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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx6.1

Z-value: 1.32

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Transcription factors associated with nkx6.1

Gene Symbol Gene ID Gene Info
ENSDARG00000022569 NK6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx6.1dr11_v1_chr21_+_19070921_19070921-0.742.9e-04Click!

Activity profile of nkx6.1 motif

Sorted Z-values of nkx6.1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_30244356 10.81 ENSDART00000036050
ENSDART00000150080
retinoschisin 1a
chr1_-_43905252 8.39 ENSDART00000135477
ENSDART00000132089
si:dkey-22i16.3
chr20_-_40755614 6.06 ENSDART00000061247
connexin 32.3
chr3_-_50443607 5.59 ENSDART00000074036
recoverin a
chr25_+_29160102 5.56 ENSDART00000162854
pyruvate kinase M1/2b
chr5_-_30620625 5.55 ENSDART00000098273
transcobalamin like
chr5_-_23362602 5.50 ENSDART00000137120
glutamate receptor, ionotropic, AMPA 3a
chr7_+_14291323 4.97 ENSDART00000053521
Rh family, C glycoprotein a
chr23_+_40460333 4.71 ENSDART00000184658
SOGA family member 3b
chr16_+_46111849 4.52 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr18_+_46773198 4.24 ENSDART00000174647

chr15_+_6109861 4.20 ENSDART00000185154
Purkinje cell protein 4
chr13_+_29462249 3.77 ENSDART00000147903
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1a
chr17_-_37395460 3.76 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr19_+_10339538 3.44 ENSDART00000151808
ENSDART00000151235
recoverin 3
chr5_-_44829719 3.44 ENSDART00000019104
fructose-1,6-bisphosphatase 2
chr1_-_43915423 3.30 ENSDART00000181915
ENSDART00000113673
secretory calcium-binding phosphoprotein 5
chr14_+_49135264 3.15 ENSDART00000084119
si:ch1073-44g3.1
chr17_-_16965809 3.14 ENSDART00000153697
neurexin 3a
chr9_+_34641237 3.08 ENSDART00000133996
short stature homeobox
chr10_-_17159761 3.00 ENSDART00000080449
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr5_-_38155005 2.98 ENSDART00000097770
guanylate cyclase 2D, retinal
chr17_-_12389259 2.97 ENSDART00000185724
synaptosomal-associated protein, 25b
chr8_-_25329967 2.95 ENSDART00000139682
EPS8-like 3b
chr9_+_33357011 2.93 ENSDART00000088569
nyctalopin
chr1_-_22512063 2.91 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr16_-_28658341 2.88 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr1_-_23308225 2.85 ENSDART00000137567
ENSDART00000008201
small integral membrane protein 14
chr12_+_24342303 2.76 ENSDART00000111239
neurexin 1a
chr22_+_28320792 2.75 ENSDART00000160562
ENSDART00000164138
interphotoreceptor matrix proteoglycan 2b
interphotoreceptor matrix proteoglycan 2b
chr20_+_18551657 2.74 ENSDART00000147001
si:dkeyp-72h1.1
chr3_+_1015867 2.69 ENSDART00000109912
si:ch1073-464p5.5
chr10_+_25726694 2.68 ENSDART00000140308
UDP glucuronosyltransferase 5 family, polypeptide D1
chr19_-_6988837 2.61 ENSDART00000145741
ENSDART00000167640
zinc finger protein 384 like
chr16_+_5774977 2.61 ENSDART00000134202
cholecystokinin a
chr20_+_4060839 2.61 ENSDART00000178565
tripartite motif containing 67
chr21_-_42100471 2.60 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_-_27329214 2.54 ENSDART00000145835
thioredoxin related transmembrane protein 3a
chr13_+_23988442 2.52 ENSDART00000010918
angiotensinogen
chr11_+_13223625 2.50 ENSDART00000161275
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr14_-_2933185 2.49 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr10_+_29698467 2.49 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr16_-_45178430 2.38 ENSDART00000165186
si:dkey-33i11.9
chr6_-_12588044 2.38 ENSDART00000047896
solute carrier family 15 (oligopeptide transporter), member 1b
chr5_-_50992690 2.35 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
3-hydroxy-3-methylglutaryl-CoA reductase a
chr10_+_22381802 2.35 ENSDART00000112484
neuroligin 2b
chr23_+_20563779 2.31 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr14_+_50770537 2.30 ENSDART00000158723
synuclein, beta
chr5_+_63668735 2.28 ENSDART00000134261
ENSDART00000097330
dynamin 1b
chr1_-_50859053 2.28 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr18_+_9637744 2.26 ENSDART00000190171
piccolo presynaptic cytomatrix protein b
chr15_+_36457888 2.26 ENSDART00000155100
si:dkey-262k9.2
chr21_+_13366353 2.26 ENSDART00000151630
si:ch73-62l21.1
chr22_+_35068046 2.25 ENSDART00000161660
ENSDART00000169573
si:ch73-173h19.3
chr18_+_15644559 2.24 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr3_-_41791178 2.21 ENSDART00000049687
galectin-related inter-fiber protein
chr13_+_38430466 2.16 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr4_+_7391400 2.16 ENSDART00000169111
ENSDART00000186395
troponin I4a
chr20_-_40754794 2.16 ENSDART00000187251
connexin 32.3
chr17_+_15433518 2.14 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr2_+_37227011 2.05 ENSDART00000126587
ENSDART00000084958
sterile alpha motif domain containing 7
chr15_-_16098531 2.05 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr7_-_24699985 2.04 ENSDART00000052802
calbindin 2b
chr20_-_29420713 2.04 ENSDART00000147464
ryanodine receptor 3
chr12_+_31713239 2.03 ENSDART00000122379
hyaluronan binding protein 2
chr14_+_5936996 2.02 ENSDART00000097144
ENSDART00000126777
potassium channel tetramerization domain containing 8
chr17_+_30448452 1.98 ENSDART00000153939
lipin 1
chr10_-_24371312 1.91 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr6_-_41229787 1.90 ENSDART00000065013
synaptoporin
chr17_+_15433671 1.87 ENSDART00000149568
fatty acid binding protein 7, brain, a
chr21_+_6780340 1.87 ENSDART00000139493
ENSDART00000140478
olfactomedin 1b
chr12_-_26153101 1.84 ENSDART00000076051
opsin 4b
chr12_-_35054354 1.84 ENSDART00000075351
zgc:112285
chr3_+_23092762 1.84 ENSDART00000142884
ENSDART00000024136
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a
chr20_+_31076488 1.81 ENSDART00000136255
ENSDART00000008840
otoferlin a
chr8_+_24861264 1.81 ENSDART00000099607
solute carrier family 6 (neutral amino acid transporter), member 17
chr4_+_12612723 1.81 ENSDART00000133767
LIM domain only 3
chr16_+_20161805 1.81 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr14_-_4556896 1.81 ENSDART00000044678
ENSDART00000192863
gamma-aminobutyric acid type A receptor alpha2 subunit
chr21_+_28958471 1.80 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr24_+_5208171 1.79 ENSDART00000155926
ENSDART00000154464
si:ch73-206p6.1
chr7_+_21841037 1.79 ENSDART00000077503
transmembrane 4 L six family member 5
chr22_+_8753365 1.75 ENSDART00000106086
si:dkey-182g1.2
chr8_-_46894362 1.74 ENSDART00000111124
acyl-CoA thioesterase 7
chr12_-_35787801 1.74 ENSDART00000171682
apoptosis-associated tyrosine kinase b
chr5_+_20147830 1.73 ENSDART00000098727
SV2 related protein a
chr21_+_8427059 1.72 ENSDART00000143151
DENN/MADD domain containing 1A
chr2_+_50608099 1.71 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr1_+_33969015 1.70 ENSDART00000042984
ENSDART00000146530
eph receptor A6
chr2_+_20332044 1.70 ENSDART00000112131
phospholipid phosphatase related 4a
chr4_+_7391110 1.69 ENSDART00000160708
ENSDART00000187823
troponin I4a
chr4_+_21129752 1.65 ENSDART00000169764
synaptotagmin Ia
chr20_-_39271844 1.65 ENSDART00000192708
clusterin
chr7_+_25059845 1.63 ENSDART00000077215
protein phosphatase 2, regulatory subunit B', beta
chr2_-_37465517 1.63 ENSDART00000139983
si:dkey-57k2.6
chr16_+_13818500 1.62 ENSDART00000135245
folliculin
chr16_-_52540056 1.61 ENSDART00000188304

chr15_+_21276735 1.61 ENSDART00000111213
ubiquitin associated and SH3 domain containing Bb
chr9_+_54417141 1.61 ENSDART00000056810
dopamine receptor D1b
chr16_+_34531486 1.59 ENSDART00000043291
progestin and adipoQ receptor family member VII, b
chr3_-_13146631 1.59 ENSDART00000172460
protein kinase, cAMP-dependent, regulatory, type I, beta
chr5_+_36611128 1.59 ENSDART00000097684
neuro-oncological ventral antigen 1
chr16_+_2820340 1.57 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
chr5_-_43071058 1.56 ENSDART00000165546
si:dkey-245n4.2
chr11_-_6188413 1.56 ENSDART00000109972
chemokine (C-C motif) ligand 44
chr7_-_28147838 1.55 ENSDART00000158921
LIM domain only 1
chr7_-_28148310 1.55 ENSDART00000044208
LIM domain only 1
chr9_-_43538328 1.55 ENSDART00000140526
zinc finger protein 385B
chr13_+_38521152 1.54 ENSDART00000145292
adhesion G protein-coupled receptor B3
chr4_-_8903240 1.54 ENSDART00000129983
metallophosphoesterase domain containing 1
chr7_+_38510197 1.53 ENSDART00000173468
ENSDART00000100479
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr19_-_205104 1.53 ENSDART00000011890
zinc finger and BTB domain containing 22a
chr24_-_38110779 1.52 ENSDART00000147783
c-reactive protein, pentraxin-related
chr10_+_32683089 1.52 ENSDART00000063551
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr22_-_13851297 1.51 ENSDART00000080306
S100 calcium binding protein, beta (neural)
chr6_-_38419318 1.47 ENSDART00000138026
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr22_+_8753092 1.46 ENSDART00000140720
si:dkey-182g1.2
chr13_-_45475289 1.46 ENSDART00000043345
arginine/serine-rich protein 1
chr7_+_25033924 1.45 ENSDART00000170873
sb:cb1058
chr19_-_5103313 1.45 ENSDART00000037007
triosephosphate isomerase 1a
chr21_-_40174647 1.45 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
solute carrier organic anion transporter family, member 2B1
chr23_-_306796 1.45 ENSDART00000143125
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr3_-_28258462 1.43 ENSDART00000191573
RNA binding fox-1 homolog 1
chr18_+_10884996 1.42 ENSDART00000147613
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr3_+_29714775 1.42 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr1_+_8601935 1.42 ENSDART00000152367
si:ch211-160d14.6
chr20_+_25879826 1.41 ENSDART00000018519
zgc:153896
chr12_+_18681477 1.40 ENSDART00000127981
ENSDART00000143979
regulator of G protein signaling 9b
chr5_+_51443009 1.39 ENSDART00000083350
Ras protein-specific guanine nucleotide-releasing factor 2b
chr19_-_6631900 1.39 ENSDART00000144571
poliovirus receptor-related 2 like
chr8_-_13184989 1.38 ENSDART00000135738
zgc:194990
chr11_-_37509001 1.38 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr22_-_15010688 1.37 ENSDART00000139892
extracellular leucine-rich repeat and fibronectin type III domain containing 2a
chr2_+_10127762 1.36 ENSDART00000100726
insulin-like 5b
chr25_-_4313699 1.36 ENSDART00000154038
synaptotagmin VIIa
chr8_-_14126646 1.35 ENSDART00000027225
biglycan a
chr3_+_33341640 1.34 ENSDART00000186352
peptide YYa
chr16_-_38118003 1.34 ENSDART00000058667
si:dkey-23o4.6
chr6_-_10320676 1.34 ENSDART00000151247
sodium channel, voltage-gated, type I like, alpha b
chr3_+_17537352 1.33 ENSDART00000104549
hypocretin (orexin) neuropeptide precursor
chr23_-_38497705 1.33 ENSDART00000109493
teashirt zinc finger homeobox 2
chr15_-_6247775 1.32 ENSDART00000148350
Down syndrome cell adhesion molecule b
chr1_+_11977426 1.31 ENSDART00000103399
tetraspanin 5b
chr17_-_19019635 1.30 ENSDART00000126666
fibronectin leucine rich transmembrane protein 2
chr5_-_6567464 1.30 ENSDART00000184985
tankyrase 1 binding protein 1
chr23_-_1348933 1.28 ENSDART00000168981

chr3_-_33395233 1.28 ENSDART00000167349
si:dkey-283b1.6
chr1_-_43899422 1.28 ENSDART00000134649
si:dkey-22i16.2
chr23_-_32162810 1.26 ENSDART00000155905
nuclear receptor subfamily 4, group A, member 1
chr15_+_22311803 1.26 ENSDART00000150182
hepatic and glial cell adhesion molecule a
chr12_-_19007834 1.26 ENSDART00000153248
chondroadherin-like b
chr3_+_28953274 1.26 ENSDART00000133528
ENSDART00000103602
lectin, galactoside-binding, soluble, 2a
chr1_+_52929185 1.26 ENSDART00000147683
inositol polyphosphate-4-phosphatase type II B
chr6_+_23887314 1.26 ENSDART00000163188
zinc finger protein 648
chr5_-_25174420 1.25 ENSDART00000141554
ATP-binding cassette, sub-family A (ABC1), member 2
chr3_+_34919810 1.25 ENSDART00000055264
carbonic anhydrase Xb
chr10_+_41765616 1.25 ENSDART00000170682
ring finger protein 34b
chr16_+_17389116 1.25 ENSDART00000103750
ENSDART00000173448
family with sequence similarity 131, member Bb
chr1_+_52392511 1.24 ENSDART00000144025
si:ch211-217k17.8
chr4_+_11384891 1.24 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr1_-_5455498 1.23 ENSDART00000040368
ENSDART00000114035
motor neuron and pancreas homeobox 2b
chr13_-_33170733 1.22 ENSDART00000057382
fibulin 5
chr24_-_1985007 1.21 ENSDART00000189870
par-3 family cell polarity regulator
chr1_-_19215336 1.19 ENSDART00000162949
ENSDART00000170680
protein tyrosine phosphatase, receptor type, D, b
chr23_+_21638258 1.19 ENSDART00000104188
immunoglobin superfamily, member 21b
chr19_-_5103141 1.19 ENSDART00000150952
triosephosphate isomerase 1a
chr9_+_52398531 1.19 ENSDART00000126215
death associated protein 1b
chr10_-_13343831 1.19 ENSDART00000135941
interleukin 11 receptor, alpha
chr10_-_8060573 1.18 ENSDART00000147104
ENSDART00000099030
si:ch211-251f6.6
chr1_-_12160981 1.18 ENSDART00000162146
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
chr19_-_31522625 1.17 ENSDART00000158438
ENSDART00000035049
N-terminal EF-hand calcium binding protein 1
chr8_-_20230559 1.16 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr16_-_17162843 1.16 ENSDART00000089386
intermediate filament family orphan 1b
chr20_-_2949028 1.16 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cyclin-dependent kinase 19
chr21_+_17768174 1.15 ENSDART00000141380
retinoid X receptor, alpha a
chr21_-_22827548 1.15 ENSDART00000079161
angiopoietin-like 5
chr23_+_28731379 1.14 ENSDART00000047378
cortistatin
chr24_+_13316737 1.14 ENSDART00000191658
somatomedin B and thrombospondin type 1 domain containing
chr2_+_6963296 1.13 ENSDART00000147146
discoidin domain receptor tyrosine kinase 2b
chr13_+_25449681 1.12 ENSDART00000101328
atonal bHLH transcription factor 7
chr3_-_35800221 1.11 ENSDART00000031390
CASK interacting protein 1
chr7_-_69521481 1.11 ENSDART00000148465
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr23_-_20051369 1.10 ENSDART00000049836
biglycan b
chr6_-_35779348 1.10 ENSDART00000191159
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 1
chr10_+_37137464 1.09 ENSDART00000114909
CUE domain containing 1a
chr9_+_31795343 1.09 ENSDART00000139584
integrin, beta-like 1
chr23_-_35790235 1.09 ENSDART00000142369
ENSDART00000141141
ENSDART00000011004
major facilitator superfamily domain containing 5
chr1_-_45042210 1.08 ENSDART00000073694
SMU1, DNA replication regulator and spliceosomal factor b
chr16_+_23431189 1.08 ENSDART00000004679
ictacalcin
chr25_+_24291156 1.07 ENSDART00000083407
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr19_-_7358184 1.07 ENSDART00000092379
oxidation resistance 1b
chr7_+_71547747 1.07 ENSDART00000180869
adenylate cyclase activating polypeptide 1a
chr13_+_4225173 1.07 ENSDART00000058242
ENSDART00000143456
male-enhanced antigen 1
chr23_+_20110086 1.06 ENSDART00000054664
troponin C type 1b (slow)
chr19_+_42470396 1.06 ENSDART00000191679
si:dkey-166k12.1
chr8_-_34052019 1.06 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pre-B-cell leukemia homeobox 3b
chr11_+_28476298 1.06 ENSDART00000122319
leucine rich repeat containing 38b
chr14_-_1454045 1.05 ENSDART00000161460
phosphoethanolamine methyltransferase
chr7_+_17229980 1.05 ENSDART00000184910
solute carrier family 6 (neurotransmitter transporter), member 5
chr19_+_5480327 1.04 ENSDART00000148794
junction plakoglobin b

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx6.1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
1.1 3.4 GO:0005985 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.8 9.0 GO:0036368 cone photoresponse recovery(GO:0036368)
0.7 3.7 GO:0016322 neuron remodeling(GO:0016322)
0.7 2.6 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6 2.5 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.6 2.5 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.6 5.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 1.8 GO:0015824 proline transport(GO:0015824)
0.5 2.6 GO:0070208 protein heterotrimerization(GO:0070208)
0.5 2.0 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.5 2.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.5 4.9 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.5 1.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.4 1.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.3 1.3 GO:0042755 eating behavior(GO:0042755)
0.3 0.9 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.3 2.2 GO:2001271 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 0.9 GO:0021611 facial nerve formation(GO:0021611)
0.3 1.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 2.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 2.4 GO:0006857 oligopeptide transport(GO:0006857)
0.2 0.7 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.2 0.7 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.2 1.0 GO:0003241 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 0.9 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 1.6 GO:0042311 vasodilation(GO:0042311)
0.2 2.3 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 3.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 1.0 GO:0002159 desmosome assembly(GO:0002159)
0.2 0.6 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.2 1.4 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 1.0 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753) cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.2 3.7 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 0.8 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 1.2 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 1.3 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.2 0.8 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.1 2.7 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.1 1.3 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 2.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 1.8 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.5 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.1 1.0 GO:0043092 amino acid import(GO:0043090) L-amino acid import(GO:0043092)
0.1 1.0 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.4 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
0.1 1.8 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 2.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 3.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:2000639 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 5.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 2.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.9 GO:0007634 optokinetic behavior(GO:0007634)
0.1 0.3 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 4.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 0.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.0 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.1 0.7 GO:0070285 pigment cell development(GO:0070285)
0.1 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 7.3 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.1 2.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.0 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.7 GO:0007141 male meiosis I(GO:0007141)
0.1 2.9 GO:0009636 response to toxic substance(GO:0009636)
0.1 1.4 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 0.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.4 GO:0016038 absorption of visible light(GO:0016038)
0.1 1.6 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 1.3 GO:0090303 positive regulation of wound healing(GO:0090303)
0.1 0.9 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.7 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 1.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 2.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 1.0 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.1 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.1 1.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 2.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.6 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 1.6 GO:0001556 oocyte maturation(GO:0001556)
0.1 0.2 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 2.6 GO:0007586 digestion(GO:0007586)
0.1 1.7 GO:0007631 feeding behavior(GO:0007631)
0.1 1.3 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.1 2.3 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 2.4 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.0 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.2 GO:0060292 long term synaptic depression(GO:0060292)
0.1 1.2 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 2.0 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 1.1 GO:0032526 response to retinoic acid(GO:0032526)
0.1 2.3 GO:0036269 swimming behavior(GO:0036269)
0.1 1.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.0 GO:0007413 axonal fasciculation(GO:0007413)
0.0 2.2 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.4 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.3 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.0 0.1 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.8 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 3.2 GO:0007596 blood coagulation(GO:0007596)
0.0 0.5 GO:0032418 lysosome localization(GO:0032418)
0.0 0.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.7 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.4 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.2 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 0.4 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.8 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.6 GO:0048512 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.0 5.5 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.8 GO:0006825 copper ion transport(GO:0006825)
0.0 0.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.1 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.7 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.9 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.4 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 3.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.5 GO:0045471 response to ethanol(GO:0045471)
0.0 0.7 GO:0048570 notochord morphogenesis(GO:0048570)
0.0 1.5 GO:0030282 bone mineralization(GO:0030282)
0.0 0.4 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.2 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.7 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.1 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.3 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 1.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 3.7 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 2.4 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.1 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0 0.3 GO:0098969 neurotransmitter receptor transport to plasma membrane(GO:0098877) neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540)
0.0 4.0 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 0.7 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 1.5 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.8 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.6 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.0 0.6 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 1.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.7 GO:1903844 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.9 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.0 0.1 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 1.7 GO:0015698 inorganic anion transport(GO:0015698)
0.0 0.5 GO:1990573 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.5 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.5 GO:0043648 dicarboxylic acid metabolic process(GO:0043648)
0.0 0.9 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 2.0 GO:0007601 visual perception(GO:0007601)
0.0 0.9 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 1.4 GO:0008284 positive regulation of cell proliferation(GO:0008284)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0060077 inhibitory synapse(GO:0060077)
0.6 3.7 GO:0043083 synaptic cleft(GO:0043083)
0.5 3.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5 4.9 GO:0098982 GABA-ergic synapse(GO:0098982)
0.3 2.8 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.3 1.7 GO:0042584 chromaffin granule membrane(GO:0042584)
0.3 1.7 GO:0042583 chromaffin granule(GO:0042583)
0.3 1.8 GO:0005955 calcineurin complex(GO:0005955)
0.2 3.7 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 1.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.5 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 0.6 GO:0044609 DBIRD complex(GO:0044609)
0.2 6.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 5.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 4.3 GO:0043679 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.1 2.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 5.9 GO:0005861 troponin complex(GO:0005861)
0.1 2.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.1 9.0 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.4 GO:0016600 flotillin complex(GO:0016600)
0.1 3.0 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.7 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.6 GO:0032420 stereocilium(GO:0032420)
0.1 1.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.0 GO:0030057 desmosome(GO:0030057)
0.1 0.4 GO:0071914 prominosome(GO:0071914)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 2.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0043235 receptor complex(GO:0043235)
0.0 1.3 GO:0043204 perikaryon(GO:0043204)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.4 GO:0008305 integrin complex(GO:0008305)
0.0 5.8 GO:0030424 axon(GO:0030424)
0.0 3.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.8 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 20.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.0 0.3 GO:0005921 gap junction(GO:0005921)
0.0 1.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 3.3 GO:0009986 cell surface(GO:0009986)
0.0 15.8 GO:0005615 extracellular space(GO:0005615)
0.0 0.4 GO:0030496 midbody(GO:0030496)
0.0 1.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
1.0 2.9 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
0.9 5.6 GO:0004743 pyruvate kinase activity(GO:0004743)
0.8 2.3 GO:1903136 cuprous ion binding(GO:1903136)
0.7 2.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.7 2.2 GO:0048030 disaccharide binding(GO:0048030)
0.7 1.4 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.7 2.6 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.7 2.0 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.6 2.5 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.6 3.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.5 1.6 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.4 1.5 GO:0044548 S100 protein binding(GO:0044548)
0.4 2.2 GO:0032052 bile acid binding(GO:0032052)
0.4 5.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.4 2.5 GO:0016972 thiol oxidase activity(GO:0016972)
0.4 2.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 2.4 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.3 1.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 1.2 GO:0070513 death domain binding(GO:0070513)
0.3 2.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.3 4.1 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.3 1.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 4.9 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.3 1.3 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.3 1.3 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.3 4.0 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.1 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.3 2.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 3.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 1.1 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.2 1.0 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.2 5.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 0.6 GO:0004061 arylformamidase activity(GO:0004061)
0.2 0.8 GO:0016531 copper chaperone activity(GO:0016531)
0.2 1.0 GO:0017040 ceramidase activity(GO:0017040)
0.2 1.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.7 GO:0005542 folic acid binding(GO:0005542) ammonia-lyase activity(GO:0016841)
0.1 0.7 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 3.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 4.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.3 GO:0016936 galactoside binding(GO:0016936)
0.1 1.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 3.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 4.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 3.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.4 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.1 1.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 2.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.5 GO:0043295 glutathione binding(GO:0043295)
0.1 0.4 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 2.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.6 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 1.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 3.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.0 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 2.1 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.1 1.3 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.1 2.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.7 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.8 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.1 3.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 2.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.9 GO:0016917 GABA receptor activity(GO:0016917)
0.0 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 1.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.4 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.4 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 2.4 GO:0050661 NADP binding(GO:0050661)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.0 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.2 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.1 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 3.6 GO:0015293 symporter activity(GO:0015293)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 1.9 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.0 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)
0.0 1.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.9 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0050699 WW domain binding(GO:0050699)
0.0 1.5 GO:0016247 channel regulator activity(GO:0016247)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 2.2 GO:0019955 cytokine binding(GO:0019955)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 1.0 GO:0044325 ion channel binding(GO:0044325)
0.0 1.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.6 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 2.5 GO:0015399 primary active transmembrane transporter activity(GO:0015399)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.5 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.3 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 10.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.1 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.6 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 PID CONE PATHWAY Visual signal transduction: Cones
0.2 3.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.3 2.9 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 1.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 2.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 0.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 1.5 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 1.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 1.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 2.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 2.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 4.0 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 1.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 5.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.4 REACTOME OPSINS Genes involved in Opsins
0.0 0.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.0 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 1.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events