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PRJEB1986: zebrafish developmental stages transcriptome

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Results for lmx1ba+lmx1bb_lmx1al

Z-value: 0.46

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Transcription factors associated with lmx1ba+lmx1bb_lmx1al

Gene Symbol Gene ID Gene Info
ENSDARG00000068365 LIM homeobox transcription factor 1, beta b
ENSDARG00000104815 LIM homeobox transcription factor 1, beta a
ENSDARG00000077915 LIM homeobox transcription factor 1, alpha-like

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lmx1aldr11_v1_chr3_+_52806347_52806441-0.812.4e-05Click!
lmx1badr11_v1_chr5_-_5147220_5147336-0.381.1e-01Click!
lmx1bbdr11_v1_chr8_-_33381913_333819130.292.3e-01Click!

Activity profile of lmx1ba+lmx1bb_lmx1al motif

Sorted Z-values of lmx1ba+lmx1bb_lmx1al motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_29509133 2.46 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr2_-_7246848 1.79 ENSDART00000146434
zgc:153115
chr7_+_19552381 1.57 ENSDART00000169060
si:ch211-212k18.5
chr12_-_35830625 1.42 ENSDART00000180028

chr18_+_19456648 1.33 ENSDART00000079695
zwilch kinetochore protein
chr2_+_33326522 1.27 ENSDART00000056655
Kruppel-like factor 17
chr24_-_21923930 1.14 ENSDART00000131944
transgelin 3b
chr23_-_17003533 1.13 ENSDART00000080545
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr4_+_306036 1.08 ENSDART00000103659
mesogenin 1
chr17_+_30369396 1.07 ENSDART00000076611
growth regulation by estrogen in breast cancer 1
chr6_+_41191482 0.99 ENSDART00000000877
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr2_+_20793982 0.98 ENSDART00000014785
proteoglycan 4a
chr23_+_31913292 0.96 ENSDART00000136910
armadillo repeat containing 1, like
chr16_+_23961276 0.96 ENSDART00000192754
apolipoprotein Eb
chr5_-_20194876 0.95 ENSDART00000122587
D-amino-acid oxidase, tandem duplicate 1
chr23_-_31913069 0.93 ENSDART00000135526
mitochondrial fission regulator 2
chr11_-_41853874 0.92 ENSDART00000002556
MRT4 homolog, ribosome maturation factor
chr2_+_30032303 0.91 ENSDART00000151841
RNA binding motif protein 33b
chr24_+_19415124 0.89 ENSDART00000186931
sulfatase 1
chr19_+_30884706 0.84 ENSDART00000052126
tyrosyl-tRNA synthetase
chr22_+_16535575 0.84 ENSDART00000083063
T-cell acute lymphocytic leukemia 1
chr2_+_16482338 0.80 ENSDART00000143912
F-box protein 36b
chr23_-_31913231 0.80 ENSDART00000146852
ENSDART00000085054
mitochondrial fission regulator 2
chr8_+_21353878 0.77 ENSDART00000056420
aminolevulinate, delta-, synthase 2
chr8_+_50953776 0.76 ENSDART00000013870
zgc:56596
chr10_+_7593185 0.76 ENSDART00000162617
ENSDART00000162590
ENSDART00000171744
protein phosphatase 2, catalytic subunit, beta isozyme
chr11_+_35050253 0.75 ENSDART00000124800
family with sequence similarity 212, member Aa
chr10_-_21362320 0.75 ENSDART00000189789
avidin
chr10_-_21362071 0.75 ENSDART00000125167
avidin
chr3_-_16719244 0.74 ENSDART00000055859
polymerase (DNA directed), delta 1, catalytic subunit
chr15_-_43284021 0.73 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr16_-_42894628 0.72 ENSDART00000045600
hemochromatosis type 2
chr17_+_24722646 0.71 ENSDART00000138356
mitochondrial fission regulator 1-like
chr9_+_8396755 0.70 ENSDART00000043067
zgc:171776
chr20_-_20930926 0.70 ENSDART00000123909
BTB (POZ) domain containing 6b
chr18_-_33979693 0.69 ENSDART00000021215
si:ch211-203b20.7
chr17_+_16090436 0.69 ENSDART00000136059
ENSDART00000138734
zinc finger protein 395a
chr15_+_34988148 0.68 ENSDART00000076269
coiled-coil domain containing 105
chr1_-_55248496 0.67 ENSDART00000098615
nanos homolog 3
chr1_+_513986 0.67 ENSDART00000109083
ENSDART00000081945
thioredoxin-like 4B
chr14_+_22113331 0.66 ENSDART00000109759
thioredoxin-related transmembrane protein 2a
chr23_+_11285662 0.66 ENSDART00000111028
cell adhesion molecule L1-like a
chr11_-_35171162 0.65 ENSDART00000017393
TRAF-interacting protein
chr20_-_22476255 0.65 ENSDART00000103510
platelet-derived growth factor receptor, alpha polypeptide
chr18_+_619619 0.65 ENSDART00000159846
protogenin homolog a (Gallus gallus)
chr20_-_37490612 0.65 ENSDART00000185458
si:ch211-202p1.5
chr7_+_24023653 0.64 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr11_+_17984354 0.63 ENSDART00000179986
RNA pseudouridylate synthase domain containing 4
chr11_-_41220794 0.63 ENSDART00000192895
mitochondrial ribosomal protein S16
chr6_-_40922971 0.63 ENSDART00000155363
SFI1 centrin binding protein
chr2_-_26596794 0.62 ENSDART00000134685
ENSDART00000056787
zgc:113691
chr6_-_43283122 0.61 ENSDART00000186022
FERM domain containing 4Ba
chr20_-_20931197 0.61 ENSDART00000152726
BTB (POZ) domain containing 6b
chr17_-_16422654 0.61 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr5_-_12219572 0.60 ENSDART00000167834
nitric oxide synthase 1 (neuronal)
chr25_+_18475032 0.60 ENSDART00000073564
testis derived transcript (3 LIM domains)
chr14_-_22113600 0.60 ENSDART00000113752
si:dkey-6i22.5
chr21_-_15200556 0.59 ENSDART00000141809
splicing factor SWAP
chr19_+_30884960 0.56 ENSDART00000140603
ENSDART00000183224
ENSDART00000135484
ENSDART00000139599
tyrosyl-tRNA synthetase
chr7_+_20471315 0.56 ENSDART00000173714
si:dkey-19b23.13
chr13_-_12602920 0.55 ENSDART00000102311
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr15_+_31344472 0.55 ENSDART00000146695
ENSDART00000159182
ENSDART00000060125
odorant receptor, family D, subfamily 107, member 1
chr19_+_2631565 0.55 ENSDART00000171487
family with sequence similarity 126, member A
chr18_-_14677936 0.55 ENSDART00000111995
si:dkey-238o13.4
chr8_-_39822917 0.55 ENSDART00000067843
zgc:162025
chr2_+_36721357 0.54 ENSDART00000019063
programmed cell death 10b
chr24_-_35561672 0.53 ENSDART00000058564
minichromosome maintenance complex component 4
chr16_-_29387215 0.53 ENSDART00000148787
S100 calcium binding protein A1
chr16_-_17347727 0.53 ENSDART00000144392
zyxin
chr25_-_21031007 0.52 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr3_+_27798094 0.52 ENSDART00000075100
ENSDART00000151437
calcium regulated heat stable protein 1
chr2_+_41526904 0.51 ENSDART00000127520
activin A receptor, type 1 like
chr18_+_24921587 0.50 ENSDART00000191345
repulsive guidance molecule family member a
chr21_-_23331619 0.50 ENSDART00000007806
zinc finger and BTB domain containing 16a
chr10_+_16092671 0.49 ENSDART00000182761
ENSDART00000154835
multiple EGF-like-domains 10
chr7_+_72003301 0.49 ENSDART00000012918
ENSDART00000182268
ENSDART00000185750
proteasome 26S subunit, non-ATPase 9
chr13_+_27232848 0.49 ENSDART00000138043
Ras and Rab interactor 2
chr21_-_20711739 0.48 ENSDART00000190918

chr23_-_16485190 0.48 ENSDART00000155038
si:dkeyp-100a5.4
chr3_+_46635527 0.48 ENSDART00000153971
si:dkey-248g21.1
chr20_+_11731039 0.47 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
chr15_+_857148 0.47 ENSDART00000156949
si:dkey-7i4.13
chr5_+_66433287 0.47 ENSDART00000170757
kinetochore associated 1
chr8_-_37249813 0.47 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
RNA binding motif protein 39b
chr10_+_6884627 0.46 ENSDART00000125262
ENSDART00000121729
ENSDART00000105384
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr2_-_38363017 0.46 ENSDART00000088026
protein arginine methyltransferase 5
chr16_-_42056137 0.46 ENSDART00000102798
zona pellucida glycoprotein 3d tandem duplicate 2
chr5_+_6954162 0.45 ENSDART00000086666
sperm-tail PG-rich repeat containing 2
chr18_-_15551360 0.44 ENSDART00000159915
ENSDART00000172690
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr8_+_11425048 0.43 ENSDART00000018739
tight junction protein 2b (zona occludens 2)
chr22_+_18315490 0.43 ENSDART00000160413
GATA zinc finger domain containing 2Ab
chr8_+_23355484 0.43 ENSDART00000085361
ENSDART00000125729
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr1_-_26444075 0.42 ENSDART00000125690
integrator complex subunit 12
chr15_-_4528326 0.41 ENSDART00000158122
ENSDART00000155619
ENSDART00000128602
transcription factor Dp-2
chr7_-_30174882 0.41 ENSDART00000110409
FERM domain containing 5
chr13_+_25720969 0.41 ENSDART00000046050
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr16_-_16761164 0.41 ENSDART00000135872
si:dkey-27n14.1
chr18_-_19456269 0.40 ENSDART00000060363
ribosomal protein L4
chr7_-_67248829 0.40 ENSDART00000192442
zinc finger protein 143a
chr3_-_30488063 0.40 ENSDART00000055393
ENSDART00000151367
mediator complex subunit 25
chr8_+_45334255 0.40 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
poly(A) binding protein, cytoplasmic 1-like
chr8_-_50888806 0.40 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr23_+_39695827 0.39 ENSDART00000113893
ENSDART00000186679
transmembrane and coiled-coil domains 4
chr23_-_6749820 0.39 ENSDART00000128772
prostaglandin E synthase 3b (cytosolic)
chr12_+_48803098 0.38 ENSDART00000074768
peptidylprolyl isomerase Fb
chr16_-_55028740 0.38 ENSDART00000156368
ENSDART00000161704
zgc:114181
chr6_+_21001264 0.38 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr20_+_29209615 0.38 ENSDART00000062350
katanin p80 subunit B-like 1
chr20_+_46492175 0.38 ENSDART00000060695
zinc finger CCCH-type containing 14
chr11_-_17755444 0.38 ENSDART00000154627
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr20_-_23426339 0.37 ENSDART00000004625
zygote arrest 1
chr8_+_16758304 0.37 ENSDART00000133514
ELOVL fatty acid elongase 7a
chr4_+_19700308 0.37 ENSDART00000027919
paired box 4
chr8_-_37249991 0.37 ENSDART00000189275
ENSDART00000178556
RNA binding motif protein 39b
chr16_+_13818743 0.37 ENSDART00000090191
folliculin
chr17_-_11439815 0.37 ENSDART00000130105
proteasome subunit alpha 3
chr11_+_33818179 0.37 ENSDART00000109418
speckle-type POZ protein-like b
chr11_-_33868881 0.37 ENSDART00000163295
ENSDART00000172633
ENSDART00000171439
si:ch211-227n13.3
chr15_-_23522653 0.36 ENSDART00000144685
hydroxymethylbilane synthase, b
chr8_-_12867128 0.36 ENSDART00000142201
solute carrier family 2 (facilitated glucose transporter), member 6
chr19_-_5699703 0.36 ENSDART00000082050
zgc:174904
chr23_+_31912882 0.36 ENSDART00000140505
armadillo repeat containing 1, like
chr5_-_41307550 0.36 ENSDART00000143446
natriuretic peptide receptor 3
chr3_-_15081874 0.36 ENSDART00000192532
NME/NM23 nucleoside diphosphate kinase 4
chr13_+_45431660 0.35 ENSDART00000099950
SYF2 pre-mRNA-splicing factor
chr13_+_22295905 0.35 ENSDART00000180133
ENSDART00000181125
ubiquitin specific peptidase 54a
chr24_+_28383278 0.35 ENSDART00000018095
SH3-domain GRB2-like endophilin B1a
chr6_-_8392104 0.35 ENSDART00000081561
ENSDART00000181178
interleukin enhancer binding factor 3a
chr17_-_48944465 0.34 ENSDART00000154110
si:ch1073-80i24.3
chr3_+_28860283 0.34 ENSDART00000077235
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr21_+_25777425 0.34 ENSDART00000021620
claudin d
chr16_+_54209504 0.34 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr25_+_3759553 0.33 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
THO complex 5
chr10_-_15340362 0.33 ENSDART00000148119
ENSDART00000127277
ENSDART00000154037
ENSDART00000189109
pumilio RNA-binding family member 3
chr7_+_29167744 0.33 ENSDART00000076345
solute carrier family 38, member 8b
chr14_-_33945692 0.33 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr22_-_20166660 0.33 ENSDART00000085913
ENSDART00000188241
BTB (POZ) domain containing 2a
chr14_-_26392475 0.33 ENSDART00000170614
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr10_-_43771447 0.32 ENSDART00000052307
arrestin domain containing 3b
chr18_+_38807239 0.32 ENSDART00000184332
family with sequence similarity 214, member A
chr7_+_20503344 0.32 ENSDART00000157699
si:dkey-19b23.12
chr2_-_28085884 0.31 ENSDART00000131506
cadherin 6
chr19_+_42432625 0.31 ENSDART00000076938
pogo transposable element derived with ZNF domain a
chr22_+_38037530 0.31 ENSDART00000012212
COMM domain containing 2
chr5_+_32076109 0.30 ENSDART00000051357
ENSDART00000144510
zinc finger, matrin-type 5
chr15_-_21877726 0.30 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr7_+_7696665 0.30 ENSDART00000091099
INO80 complex subunit B
chr5_+_35786141 0.30 ENSDART00000022043
ENSDART00000127383
StAR-related lipid transfer (START) domain containing 8
chr6_+_40922572 0.30 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr12_+_33817327 0.30 ENSDART00000111486
mitochondrial ribosomal protein L43
chr7_+_56577906 0.29 ENSDART00000184023
haptoglobin
chr3_-_39695856 0.29 ENSDART00000148247
B9 protein domain 1
chr20_+_25586099 0.29 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr24_-_4450238 0.29 ENSDART00000066835
frizzled class receptor 8a
chr8_+_18010568 0.29 ENSDART00000121984
single stranded DNA binding protein 3b
chr4_+_11723852 0.29 ENSDART00000028820
muskelin 1, intracellular mediator containing kelch motifs
chr17_+_23462972 0.29 ENSDART00000112959
ENSDART00000192168
ankyrin repeat domain 1a (cardiac muscle)
chr13_-_31017960 0.29 ENSDART00000145287
WDFY family member 4
chr13_-_31008275 0.29 ENSDART00000139394
WDFY family member 4
chr3_+_17933132 0.29 ENSDART00000104299
ENSDART00000162144
ENSDART00000162242
ENSDART00000166289
ENSDART00000171101
ENSDART00000164853
2',3'-cyclic nucleotide 3' phosphodiesterase
chr14_-_26392146 0.28 ENSDART00000037999
xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr24_-_17067284 0.28 ENSDART00000111237
armadillo repeat containing 3
chr17_+_28103675 0.28 ENSDART00000188078
zgc:91908
chr24_-_2450597 0.28 ENSDART00000188080
ENSDART00000093331
ras responsive element binding protein 1a
chr2_-_32384683 0.28 ENSDART00000182942
ENSDART00000141757
upstream binding transcription factor, like
chr15_-_16177603 0.28 ENSDART00000156352
si:ch211-259g3.4
chr10_+_11767791 0.28 ENSDART00000092047
peptidylprolyl isomerase domain and WD repeat containing 1
chr11_+_35171406 0.28 ENSDART00000110839
MON1 secretory trafficking family member A
chr23_-_6660985 0.28 ENSDART00000162405

chr6_-_20952187 0.27 ENSDART00000074327
insulin-like growth factor binding protein 2a
chr21_+_28478663 0.27 ENSDART00000077887
ENSDART00000134150
solute carrier family 22 (organic anion transporter), member 6, like
chr11_+_39135050 0.27 ENSDART00000180571
ENSDART00000189685
cell division cycle 42
chr23_+_36122058 0.27 ENSDART00000184448
homeobox C3a
chr2_+_19522082 0.27 ENSDART00000146098
Pim proto-oncogene, serine/threonine kinase, related 49
chr3_-_4501026 0.27 ENSDART00000163052
zgc:162198
chr16_+_6750756 0.27 ENSDART00000149720
zinc finger protein 236
chr20_+_29209767 0.27 ENSDART00000141252
katanin p80 subunit B-like 1
chr1_-_40911332 0.27 ENSDART00000027463
H6 family homeobox 4
chr6_-_8311044 0.26 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr20_-_48485354 0.26 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr13_-_35808904 0.26 ENSDART00000171667
mitogen-activated protein kinase kinase kinase 4
chr25_-_18435481 0.26 ENSDART00000004771
POC1 centriolar protein B
chr5_+_60590796 0.26 ENSDART00000159859
transmembrane protein 132E
chr22_-_20924564 0.26 ENSDART00000100642
ENSDART00000032770
elongation factor RNA polymerase II
chr18_+_20560616 0.26 ENSDART00000136710
ENSDART00000151974
ENSDART00000121699
ENSDART00000040074
WEE1 homolog 2 (S. pombe)
chr23_-_25779995 0.26 ENSDART00000110670
si:dkey-21c19.3
chr7_+_56577522 0.26 ENSDART00000149130
ENSDART00000149624
haptoglobin
chr17_-_49438873 0.26 ENSDART00000004424
zinc finger protein 292a
chr21_-_31290582 0.26 ENSDART00000065362
carbonic anhydrase IV c
chr19_+_28256076 0.25 ENSDART00000133354
iroquois homeobox 4b
chr1_+_36911471 0.25 ENSDART00000148640
Rho GTPase activating protein 10
chr12_-_33972798 0.25 ENSDART00000105545
ADP-ribosylation factor-like 3
chr5_+_41477954 0.25 ENSDART00000185871
protein inhibitor of activated STAT, 2
chr3_-_39696066 0.25 ENSDART00000015393
B9 protein domain 1
chr11_-_40728380 0.25 ENSDART00000023745
coiled-coil domain containing 114
chr24_-_30862168 0.25 ENSDART00000168540
polypyrimidine tract binding protein 2a
chr24_+_28953089 0.24 ENSDART00000153761
RNA-binding region (RNP1, RRM) containing 3
chr16_+_23913943 0.24 ENSDART00000175404
ENSDART00000129525
apolipoprotein A-IV b, tandem duplicate 1
chr16_-_38609146 0.24 ENSDART00000144651
eukaryotic translation initiation factor 3, subunit E, a
chr21_+_6394929 0.24 ENSDART00000138600
si:ch211-225g23.1

Network of associatons between targets according to the STRING database.

First level regulatory network of lmx1ba+lmx1bb_lmx1al

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0048785 hatching gland development(GO:0048785)
0.4 1.1 GO:0048341 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341)
0.3 1.0 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.3 0.8 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.2 1.0 GO:0009078 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.2 1.1 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.2 0.6 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.2 0.9 GO:0000012 single strand break repair(GO:0000012)
0.2 0.7 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.2 0.5 GO:1903358 regulation of Golgi organization(GO:1903358)
0.2 0.7 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 1.3 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395)
0.1 0.8 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 0.8 GO:0097065 anterior head development(GO:0097065)
0.1 0.7 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 0.6 GO:0014826 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.5 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.4 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441) negative regulation of mRNA polyadenylation(GO:1900364)
0.1 0.5 GO:0034969 histone arginine methylation(GO:0034969)
0.1 0.9 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.4 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.3 GO:0060898 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.7 GO:1902292 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.1 1.1 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.2 GO:0010662 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.1 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.3 GO:0015871 choline transport(GO:0015871)
0.1 0.6 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.3 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) high-density lipoprotein particle assembly(GO:0034380)
0.1 2.2 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.2 GO:0061549 sympathetic ganglion development(GO:0061549)
0.0 0.5 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.6 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.4 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.1 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.4 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.2 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.0 0.2 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.5 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 0.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.6 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.0 0.4 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.2 GO:0071800 podosome assembly(GO:0071800)
0.0 0.8 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.3 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.3 GO:0040014 regulation of multicellular organism growth(GO:0040014)
0.0 0.5 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441)
0.0 0.1 GO:0032875 regulation of DNA endoreduplication(GO:0032875) positive regulation of DNA endoreduplication(GO:0032877) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.0 0.2 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.0 0.2 GO:0046294 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.0 0.2 GO:0043584 nose development(GO:0043584)
0.0 0.1 GO:2000381 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) negative regulation of mesoderm development(GO:2000381)
0.0 0.4 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.3 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 2.0 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.4 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 0.4 GO:0060021 palate development(GO:0060021)
0.0 0.1 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.4 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.0 0.3 GO:0008354 germ cell migration(GO:0008354)
0.0 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.4 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.2 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0090308 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0015743 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.1 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.2 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.1 GO:1902547 regulation of vascular endothelial growth factor signaling pathway(GO:1900746) regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902547)
0.0 0.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.1 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.3 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.3 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.5 GO:0043277 apoptotic cell clearance(GO:0043277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 0.5 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.2 0.6 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 0.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.5 GO:0070724 BMP receptor complex(GO:0070724)
0.1 0.3 GO:0097189 apoptotic body(GO:0097189)
0.1 0.6 GO:0071818 BAT3 complex(GO:0071818)
0.1 0.2 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.0 0.3 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.0 0.6 GO:0070187 telosome(GO:0070187)
0.0 0.4 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.9 GO:0043186 P granule(GO:0043186)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 1.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.0 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 1.1 GO:0005795 Golgi stack(GO:0005795)
0.0 1.4 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 1.5 GO:0009374 biotin binding(GO:0009374)
0.3 0.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 1.0 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.2 0.6 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.2 0.7 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.2 0.5 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 1.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.5 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.2 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.7 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.4 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.4 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.1 0.3 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.2 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1 0.2 GO:0072545 tyrosine binding(GO:0072545)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.0 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.5 GO:0032190 acrosin binding(GO:0032190)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 1.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.7 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.3 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.1 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 0.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.6 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.6 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 1.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME BASE EXCISION REPAIR Genes involved in Base Excision Repair
0.0 1.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters