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PRJEB1986: zebrafish developmental stages transcriptome

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Results for mtf1

Z-value: 0.51

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Transcription factors associated with mtf1

Gene Symbol Gene ID Gene Info
ENSDARG00000102898 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mtf1dr11_v1_chr16_+_4132537_4132537-0.351.4e-01Click!

Activity profile of mtf1 motif

Sorted Z-values of mtf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_10832092 1.01 ENSDART00000191851
translocase of outer mitochondrial membrane 40 homolog, like
chr7_+_49715750 0.99 ENSDART00000019446
achaete-scute family bHLH transcription factor 1b
chr23_-_45705525 0.86 ENSDART00000148959
endothelin receptor type Ab
chr2_-_7666021 0.72 ENSDART00000180007

chr16_-_7692568 0.70 ENSDART00000148980
Pim proto-oncogene, serine/threonine kinase, related 209
chr4_+_38981587 0.68 ENSDART00000142713
si:dkey-66k12.3
chr20_+_700616 0.67 ENSDART00000168166
SUMO1/sentrin specific peptidase 6a
chr11_-_18017287 0.66 ENSDART00000155443
glutamine-rich 1
chr22_-_14247276 0.65 ENSDART00000033332
si:ch211-246m6.5
chr1_-_35928942 0.63 ENSDART00000033566
SMAD family member 1
chr1_-_35929143 0.62 ENSDART00000185002
SMAD family member 1
chr1_-_54972170 0.61 ENSDART00000150548
ENSDART00000038330
KH-type splicing regulatory protein
chr8_+_22355909 0.59 ENSDART00000146457
ENSDART00000142883
zgc:153631
chr20_-_36408836 0.57 ENSDART00000076419
lamin B receptor
chr11_-_18017918 0.56 ENSDART00000040171
glutamine-rich 1
chr25_+_17313568 0.53 ENSDART00000125459
CCR4-NOT transcription complex, subunit 1
chr23_+_36178104 0.52 ENSDART00000103131
homeobox C1a
chr19_+_43017931 0.52 ENSDART00000132213
sodium/potassium transporting ATPase interacting 1
chr8_+_26059677 0.50 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr11_-_27827442 0.48 ENSDART00000121847
ENSDART00000132018
ENSDART00000145744
ENSDART00000134677
ENSDART00000130800
cleavage stimulation factor, 3' pre-RNA, subunit 1
chr25_+_3008263 0.48 ENSDART00000160484
neogenin 1b
chr3_+_1211242 0.47 ENSDART00000171287
ENSDART00000165769
polymerase (DNA-directed), delta interacting protein 3
chr1_-_54971968 0.46 ENSDART00000140016
KH-type splicing regulatory protein
chr14_-_31619408 0.46 ENSDART00000173277
membrane magnesium transporter 1
chr25_-_23526058 0.43 ENSDART00000191331
ENSDART00000062930
pleckstrin homology-like domain, family A, member 2
chr13_+_24671481 0.41 ENSDART00000001678
ADAM metallopeptidase domain 8a
chr3_+_53052769 0.41 ENSDART00000156935
pre-B-cell leukemia transcription factor 4
chr2_+_314249 0.40 ENSDART00000082086
zgc:113452
chr7_+_25323742 0.40 ENSDART00000110347
cytochrome P450, family 26, subfamily b, polypeptide 1
chr23_+_20931030 0.39 ENSDART00000167014
paired box 7b
chr8_-_39977026 0.37 ENSDART00000141707
aspartate beta-hydroxylase domain containing 2
chr6_+_31684 0.37 ENSDART00000188853
ENSDART00000184553

chr20_+_560805 0.36 ENSDART00000152149
si:dkey-121j17.6
chr8_+_1065458 0.36 ENSDART00000081432
sepiapterin reductase b
chr13_-_45022301 0.36 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
KH domain containing, RNA binding, signal transduction associated 1a
chr10_+_5954787 0.36 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr11_-_3334248 0.34 ENSDART00000154314
ENSDART00000121861
peripherin
chr23_+_32101361 0.33 ENSDART00000138849
zgc:56699
chr7_-_38861741 0.33 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
PHD finger protein 21Aa
chr6_-_37513133 0.32 ENSDART00000147826
jade family PHD finger 3
chr17_+_37215820 0.32 ENSDART00000104009
solute carrier family 30 (zinc transporter), member 1b
chr3_+_30500968 0.32 ENSDART00000103447
si:dkey-13n23.3
chr1_-_44000940 0.31 ENSDART00000134932
ENSDART00000138447
zgc:66472
chr1_-_59251874 0.31 ENSDART00000168919
olfactomedin 2b
chr23_-_20309505 0.29 ENSDART00000130856
laminin, beta 2-like
chr6_+_7553085 0.29 ENSDART00000150939
ENSDART00000151114
myosin, heavy chain 10, non-muscle
chr23_+_32101202 0.28 ENSDART00000000992
zgc:56699
chr24_-_4450238 0.27 ENSDART00000066835
frizzled class receptor 8a
chr2_+_327081 0.27 ENSDART00000155595
zgc:174263
chr3_+_18756231 0.25 ENSDART00000089679
nuclear prelamin A recognition factor-like
chr4_-_28334464 0.25 ENSDART00000123617
cadherin EGF LAG seven-pass G-type receptor 1a
chr9_+_156142 0.24 ENSDART00000171501
claudin 10b
chr18_-_7454422 0.24 ENSDART00000124709
putative pyruvate dehydrogenase phosphatase isoenzyme 2
chr11_-_16115804 0.23 ENSDART00000143436
ENSDART00000157928
ribosome production factor 1 homolog
chr24_-_19718077 0.23 ENSDART00000109107
ENSDART00000056082
cysteine-serine-rich nuclear protein 1b
chr4_+_57099307 0.23 ENSDART00000131654
si:ch211-238e22.2
chr18_-_50947868 0.23 ENSDART00000174276
suppression of tumorigenicity 7
chr23_-_18057270 0.22 ENSDART00000173385
zgc:92287
chr1_-_53750522 0.22 ENSDART00000190755
v-akt murine thymoma viral oncogene homolog 3b
chr12_-_48312647 0.22 ENSDART00000114415
activating signal cointegrator 1 complex subunit 1
chr6_-_7686594 0.22 ENSDART00000091836
ENSDART00000151697
ubinuclein 2a
chr22_+_569565 0.22 ENSDART00000037069
ubiquitin specific peptidase 49
chr19_+_37701450 0.21 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr23_+_4348479 0.21 ENSDART00000182425
v-myb avian myeloblastosis viral oncogene homolog-like 2a
chr1_+_44906517 0.21 ENSDART00000142820
wu:fc21g02
chr22_+_26703026 0.21 ENSDART00000158756
CREB binding protein a
chr23_+_23485858 0.21 ENSDART00000114067
agrin
chr16_-_19026414 0.20 ENSDART00000141208
Pim proto-oncogene, serine/threonine kinase, related 98
chr20_+_39250673 0.20 ENSDART00000153003
RALBP1 associated Eps domain containing 1
chr7_+_21275152 0.20 ENSDART00000173612
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr10_+_21434649 0.19 ENSDART00000193938
ENSDART00000064558
eukaryotic translation termination factor 1b
chr6_+_11397269 0.19 ENSDART00000114260
SUMO1/sentrin/SMT3 specific peptidase 2
chr6_+_6780873 0.19 ENSDART00000011865
Sec23 homolog B, COPII coat complex component
chr16_-_19026733 0.19 ENSDART00000104826
Pim proto-oncogene, serine/threonine kinase, related 98
chr24_+_28525507 0.19 ENSDART00000191121
Rho GTPase activating protein 29a
chr16_+_26449615 0.18 ENSDART00000039746
erythrocyte membrane protein band 4.1b
chr20_-_48470599 0.18 ENSDART00000166857

chr8_-_53926228 0.17 ENSDART00000015554
UbiA prenyltransferase domain containing 1
chr3_+_3469600 0.17 ENSDART00000113616
zgc:171426
chr20_+_13894123 0.17 ENSDART00000007744
solute carrier family 30 (zinc transporter), member 1a
chr23_+_4348265 0.17 ENSDART00000136287
v-myb avian myeloblastosis viral oncogene homolog-like 2a
chr7_+_39410180 0.17 ENSDART00000168641

chr24_-_3477103 0.16 ENSDART00000143723
isopentenyl-diphosphate delta isomerase 1
chr2_-_43739740 0.16 ENSDART00000113849
kinesin family member 5B, a
chr14_+_5117072 0.15 ENSDART00000189628
nanos homolog 1
chr22_-_37349967 0.15 ENSDART00000104493
SRY (sex determining region Y)-box 2
chr19_-_19556778 0.15 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr7_+_59169081 0.14 ENSDART00000167980
oligosaccharyltransferase complex subunit
chr3_+_30501135 0.14 ENSDART00000165869
si:dkey-13n23.3
chr2_+_41876595 0.14 ENSDART00000112243
cytokine receptor-like factor 1a
chr21_+_21621042 0.13 ENSDART00000134907
transforming growth factor, beta 1b
chr3_+_23221047 0.13 ENSDART00000009393
collagen, type I, alpha 1a
chr18_+_18000887 0.13 ENSDART00000147797
si:ch211-212o1.2
chr24_+_10397865 0.12 ENSDART00000155557
si:ch211-69l10.4
chr4_+_31085014 0.12 ENSDART00000172541
si:dkey-47k16.4
chr8_+_38417461 0.12 ENSDART00000132718
NK6 homeobox 3
chr20_-_54259780 0.12 ENSDART00000172631
FK506 binding protein 3
chr12_+_48851381 0.12 ENSDART00000187241
ENSDART00000187796
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr12_-_41759686 0.11 ENSDART00000172175
ENSDART00000165152
protein phosphatase 2, regulatory subunit B, delta
chr12_+_20149707 0.11 ENSDART00000181942
forkhead box J1b
chr19_+_31183495 0.11 ENSDART00000088618
mesenchyme homeobox 2b
chr23_+_45611980 0.11 ENSDART00000181582
doublecortin-like kinase 2b
chr7_+_74150839 0.10 ENSDART00000160195
protein phosphatase 1, catalytic subunit, beta isoform, like
chr1_-_16394814 0.10 ENSDART00000013024
fibroblast growth factor 20a
chr15_-_43284021 0.10 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr4_+_8376362 0.10 ENSDART00000138653
ENSDART00000132647
ELKS/RAB6-interacting/CAST family member 1b
chr6_-_20875111 0.10 ENSDART00000115118
ENSDART00000159916
tensin 1a
chr7_+_27691647 0.09 ENSDART00000079091
cytochrome P450, family 2, subfamily R, polypeptide 1
chr9_-_3519717 0.09 ENSDART00000145043
ddb1 and cul4 associated factor 17
chr12_-_49165751 0.09 ENSDART00000148491
ENSDART00000112479
acyl-CoA dehydrogenase short/branched chain
chr6_-_9707599 0.08 ENSDART00000039280
frizzled class receptor 7b
chr4_-_28335184 0.08 ENSDART00000178149
ENSDART00000043737
cadherin EGF LAG seven-pass G-type receptor 1a
chr2_+_33457310 0.08 ENSDART00000056657
zgc:113531
chr19_-_11336782 0.07 ENSDART00000131014
septin 7a
chr18_+_8231138 0.07 ENSDART00000140193
arylsulfatase A
chr24_-_25166416 0.06 ENSDART00000111552
ENSDART00000169495
pleckstrin homology-like domain, family B, member 2b
chr3_+_23029934 0.06 ENSDART00000110343
N-acetylglutamate synthase
chr24_-_25166720 0.06 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr5_-_24270989 0.06 ENSDART00000146251
si:ch211-137i24.12
chr24_-_37877554 0.05 ENSDART00000132219
transmembrane protein 204
chr12_-_44070043 0.05 ENSDART00000180059
si:ch73-329n5.3
chr4_+_58667348 0.05 ENSDART00000186596
ENSDART00000180673

chr12_-_45875946 0.05 ENSDART00000149970
paired box 2b
chr12_-_25294096 0.04 ENSDART00000183398
hydroxycarboxylic acid receptor 1-4
chr13_-_31017960 0.04 ENSDART00000145287
WDFY family member 4
chr5_+_30596822 0.04 ENSDART00000188375
histone H4 transcription factor
chr13_+_52006253 0.04 ENSDART00000181259

chr21_+_25777425 0.03 ENSDART00000021620
claudin d
chr22_+_29027037 0.03 ENSDART00000170071
Pim proto-oncogene, serine/threonine kinase, related 97
chr9_-_128036 0.02 ENSDART00000165960

chr22_+_28888781 0.02 ENSDART00000145629
Pim proto-oncogene, serine/threonine kinase, related 98
chr22_+_28995391 0.02 ENSDART00000164486
Pim proto-oncogene, serine/threonine kinase, related 99
chr16_+_11029762 0.02 ENSDART00000091183
Ets2 repressor factor like 3
chr16_+_35395597 0.02 ENSDART00000158143
si:dkey-34d22.5
chr7_+_65121743 0.01 ENSDART00000108471
importin 7
chr4_-_72513569 0.01 ENSDART00000174130

chr17_+_25481466 0.00 ENSDART00000139451
crystallin beta-gamma domain containing 1a
chr22_+_29009541 0.00 ENSDART00000169449
Pim proto-oncogene, serine/threonine kinase, related 97
chr15_-_18429550 0.00 ENSDART00000136208
neural cell adhesion molecule 1b
chr14_-_33177935 0.00 ENSDART00000180583
ENSDART00000078856
discs, large homolog 3 (Drosophila)
chr19_-_33212023 0.00 ENSDART00000189209
tribbles pseudokinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.7 GO:0090230 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.2 0.5 GO:0010312 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.1 0.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.9 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.3 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.4 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.1 0.4 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.2 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 0.5 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.1 0.2 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.1 0.2 GO:0071498 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.1 1.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.6 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.4 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.3 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.0 0.2 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.2 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.1 GO:0021982 pineal gland development(GO:0021982)
0.0 0.6 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.4 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.0 GO:0021575 hindbrain morphogenesis(GO:0021575)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.1 GO:0007260 tyrosine phosphorylation of STAT protein(GO:0007260) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.3 GO:0097361 CIA complex(GO:0097361)
0.1 1.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.5 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.3 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.9 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 1.1 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.5 GO:0042974 estrogen receptor binding(GO:0030331) retinoic acid receptor binding(GO:0042974)
0.1 0.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.0 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.2 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.5 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.4 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.5 GO:0008200 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis