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PRJEB1986: zebrafish developmental stages transcriptome

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Results for pknox2

Z-value: 0.91

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Transcription factors associated with pknox2

Gene Symbol Gene ID Gene Info
ENSDARG00000055349 pbx/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pknox2dr11_v1_chr10_-_31220558_31220558-0.252.9e-01Click!

Activity profile of pknox2 motif

Sorted Z-values of pknox2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_26288301 3.15 ENSDART00000017668
polypyrimidine tract binding protein 1a
chr15_-_20528494 2.85 ENSDART00000048423
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr3_-_10312232 2.75 ENSDART00000081766
noggin 1
chr8_-_18613948 2.49 ENSDART00000089172
coproporphyrinogen oxidase
chr14_-_41468892 2.25 ENSDART00000173099
ENSDART00000003170
MID1 interacting protein 1, like
chr23_-_31060350 2.18 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
chr20_-_28433990 2.17 ENSDART00000182824
ENSDART00000193381
WD repeat domain 21
chr3_+_28576173 2.07 ENSDART00000151189
septin 12
chr12_-_48168135 2.06 ENSDART00000186624
phosphatase domain containing, paladin 1a
chr6_+_14949950 2.02 ENSDART00000149202
ENSDART00000149949
POU class 3 homeobox 3b
chr16_+_40575742 1.93 ENSDART00000161503
cyclin E2
chr22_+_25086942 1.92 ENSDART00000061117
ribosome binding protein 1b
chr2_+_45081489 1.92 ENSDART00000123966
cholinergic receptor, nicotinic, gamma
chr18_+_24562188 1.89 ENSDART00000099463
LysM, putative peptidoglycan-binding, domain containing 4
chr17_-_7792376 1.87 ENSDART00000064655
zinc finger and BTB domain containing 2a
chr22_+_25086567 1.83 ENSDART00000192114
ENSDART00000177284
ENSDART00000180296
ENSDART00000190384
ribosome binding protein 1b
chr4_+_12931763 1.76 ENSDART00000016382
wnt inhibitory factor 1
chr23_+_37815645 1.75 ENSDART00000011627
iroquois homeobox 7
chr16_-_13595027 1.74 ENSDART00000060004
ntl-dependent gene 5
chr4_-_20081621 1.65 ENSDART00000024647
DENN/MADD domain containing 6B
chr5_-_12219572 1.64 ENSDART00000167834
nitric oxide synthase 1 (neuronal)
chr10_+_42521943 1.59 ENSDART00000010420
ENSDART00000075303
ARP1 actin related protein 1, centractin
chr15_+_36309070 1.58 ENSDART00000157034
geminin coiled-coil domain containing
chr8_-_4760723 1.57 ENSDART00000064201
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr2_+_19195841 1.55 ENSDART00000163137
ENSDART00000161095
ELOVL fatty acid elongase 1a
chr25_+_3549401 1.54 ENSDART00000166312
coiled-coil domain containing 77
chr12_+_36971952 1.51 ENSDART00000125900
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
chr17_+_23964132 1.50 ENSDART00000154823
exportin 1 (CRM1 homolog, yeast) b
chr20_+_32478151 1.43 ENSDART00000145269
osteopetrosis associated transmembrane protein 1
chr19_+_25465025 1.39 ENSDART00000018553
replication protein A3
chr19_+_18799319 1.36 ENSDART00000171843
dimethylarginine dimethylaminohydrolase 2
chr8_-_17184482 1.36 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr20_-_20270191 1.35 ENSDART00000009356
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr22_-_37834312 1.34 ENSDART00000076128
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr19_-_15281996 1.34 ENSDART00000103784
endothelin 2
chr7_-_28565230 1.32 ENSDART00000028887
TMEM9 domain family, member B
chr7_-_26262978 1.30 ENSDART00000137769
adaptor-related protein complex 1, sigma 1 subunit
chr16_-_7239457 1.25 ENSDART00000148992
ENSDART00000149260
5'-nucleotidase, cytosolic IIIA
chr11_-_15874974 1.24 ENSDART00000166551
ENSDART00000129526
ENSDART00000165836
RAP1A, member of RAS oncogene family b
chr7_+_57089354 1.24 ENSDART00000140702
secretory carrier membrane protein 2, like
chr10_+_25982212 1.22 ENSDART00000128292
ENSDART00000108808
Fras1 related extracellular matrix protein 2a
chr2_-_11027258 1.20 ENSDART00000081072
ENSDART00000193824
ENSDART00000187036
ENSDART00000097741
single stranded DNA binding protein 3a
chr20_-_28433616 1.19 ENSDART00000169289
WD repeat domain 21
chr21_+_26539157 1.17 ENSDART00000021121
syntaxin 5A, like
chr2_-_45510699 1.17 ENSDART00000024034
ENSDART00000145634
G protein signaling modulator 2
chr19_-_30800004 1.16 ENSDART00000128560
ENSDART00000045504
ENSDART00000125893
tRNA isopentenyltransferase 1
chr16_-_52646789 1.14 ENSDART00000035761
ubiquitin protein ligase E3 component n-recognin 5
chr12_+_18899396 1.12 ENSDART00000105858
X-ray repair complementing defective repair in Chinese hamster cells 6
chr21_-_34658266 1.12 ENSDART00000023038
dachshund a
chr11_-_10456387 1.10 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr10_+_20590190 1.07 ENSDART00000131819
leucine zipper-EF-hand containing transmembrane protein 2
chr14_+_22022441 1.07 ENSDART00000149121
cardiotrophin-like cytokine factor 1
chr2_-_24402341 1.05 ENSDART00000155442
ENSDART00000088572
zgc:154006
chr8_+_30425700 1.00 ENSDART00000012132
COBW domain containing
chr18_+_17786548 0.98 ENSDART00000189493
ENSDART00000146133
si:ch211-216l23.1
chr24_+_29352039 0.97 ENSDART00000101641
protein arginine methyltransferase 6
chr21_-_38153824 0.97 ENSDART00000151226
Kruppel-like factor 5 like
chr5_-_17601759 0.96 ENSDART00000138387
si:ch211-130h14.6
chr8_+_25959940 0.96 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
chr24_+_33392698 0.95 ENSDART00000122579
si:ch73-173p19.1
chr18_+_17786710 0.95 ENSDART00000190203
ENSDART00000187095
ENSDART00000083296
si:ch211-216l23.1
chr17_-_14780578 0.94 ENSDART00000154690
si:ch211-266o15.1
chr7_-_26263183 0.93 ENSDART00000079357
ENSDART00000190369
ENSDART00000193154
ENSDART00000101109
adaptor-related protein complex 1, sigma 1 subunit
chr23_-_9768700 0.92 ENSDART00000045126
laminin, alpha 5
chr21_+_43882274 0.92 ENSDART00000075672
steroid receptor RNA activator 1
chr7_-_56766100 0.90 ENSDART00000189934
casein kinase 2, alpha prime polypeptide a
chr6_+_41452979 0.90 ENSDART00000007353
WD repeat domain 82
chr10_+_20589969 0.88 ENSDART00000183042
leucine zipper-EF-hand containing transmembrane protein 2
chr9_+_34151367 0.87 ENSDART00000143991
G protein-coupled receptor 161
chr4_+_25693463 0.87 ENSDART00000132864
acyl-CoA thioesterase 18
chr12_-_17201028 0.86 ENSDART00000020541
lipase, gastric
chr13_-_42749916 0.84 ENSDART00000140019
calpain 2, (m/II) large subunit a
chr17_-_36860988 0.83 ENSDART00000154981
SUMO1/sentrin specific peptidase 6b
chr16_+_13855039 0.82 ENSDART00000113764
ENSDART00000143983
zgc:174888
chr20_+_47434709 0.81 ENSDART00000067776
RAB10, member RAS oncogene family
chr23_+_1661743 0.81 ENSDART00000044776
syntaxin binding protein 3
chr11_+_44503774 0.80 ENSDART00000169295
endoplasmic reticulum oxidoreductase beta
chr25_+_14870043 0.80 ENSDART00000035714
ENSDART00000171835
DnaJ (Hsp40) homolog, subfamily C, member 24
chr22_-_21046654 0.80 ENSDART00000064902
single stranded DNA binding protein 4
chr22_+_2417105 0.80 ENSDART00000106415
zgc:113220
chr4_-_16345227 0.79 ENSDART00000079521
keratocan
chr11_-_843811 0.78 ENSDART00000173331
ATG7 autophagy related 7 homolog (S. cerevisiae)
chr23_+_18103080 0.76 ENSDART00000010270
major facilitator superfamily domain containing 4Ab
chr20_+_21391181 0.74 ENSDART00000185158
ENSDART00000049586
ENSDART00000024922
jagged 2b
chr22_-_21046843 0.74 ENSDART00000133982
single stranded DNA binding protein 4
chr2_+_15128418 0.73 ENSDART00000141921
Rho GTPase activating protein 29b
chr5_-_69437422 0.70 ENSDART00000073676
iron-sulfur cluster assembly 1
chr23_-_24263474 0.70 ENSDART00000160312
heat shock protein family, member 7 (cardiovascular)
chr12_+_3871452 0.69 ENSDART00000066546
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr1_-_19431510 0.68 ENSDART00000089025
leucine aminopeptidase 3
chr22_-_17677947 0.67 ENSDART00000139911
tight junction protein 3
chr5_+_22307605 0.67 ENSDART00000138154
Rho GTPase activating protein 20b
chr19_+_42693855 0.67 ENSDART00000136873
cytoplasmic linker associated protein 2
chr19_-_9712530 0.67 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr14_+_29941266 0.65 ENSDART00000112757
family with sequence similarity 149 member A
chr22_+_18316144 0.65 ENSDART00000137985
GATA zinc finger domain containing 2Ab
chr13_+_33655404 0.64 ENSDART00000023379
mitochondrial genome maintenance exonuclease 1
chr8_+_21437908 0.64 ENSDART00000142758
si:dkey-163f12.10
chr7_+_20467549 0.64 ENSDART00000173724
si:dkey-33c9.8
chr8_-_32385989 0.61 ENSDART00000143716
ENSDART00000098850
lipase, endothelial
chr15_+_23528010 0.61 ENSDART00000152786
si:dkey-182i3.8
chr22_-_20720427 0.61 ENSDART00000105532
ornithine decarboxylase antizyme 1a
chr25_+_19008497 0.60 ENSDART00000104420
SAMM50 sorting and assembly machinery component
chr17_-_23673864 0.59 ENSDART00000104738
ENSDART00000128958
phosphatase and tensin homolog A
chr19_+_43905671 0.59 ENSDART00000168725
ENSDART00000133628
ankyrin repeat and IBR domain containing 1a
chr9_-_12885201 0.58 ENSDART00000124957
ankyrin repeat and zinc finger domain containing 1
chr2_+_30489846 0.58 ENSDART00000145732
membrane-associated ring finger (C3HC4) 6
chr11_-_19598809 0.57 ENSDART00000110499
ataxin 7
chr15_+_23528310 0.57 ENSDART00000152523
si:dkey-182i3.8
chr5_-_60159116 0.57 ENSDART00000147675
si:dkey-280e8.1
chr10_+_28160265 0.55 ENSDART00000022484
ring finger protein, transmembrane 1
chr3_-_20793655 0.53 ENSDART00000163473
ENSDART00000159457
speckle-type POZ protein
chr19_+_32553874 0.53 ENSDART00000078197
hes-related family bHLH transcription factor with YRPW motif-like
chr5_-_32489796 0.52 ENSDART00000168870
G protein-coupled receptor 107
chr20_-_46114467 0.50 ENSDART00000126495
trace amine associated receptor 12i
chr20_+_27712714 0.50 ENSDART00000008306
zinc finger and BTB domain containing 1
chr23_+_25893020 0.50 ENSDART00000144769
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr11_+_5880562 0.49 ENSDART00000129663
ENSDART00000130768
ENSDART00000160909
DAZ associated protein 1
chr15_-_28587147 0.48 ENSDART00000156049
slingshot protein phosphatase 2a
chr10_+_11355841 0.47 ENSDART00000193067
ENSDART00000064215
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr3_-_40836081 0.47 ENSDART00000143135
WD repeat domain, phosphoinositide interacting 2
chr7_-_19369002 0.46 ENSDART00000165680
netrin 4
chr12_+_28854963 0.46 ENSDART00000153227
nuclear factor, erythroid 2-like 1b
chr7_-_37555208 0.45 ENSDART00000148905
ENSDART00000150229
cylindromatosis (turban tumor syndrome), a
chr9_+_27876146 0.45 ENSDART00000133997
armadillo repeat containing 8
chr7_+_52761841 0.45 ENSDART00000111444
diphosphoinositol pentakisphosphate kinase 1a
chr9_-_33328948 0.44 ENSDART00000006948
ribosomal protein L8
chr20_+_329032 0.44 ENSDART00000036635
FYN proto-oncogene, Src family tyrosine kinase b
chr9_-_48281941 0.44 ENSDART00000099787
kelch-like family member 41a
chr10_+_36695597 0.42 ENSDART00000169015
ENSDART00000171392
RAB6A, member RAS oncogene family
chr9_-_24970018 0.42 ENSDART00000026924
dynein, axonemal, heavy chain 7
chr13_-_7233811 0.42 ENSDART00000162026
ninein-like
chr3_-_36260102 0.41 ENSDART00000126588
Rac family small GTPase 3a
chr19_-_81477 0.40 ENSDART00000159815
heterogeneous nuclear ribonucleoprotein R
chr5_-_41124241 0.39 ENSDART00000083561
myotubularin related protein 12
chr17_-_51679222 0.39 ENSDART00000155062
ATPase H+ transporting V1 subunit C2
chr2_-_55861351 0.38 ENSDART00000059003
retinal homeobox gene 2
chr21_+_38312549 0.35 ENSDART00000065159
zgc:158291
chr13_+_35765317 0.35 ENSDART00000100156
ENSDART00000167650
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr24_+_10413484 0.34 ENSDART00000111014
MYC proto-oncogene, bHLH transcription factor a
chr23_+_3734491 0.34 ENSDART00000185982
small integral membrane protein 29
chr9_-_30274412 0.33 ENSDART00000089526
ornithine carbamoyltransferase
chr17_-_43666166 0.33 ENSDART00000077990
early growth response 2a
chr7_+_30725473 0.31 ENSDART00000085716
myotubularin related protein 10
chr8_+_45294767 0.30 ENSDART00000191527
ubiquitin associated protein 2b
chr1_-_19402802 0.30 ENSDART00000135552
RNA binding motif protein 47
chr7_-_56766973 0.30 ENSDART00000020967
casein kinase 2, alpha prime polypeptide a
chr22_-_22231720 0.30 ENSDART00000160165
adaptor-related protein complex 3, delta 1 subunit
chr18_+_29402623 0.30 ENSDART00000014703
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
chr5_+_72145468 0.29 ENSDART00000148626
c-abl oncogene 1, non-receptor tyrosine kinase
chr9_+_33267211 0.29 ENSDART00000025635
ubiquitin specific peptidase 9
chr11_+_28218141 0.28 ENSDART00000043756
eph receptor B2b
chr24_-_21511737 0.28 ENSDART00000109587
ring finger protein (C3H2C3 type) 6
chr5_+_57743815 0.27 ENSDART00000005090
ALG9, alpha-1,2-mannosyltransferase
chr4_+_16787488 0.27 ENSDART00000143006
golgi transport 1Ba
chr21_-_588858 0.26 ENSDART00000168983
transmembrane protein 38B
chr6_+_53288018 0.25 ENSDART00000170319
cysteinyl leukotriene receptor 3
chr1_+_57145072 0.19 ENSDART00000152776
si:ch73-94k4.4
chr20_-_7547080 0.18 ENSDART00000146135
ubiquitin specific peptidase 24
chr3_-_23596532 0.18 ENSDART00000124921
ubiquitin-conjugating enzyme E2Z
chr23_+_24705424 0.14 ENSDART00000104029
C1q and TNF related 12
chr13_+_28417297 0.14 ENSDART00000043658
solute carrier family 2 (facilitated glucose transporter), member 15a
chr3_-_25646149 0.14 ENSDART00000122735
ubiquitin specific peptidase 43b
chr6_-_23931442 0.13 ENSDART00000160547
SEC16 homolog B, endoplasmic reticulum export factor
chr3_-_15889508 0.07 ENSDART00000148363
cramped chromatin regulator homolog 1
chr8_+_24745041 0.06 ENSDART00000148872
solute carrier family 16, member 4
chr12_-_44307963 0.06 ENSDART00000161009
si:ch73-329n5.1
chr10_+_37500234 0.06 ENSDART00000132096
ENSDART00000099473
musashi RNA-binding protein 2a
chr25_-_8138122 0.05 ENSDART00000104659
secretion regulating guanine nucleotide exchange factor
chr12_-_36740781 0.05 ENSDART00000105484
si:ch211-216b21.2
chr3_-_16055432 0.05 ENSDART00000123621
ENSDART00000023859
ATPase H+ transporting V0 subunit ca
chr16_-_563732 0.05 ENSDART00000183394
iroquois homeobox 2a
chr25_+_3549584 0.04 ENSDART00000165913
coiled-coil domain containing 77
chr8_+_25616946 0.02 ENSDART00000133983
solute carrier family 38, member 5a
chr20_+_26690036 0.02 ENSDART00000103232
forkhead box F2b
chr14_+_30340251 0.01 ENSDART00000148448
microtubule associated tumor suppressor 1a
chr12_-_36740306 0.00 ENSDART00000153259
si:ch211-216b21.2

Network of associatons between targets according to the STRING database.

First level regulatory network of pknox2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0060467 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
0.5 1.6 GO:0098924 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.3 1.4 GO:0045428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.3 1.6 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.3 0.9 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.3 1.3 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.3 2.8 GO:0042664 negative regulation of endodermal cell fate specification(GO:0042664)
0.2 1.2 GO:0051591 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 1.0 GO:0034969 histone arginine methylation(GO:0034969)
0.2 1.1 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.2 0.6 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.2 0.8 GO:0090234 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.2 0.6 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.2 1.1 GO:1902914 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.2 1.8 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.2 1.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 1.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 2.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 2.5 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 1.1 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.1 0.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.6 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.1 0.8 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.6 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.1 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.7 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 1.9 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 1.1 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 0.4 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 3.3 GO:0048794 swim bladder development(GO:0048794)
0.1 0.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.8 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.7 GO:0030104 water homeostasis(GO:0030104)
0.1 1.3 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 1.0 GO:0032418 lysosome localization(GO:0032418)
0.1 1.4 GO:0006298 mismatch repair(GO:0006298)
0.1 1.2 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 1.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.6 GO:0021684 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.3 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.9 GO:0035141 medial fin morphogenesis(GO:0035141)
0.0 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 2.2 GO:0071166 ribonucleoprotein complex localization(GO:0071166)
0.0 0.7 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.6 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.5 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 1.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:0046324 regulation of glucose import(GO:0046324)
0.0 1.2 GO:0048278 vesicle docking(GO:0048278)
0.0 0.7 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0070863 regulation of protein exit from endoplasmic reticulum(GO:0070861) positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 1.1 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 2.1 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.2 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.2 GO:0033334 fin morphogenesis(GO:0033334)
0.0 0.4 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 1.2 GO:0006400 tRNA modification(GO:0006400)
0.0 1.2 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.6 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.3 1.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 2.8 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 1.6 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.2 1.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.6 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 1.4 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.5 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 2.1 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 5.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.7 GO:0045180 basal cortex(GO:0045180)
0.0 2.5 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.0 1.6 GO:0042383 sarcolemma(GO:0042383)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.4 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.0 1.2 GO:0031201 SNARE complex(GO:0031201)
0.0 0.8 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 1.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 1.0 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.2 1.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.2 0.8 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.2 0.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 1.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.6 GO:0051800 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.4 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.3 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.8 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.5 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.6 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.1 1.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.5 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.3 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 1.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.5 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.8 GO:0016864 protein disulfide isomerase activity(GO:0003756) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.8 GO:0015149 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 0.8 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 2.0 GO:0043022 ribosome binding(GO:0043022)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0030145 manganese ion binding(GO:0030145)
0.0 2.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.1 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 3.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.3 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.2 2.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 2.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.7 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 2.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.8 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor