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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx6.3

Z-value: 0.27

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Transcription factors associated with nkx6.3

Gene Symbol Gene ID Gene Info
nkx6.3
ENSDARG00000060529 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx6.3dr11_v1_chr8_+_38415374_384153740.483.8e-02Click!

Activity profile of nkx6.3 motif

Sorted Z-values of nkx6.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_12173554 0.53 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr16_+_46111849 0.53 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr17_+_15433671 0.45 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433518 0.45 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr2_+_2223837 0.41 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr18_-_17485419 0.34 ENSDART00000018764
foxl1
forkhead box L1
chr5_-_30620625 0.33 ENSDART00000098273
tcnl
transcobalamin like
chr20_+_40457599 0.26 ENSDART00000017553
serinc1
serine incorporator 1
chr6_-_37469775 0.25 ENSDART00000156546
plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr20_-_48485354 0.22 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr13_+_31286076 0.22 ENSDART00000142725
gdf10a
growth differentiation factor 10a
chr9_-_43538328 0.21 ENSDART00000140526
znf385b
zinc finger protein 385B
chr11_-_2838699 0.20 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr8_+_8927870 0.20 ENSDART00000081985
pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr2_-_7845110 0.18 ENSDART00000091987
si:ch211-38m6.7
si:ch211-38m6.7
chr14_+_14662116 0.17 ENSDART00000161693
cetn2
centrin, EF-hand protein, 2
chr21_+_34088377 0.17 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr15_+_31344472 0.16 ENSDART00000146695
ENSDART00000159182
ENSDART00000060125
or107-1
odorant receptor, family D, subfamily 107, member 1
chr25_-_3058687 0.15 ENSDART00000149117
ENSDART00000137950
si:ch1073-296i8.2
si:ch1073-296i8.2
chr20_-_40755614 0.15 ENSDART00000061247
cx32.3
connexin 32.3
chr2_+_6243144 0.14 ENSDART00000058258
gng5
guanine nucleotide binding protein (G protein), gamma 5
chr11_-_44801968 0.13 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr4_-_2637689 0.12 ENSDART00000192550
ENSDART00000021953
ENSDART00000150344
cog5
component of oligomeric golgi complex 5
chr20_-_43750771 0.12 ENSDART00000100605
ttc32
tetratricopeptide repeat domain 32
chr12_-_10409961 0.11 ENSDART00000149521
ENSDART00000052001
eef2k
eukaryotic elongation factor 2 kinase
chr11_-_2478374 0.11 ENSDART00000173205
si:ch73-267c23.10
si:ch73-267c23.10
chr10_+_2582254 0.10 ENSDART00000016103
nxnl2
nucleoredoxin like 2
chr25_-_8660726 0.10 ENSDART00000168010
ENSDART00000171709
ENSDART00000163426
unc45a
unc-45 myosin chaperone A
chr20_-_45060241 0.10 ENSDART00000185227
klhl29
kelch-like family member 29
chr4_+_2637947 0.08 ENSDART00000130623
dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr3_+_18795570 0.08 ENSDART00000042368
fahd1
fumarylacetoacetate hydrolase domain containing 1
chr2_-_9818640 0.07 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr11_-_34219211 0.06 ENSDART00000098472
tmem44
transmembrane protein 44
chr15_-_43284021 0.06 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr16_-_12173399 0.06 ENSDART00000142574
clstn3
calsyntenin 3
chr9_-_9415000 0.06 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr21_-_26918901 0.05 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr8_+_50953776 0.05 ENSDART00000013870
zgc:56596
zgc:56596
chr3_+_45687266 0.05 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr4_+_4509996 0.05 ENSDART00000028694
gnsa
glucosamine (N-acetyl)-6-sulfatase a
chr21_+_28445052 0.04 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr24_+_16985181 0.03 ENSDART00000135580
eif2s3
eukaryotic translation initiation factor 2, subunit 3 gamma
chr3_-_26787430 0.02 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr23_-_35790235 0.01 ENSDART00000142369
ENSDART00000141141
ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr6_+_54187643 0.01 ENSDART00000056830
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr3_-_21010979 0.01 ENSDART00000109578
fam117aa
family with sequence similarity 117, member Aa
chr21_+_43328685 0.01 ENSDART00000109620
ENSDART00000139668
sept8a
septin 8a
chr23_-_16485190 0.00 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx6.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.2 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.4 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.2 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.0 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling