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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx2.1

Z-value: 0.40

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Transcription factors associated with nkx2.1

Gene Symbol Gene ID Gene Info
nkx2.1
ENSDARG00000019835 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.1dr11_v1_chr17_+_38262408_382624080.691.0e-03Click!

Activity profile of nkx2.1 motif

Sorted Z-values of nkx2.1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_59571758 1.03 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr20_+_48782068 0.97 ENSDART00000159275
nkx2.2b
NK2 homeobox 2b
chr13_+_10023256 0.94 ENSDART00000110035
srbd1
S1 RNA binding domain 1
chr5_-_54712159 0.85 ENSDART00000149207
ccnb1
cyclin B1
chr2_+_19195841 0.78 ENSDART00000163137
ENSDART00000161095
elovl1a
ELOVL fatty acid elongase 1a
chr11_-_308838 0.65 ENSDART00000112538
poc1a
POC1 centriolar protein A
chr15_-_23508214 0.65 ENSDART00000115051
abcg4b
ATP-binding cassette, sub-family G (WHITE), member 4b
chr4_-_2052687 0.61 ENSDART00000138291
ENSDART00000150844
cpsf6
cleavage and polyadenylation specific factor 6
chr17_+_48314724 0.59 ENSDART00000125617
smoc1
SPARC related modular calcium binding 1
chr6_+_38880166 0.57 ENSDART00000019939
ENSDART00000144286
bin2b
bridging integrator 2b
chr22_-_24248420 0.53 ENSDART00000165433
rgs2
regulator of G protein signaling 2
chr3_+_24207243 0.51 ENSDART00000023454
ENSDART00000136400
adsl
adenylosuccinate lyase
chr6_+_38879961 0.48 ENSDART00000184798
bin2b
bridging integrator 2b
chr7_-_24875421 0.47 ENSDART00000173920
adad2
adenosine deaminase domain containing 2
chr19_+_7292654 0.47 ENSDART00000140459
ccdc127b
coiled-coil domain containing 127b
chr11_-_3987885 0.47 ENSDART00000058735
glt8d1
glycosyltransferase 8 domain containing 1
chr4_-_20314749 0.46 ENSDART00000066894
ENSDART00000188123
dcp1b
decapping mRNA 1B
chr2_-_59345920 0.46 ENSDART00000134662
ftr37
finTRIM family, member 37
chr8_-_44298964 0.45 ENSDART00000098520
fzd10
frizzled class receptor 10
chr1_+_57040472 0.44 ENSDART00000181365
si:ch211-1f22.16
si:ch211-1f22.16
chr7_+_24390939 0.42 ENSDART00000087494
ENSDART00000125463
haus3
HAUS augmin-like complex, subunit 3
chr3_-_23461954 0.41 ENSDART00000040065
casc3
cancer susceptibility candidate 3
chr1_+_27977297 0.40 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr3_-_33422738 0.40 ENSDART00000075493
ccdc103
coiled-coil domain containing 103
chr7_+_16991711 0.39 ENSDART00000173660
nav2a
neuron navigator 2a
chr3_+_22335030 0.39 ENSDART00000055676
zgc:103564
zgc:103564
chr25_-_28674739 0.37 ENSDART00000067073
lrrc10
leucine rich repeat containing 10
chr21_+_34088377 0.37 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr8_-_20243389 0.36 ENSDART00000184904
acer1
alkaline ceramidase 1
chr3_+_17933132 0.36 ENSDART00000104299
ENSDART00000162144
ENSDART00000162242
ENSDART00000166289
ENSDART00000171101
ENSDART00000164853
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr17_+_23975762 0.35 ENSDART00000155941
xpo1b
exportin 1 (CRM1 homolog, yeast) b
chr6_+_52931841 0.35 ENSDART00000174358
si:dkeyp-3f10.12
si:dkeyp-3f10.12
chr3_+_39600562 0.34 ENSDART00000134309
ENSDART00000007170
prpsap2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr2_-_37401600 0.33 ENSDART00000015723
prkci
protein kinase C, iota
chr15_-_23482088 0.33 ENSDART00000185823
ENSDART00000185523
nlrx1
NLR family member X1
chr11_-_24063196 0.33 ENSDART00000036513
trib3
tribbles pseudokinase 3
chr7_-_30639385 0.32 ENSDART00000173618
myo1ea
myosin IE, a
chr2_+_26237322 0.30 ENSDART00000030520
palm1b
paralemmin 1b
chr23_-_33558161 0.29 ENSDART00000018301
itga5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr4_-_9054947 0.29 ENSDART00000109764
si:dkey-48p11.3
si:dkey-48p11.3
chr18_+_44631789 0.28 ENSDART00000144271
bicra
BRD4 interacting chromatin remodeling complex associated protein
chr20_-_38827623 0.26 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr3_+_32118670 0.26 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr3_-_7464250 0.24 ENSDART00000159873
znf1001
zinc finger protein 1001
chr20_+_46255057 0.24 ENSDART00000100536
taar14i
trace amine associated receptor 14i
chr11_-_8271374 0.24 ENSDART00000168253
pimr202
Pim proto-oncogene, serine/threonine kinase, related 202
chr4_+_76748500 0.24 ENSDART00000075607
ms4a17a.10
membrane-spanning 4-domains, subfamily A, member 17A.10
chr13_-_36579086 0.24 ENSDART00000146671
lgals3a
lectin, galactoside binding soluble 3a
chr1_+_16621345 0.24 ENSDART00000149026
pcm1
pericentriolar material 1
chr11_+_25596038 0.23 ENSDART00000140856
ccdc120
coiled-coil domain containing 120
chr17_-_12249990 0.23 ENSDART00000177889
ENSDART00000155545
ahctf1
AT hook containing transcription factor 1
chr4_+_37406676 0.22 ENSDART00000130981
si:ch73-134f24.1
si:ch73-134f24.1
chr2_+_314249 0.21 ENSDART00000082086
zgc:113452
zgc:113452
chr6_-_18531760 0.21 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr17_+_24597001 0.21 ENSDART00000191834
rlf
rearranged L-myc fusion
chr7_-_3894831 0.20 ENSDART00000172921
si:dkey-88n24.11
si:dkey-88n24.11
chr22_+_38762693 0.19 ENSDART00000015016
ENSDART00000150187
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr6_+_18531932 0.19 ENSDART00000165271
suz12b
SUZ12 polycomb repressive complex 2b subunit
chr15_-_31357634 0.19 ENSDART00000127485
or111-2
odorant receptor, family D, subfamily 111, member 2
chr14_-_11507211 0.19 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
zgc:174917
chr14_+_10656975 0.19 ENSDART00000127594
ENSDART00000125865
atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr19_+_7292445 0.18 ENSDART00000026634
ccdc127b
coiled-coil domain containing 127b
chr14_-_33478963 0.17 ENSDART00000132813
lamp2
lysosomal-associated membrane protein 2
chr1_+_46026457 0.17 ENSDART00000132705
si:ch211-138g9.2
si:ch211-138g9.2
chr18_+_808911 0.17 ENSDART00000172518
cox5ab
cytochrome c oxidase subunit Vab
chr14_-_16476863 0.16 ENSDART00000089021
canx
calnexin
chr15_-_29012493 0.16 ENSDART00000060018
dharma
dharma
chr11_+_12879635 0.16 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
si:dkey-11m19.5
chr1_-_23294753 0.16 ENSDART00000013263
ugdh
UDP-glucose 6-dehydrogenase
chr4_-_3805992 0.16 ENSDART00000190125
si:dkey-61f9.1
si:dkey-61f9.1
chr22_+_39096911 0.15 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr12_-_19862912 0.15 ENSDART00000145788
shisa9a
shisa family member 9a
chr25_-_17590971 0.14 ENSDART00000189942
mmp15a
matrix metallopeptidase 15a
chr19_-_24224142 0.14 ENSDART00000136409
ENSDART00000114390
prf1.8
perforin 1.8
chr13_+_46927350 0.13 ENSDART00000165041
ENSDART00000167931
mtrf1l
mitochondrial translational release factor 1-like
chr7_-_48733662 0.12 ENSDART00000191675
traf6
TNF receptor-associated factor 6
chr25_-_20691075 0.11 ENSDART00000067373
edc3
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr25_+_25124684 0.11 ENSDART00000167542
ldha
lactate dehydrogenase A4
chr1_+_54835131 0.10 ENSDART00000145070
si:ch211-196h16.4
si:ch211-196h16.4
chr15_-_4053149 0.10 ENSDART00000189076
CR626884.4

chr4_-_50926767 0.10 ENSDART00000183430
si:ch211-208f21.3
si:ch211-208f21.3
chr18_-_22701800 0.10 ENSDART00000135098
si:ch73-113g13.3
si:ch73-113g13.3
chr13_+_27040887 0.09 ENSDART00000132714
soul2
heme-binding protein soul2
chr11_-_36040549 0.09 ENSDART00000112684
setmar
SET domain and mariner transposase fusion gene
chr11_-_8226088 0.09 ENSDART00000173364
si:cabz01021067.1
si:cabz01021067.1
chr12_-_30583668 0.09 ENSDART00000153406
casp7
caspase 7, apoptosis-related cysteine peptidase
chr1_-_58000438 0.08 ENSDART00000163761
si:ch211-114l13.9
si:ch211-114l13.9
chr21_+_45502621 0.08 ENSDART00000166719
si:dkey-223p19.2
si:dkey-223p19.2
chr13_-_10727550 0.08 ENSDART00000190925
ppm1ba
protein phosphatase, Mg2+/Mn2+ dependent, 1Ba
chr25_+_19485198 0.07 ENSDART00000156730
glsl
glutaminase like
chr1_+_55662491 0.07 ENSDART00000152386
adgre8
adhesion G protein-coupled receptor E8
chr1_+_55583116 0.07 ENSDART00000152163
adgre19
adhesion G protein-coupled receptor E19
chr12_+_20506197 0.06 ENSDART00000153010
si:zfos-754c12.2
si:zfos-754c12.2
chr5_-_35456269 0.06 ENSDART00000051312
ttc33
tetratricopeptide repeat domain 33
chr8_-_36469117 0.05 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr4_+_76403698 0.05 ENSDART00000184821
ENSDART00000169373
FP074874.2
FP074874.1


chr11_+_583725 0.04 ENSDART00000189415
mkrn2os.2
MKRN2 opposite strand, tandem duplicate 2
chr12_+_30788912 0.04 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr7_-_59123066 0.04 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr7_+_48555626 0.04 ENSDART00000125483
ENSDART00000083514
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr4_-_17838179 0.04 ENSDART00000146931
avpr2l
arginine vasopressin receptor 2, like
chr9_-_7089303 0.04 ENSDART00000146609
coa5
cytochrome C oxidase assembly factor 5
chr2_-_11119303 0.03 ENSDART00000135450
ENSDART00000131836
cryz
crystallin, zeta (quinone reductase)
chr11_-_5939861 0.03 ENSDART00000110033
abhd8b
abhydrolase domain containing 8b
chr21_-_2348838 0.02 ENSDART00000160337
si:ch73-299h12.8
si:ch73-299h12.8
chr11_+_37909654 0.01 ENSDART00000172211
si:ch211-112f3.4
si:ch211-112f3.4

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0046831 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.2 1.1 GO:0071800 podosome assembly(GO:0071800)
0.1 0.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.5 GO:0090299 regulation of neural crest formation(GO:0090299)
0.1 0.6 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.8 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.3 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.1 0.3 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.3 GO:0045217 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) cell-cell junction maintenance(GO:0045217)
0.1 0.2 GO:0048320 axial mesoderm formation(GO:0048320)
0.1 0.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 1.0 GO:0021508 floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.0 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.3 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 0.5 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.8 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.4 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.0 0.6 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.2 GO:0003190 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.6 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.2 0.6 GO:0042382 paraspeckles(GO:0042382)
0.2 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.4 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.3 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.3 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.3 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.1 0.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.4 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.2 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.5 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.2 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.0 0.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.3 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.2 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.5 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling