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PRJEB1986: zebrafish developmental stages transcriptome

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Results for nfkb1_rela

Z-value: 0.94

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Transcription factors associated with nfkb1_rela

Gene Symbol Gene ID Gene Info
ENSDARG00000105261 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
ENSDARG00000098696 v-rel avian reticuloendotheliosis viral oncogene homolog A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfkb1dr11_v1_chr14_-_49859747_498598230.351.4e-01Click!
reladr11_v1_chr7_-_804515_804515-0.341.6e-01Click!

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_50175069 2.93 ENSDART00000192979
lens intrinsic membrane protein 2.5
chr3_-_28120092 2.83 ENSDART00000151143
RNA binding fox-1 homolog 1
chr23_+_45579497 2.60 ENSDART00000110381
early growth response 4
chr2_+_42191592 2.27 ENSDART00000144716
caveolae associated protein 4a
chr21_+_28958471 2.22 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr19_+_19412692 2.21 ENSDART00000113580
wu:fc38h03
chr3_-_32170850 2.21 ENSDART00000055307
ENSDART00000157366
troponin T type 1 (skeletal, slow)
chr3_+_11568523 2.10 ENSDART00000179668

chr25_+_37397031 1.95 ENSDART00000193643
ENSDART00000169132
solute carrier family 1 (glial high affinity glutamate transporter), member 2b
chr1_-_30039331 1.74 ENSDART00000086935
ENSDART00000143800
zgc:153256
chr15_-_24869826 1.71 ENSDART00000127047
tumor suppressor candidate 5a
chr6_-_10305918 1.69 ENSDART00000090994
sodium channel, voltage-gated, type I like, alpha b
chr10_-_39011514 1.63 ENSDART00000075123
Purkinje cell protein 4a
chr6_-_607063 1.61 ENSDART00000189900
lectin, galactoside-binding, soluble, 2b
chr3_+_46459540 1.61 ENSDART00000188150
si:ch211-66e2.5
chr18_-_5527050 1.60 ENSDART00000145400
ENSDART00000132498
ENSDART00000146209
zgc:153317
chr1_-_45888608 1.59 ENSDART00000139219
patatin-like phospholipase domain containing 6
chr22_+_14051245 1.57 ENSDART00000043711
ENSDART00000164259
aldehyde oxidase 6
chr13_-_9318891 1.56 ENSDART00000137364
si:dkey-33c12.3
chr14_-_49859747 1.55 ENSDART00000169456
ENSDART00000164967
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr6_+_2195625 1.52 ENSDART00000155659
activin A receptor type 1Bb
chr1_+_42225060 1.51 ENSDART00000138740
ENSDART00000101306
catenin (cadherin-associated protein), alpha 2
chr6_+_48664275 1.51 ENSDART00000161184
si:dkey-238f9.1
chr14_-_4121052 1.49 ENSDART00000167074
interferon regulatory factor 2
chr4_+_18806251 1.45 ENSDART00000138662
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr1_+_32528097 1.43 ENSDART00000128317
neuroligin 4a
chr14_-_31080183 1.42 ENSDART00000173282
muscleblind-like splicing regulator 3
chr20_+_28434196 1.37 ENSDART00000034245
D4, zinc and double PHD fingers, family 3
chr20_+_16881883 1.34 ENSDART00000130107
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr20_+_33981946 1.33 ENSDART00000131775
si:dkey-51e6.1
chr14_+_3038473 1.33 ENSDART00000026021
ENSDART00000150000
CD74 molecule, major histocompatibility complex, class II invariant chain a
chr13_-_22843562 1.32 ENSDART00000142738
phenazine biosynthesis like protein domain containing
chr1_+_16397063 1.30 ENSDART00000159794
mitochondrial calcium uptake family, member 3a
chr2_-_51772438 1.29 ENSDART00000170241
Danio rerio three-finger protein 5 (LOC100003647), mRNA.
chr22_-_38137908 1.28 ENSDART00000104528
transmembrane 4 L six family member 4
chr17_-_51195651 1.26 ENSDART00000191205
ENSDART00000088185
papilin a, proteoglycan-like sulfated glycoprotein
chr16_+_1803462 1.25 ENSDART00000183974
glutamate ionotropic receptor kainate type subunit 2
chr8_-_46572298 1.25 ENSDART00000030470
sulfotransferase family 1, cytosolic sulfotransferase 3
chr23_-_32162810 1.24 ENSDART00000155905
nuclear receptor subfamily 4, group A, member 1
chr1_+_51896147 1.23 ENSDART00000167139
nuclear factor I/Xa
chr22_+_110158 1.23 ENSDART00000143698
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr1_+_16396870 1.21 ENSDART00000189245
ENSDART00000113266
mitochondrial calcium uptake family, member 3a
chr4_+_3389866 1.21 ENSDART00000153834
synaptophysin-like 1
chr21_+_25226558 1.19 ENSDART00000168480
syncollin, tandem duplicate 2
chr13_-_2010191 1.19 ENSDART00000161021
ENSDART00000124134
GDNF family receptor alpha like
chr4_-_149334 1.18 ENSDART00000163280
TANK-binding kinase 1
chr25_-_27843066 1.16 ENSDART00000179684
ENSDART00000186000
ENSDART00000190065
ankyrin repeat and SOCS box containing 15a
chr14_-_4120636 1.16 ENSDART00000059230
interferon regulatory factor 2
chr25_+_5821910 1.14 ENSDART00000161035
chromosome 12 open reading frame 75
chr7_+_39634873 1.14 ENSDART00000114774
protein tyrosine phosphatase, non-receptor type 5
chr23_-_12423778 1.13 ENSDART00000124091
WAP four-disulfide core domain 2
chr7_-_16204885 1.12 ENSDART00000171008
bloodthirsty-related gene family, member 5
chr19_+_1606185 1.12 ENSDART00000092183
leucine rich repeat containing 3B
chr24_+_26006730 1.10 ENSDART00000140384
ENSDART00000139184
chemokine (C-C motif) ligand 20b
chr11_-_32723851 1.05 ENSDART00000155592
protocadherin 17
chr14_-_7888748 1.04 ENSDART00000166293
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_+_48634927 1.04 ENSDART00000168441
zgc:165653
chr14_-_30967284 1.04 ENSDART00000149435
interleukin 2 receptor, gamma b
chr14_-_30642819 1.03 ENSDART00000078154
neuronal PAS domain protein 4a
chr13_+_27316934 1.01 ENSDART00000164533
eukaryotic translation elongation factor 1 alpha 1a
chr22_-_20011476 1.01 ENSDART00000093312
ENSDART00000093310
cugbp, Elav-like family member 5a
chr2_+_45191049 1.01 ENSDART00000165392
chemokine (C-C motif) ligand 20a, duplicate 3
chr19_-_44801918 0.98 ENSDART00000108507
si:ch211-233f16.1
chr1_+_12135129 0.97 ENSDART00000126020
serine peptidase inhibitor, Kazal type 4
chr12_+_7445595 0.96 ENSDART00000103536
ENSDART00000152524
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr17_+_20205185 0.96 ENSDART00000167007
gonadotropin-releasing hormone 3
chr12_+_26471712 0.95 ENSDART00000162115
nudE neurodevelopment protein 1-like 1a
chr16_-_27749172 0.91 ENSDART00000145198
STEAP family member 4
chr12_+_49100365 0.90 ENSDART00000171905

chr21_-_435466 0.89 ENSDART00000110297
Kruppel-like factor 4
chr20_+_22045089 0.88 ENSDART00000063564
ENSDART00000187013
ENSDART00000161552
ENSDART00000174478
ENSDART00000063568
ENSDART00000152247
neuromedin U
chr16_-_12984631 0.87 ENSDART00000184863
calcium channel, voltage-dependent, gamma subunit 7b
chr13_+_27316632 0.87 ENSDART00000016121
eukaryotic translation elongation factor 1 alpha 1a
chr1_+_54677173 0.86 ENSDART00000114705
G protein-coupled receptor, class C, group 5, member Bb
chr14_+_36889893 0.86 ENSDART00000124159
si:ch211-132p1.3
chr3_-_40976463 0.84 ENSDART00000128450
ENSDART00000018676
cytochrome P450, family 3, subfamily c, polypeptide 1
chr2_-_50966124 0.84 ENSDART00000170470
growth hormone releasing hormone receptor a
chr25_+_10458990 0.83 ENSDART00000130354
ENSDART00000044738
RIC8 guanine nucleotide exchange factor A
chr17_+_1063988 0.81 ENSDART00000160400
GTP cyclohydrolase I feedback regulator
chr16_-_16590780 0.80 ENSDART00000059841
si:ch211-257p13.3
chr3_-_21242460 0.80 ENSDART00000007293
titin-cap (telethonin)
chr13_-_45795722 0.80 ENSDART00000141779
fibronectin type III domain containing 5a
chr4_-_25485214 0.78 ENSDART00000159941
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr20_-_8321280 0.78 ENSDART00000083906
ENSDART00000186477
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr10_-_14536399 0.78 ENSDART00000186501
haloacid dehalogenase-like hydrolase domain containing 2
chr19_-_11208782 0.78 ENSDART00000044426
ENSDART00000189754
si:dkey-240h12.4
chr13_+_12739283 0.77 ENSDART00000102279
leucine rich repeat and Ig domain containing 2b
chr9_+_53707240 0.77 ENSDART00000171490
si:ch211-199f5.1
chr14_+_45028062 0.76 ENSDART00000184717
ENSDART00000185481
ATPase phospholipid transporting 8A1
chr24_-_12689571 0.76 ENSDART00000015517
programmed cell death 6
chr4_-_25485404 0.75 ENSDART00000041402
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr14_+_36885524 0.75 ENSDART00000032547
leukocyte cell-derived chemotaxin 2 like
chr9_+_993477 0.75 ENSDART00000182045

chr2_-_57227542 0.75 ENSDART00000182675
ENSDART00000159480
BTB (POZ) domain containing 2b
chr9_-_6380653 0.74 ENSDART00000078523
esophageal cancer related gene 4a
chr9_+_31752628 0.74 ENSDART00000060054
integrin, beta-like 1
chr17_+_8175998 0.74 ENSDART00000131200
myc target 1b
chr8_+_53269657 0.73 ENSDART00000184212
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr16_-_41004731 0.73 ENSDART00000102591
si:dkey-201i6.2
chr4_+_13810811 0.72 ENSDART00000067168
PDZ domain containing ring finger 4
chr24_-_33703504 0.71 ENSDART00000079292
caveolae associated protein 4b
chr2_+_6963296 0.71 ENSDART00000147146
discoidin domain receptor tyrosine kinase 2b
chr25_-_35960229 0.70 ENSDART00000073434
sorting nexin 20
chr14_+_49376011 0.69 ENSDART00000020961
TNFAIP3 interacting protein 1
chr21_-_43088991 0.68 ENSDART00000189683
si:ch73-68b22.2
chr16_+_46148990 0.68 ENSDART00000083919
synaptic vesicle glycoprotein 2A
chr2_-_9857932 0.67 ENSDART00000154490
si:ch211-252f13.5
chr14_+_1719367 0.67 ENSDART00000157696
transient receptor potential cation channel, subfamily C, member 7b
chr20_+_48100261 0.67 ENSDART00000158604
XK related 5a
chr12_-_26153101 0.66 ENSDART00000076051
opsin 4b
chr25_-_1235457 0.65 ENSDART00000093093
coronin, actin binding protein, 2Bb
chr16_+_10346277 0.65 ENSDART00000081092
si:dkeyp-77h1.4
chr14_-_2221877 0.64 ENSDART00000106704
protocadherin 2 alpha b 1
chr23_+_3616224 0.63 ENSDART00000190917
si:dkey-9l20.3
chr12_+_20641471 0.63 ENSDART00000133654
calcium binding and coiled-coil domain 2
chr2_+_21356242 0.63 ENSDART00000145670
ENSDART00000146600
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b
chr5_-_38342992 0.62 ENSDART00000140337
misshapen-like kinase 1
chr21_-_22693730 0.62 ENSDART00000158342
grass carp reovirus (GCRV)-induced gene 2d
chr17_-_722218 0.62 ENSDART00000160385
solute carrier family 25 member 29
chr3_-_52644737 0.61 ENSDART00000126180
si:dkey-210j14.3
chr15_+_17100412 0.61 ENSDART00000154418
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr11_-_11458208 0.61 ENSDART00000005485
keratin 93
chr23_-_437467 0.61 ENSDART00000192106
tetraspanin 2b
chr13_-_27916439 0.60 ENSDART00000139081
ENSDART00000087097
opioid growth factor receptor-like 1
chr24_-_11127493 0.60 ENSDART00000144066
myosin VIIA and Rab interacting protein
chr14_+_49381828 0.60 ENSDART00000169441
TNFAIP3 interacting protein 1
chr9_-_23894392 0.59 ENSDART00000133417
ankyrin repeat and SOCS box containing 18
chr20_-_20533865 0.59 ENSDART00000125039
SIX homeobox 6b
chr8_-_20230559 0.59 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr21_-_44009169 0.59 ENSDART00000028960
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2
chr16_+_26766423 0.58 ENSDART00000048036
GTP binding protein overexpressed in skeletal muscle
chr2_-_53592532 0.58 ENSDART00000184066
chemokine (C-C motif) ligand 25a
chr21_-_3201027 0.58 ENSDART00000161256
zinc finger and BTB domain containing 7C
chr23_+_3591690 0.58 ENSDART00000180822
si:dkey-9l20.3
chr8_+_25302172 0.58 ENSDART00000046182
ENSDART00000145316
glutathione S-transferase mu tandem duplicate 3
chr7_+_39758714 0.57 ENSDART00000111278
sortilin-related VPS10 domain containing receptor 2
chr1_+_41690402 0.57 ENSDART00000177298
F-box protein 41
chr16_+_54691594 0.57 ENSDART00000168991

chr16_-_22225295 0.57 ENSDART00000163519

chr5_+_9382301 0.57 ENSDART00000124017
UDP glucuronosyltransferase 2 family, polypeptide A7
chr24_+_29449690 0.56 ENSDART00000105743
ENSDART00000193556
ENSDART00000145816
netrin g1a
chr9_+_41156287 0.55 ENSDART00000189195
ENSDART00000186270
signal transducer and activator of transcription 4
chr5_+_30608057 0.55 ENSDART00000133583
si:ch211-117m20.4
chr9_-_32604414 0.55 ENSDART00000088876
ENSDART00000166502
SATB homeobox 2
chr11_+_40544269 0.55 ENSDART00000175424
ENSDART00000184673
membrane metallo-endopeptidase-like 1
chr15_-_1962326 0.55 ENSDART00000179669
dedicator of cytokinesis 10
chr20_+_37383034 0.55 ENSDART00000134997
ENSDART00000145927
adhesion G protein-coupled receptor G6
chr14_-_1646360 0.54 ENSDART00000186528

chr3_+_55131289 0.53 ENSDART00000111585

chr18_-_6460102 0.53 ENSDART00000137037
IQ motif and Sec7 domain 3b
chr6_-_442163 0.53 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
GRB2-related adaptor protein 2b
chr22_-_31517300 0.52 ENSDART00000164799
solute carrier family 6 (neurotransmitter transporter), member 6b
chr19_-_46088429 0.52 ENSDART00000161385
phosphatidylserine synthase 1b
chr8_+_53452681 0.52 ENSDART00000166705
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr16_-_11798994 0.51 ENSDART00000135408
cornifelin
chr3_+_13190012 0.51 ENSDART00000179747
ENSDART00000109876
ENSDART00000124824
ENSDART00000130261
Sad1 and UNC84 domain containing 1
chr1_+_31113951 0.51 ENSDART00000129362
eukaryotic translation elongation factor 1 alpha 1b
chr25_-_1333676 0.51 ENSDART00000183182
ENSDART00000188907
CLN6, transmembrane ER protein b
chr16_+_23403602 0.50 ENSDART00000159848
S100 calcium binding protein W
chr12_+_22576404 0.50 ENSDART00000172053
capping protein (actin filament), gelsolin-like b
chr18_+_2563756 0.50 ENSDART00000164147
purinergic receptor P2Y2, tandem duplicate 1
chr20_-_45040916 0.49 ENSDART00000190001
kelch-like family member 29
chr11_-_396724 0.49 ENSDART00000184375

chr13_+_30692669 0.49 ENSDART00000187818

chr14_-_2267515 0.49 ENSDART00000180988
ENSDART00000130712
protocadherin 2 alpha a 15
chr7_-_15413019 0.48 ENSDART00000172147
si:ch211-106j24.1
chr6_+_49771626 0.48 ENSDART00000134207
cathepsin Z
chr12_+_41420355 0.48 ENSDART00000158811
enhancer of polycomb homolog 1 (Drosophila) a
chr15_+_14109652 0.48 ENSDART00000156370
chloride channel accessory 1
chr19_-_42249597 0.48 ENSDART00000184762

chr15_+_42235449 0.47 ENSDART00000114801
ENSDART00000182053
sphingosine-1-phosphate phosphatase 2
chr12_+_5081759 0.47 ENSDART00000164178
proline-rich transmembrane protein 2
chr12_-_3903886 0.47 ENSDART00000184214
ENSDART00000041082
glycerophosphodiester phosphodiesterase domain containing 3b
chr7_+_57677120 0.47 ENSDART00000110623
arylsulfatase family, member J
chr22_-_6801876 0.47 ENSDART00000135726
si:ch1073-188e1.1
chr22_-_34591295 0.47 ENSDART00000044429
ring finger protein 123
chr16_+_32995882 0.47 ENSDART00000170157
protease, serine, 35
chr11_-_36765376 0.46 ENSDART00000163210
calcium channel, voltage dependent, alpha2/delta subunit 3
chr5_+_58996765 0.45 ENSDART00000062175
derlin 2
chr25_+_8955530 0.44 ENSDART00000156444
si:ch211-256a21.4
chr5_-_41841675 0.44 ENSDART00000141683
si:dkey-65b12.6
chr4_+_7888047 0.44 ENSDART00000104676
calcium/calmodulin-dependent protein kinase 1Da
chr1_-_52431220 0.44 ENSDART00000111256
zgc:194101
chr23_-_43609595 0.44 ENSDART00000172222

chr14_-_2209742 0.44 ENSDART00000054889
protocadherin 2 alpha b 5
chr18_+_27738349 0.43 ENSDART00000187816
tetraspanin 18b
chr4_-_33525219 0.43 ENSDART00000150491

chr12_-_25217217 0.43 ENSDART00000152931
potassium voltage-gated channel, subfamily G, member 3
chr25_-_13188214 0.42 ENSDART00000187298
si:ch211-147m6.1
chr5_+_51909740 0.42 ENSDART00000162541
thrombospondin 4a
chr10_-_9115383 0.42 ENSDART00000139324
si:dkeyp-41f9.3
chr3_-_40976288 0.42 ENSDART00000193553
cytochrome P450, family 3, subfamily c, polypeptide 1
chr19_-_307246 0.41 ENSDART00000145916
leucine rich repeat and Ig domain containing 4a
chr25_+_35706493 0.41 ENSDART00000176741
kinesin family member 21A
chr6_+_49771372 0.41 ENSDART00000063251
cathepsin Z
chr8_+_25629722 0.40 ENSDART00000026807
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr17_-_7733037 0.40 ENSDART00000064657
syntaxin 11a
chr8_-_5220125 0.40 ENSDART00000035676
BCL2 interacting protein 3 like a
chr22_-_16180467 0.40 ENSDART00000171331
ENSDART00000185607
vascular cell adhesion molecule 1b
chr10_-_29120515 0.40 ENSDART00000162016
ENSDART00000149140
zona pellucida-like domain containing 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.5 1.4 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468)
0.4 1.3 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.4 1.3 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.4 1.3 GO:0030857 negative regulation of epithelial cell differentiation(GO:0030857)
0.4 1.5 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.3 2.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.3 3.9 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.2 0.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 0.9 GO:0015677 copper ion import(GO:0015677)
0.2 1.0 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.2 0.8 GO:0035994 response to muscle stretch(GO:0035994)
0.2 0.6 GO:0072679 thymocyte migration(GO:0072679)
0.2 0.5 GO:0060879 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.2 0.9 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 2.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 1.2 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.1 0.5 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.1 0.6 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 1.6 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.1 0.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.3 GO:0003097 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.1 0.7 GO:0033292 T-tubule organization(GO:0033292)
0.1 0.8 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 1.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 2.0 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.1 1.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.2 GO:0045191 response to protozoan(GO:0001562) TRIF-dependent toll-like receptor signaling pathway(GO:0035666) defense response to protozoan(GO:0042832) regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.1 1.3 GO:0006584 catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712)
0.1 0.9 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.1 0.2 GO:0060945 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.1 1.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.7 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 0.2 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 0.6 GO:0031639 plasminogen activation(GO:0031639)
0.1 0.9 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 1.4 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 2.4 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.5 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 1.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0035777 pronephric distal tubule development(GO:0035777)
0.0 0.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.2 GO:0090134 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.0 0.4 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.4 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.3 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 2.1 GO:0006414 translational elongation(GO:0006414)
0.0 0.5 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0006953 acute-phase response(GO:0006953)
0.0 0.3 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.0 0.2 GO:0007141 male meiosis I(GO:0007141)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 1.1 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.4 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.9 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.1 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.4 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.1 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.9 GO:0097696 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)
0.0 0.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.6 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.0 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0008207 C21-steroid hormone metabolic process(GO:0008207)
0.0 1.2 GO:0048741 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.5 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.2 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.5 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.3 GO:0005955 calcineurin complex(GO:0005955)
0.2 2.5 GO:1990246 uniplex complex(GO:1990246)
0.2 1.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.9 GO:0070062 extracellular exosome(GO:0070062)
0.1 1.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.5 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.5 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 2.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.4 GO:0030314 junctional membrane complex(GO:0030314)
0.1 3.0 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.1 2.3 GO:0005861 troponin complex(GO:0005861)
0.1 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.8 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0070743 interleukin-12 complex(GO:0043514) interleukin-23 complex(GO:0070743)
0.0 0.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 2.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0008305 integrin complex(GO:0008305)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.1 GO:0034703 cation channel complex(GO:0034703)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.3 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 1.6 GO:0004031 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.3 1.3 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.3 1.0 GO:0031530 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.3 1.2 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.3 1.5 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 0.9 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 1.6 GO:0016936 galactoside binding(GO:0016936)
0.2 0.5 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 1.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 1.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 2.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.3 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 1.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 0.2 GO:0031704 apelin receptor binding(GO:0031704)
0.1 1.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.6 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.6 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.2 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1 2.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0043295 glutathione binding(GO:0043295)
0.0 2.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.3 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 2.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0019972 interleukin-12 binding(GO:0019972) interleukin-12 alpha subunit binding(GO:0042164)
0.0 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0005549 olfactory receptor activity(GO:0004984) odorant binding(GO:0005549)
0.0 0.4 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.2 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.0 0.5 GO:0043236 laminin binding(GO:0043236)
0.0 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 3.0 GO:0008201 heparin binding(GO:0008201)
0.0 0.5 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.0 2.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.4 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.9 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 1.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 2.3 GO:0015293 symporter activity(GO:0015293)
0.0 0.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)
0.0 0.3 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 0.2 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 3.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 3.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.2 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport