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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nkx1.2lb

Z-value: 0.49

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Transcription factors associated with nkx1.2lb

Gene Symbol Gene ID Gene Info
nkx1.2lb
ENSDARG00000099427 NK1 transcription factor related 2-like,b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx1.2lbdr11_v1_chr14_+_15064870_150648700.097.1e-01Click!

Activity profile of nkx1.2lb motif

Sorted Z-values of nkx1.2lb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_306036 1.80 ENSDART00000103659
msgn1
mesogenin 1
chr7_-_64971839 0.96 ENSDART00000164682
sinhcafl
SIN3-HDAC complex associated factor, like
chr17_-_15189397 0.95 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr8_-_16697615 0.93 ENSDART00000187929
rpe65b
retinal pigment epithelium-specific protein 65b
chr12_-_43685802 0.87 ENSDART00000170723
zgc:112964
zgc:112964
chr8_-_50888806 0.84 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr8_-_20243389 0.82 ENSDART00000184904
acer1
alkaline ceramidase 1
chr8_-_39822917 0.79 ENSDART00000067843
zgc:162025
zgc:162025
chr4_+_6032640 0.78 ENSDART00000157487
tfec
transcription factor EC
chr20_+_36812368 0.77 ENSDART00000062931
abracl
ABRA C-terminal like
chr21_-_31013817 0.65 ENSDART00000065504
ncbp3
nuclear cap binding subunit 3
chr17_+_16429826 0.65 ENSDART00000136078
efcab11
EF-hand calcium binding domain 11
chr23_+_29358188 0.64 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr5_-_22052852 0.62 ENSDART00000002938
mtmr8
myotubularin related protein 8
chr13_-_9213207 0.61 ENSDART00000139861
ENSDART00000140524
HTRA2 (1 of many)
si:dkey-33c12.11
chr11_+_16153207 0.58 ENSDART00000192356
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr7_+_24881680 0.58 ENSDART00000058843
krcp
kelch repeat-containing protein
chr17_+_24821627 0.54 ENSDART00000112389
wdr43
WD repeat domain 43
chr2_+_6253246 0.54 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr11_-_16152400 0.54 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr21_-_15200556 0.53 ENSDART00000141809
sfswap
splicing factor SWAP
chr21_-_26071773 0.53 ENSDART00000141382
rab34b
RAB34, member RAS oncogene family b
chr5_-_51619742 0.52 ENSDART00000188537
otpb
orthopedia homeobox b
chr18_+_9171778 0.52 ENSDART00000101192
sema3d
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr11_+_16152316 0.51 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr10_+_39212898 0.51 ENSDART00000159501
stt3a
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr15_-_25518084 0.50 ENSDART00000158594
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr23_-_24263474 0.49 ENSDART00000160312
hspb7
heat shock protein family, member 7 (cardiovascular)
chr13_-_9159852 0.47 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
HTRA2 (1 of many)
si:dkey-112g5.16
chr21_+_4410733 0.47 ENSDART00000136831
ENSDART00000131612
HTRA2 (1 of many)
si:dkey-84o3.7
chr8_+_18011522 0.45 ENSDART00000136756
ssbp3b
single stranded DNA binding protein 3b
chr6_-_7720332 0.45 ENSDART00000135945
rpsa
ribosomal protein SA
chr2_+_10006839 0.44 ENSDART00000160304
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr21_+_4328348 0.44 ENSDART00000131658
ENSDART00000143799
HTRA2 (1 of many)
si:dkey-84o3.7
chr13_-_9236905 0.44 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-33c12.12
si:dkey-112g5.12
chr23_+_43255328 0.44 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr10_-_34002185 0.43 ENSDART00000046599
zar1l
zygote arrest 1-like
chr9_+_43799829 0.41 ENSDART00000186240
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr13_-_9045879 0.40 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
si:dkey-112g5.11
chr5_-_33298352 0.40 ENSDART00000015076
zgc:103692
zgc:103692
chr21_+_4348600 0.38 ENSDART00000138463
HTRA2 (1 of many)
si:dkey-84o3.2
chr13_+_9521629 0.37 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
si:dkey-19p15.4
chr13_+_9468535 0.37 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr1_-_48933 0.35 ENSDART00000171162
ildr1a
immunoglobulin-like domain containing receptor 1a
chr6_-_47840465 0.35 ENSDART00000141986
lrig2
leucine-rich repeats and immunoglobulin-like domains 2
chr17_+_21902058 0.34 ENSDART00000142178
plekha1a
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr11_+_12811906 0.34 ENSDART00000123445
rtel1
regulator of telomere elongation helicase 1
chr1_-_8140763 0.34 ENSDART00000091508
FAM83G
si:dkeyp-9d4.4
chr23_-_31913069 0.33 ENSDART00000135526
mtfr2
mitochondrial fission regulator 2
chr13_+_35955562 0.33 ENSDART00000137377
si:ch211-67f13.7
si:ch211-67f13.7
chr13_-_9257728 0.33 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
HTRA2 (1 of many)
zgc:173425
chr25_+_20272145 0.33 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr21_+_4368735 0.32 ENSDART00000182817
CT027677.1

chr6_+_52877147 0.32 ENSDART00000174370
or137-8
odorant receptor, family H, subfamily 137, member 8
chr2_-_24317240 0.32 ENSDART00000078975
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr13_-_36798204 0.32 ENSDART00000012357
sav1
salvador family WW domain containing protein 1
chr4_-_29753895 0.32 ENSDART00000150742
si:dkey-191j3.1
si:dkey-191j3.1
chr21_+_4429001 0.31 ENSDART00000134520
HTRA2 (1 of many)
si:dkey-84o3.6
chr13_-_9070754 0.31 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
si:dkey-112g5.12
chr13_-_9111927 0.30 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-19p15.4
si:dkey-112g5.12
chr9_+_35015747 0.30 ENSDART00000140110
gabpa
GA binding protein transcription factor, alpha subunit
chr6_+_7421898 0.30 ENSDART00000043946
ccdc65
coiled-coil domain containing 65
chr13_-_9184132 0.29 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
HTRA2 (1 of many)
si:dkey-33c12.10
chr20_-_37813863 0.29 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr2_+_25315591 0.28 ENSDART00000161386
fndc3ba
fibronectin type III domain containing 3Ba
chr14_-_215051 0.27 ENSDART00000054822
nkx3.2
NK3 homeobox 2
chr4_+_63790028 0.27 ENSDART00000160964
si:dkey-92j16.2
si:dkey-92j16.2
chr21_+_16145980 0.27 ENSDART00000135119
qrfpr4
pyroglutamylated RFamide peptide receptor 4
chr12_-_4249000 0.27 ENSDART00000059298
zgc:92313
zgc:92313
chr6_+_23026714 0.26 ENSDART00000124948
srp68
signal recognition particle 68
chr21_-_21570134 0.26 ENSDART00000174388
or133-4
odorant receptor, family H, subfamily 133, member 4
chr4_+_11458078 0.25 ENSDART00000037600
ankrd16
ankyrin repeat domain 16
chr13_+_411607 0.25 ENSDART00000186483
CU570800.3

chr12_-_19119176 0.25 ENSDART00000149180
aco2
aconitase 2, mitochondrial
chr13_+_9496748 0.25 ENSDART00000147050
ENSDART00000102120
CR848040.4

chr6_-_12275836 0.24 ENSDART00000189980
pkp4
plakophilin 4
chr7_-_40630698 0.23 ENSDART00000134547
ube3c
ubiquitin protein ligase E3C
chr25_-_27819838 0.23 ENSDART00000067106
lmod2a
leiomodin 2 (cardiac) a
chr19_-_18313303 0.22 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
si:dkey-208k4.2
chr10_+_27021164 0.21 ENSDART00000183538
BX248510.12

chr18_+_13236255 0.20 ENSDART00000091560
tldc1
TBC/LysM-associated domain containing 1
chr24_-_32582378 0.19 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr6_+_31368071 0.19 ENSDART00000038990
jak1
Janus kinase 1
chr22_-_17458070 0.19 ENSDART00000139658
si:ch211-197g15.10
si:ch211-197g15.10
chr13_-_17723417 0.18 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr8_-_29658171 0.18 ENSDART00000147755
mpeg1.3
macrophage expressed 1, tandem duplicate 3
chr19_-_10810006 0.16 ENSDART00000151157
si:dkey-3n22.9
si:dkey-3n22.9
chr8_-_17822259 0.16 ENSDART00000063587
st6galnac5b
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5b
chr20_-_14114078 0.16 ENSDART00000168434
ENSDART00000104032
si:ch211-223m11.2
si:ch211-223m11.2
chr7_+_34453185 0.15 ENSDART00000173875
ENSDART00000173921
ENSDART00000173995
si:cabz01009626.1
si:cabz01009626.1
chr19_+_26718074 0.15 ENSDART00000134455
zgc:100906
zgc:100906
chr16_+_10318893 0.15 ENSDART00000055380
tubb5
tubulin, beta 5
chr2_+_19522082 0.14 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr11_+_31864921 0.14 ENSDART00000180252
diaph3
diaphanous-related formin 3
chr13_-_6279684 0.14 ENSDART00000092105
agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr7_-_59123066 0.14 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr17_-_53329704 0.14 ENSDART00000193895
exd1
exonuclease 3'-5' domain containing 1
chr2_+_10007113 0.13 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr2_+_19578079 0.13 ENSDART00000144413
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr13_-_30142087 0.11 ENSDART00000110157
tysnd1
trypsin domain containing 1
chr1_-_44812014 0.11 ENSDART00000139044
si:dkey-9i23.8
si:dkey-9i23.8
chr4_-_9891874 0.11 ENSDART00000067193
adm2a
adrenomedullin 2a
chr20_+_14114258 0.08 ENSDART00000044937
kcns3b
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr13_-_36663358 0.07 ENSDART00000085319
sos2
son of sevenless homolog 2 (Drosophila)
chr7_+_26173751 0.07 ENSDART00000065131
si:ch211-196f2.7
si:ch211-196f2.7
chr4_+_73215536 0.06 ENSDART00000174290
LO018260.2
Danio rerio protein NLRC3-like (LOC101883187), mRNA.
chr25_-_7705487 0.06 ENSDART00000128099
prdm11
PR domain containing 11
chr3_-_40836081 0.06 ENSDART00000143135
wipi2
WD repeat domain, phosphoinositide interacting 2
chr25_+_469855 0.06 ENSDART00000104717
rsl24d1
ribosomal L24 domain containing 1
chr25_+_36312459 0.05 ENSDART00000182484
CR354435.5

chr8_-_4031121 0.04 ENSDART00000169474
ENSDART00000163754
mtmr3
myotubularin related protein 3
chr14_+_45306073 0.03 ENSDART00000034606
ENSDART00000173301
sfxn5b
sideroflexin 5b
chr12_+_3078221 0.01 ENSDART00000148835
ENSDART00000149427
sgca
sarcoglycan, alpha
chr1_-_50791280 0.00 ENSDART00000181224
CABZ01031870.1

chr1_+_55758257 0.00 ENSDART00000139312
tecrb
trans-2,3-enoyl-CoA reductase b

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx1.2lb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.2 0.9 GO:0016116 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.1 0.8 GO:0097065 anterior head development(GO:0097065)
0.1 0.7 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.5 GO:0007508 larval development(GO:0002164) larval heart development(GO:0007508)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.5 GO:0021767 mammillary body development(GO:0021767)
0.1 0.8 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.8 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.5 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.5 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.6 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.3 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.0 0.3 GO:0003352 regulation of cilium movement(GO:0003352)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.1 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.8 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.5 GO:0043687 protein N-linked glycosylation via asparagine(GO:0018279) post-translational protein modification(GO:0043687)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0014823 response to activity(GO:0014823)
0.0 0.6 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.2 GO:0033077 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.3 GO:0006376 mRNA splice site selection(GO:0006376)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.9 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.3 GO:0005858 axonemal dynein complex(GO:0005858)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.1 0.8 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.2 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 0.8 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.6 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.9 GO:0032190 acrosin binding(GO:0032190)
0.1 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.1 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0043236 laminin binding(GO:0043236)
0.0 0.3 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)