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PRJEB1986: zebrafish developmental stages transcriptome

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Results for phox2a

Z-value: 0.63

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Transcription factors associated with phox2a

Gene Symbol Gene ID Gene Info
phox2a
ENSDARG00000007406 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phox2adr11_v1_chr15_+_47440477_47440477-0.135.9e-01Click!

Activity profile of phox2a motif

Sorted Z-values of phox2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_30620625 3.65 ENSDART00000098273
tcnl
transcobalamin like
chr16_-_11798994 2.37 ENSDART00000135408
cnfn
cornifelin
chr22_+_7738966 2.08 ENSDART00000147073
si:ch73-44m9.5
si:ch73-44m9.5
chr14_+_17376940 1.70 ENSDART00000054590
ENSDART00000010148
spon2b
spondin 2b, extracellular matrix protein
chr8_+_16025554 1.68 ENSDART00000110171
elavl4
ELAV like neuron-specific RNA binding protein 4
chr21_-_42100471 1.63 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_+_50608099 1.52 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr2_+_2223837 1.44 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr4_+_21129752 1.39 ENSDART00000169764
syt1a
synaptotagmin Ia
chr17_+_15433518 1.33 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 1.18 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr9_-_43538328 0.86 ENSDART00000140526
znf385b
zinc finger protein 385B
chr11_-_2838699 0.86 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr17_-_200316 0.83 ENSDART00000190561
CABZ01083778.1

chr14_+_40874608 0.77 ENSDART00000168448
si:ch211-106m9.1
si:ch211-106m9.1
chr1_-_15797663 0.59 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr14_-_7207961 0.55 ENSDART00000167994
ENSDART00000166532
stox2b
storkhead box 2b
chr12_-_33357655 0.55 ENSDART00000066233
ENSDART00000148165
slc16a3
solute carrier family 16 (monocarboxylate transporter), member 3
chr5_+_37903790 0.54 ENSDART00000162470
tmprss4b
transmembrane protease, serine 4b
chr11_-_42554290 0.54 ENSDART00000130573
atp6ap1la
ATPase H+ transporting accessory protein 1 like a
chr9_-_9415000 0.53 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr6_-_35779348 0.52 ENSDART00000191159
brinp3a.1
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1
chr1_+_23161369 0.48 ENSDART00000162827
si:dkey-92j12.5
si:dkey-92j12.5
chr3_-_56541723 0.48 ENSDART00000156398
ENSDART00000050576
ENSDART00000184874
si:ch211-189a21.1
cyth1a
si:ch211-189a21.1
cytohesin 1a
chr10_-_22918214 0.46 ENSDART00000163908
rnasekb
ribonuclease, RNase K b
chr3_-_20040636 0.45 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr19_+_5480327 0.44 ENSDART00000148794
jupb
junction plakoglobin b
chr18_+_28106139 0.41 ENSDART00000089615
kiaa1549lb
KIAA1549-like b
chr16_-_25568512 0.41 ENSDART00000149411
atxn1b
ataxin 1b
chr6_+_24420523 0.40 ENSDART00000185461
tgfbr3
transforming growth factor, beta receptor III
chr12_-_6880694 0.38 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr22_-_10121880 0.38 ENSDART00000002348
rdh5
retinol dehydrogenase 5 (11-cis/9-cis)
chr20_-_43663494 0.38 ENSDART00000144564
BX470188.1

chr21_-_13123176 0.37 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr5_+_4054704 0.33 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr20_+_41756996 0.32 ENSDART00000186393
fam184a
family with sequence similarity 184, member A
chr6_+_13117598 0.30 ENSDART00000104744
casp8l1
caspase 8, apoptosis-related cysteine peptidase, like 1
chr21_+_32820175 0.29 ENSDART00000076903
adra2db
adrenergic, alpha-2D-, receptor b
chr2_-_9818640 0.26 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr21_-_32060993 0.26 ENSDART00000131651
si:ch211-160j14.2
si:ch211-160j14.2
chr1_-_44704261 0.25 ENSDART00000133210
si:dkey-28b4.8
si:dkey-28b4.8
chr10_+_42423318 0.24 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr10_-_11261565 0.23 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr15_-_14552101 0.22 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr15_-_22074315 0.20 ENSDART00000149830
drd2a
dopamine receptor D2a
chr21_-_43616586 0.16 ENSDART00000036537
htr2cl2
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2
chr2_-_7845110 0.13 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr10_+_11261576 0.13 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr17_+_49281597 0.09 ENSDART00000155599
zgc:113176
zgc:113176
chr20_-_29864390 0.07 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr4_-_1801519 0.03 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr2_+_29842878 0.02 ENSDART00000131376
si:ch211-207d6.2
si:ch211-207d6.2
chr13_+_255067 0.01 ENSDART00000102505
foxg1d
forkhead box G1d

Network of associatons between targets according to the STRING database.

First level regulatory network of phox2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.4 GO:0002159 desmosome assembly(GO:0002159)
0.1 1.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.4 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.1 1.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.3 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.1 0.9 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.1 0.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.9 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.5 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.5 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.5 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 1.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.7 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.6 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.3 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 2.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters