dr11_v1_chr17_-_52521002_52521002-0.058.3e-01Click!

Activity profile of prox1a+prox2+prox3 motif

Sorted Z-values of prox1a+prox2+prox3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_23219367 0.69 ENSDART00000003646
optc
opticin
chr13_+_7442023 0.64 ENSDART00000080975
tnfaip2b
tumor necrosis factor, alpha-induced protein 2b
chr4_+_5196469 0.58 ENSDART00000067386
rad51ap1
RAD51 associated protein 1
chr14_+_31751260 0.52 ENSDART00000169796
si:dkeyp-11e3.1
si:dkeyp-11e3.1
chr7_+_20917966 0.48 ENSDART00000129161
wrap53
WD repeat containing, antisense to TP53
chr7_-_44604540 0.47 ENSDART00000149186
tk2
thymidine kinase 2, mitochondrial
chr22_+_10678141 0.47 ENSDART00000193341
hyal2b
hyaluronoglucosaminidase 2b
chr7_-_44605050 0.46 ENSDART00000148471
ENSDART00000149072
tk2
thymidine kinase 2, mitochondrial
chr17_-_106291 0.43 ENSDART00000160738
arhgap11a
Rho GTPase activating protein 11A
chr14_-_28473639 0.40 ENSDART00000173007
nxt2
nuclear transport factor 2-like export factor 2
chr14_-_30971264 0.37 ENSDART00000010512
zgc:92907
zgc:92907
chr5_-_61638125 0.37 ENSDART00000134314
si:dkey-261j4.3
si:dkey-261j4.3
chr12_+_27117609 0.35 ENSDART00000076154
hoxb8b
homeobox B8b
chr25_+_16312258 0.35 ENSDART00000064187
parvaa
parvin, alpha a
chr13_+_47050726 0.34 ENSDART00000140045
anapc1
anaphase promoting complex subunit 1
chr3_+_22335030 0.33 ENSDART00000055676
zgc:103564
zgc:103564
chr16_+_42772678 0.32 ENSDART00000155575
si:ch211-135n15.2
si:ch211-135n15.2
chr3_+_21200763 0.32 ENSDART00000067841
zgc:112038
zgc:112038
chr23_+_21663631 0.31 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr4_+_77973876 0.30 ENSDART00000057423
terfa
telomeric repeat binding factor a
chr7_-_38087865 0.29 ENSDART00000052366
cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr12_+_6065661 0.29 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr9_+_8968702 0.28 ENSDART00000008490
ube2al
ubiquitin conjugating enzyme E2 A, like
chr23_-_5759242 0.28 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr10_-_38316134 0.27 ENSDART00000149580
nrip1b
nuclear receptor interacting protein 1b
chr2_-_30055432 0.27 ENSDART00000056747
shhb
sonic hedgehog b
chr18_-_34549721 0.26 ENSDART00000137101
ENSDART00000021880
ssr3
signal sequence receptor, gamma
chr14_-_6286966 0.25 ENSDART00000168174
elp1
elongator complex protein 1
chr5_+_27440325 0.25 ENSDART00000185815
ENSDART00000144013
loxl2b
lysyl oxidase-like 2b
chr16_+_51154918 0.25 ENSDART00000058290
dhdds
dehydrodolichyl diphosphate synthase
chr9_+_21401189 0.24 ENSDART00000062669
cx30.3
connexin 30.3
chr15_-_23475051 0.24 ENSDART00000152460
nlrx1
NLR family member X1
chr9_-_23033818 0.24 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr11_-_25461336 0.23 ENSDART00000014945
hcfc1a
host cell factor C1a
chr14_+_24840669 0.22 ENSDART00000106039
arhgef37
Rho guanine nucleotide exchange factor (GEF) 37
chr13_+_11829072 0.21 ENSDART00000079356
ENSDART00000170160
sufu
suppressor of fused homolog (Drosophila)
chr13_-_35765028 0.21 ENSDART00000157391
erlec1
endoplasmic reticulum lectin 1
chr10_-_8294965 0.20 ENSDART00000167380
plpp1a
phospholipid phosphatase 1a
chr1_-_59065217 0.20 ENSDART00000188972
CABZ01080042.1

chr12_-_18898413 0.20 ENSDART00000181281
ENSDART00000121866
desi1b
desumoylating isopeptidase 1b
chr10_+_7719796 0.20 ENSDART00000191795
ggcx
gamma-glutamyl carboxylase
chr6_-_32411703 0.20 ENSDART00000151002
ENSDART00000078908
usp1
ubiquitin specific peptidase 1
chr14_+_28473173 0.19 ENSDART00000017075
xiap
X-linked inhibitor of apoptosis
chr22_+_2198246 0.19 ENSDART00000165168
ENSDART00000157485
ENSDART00000168713
znf1157
znf1166
zinc finger protein 1157
zinc finger protein 1166
chr5_+_13870340 0.19 ENSDART00000160690
hk2
hexokinase 2
chr3_+_11072958 0.18 ENSDART00000158899
mrps7
mitochondrial ribosomal protein S7
chr15_+_32711663 0.18 ENSDART00000157854
ENSDART00000167515
postnb
periostin, osteoblast specific factor b
chr19_+_19989380 0.18 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr3_-_15667713 0.18 ENSDART00000026658
zgc:66474
zgc:66474
chr8_+_30600386 0.18 ENSDART00000164976
specc1la
sperm antigen with calponin homology and coiled-coil domains 1-like a
chr10_-_8295294 0.17 ENSDART00000075412
ENSDART00000163803
plpp1a
phospholipid phosphatase 1a
chr10_-_36253958 0.17 ENSDART00000126288
or110-2
odorant receptor, family D, subfamily 110, member 2
chr10_+_29266392 0.16 ENSDART00000153577
crebzf
CREB/ATF bZIP transcription factor
chr21_-_303766 0.16 ENSDART00000150913
lhfpl2a
LHFPL tetraspan subfamily member 2a
chr19_+_42886413 0.16 ENSDART00000151298
arpp21
cAMP-regulated phosphoprotein, 21
chr4_+_3455146 0.15 ENSDART00000180124
znf800b
zinc finger protein 800b
chr25_+_22587306 0.15 ENSDART00000067479
stra6
stimulated by retinoic acid 6
chr23_+_36118738 0.15 ENSDART00000139319
hoxc5a
homeobox C5a
chr22_+_9239831 0.14 ENSDART00000133720
si:ch211-250k18.5
si:ch211-250k18.5
chr22_+_9287929 0.14 ENSDART00000193522
si:ch211-250k18.7
si:ch211-250k18.7
chr1_-_9486214 0.14 ENSDART00000137821
micall2b
mical-like 2b
chr2_+_2470687 0.14 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr6_-_34006917 0.13 ENSDART00000190702
ENSDART00000184003
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr22_-_23591493 0.13 ENSDART00000170266
f13b
coagulation factor XIII, B polypeptide
chr7_-_44604821 0.12 ENSDART00000148967
tk2
thymidine kinase 2, mitochondrial
chr20_+_192170 0.12 ENSDART00000189675
cx28.8
connexin 28.8
chr5_-_51484156 0.12 ENSDART00000162064
CR388055.1

chr8_+_11325310 0.12 ENSDART00000142577
fxn
frataxin
chr1_+_6161930 0.12 ENSDART00000037036
cnppd1
cyclin Pas1/PHO80 domain containing 1
chr5_-_69707787 0.12 ENSDART00000108820
ENSDART00000149692
dguok
deoxyguanosine kinase
chr18_+_33264609 0.11 ENSDART00000050639
v2ra20
vomeronasal 2 receptor, a20
chr23_+_16889352 0.10 ENSDART00000145275
si:dkey-147f3.8
si:dkey-147f3.8
chr14_-_28566238 0.10 ENSDART00000172547
insb
preproinsulin b
chr9_-_42696408 0.10 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr19_+_7929704 0.10 ENSDART00000147015
si:dkey-266f7.4
si:dkey-266f7.4
chr16_+_39196727 0.09 ENSDART00000017017
zdhhc3a
zinc finger, DHHC-type containing 3a
chr22_-_23591340 0.09 ENSDART00000167024
f13b
coagulation factor XIII, B polypeptide
chr4_+_3455665 0.09 ENSDART00000058277
znf800b
zinc finger protein 800b
chr13_+_35765317 0.08 ENSDART00000100156
ENSDART00000167650
agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr25_-_10630496 0.08 ENSDART00000153639
ENSDART00000181722
ENSDART00000177834
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr19_-_13950231 0.08 ENSDART00000168665
sh3bgrl3
SH3 domain binding glutamate-rich protein like 3
chr7_+_57866292 0.08 ENSDART00000138757
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr4_-_5913338 0.08 ENSDART00000183590
arl1
ADP-ribosylation factor-like 1
chr16_-_13680692 0.07 ENSDART00000047452
ube2s
ubiquitin-conjugating enzyme E2S
chr5_+_37785152 0.07 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr15_+_37954666 0.06 ENSDART00000126534
ENSDART00000155548
si:dkey-238d18.7
si:dkey-238d18.7
chr17_-_10059557 0.06 ENSDART00000092209
ENSDART00000161243
baz1a
bromodomain adjacent to zinc finger domain, 1A
chr10_+_6697369 0.06 ENSDART00000148606
si:ch211-57m13.8
si:ch211-57m13.8
chr2_+_25658112 0.06 ENSDART00000051234
tnika
TRAF2 and NCK interacting kinase a
chr20_-_54014373 0.06 ENSDART00000152934
si:dkey-241l7.6
si:dkey-241l7.6
chr20_-_40717900 0.06 ENSDART00000181663
cx43
connexin 43
chr1_-_9485939 0.05 ENSDART00000157814
micall2b
mical-like 2b
chr16_+_11779761 0.05 ENSDART00000140297
si:dkey-250k15.4
si:dkey-250k15.4
chr10_-_2713228 0.03 ENSDART00000123754
ENSDART00000126236
mier3a
mesoderm induction early response 1, family member 3 a
chr10_+_43037064 0.03 ENSDART00000160159
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr17_-_31639845 0.02 ENSDART00000154196
znf839
zinc finger protein 839
chr19_-_22621811 0.02 ENSDART00000090669
pleca
plectin a
chr19_-_21766461 0.02 ENSDART00000104279
znf516
zinc finger protein 516
chr22_+_36692681 0.02 ENSDART00000186398
trim35-33
tripartite motif containing 35-33
chr9_+_38684871 0.01 ENSDART00000147938
ENSDART00000004462
heg1
heart development protein with EGF-like domains 1
chr7_+_7019911 0.01 ENSDART00000172421
rbm14b
RNA binding motif protein 14b
chr4_+_30788743 0.01 ENSDART00000184557
si:dkey-178j11.5
si:dkey-178j11.5
chr4_-_75899294 0.01 ENSDART00000157887
si:dkey-261j11.3
si:dkey-261j11.3
chr5_-_62306819 0.00 ENSDART00000168993
spata22
spermatogenesis associated 22
chr13_-_16066997 0.00 ENSDART00000184790
SPATA48
spermatogenesis associated 48
chr17_+_48164536 0.00 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr23_-_13877898 0.00 ENSDART00000138696
g6pd
glucose-6-phosphate dehydrogenase
chr16_-_54919260 0.00 ENSDART00000156533
kdf1a
keratinocyte differentiation factor 1a
chr23_+_35672542 0.00 ENSDART00000046268
pmelb
premelanosome protein b
chr8_+_25616946 0.00 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a

Network of associatons between targets according to the STRING database.

First level regulatory network of prox1a+prox2+prox3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.1 0.3 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 0.3 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.1 0.6 GO:0051601 exocyst localization(GO:0051601)
0.1 0.3 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.2 GO:0046823 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.0 0.2 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0060956 cardiac endothelial cell differentiation(GO:0003348) endocardial cell differentiation(GO:0060956)
0.0 0.2 GO:0071938 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.0 0.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.3 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.2 GO:0046546 development of primary male sexual characteristics(GO:0046546)
0.0 0.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.3 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.2 GO:0016203 muscle attachment(GO:0016203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1904423 dehydrodolichyl diphosphate synthase complex(GO:1904423)
0.1 0.3 GO:0033503 HULC complex(GO:0033503)
0.1 0.2 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.4 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.1 0.5 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.2 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 0.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.3 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.1 GO:0019107 myristoyltransferase activity(GO:0019107)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.2 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis