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PRJEB1986: zebrafish developmental stages transcriptome

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Results for mycb

Z-value: 0.76

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Transcription factors associated with mycb

Gene Symbol Gene ID Gene Info
ENSDARG00000007241 MYC proto-oncogene, bHLH transcription factor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mycbdr11_v1_chr2_+_32016256_320162560.915.1e-08Click!

Activity profile of mycb motif

Sorted Z-values of mycb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_8765428 2.49 ENSDART00000167793
MYB binding protein (P160) 1a
chr14_-_12822 2.13 ENSDART00000180650
ENSDART00000188819
muscle segment homeobox 1a
chr13_+_48359573 1.76 ENSDART00000161959
ENSDART00000165311
mutS homolog 6 (E. coli)
chr9_-_11587070 1.71 ENSDART00000030995
uridine monophosphate synthetase
chr1_-_19648227 1.71 ENSDART00000054574
polymerase (RNA) I polypeptide E
chr13_-_25199260 1.57 ENSDART00000057605
adenosine kinase a
chr10_+_16036573 1.57 ENSDART00000188757
lamin B1
chr12_-_4301234 1.55 ENSDART00000152377
ENSDART00000152521
carbonic anhydrase XVb
chr22_+_5118361 1.54 ENSDART00000168371
ENSDART00000170222
ENSDART00000158846
muscle-specific beta 1 integrin binding protein
chr19_-_24555623 1.53 ENSDART00000176022
polymerase (RNA) III (DNA directed) polypeptide G like a
chr5_+_68807170 1.53 ENSDART00000017849
hairy and enhancer of split related-7
chr13_+_13930263 1.50 ENSDART00000079154
ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase)
chr10_+_16036246 1.46 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lamin B1
chr16_+_23960933 1.45 ENSDART00000146077
apolipoprotein Eb
chr16_+_23960744 1.44 ENSDART00000058965
apolipoprotein Eb
chr19_-_24555935 1.33 ENSDART00000132660
ENSDART00000162801
polymerase (RNA) III (DNA directed) polypeptide G like a
chr13_-_35892051 1.32 ENSDART00000145884
transforming, acidic coiled-coil containing protein 3
chr9_+_38158570 1.30 ENSDART00000059549
ENSDART00000133060
nucleolar protein interacting with the FHA domain of MKI67
chr10_+_39283985 1.29 ENSDART00000016464
decapping enzyme, scavenger
chr25_+_17405201 1.27 ENSDART00000164349
E2F transcription factor 4
chr23_-_28025943 1.26 ENSDART00000181146
Sp5 transcription factor-like
chr25_+_17405458 1.26 ENSDART00000186711
E2F transcription factor 4
chr17_-_48705993 1.25 ENSDART00000030934
potassium channel, subfamily K, member 5a
chr11_+_2198831 1.25 ENSDART00000160515
homeobox C6b
chr13_+_15702142 1.23 ENSDART00000135960
tRNA methyltransferase 61A
chr1_-_35916247 1.19 ENSDART00000181541
SMAD family member 1
chr3_-_23575007 1.18 ENSDART00000155282
ENSDART00000087726
insulin-like growth factor 2 mRNA binding protein 1
chr9_-_11676491 1.18 ENSDART00000022358
zinc finger CCCH-type containing 15
chr20_-_25645150 1.12 ENSDART00000063137
si:dkeyp-117h8.4
chr21_-_30408775 1.11 ENSDART00000101037
NHP2 ribonucleoprotein homolog (yeast)
chr16_+_23961276 1.08 ENSDART00000192754
apolipoprotein Eb
chr13_-_45022301 1.08 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
KH domain containing, RNA binding, signal transduction associated 1a
chr12_+_33975065 1.08 ENSDART00000036649
sideroflexin 2
chr5_-_54714789 1.08 ENSDART00000063357
cyclin B1
chr15_-_44052927 1.05 ENSDART00000166209
wu:fb44b02
chr13_+_25199849 1.05 ENSDART00000139209
ENSDART00000130876
adaptor-related protein complex 3, mu 1 subunit
chr9_+_27720428 1.05 ENSDART00000112415
leucine carboxyl methyltransferase 2
chr12_+_18445604 1.05 ENSDART00000078860
NADPH oxidase organizer 1b
chr25_+_19095231 1.04 ENSDART00000154066
interferon stimulated exonuclease gene
chr8_+_23355484 1.02 ENSDART00000085361
ENSDART00000125729
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr1_+_5485799 1.00 ENSDART00000022307
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr24_+_36317544 1.00 ENSDART00000048640
ENSDART00000156096
pseudouridylate synthase 3
chr5_-_54714525 0.99 ENSDART00000150138
ENSDART00000150070
cyclin B1
chr3_+_24595922 0.97 ENSDART00000169405
si:dkey-68o6.5
chr2_-_20715094 0.95 ENSDART00000155439
dual specificity phosphatase 12
chr20_-_22484621 0.95 ENSDART00000063601
GS homeobox 2
chr23_-_38160024 0.93 ENSDART00000087112
prefoldin subunit 4
chr13_-_35907768 0.91 ENSDART00000147522
MYCL proto-oncogene, bHLH transcription factor a
chr25_+_245438 0.89 ENSDART00000004689
zgc:92481
chr4_-_2945306 0.88 ENSDART00000128934
ENSDART00000019518
AE binding protein 2
chr20_+_25445826 0.88 ENSDART00000012581
phosphoribosylformylglycinamidine synthase
chr23_-_21535040 0.88 ENSDART00000010647
regulator of chromosome condensation 2
chr13_-_4992395 0.87 ENSDART00000102651
nucleolar and coiled-body phosphoprotein 1
chr14_+_22076596 0.87 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
solute carrier family 43 (amino acid system L transporter), member 1a
chr9_-_12652984 0.87 ENSDART00000052256
small ubiquitin-like modifier 3b
chr6_-_13114406 0.85 ENSDART00000188015
zgc:194469
chr9_-_21460164 0.85 ENSDART00000133469
zinc finger, MYM-type 2
chr4_-_64709908 0.85 ENSDART00000161032
si:dkey-9i5.2
chr14_+_16287968 0.84 ENSDART00000106593
pre-mRNA processing factor 19
chr8_-_46386024 0.83 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
glutaminyl-tRNA synthetase
chr20_+_25625872 0.82 ENSDART00000078385
phosphoribosyl pyrophosphate amidotransferase
chr11_+_3959495 0.81 ENSDART00000122953
guanine nucleotide binding protein-like 3 (nucleolar)
chr4_+_61171310 0.80 ENSDART00000141738
si:dkey-9p20.18
chr8_+_26059677 0.79 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr24_-_16905018 0.78 ENSDART00000066759
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr7_+_69449814 0.78 ENSDART00000109644
CTD nuclear envelope phosphatase 1b
chr18_-_127873 0.77 ENSDART00000148490
transient receptor potential cation channel, subfamily M, member 7
chr4_-_38033800 0.75 ENSDART00000159662
si:dkeyp-82b4.4
chr9_-_27719998 0.75 ENSDART00000161068
ENSDART00000148195
ENSDART00000138386
general transcription factor IIE, polypeptide 1, alpha
chr17_+_24318753 0.73 ENSDART00000064083
orthodenticle homeobox 1
chr9_-_29985390 0.72 ENSDART00000134157
interleukin 1 receptor accessory protein-like 1a
chr23_+_38159715 0.72 ENSDART00000137969
zgc:112994
chr23_-_21534455 0.71 ENSDART00000139092
regulator of chromosome condensation 2
chr18_-_5850683 0.71 ENSDART00000082087
NIP7, nucleolar pre-rRNA processing protein
chr21_-_14832369 0.70 ENSDART00000144859
pseudouridylate synthase 1
chr25_-_8513255 0.67 ENSDART00000150129
polymerase (DNA directed), gamma
chr1_-_54972170 0.66 ENSDART00000150548
ENSDART00000038330
KH-type splicing regulatory protein
chr5_+_72194444 0.65 ENSDART00000165436
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
chr6_-_10752937 0.64 ENSDART00000135093
Obg-like ATPase 1
chr5_-_61609448 0.63 ENSDART00000133426
si:dkey-261j4.5
chr13_+_39277178 0.63 ENSDART00000113259
si:dkey-85a20.4
chr6_-_58975010 0.63 ENSDART00000144911
ENSDART00000144514
methionyl-tRNA synthetase
chr10_+_29849977 0.61 ENSDART00000180242
heat shock protein 8
chr5_+_3927989 0.60 ENSDART00000030125
zinc finger, HIT-type containing 3
chr1_-_14533611 0.59 ENSDART00000180678

chr9_-_27720612 0.59 ENSDART00000000566
general transcription factor IIE, polypeptide 1, alpha
chr8_-_30979494 0.56 ENSDART00000138959
si:ch211-251j10.3
chr9_+_907459 0.56 ENSDART00000034850
ENSDART00000144114
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr16_-_31790285 0.56 ENSDART00000184655
chromodomain helicase DNA binding protein 4b
chr15_+_6652396 0.56 ENSDART00000192813
ENSDART00000157678
NOP53 ribosome biogenesis factor
chr10_+_29850330 0.55 ENSDART00000168898
heat shock protein 8
chr9_+_29985010 0.54 ENSDART00000020743
cms1 ribosomal small subunit homolog (yeast)
chr13_-_280652 0.54 ENSDART00000193627
solute carrier family 30 (zinc transporter), member 6
chr24_+_33392698 0.53 ENSDART00000122579
si:ch73-173p19.1
chr25_+_30442389 0.53 ENSDART00000003346
programmed cell death 2-like
chr16_+_16968682 0.53 ENSDART00000111074
si:ch211-120k19.1
chr7_-_39751540 0.52 ENSDART00000016803
GrpE-like 1, mitochondrial
chr7_+_1550966 0.52 ENSDART00000177863
ENSDART00000126840
SPT16 homolog, facilitates chromatin remodeling subunit
chr11_-_30636163 0.51 ENSDART00000140516
zgc:153665
chr1_-_26675969 0.51 ENSDART00000054184
tRNA methyltransferase O
chr11_+_25485774 0.50 ENSDART00000026249
guanine nucleotide binding protein-like 3 (nucleolar)-like
chr20_-_52882881 0.49 ENSDART00000111078
wu:fi04e12
chr9_+_41821613 0.49 ENSDART00000097295
collagen type XVIII alpha 1 chain a
chr6_-_32726848 0.48 ENSDART00000155294
zinc finger CCCH-type containing 3
chr21_-_11199366 0.47 ENSDART00000167666
DnaJ (Hsp40) homolog, subfamily C, member 21
chr20_-_25631256 0.46 ENSDART00000048164
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr8_-_13678415 0.44 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
chr17_+_51682429 0.44 ENSDART00000004379
nucleolar protein 10
chr20_-_48470599 0.44 ENSDART00000166857

chr16_+_16969060 0.44 ENSDART00000182819
ENSDART00000191876
si:ch211-120k19.1
ribosomal protein L18
chr7_+_41322407 0.43 ENSDART00000114076
ENSDART00000139093
DPH2 homolog (S. cerevisiae)
chr22_-_20733822 0.43 ENSDART00000133780
si:dkey-3k20.1
chr16_-_38629208 0.42 ENSDART00000126705
eukaryotic translation initiation factor 3, subunit E, a
chr2_-_42375275 0.42 ENSDART00000026339
GTP binding protein 4
chr23_-_21534738 0.42 ENSDART00000134587
regulator of chromosome condensation 2
chr6_-_39080630 0.42 ENSDART00000021520
ENSDART00000128308
eukaryotic translation initiation factor 4Bb
chr14_+_20941038 0.42 ENSDART00000182539
zgc:66433
chr24_+_16905188 0.41 ENSDART00000066760
chaperonin containing TCP1, subunit 5 (epsilon)
chr17_+_13099476 0.41 ENSDART00000012670
pinin, desmosome associated protein
chr2_-_37803614 0.40 ENSDART00000154124
nuclear factor of activated T cells 4
chr23_+_23485858 0.39 ENSDART00000114067
agrin
chr7_-_38714544 0.39 ENSDART00000139382
F-box protein 3
chr14_+_28432737 0.39 ENSDART00000026846
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
chr19_-_26964348 0.39 ENSDART00000103955
zinc finger and BTB domain containing 12, tandem duplicate 2
chr8_-_40251126 0.38 ENSDART00000180435
lysine (K)-specific demethylase 2Ba
chr7_+_52887701 0.38 ENSDART00000109973
tumor protein p53 binding protein, 1
chr8_+_25295160 0.38 ENSDART00000049793
glutathione S-transferase mu, tandem duplicate 1
chr21_-_34032650 0.37 ENSDART00000138575
ENSDART00000047515
ring finger protein 145b
chr15_+_44053244 0.37 ENSDART00000059550
leucine rich repeat containing 51
chr18_+_20225961 0.37 ENSDART00000045679
transducin-like enhancer of split 3a
chr5_-_3927692 0.37 ENSDART00000146840
ENSDART00000058346
complement component 1, q subcomponent binding protein
chr1_+_17376922 0.36 ENSDART00000145068
FAT atypical cadherin 1a
chr19_-_791016 0.36 ENSDART00000037515
misato 1, mitochondrial distribution and morphology regulator
chr24_+_32668675 0.36 ENSDART00000156638
ENSDART00000155973
si:ch211-282b22.1
chr2_+_19236969 0.36 ENSDART00000163875
ENSDART00000168644
coiled-coil and C2 domain containing 1B
chr14_+_5385855 0.36 ENSDART00000031508
ladybird homeobox 2
chr1_+_31674297 0.34 ENSDART00000044214
WW domain binding protein 1-like b
chr1_-_54971968 0.34 ENSDART00000140016
KH-type splicing regulatory protein
chr8_-_23599096 0.33 ENSDART00000183096
solute carrier family 38, member 5b
chr1_-_29061285 0.32 ENSDART00000053933
ENSDART00000142350
ENSDART00000192615
gem (nuclear organelle) associated protein 8
chr13_-_9367647 0.30 ENSDART00000083362
ENSDART00000144146
si:dkey-33c12.4
chr4_+_90048 0.30 ENSDART00000166440
low density lipoprotein receptor-related protein 6
chr1_-_26676391 0.30 ENSDART00000152492
tRNA methyltransferase O
chr22_+_10713713 0.29 ENSDART00000122349
hippocampus abundant transcript 1b
chr14_+_52408619 0.28 ENSDART00000163856
nitric oxide associated 1
chr11_-_12800945 0.28 ENSDART00000191178
taxilin gamma
chr13_+_30912117 0.28 ENSDART00000133138
dorsal root ganglia homeobox
chr4_-_28375127 0.27 ENSDART00000190198
Tp53rk binding protein
chr3_+_28939759 0.26 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr10_-_14929630 0.25 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
SMAD family member 2
chr24_-_16904803 0.24 ENSDART00000165972
ENSDART00000149974
ENSDART00000149706
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr8_-_39977026 0.24 ENSDART00000141707
aspartate beta-hydroxylase domain containing 2
chr2_+_39618951 0.23 ENSDART00000077108
zgc:136870
chr13_-_48431766 0.23 ENSDART00000159688
ENSDART00000171765
F-box protein 11a
chr6_-_16456093 0.23 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr8_-_52859301 0.23 ENSDART00000162004
nuclear receptor subfamily 5, group A, member 1a
chr11_-_12801157 0.22 ENSDART00000103449
taxilin gamma
chr6_-_7735153 0.21 ENSDART00000151545
solute carrier family 25, member 38b
chr22_-_26834043 0.21 ENSDART00000087202
si:dkey-44g23.5
chr5_-_41933912 0.21 ENSDART00000097574
nuclear receptor corepressor 1
chr12_-_34716037 0.21 ENSDART00000152876
BAH domain and coiled-coil containing 1b
chr2_-_5199431 0.20 ENSDART00000063384
prohibitin 2a
chr19_-_22346582 0.20 ENSDART00000045675
ENSDART00000169065
solute carrier family 52 (riboflavin transporter), member 2
zgc:109744
chr5_-_31875645 0.20 ENSDART00000098160
transmembrane protein 119b
chr21_+_38638979 0.19 ENSDART00000143373
RNA binding motif protein, X-linked 2
chr14_-_28432699 0.19 ENSDART00000054062
NIMA-related kinase 12
chr4_-_14192254 0.19 ENSDART00000143804
pseudouridylate synthase 7-like
chr23_+_44644911 0.19 ENSDART00000140799
zgc:85858
chr14_-_28568107 0.19 ENSDART00000042850
ENSDART00000145502
preproinsulin b
chr12_+_17436904 0.19 ENSDART00000079130
ATPase family, AAA domain containing 1b
chr17_-_45370200 0.19 ENSDART00000186208
zinc finger protein 106a
chr21_+_45510448 0.18 ENSDART00000160494
ENSDART00000167914
folliculin interacting protein 1
chr6_-_39653972 0.18 ENSDART00000155859
La ribonucleoprotein domain family, member 4Ab
chr9_+_33788389 0.18 ENSDART00000144623
lysine (K)-specific demethylase 6A
chr23_+_25135858 0.17 ENSDART00000103986
family with sequence similarity 3, member A
chr2_+_19236677 0.16 ENSDART00000166292
coiled-coil and C2 domain containing 1B
chr8_-_2246143 0.16 ENSDART00000135835
si:dkeyp-117b11.3
chr8_-_13471916 0.15 ENSDART00000146558
Pim proto-oncogene, serine/threonine kinase, related 105
chr8_-_13419049 0.15 ENSDART00000133656
Pim proto-oncogene, serine/threonine kinase, related 101
chr9_-_27391908 0.15 ENSDART00000135221
nucleolus and neural progenitor protein
chr2_+_18988407 0.15 ENSDART00000170216
glutamate-ammonia ligase (glutamine synthase) a
chr7_+_20017211 0.14 ENSDART00000100808
B-cell CLL/lymphoma 6, member B
chr14_-_47882706 0.14 ENSDART00000188772
Rap guanine nucleotide exchange factor (GEF) 2
chr15_-_14589677 0.13 ENSDART00000172195
coenzyme Q8B
chr22_-_28777557 0.13 ENSDART00000135214
ENSDART00000131761
ENSDART00000005112
si:dkeyp-34c12.1
chr6_-_54078623 0.13 ENSDART00000154076
hyaluronoglucosaminidase 1
chr22_+_17261801 0.12 ENSDART00000192978
ENSDART00000193187
ENSDART00000179953
ENSDART00000134798
tudor domain containing 5
chr22_+_28969071 0.12 ENSDART00000163427
Pim proto-oncogene, serine/threonine kinase, related 95
chr21_+_3941758 0.12 ENSDART00000181345
senataxin
chr15_-_3078600 0.12 ENSDART00000172842
fibronectin type III domain containing 3A
chr8_+_31799410 0.11 ENSDART00000141226
3-oxoacid CoA transferase 1a
chr24_-_21511737 0.10 ENSDART00000109587
ring finger protein (C3H2C3 type) 6
chr14_+_4796168 0.10 ENSDART00000041468
adaptor-related protein complex 1 associated regulatory protein
chr19_+_791538 0.10 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr4_+_36489448 0.09 ENSDART00000143181
zinc finger protein 1149
chr9_-_12888082 0.09 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
chr12_-_7607114 0.09 ENSDART00000158095
solute carrier family 16, member 9b
chr22_-_607812 0.09 ENSDART00000145983
cyclin-dependent kinase inhibitor 1A
chr11_+_6456146 0.08 ENSDART00000036939
growth arrest and DNA-damage-inducible, beta a
chr2_+_258698 0.07 ENSDART00000181330
ENSDART00000181645
PH domain and leucine rich repeat protein phosphatase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of mycb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0071831 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.6 1.8 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.4 1.3 GO:0001120 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.4 1.7 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.4 1.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.3 1.0 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.3 1.7 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.3 1.7 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.3 3.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 1.5 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.3 1.6 GO:0044209 AMP salvage(GO:0044209)
0.3 0.8 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.2 2.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.2 0.8 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.2 1.2 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.2 1.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.2 0.8 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.4 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 1.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 2.9 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.4 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.1 1.7 GO:0008354 germ cell migration(GO:0008354)
0.1 0.3 GO:0089709 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.8 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.1 1.0 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.8 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.7 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.4 GO:1904105 positive regulation of convergent extension involved in gastrulation(GO:1904105)
0.1 0.2 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.1 0.5 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.1 0.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 2.1 GO:0043049 otic placode formation(GO:0043049)
0.1 0.4 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 1.5 GO:0001757 somite specification(GO:0001757)
0.1 1.9 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.7 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.4 GO:0061056 sclerotome development(GO:0061056)
0.0 0.2 GO:0045117 azole transport(GO:0045117)
0.0 0.4 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 1.0 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.5 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.2 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.2 GO:0030325 adrenal gland development(GO:0030325)
0.0 1.3 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 1.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 1.3 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 2.5 GO:0006364 rRNA processing(GO:0006364)
0.0 1.2 GO:0051028 mRNA transport(GO:0051028)
0.0 2.5 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.5 GO:0043588 skin development(GO:0043588)
0.0 0.3 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.0 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.6 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.0 0.4 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.1 GO:1904019 activation of MAPKKK activity(GO:0000185) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035)
0.0 0.1 GO:0010165 response to X-ray(GO:0010165)
0.0 0.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0032447 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.7 2.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.6 1.8 GO:0032301 MutSalpha complex(GO:0032301)
0.3 1.1 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.3 1.3 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.2 1.2 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.2 2.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.8 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 1.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.8 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.4 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.1 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0035101 FACT complex(GO:0035101)
0.0 0.1 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0032797 SMN complex(GO:0032797)
0.0 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 2.0 GO:0030496 midbody(GO:0030496)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.5 GO:0014704 intercalated disc(GO:0014704)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 9.5 GO:0005730 nucleolus(GO:0005730)
0.0 2.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.6 1.8 GO:0032143 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.4 1.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.3 1.6 GO:0004001 adenosine kinase activity(GO:0004001)
0.3 2.0 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.3 1.0 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.2 0.7 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.2 1.5 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.2 1.1 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.2 1.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 0.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.5 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 0.2 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1 0.6 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.0 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 1.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.0 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 1.4 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 0.9 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.4 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 1.7 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 1.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.8 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.9 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.3 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 1.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 2.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.1 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.2 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 2.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.3 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.9 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID ATM PATHWAY ATM pathway
0.0 0.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 2.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.0 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 2.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.7 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.3 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.9 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 1.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 2.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.1 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways