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PRJEB1986: zebrafish developmental stages transcriptome

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Results for pitx1+pitx3

Z-value: 0.68

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Transcription factors associated with pitx1+pitx3

Gene Symbol Gene ID Gene Info
pitx3
ENSDARG00000070069 paired-like homeodomain 3
pitx1
ENSDARG00000116608 paired-like homeodomain 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx3dr11_v1_chr13_-_7573670_7573670-0.831.2e-05Click!
pitx1dr11_v1_chr21_+_45819662_45819729-0.464.7e-02Click!

Activity profile of pitx1+pitx3 motif

Sorted Z-values of pitx1+pitx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_15296824 2.16 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr15_+_45640906 2.14 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr7_-_29534001 1.57 ENSDART00000124028
anxa2b
annexin A2b
chr21_+_1143141 1.45 ENSDART00000178294
CABZ01086139.1

chr2_-_24505185 1.28 ENSDART00000052065
si:rp71-39b20.4
si:rp71-39b20.4
chr2_-_32505091 1.12 ENSDART00000141884
ENSDART00000056639
faim2a
Fas apoptotic inhibitory molecule 2a
chr7_-_29021757 1.11 ENSDART00000086905
nrn1lb
neuritin 1-like b
chr23_-_28141419 1.10 ENSDART00000133039
tac3a
tachykinin 3a
chr19_+_823945 1.08 ENSDART00000142287
ppp1r18
protein phosphatase 1, regulatory subunit 18
chr20_+_29587995 1.07 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr17_+_25289431 1.04 ENSDART00000161002
kbtbd11
kelch repeat and BTB (POZ) domain containing 11
chr13_-_29505604 0.96 ENSDART00000110005
cdhr1a
cadherin-related family member 1a
chr20_+_38525567 0.83 ENSDART00000147787
znf512
zinc finger protein 512
chr4_-_77432218 0.83 ENSDART00000158683
slco1d1
solute carrier organic anion transporter family, member 1D1
chr23_+_43849190 0.83 ENSDART00000017375
cnga1
cyclic nucleotide gated channel alpha 1
chr16_-_51299061 0.79 ENSDART00000148677
serpinb1l4
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr8_+_4337312 0.78 ENSDART00000182228
myl2b
myosin, light chain 2b, regulatory, cardiac, slow
chr8_+_16990120 0.72 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr2_-_48171112 0.71 ENSDART00000156258
pfkpb
phosphofructokinase, platelet b
chr20_-_1141722 0.67 ENSDART00000152675
gabrr1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr24_-_20321012 0.66 ENSDART00000163683
map3k20
mitogen-activated protein kinase kinase kinase 20
chr25_-_8030113 0.65 ENSDART00000104674
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr8_+_694218 0.64 ENSDART00000147753
rnf165b
ring finger protein 165b
chr4_+_10365857 0.61 ENSDART00000138890
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr25_-_8030425 0.60 ENSDART00000014964
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr24_-_38079261 0.60 ENSDART00000105662
crp1
C-reactive protein 1
chr25_+_21832938 0.59 ENSDART00000148299
ckmt1
creatine kinase, mitochondrial 1
chr7_-_66864756 0.58 ENSDART00000184462
ENSDART00000189424
ampd3a
adenosine monophosphate deaminase 3a
chr9_-_40935934 0.57 ENSDART00000155604
C2orf88
Small membrane A-kinase anchor protein
chr21_+_33172526 0.54 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr24_-_20320480 0.53 ENSDART00000137366
map3k20
mitogen-activated protein kinase kinase kinase 20
chr6_+_8079974 0.53 ENSDART00000152071
si:ch211-207j7.2
si:ch211-207j7.2
chr3_-_33574576 0.52 ENSDART00000184881
CR847537.1

chr25_+_18564266 0.52 ENSDART00000172338
cav1
caveolin 1
chr2_-_48171441 0.48 ENSDART00000123040
pfkpb
phosphofructokinase, platelet b
chr2_-_31767827 0.48 ENSDART00000114928
and2
actinodin2
chr16_+_29586468 0.47 ENSDART00000148926
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr15_-_8856785 0.46 ENSDART00000192816
rab4b
RAB4B, member RAS oncogene family
chr19_-_28283844 0.44 ENSDART00000151756
ENSDART00000079104
ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr5_-_16983336 0.42 ENSDART00000038740
galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chr2_-_32738535 0.40 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr13_+_15838151 0.39 ENSDART00000008987
klc1a
kinesin light chain 1a
chr21_+_27382893 0.38 ENSDART00000005682
actn3a
actinin alpha 3a
chr5_+_22970617 0.37 ENSDART00000192859
hmgn7
high mobility group nucleosomal binding domain 7
chr10_+_6013076 0.34 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr17_-_31308658 0.27 ENSDART00000124505
bahd1
bromo adjacent homology domain containing 1
chr6_-_54126463 0.26 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr20_+_38524827 0.25 ENSDART00000153021
znf512
zinc finger protein 512
chr11_+_25504215 0.24 ENSDART00000154213
tfe3b
transcription factor binding to IGHM enhancer 3b
chr15_-_45510977 0.20 ENSDART00000090596
fgf12b
fibroblast growth factor 12b
chr16_+_33902006 0.18 ENSDART00000161807
ENSDART00000159474
gnl2
guanine nucleotide binding protein-like 2 (nucleolar)
chr17_+_23729717 0.15 ENSDART00000179026
zgc:91976
zgc:91976
chr15_-_14467394 0.14 ENSDART00000191944
numbl
numb homolog (Drosophila)-like
chr7_+_38962459 0.12 ENSDART00000173851
dgkza
diacylglycerol kinase, zeta a
chr3_+_26144765 0.11 ENSDART00000146267
ENSDART00000043932
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr6_+_41554794 0.08 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr16_-_25663846 0.07 ENSDART00000031304
derl1
derlin 1
chr20_-_1847433 0.06 ENSDART00000164211
CABZ01065425.1

chr7_-_17780048 0.06 ENSDART00000183336
si:dkey-106g10.7
si:dkey-106g10.7
chr7_+_53413445 0.06 ENSDART00000190480
znf609b
zinc finger protein 609b
chr21_-_11632403 0.04 ENSDART00000171708
ENSDART00000138619
ENSDART00000136308
ENSDART00000144770
cast
calpastatin
chr5_+_60919378 0.04 ENSDART00000184915
doc2b
double C2-like domains, beta
chr15_-_8309207 0.03 ENSDART00000143880
ENSDART00000061351
tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr4_-_20483954 0.03 ENSDART00000187240
napepld
N-acyl phosphatidylethanolamine phospholipase D
chr23_+_22335407 0.02 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr8_+_21010850 0.01 ENSDART00000100295
si:dkeyp-82a1.4
si:dkeyp-82a1.4
chr21_-_14310159 0.01 ENSDART00000155097
si:ch211-196i2.1
si:ch211-196i2.1
chr12_+_27213733 0.01 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr18_-_31916845 0.00 ENSDART00000165908
olfcs2
olfactory receptor C family, s2

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx1+pitx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.3 1.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 2.1 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.2 0.7 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.3 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 1.2 GO:0006735 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.3 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 0.2 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.0 0.6 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.6 GO:0032264 IMP salvage(GO:0032264)
0.0 1.1 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0031448 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 1.9 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 2.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.7 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.4 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.4 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.6 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.1 0.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 1.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.6 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.0 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.5 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins