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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nr2f6a+nr2f6b

Z-value: 0.60

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Transcription factors associated with nr2f6a+nr2f6b

Gene Symbol Gene ID Gene Info
nr2f6b
ENSDARG00000003165 nuclear receptor subfamily 2, group F, member 6b
nr2f6a
ENSDARG00000003607 nuclear receptor subfamily 2, group F, member 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f6adr11_v1_chr2_+_24374305_243743050.952.2e-10Click!
nr2f6bdr11_v1_chr11_+_6116503_61165030.941.7e-09Click!

Activity profile of nr2f6a+nr2f6b motif

Sorted Z-values of nr2f6a+nr2f6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_16451375 4.13 ENSDART00000192700
ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr5_+_43870389 2.00 ENSDART00000141002
zgc:112966
zgc:112966
chr4_+_12031958 1.95 ENSDART00000044154
tnnt2c
troponin T2c, cardiac
chr21_-_44512893 1.89 ENSDART00000166853
zgc:136410
zgc:136410
chr23_+_2914577 1.85 ENSDART00000184897
DHX35
zgc:158828
chr5_+_22067570 1.58 ENSDART00000045574
shisa2a
shisa family member 2a
chr13_-_37127970 1.37 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr22_-_7050 1.27 ENSDART00000127829
atad3
ATPase family, AAA domain containing 3
chr23_+_30730121 1.25 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr23_+_44634187 1.23 ENSDART00000143688
si:ch73-265d7.2
si:ch73-265d7.2
chr7_+_25000060 1.19 ENSDART00000039265
ENSDART00000141814
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr25_+_418932 1.17 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr13_-_39160018 1.14 ENSDART00000168795
col9a1b
collagen, type IX, alpha 1b
chr12_+_49125510 1.12 ENSDART00000185804
FO704607.1

chr13_-_39159810 1.12 ENSDART00000131508
col9a1b
collagen, type IX, alpha 1b
chr19_-_3056235 1.12 ENSDART00000137020
bop1
block of proliferation 1
chr2_+_6067371 1.11 ENSDART00000053868
ENSDART00000145244
aldh9a1b
aldehyde dehydrogenase 9 family, member A1b
chr9_-_25255490 1.08 ENSDART00000141502
htr2aa
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
chr12_+_26670778 1.07 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr9_+_32859967 1.06 ENSDART00000168992
si:dkey-145p14.5
si:dkey-145p14.5
chr25_+_18587338 1.03 ENSDART00000180287
met
MET proto-oncogene, receptor tyrosine kinase
chr7_+_38267136 1.00 ENSDART00000173613
gpatch1
G patch domain containing 1
chr6_+_40775800 0.95 ENSDART00000085090
si:ch211-157b11.8
si:ch211-157b11.8
chr6_+_1787160 0.94 ENSDART00000113505
myl9b
myosin, light chain 9b, regulatory
chr3_-_34561624 0.88 ENSDART00000129313
sept9a
septin 9a
chr16_+_54875530 0.88 ENSDART00000149795
nr0b2a
nuclear receptor subfamily 0, group B, member 2a
chr9_+_32860345 0.85 ENSDART00000121751
si:dkey-145p14.5
si:dkey-145p14.5
chr24_-_1021318 0.83 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr1_-_58868306 0.83 ENSDART00000166615
dnm2b
dynamin 2b
chr24_+_81527 0.75 ENSDART00000192139
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr3_+_25999477 0.72 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr5_+_49744713 0.71 ENSDART00000133384
nr2f1a
nuclear receptor subfamily 2, group F, member 1a
chr12_+_48681601 0.69 ENSDART00000187831
uros
uroporphyrinogen III synthase
chr8_+_39802506 0.68 ENSDART00000018862
hnf1a
HNF1 homeobox a
chr5_-_26330313 0.67 ENSDART00000148656
arvcfb
ARVCF, delta catenin family member b
chr22_-_3595439 0.67 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr1_-_51720633 0.65 ENSDART00000045894
rnaseh2a
ribonuclease H2, subunit A
chr11_-_6974022 0.65 ENSDART00000172851
COMP
si:ch211-43f4.1
chr5_-_3839285 0.64 ENSDART00000122292
mlxipl
MLX interacting protein like
chr22_-_15587360 0.64 ENSDART00000142717
ENSDART00000138978
tpm4a
tropomyosin 4a
chr9_-_28990649 0.62 ENSDART00000078823
ptpn4a
protein tyrosine phosphatase, non-receptor type 4a
chr1_+_12195700 0.57 ENSDART00000040307
tdrd7a
tudor domain containing 7 a
chr24_-_21172122 0.53 ENSDART00000154259
atp6v1ab
ATPase H+ transporting V1 subunit Ab
chr19_+_2631565 0.50 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr4_-_75172216 0.49 ENSDART00000127522
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr10_+_20128267 0.46 ENSDART00000064615
dmtn
dematin actin binding protein
chr14_+_30413758 0.46 ENSDART00000092953
cnot7
CCR4-NOT transcription complex, subunit 7
chr9_+_54644626 0.45 ENSDART00000190609
egfl6
EGF-like-domain, multiple 6
chr1_+_23783349 0.43 ENSDART00000007531
slit2
slit homolog 2 (Drosophila)
chr18_-_18850302 0.41 ENSDART00000131965
ENSDART00000167624
tgm2l
transglutaminase 2, like
chr19_+_2877079 0.41 ENSDART00000160847
hgh1
HGH1 homolog (S. cerevisiae)
chr20_+_46286082 0.41 ENSDART00000073519
taar14f
trace amine associated receptor 14f
chr8_+_16676894 0.41 ENSDART00000076586
si:ch211-198n5.11
si:ch211-198n5.11
chr2_-_56649883 0.38 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr18_-_43866526 0.38 ENSDART00000111309
treh
trehalase (brush-border membrane glycoprotein)
chr24_+_39034090 0.36 ENSDART00000185763
capn15
calpain 15
chr25_+_15647993 0.36 ENSDART00000186578
ENSDART00000031828
spon1b
spondin 1b
chr13_+_45980163 0.35 ENSDART00000074547
ENSDART00000005195
bsdc1
BSD domain containing 1
chr16_-_24605969 0.35 ENSDART00000163305
ENSDART00000167121
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr17_-_25303486 0.35 ENSDART00000162235
ppie
peptidylprolyl isomerase E (cyclophilin E)
chr10_+_29852677 0.33 ENSDART00000141549
hspa8
heat shock protein 8
chr14_+_30413312 0.31 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr17_+_23926796 0.27 ENSDART00000021177
pex13
peroxisomal biogenesis factor 13
chr21_-_1640547 0.25 ENSDART00000151041
zgc:152948
zgc:152948
chr16_-_50229193 0.23 ENSDART00000161782
ENSDART00000010081
etfb
electron-transfer-flavoprotein, beta polypeptide
chr3_+_39566999 0.23 ENSDART00000146867
aldoaa
aldolase a, fructose-bisphosphate, a
chr25_+_22017182 0.22 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr21_+_1119046 0.22 ENSDART00000184678
CABZ01088049.1

chr11_-_44999858 0.20 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr3_+_1179601 0.19 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr25_+_20119466 0.19 ENSDART00000104304
bpgm
2,3-bisphosphoglycerate mutase
chr17_+_33418475 0.17 ENSDART00000169145
snap23.1
synaptosomal-associated protein 23.1
chr23_-_45319592 0.17 ENSDART00000189861
ccdc171
coiled-coil domain containing 171
chr7_+_48297842 0.17 ENSDART00000052123
slc25a44b
solute carrier family 25, member 44 b
chr2_-_22659450 0.17 ENSDART00000115025
thap4
THAP domain containing 4
chr19_+_2275019 0.15 ENSDART00000136138
itgb8
integrin, beta 8
chr20_+_2281933 0.14 ENSDART00000137579
si:ch73-18b11.2
si:ch73-18b11.2
chr12_-_34580988 0.14 ENSDART00000152926
bahcc1b
BAH domain and coiled-coil containing 1b
chr10_+_11265387 0.13 ENSDART00000038888
hsdl2
hydroxysteroid dehydrogenase like 2
chr8_+_999421 0.11 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr9_-_37613792 0.09 ENSDART00000138345
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr24_-_7587401 0.09 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr2_-_41571454 0.09 ENSDART00000022643
znf622
zinc finger protein 622
chr23_+_44633858 0.07 ENSDART00000180728
si:ch73-265d7.2
si:ch73-265d7.2
chr22_-_11833317 0.07 ENSDART00000125423
ENSDART00000000192
ptpn4b
protein tyrosine phosphatase, non-receptor type 4b
chr8_-_8698607 0.05 ENSDART00000046712
zgc:86609
zgc:86609
chr3_-_41292275 0.04 ENSDART00000144088
sdk1a
sidekick cell adhesion molecule 1a
chr1_+_58353661 0.02 ENSDART00000140074
si:dkey-222h21.2
si:dkey-222h21.2
chr1_+_58119117 0.01 ENSDART00000146788
si:ch211-15j1.5
si:ch211-15j1.5
chr8_+_8699085 0.01 ENSDART00000021209
uxt
ubiquitously-expressed, prefoldin-like chaperone

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f6a+nr2f6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.1 0.4 GO:0007414 axonal defasciculation(GO:0007414)
0.1 0.4 GO:0005991 trehalose metabolic process(GO:0005991)
0.1 1.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 1.0 GO:0021707 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.7 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.1 0.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.8 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.7 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 1.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.4 GO:0006552 leucine catabolic process(GO:0006552)
0.1 0.3 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.1 1.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.6 GO:0030719 P granule organization(GO:0030719)
0.0 0.7 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.8 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.9 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 2.6 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 1.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.7 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0001966 thigmotaxis(GO:0001966)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.8 GO:1990909 Wnt signalosome(GO:1990909)
0.2 1.2 GO:0035517 PR-DUB complex(GO:0035517)
0.2 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.3 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.0 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.9 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.6 GO:0043186 P granule(GO:0043186)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.4 1.1 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.2 1.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 2.0 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.4 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 0.4 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.7 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 1.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 1.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.0 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism