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PRJEB1986: zebrafish developmental stages transcriptome

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Results for lhx8a+lhx8b

Z-value: 0.85

Motif logo

Transcription factors associated with lhx8a+lhx8b

Gene Symbol Gene ID Gene Info
ENSDARG00000002330 LIM homeobox 8a
ENSDARG00000042145 LIM homeobox 8b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx8bdr11_v1_chr8_-_17926814_17926814-0.742.9e-04Click!
lhx8adr11_v1_chr2_+_11205795_112057950.624.8e-03Click!

Activity profile of lhx8a+lhx8b motif

Sorted Z-values of lhx8a+lhx8b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22318511 3.63 ENSDART00000129295
crystallin, gamma M2d2
chr12_-_4756478 3.09 ENSDART00000152181
microtubule-associated protein tau a
chr7_+_26326462 3.08 ENSDART00000173515
zonadhesin, like
chr18_+_924949 3.02 ENSDART00000170888
ENSDART00000193163
pyruvate kinase M1/2a
chr9_-_22310919 2.68 ENSDART00000108719
crystallin, gamma M2d10
chr18_-_8877077 2.65 ENSDART00000137266
si:dkey-95h12.2
chr2_-_293036 2.54 ENSDART00000171629
si:ch73-40a17.3
chr17_-_6730247 2.38 ENSDART00000031091
visinin-like 1b
chr6_+_40661703 2.30 ENSDART00000142492
enolase 1b, (alpha)
chr4_+_5531583 2.27 ENSDART00000137500
ENSDART00000042080
si:dkey-14d8.6
chr18_-_898870 2.25 ENSDART00000151777
ENSDART00000062654
poly (ADP-ribose) polymerase family, member 6a
chr19_+_10339538 2.24 ENSDART00000151808
ENSDART00000151235
recoverin 3
chr1_+_56274613 2.19 ENSDART00000052683
complement component c3a, duplicate 3
chr13_+_23988442 2.12 ENSDART00000010918
angiotensinogen
chr16_+_45739193 1.93 ENSDART00000184852
ENSDART00000156851
ENSDART00000154704
progestin and adipoQ receptor family member VI
chr7_+_53152108 1.83 ENSDART00000171350
cadherin 29
chr7_+_2467057 1.81 ENSDART00000154517
si:dkey-125e8.3
chr19_-_40191358 1.81 ENSDART00000183919
granulin 1
chr9_-_41277347 1.81 ENSDART00000181213
glutaminase b
chr5_-_54197084 1.67 ENSDART00000163640
G protein-coupled receptor kinase 1 b
chr24_+_792429 1.64 ENSDART00000082523
inositol(myo)-1(or 4)-monophosphatase 2
chr3_-_28428198 1.62 ENSDART00000151546
RNA binding fox-1 homolog 1
chr5_+_32247310 1.62 ENSDART00000182649
myosin, heavy chain a
chr19_-_31042570 1.60 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
basic leucine zipper and W2 domains 2
chr24_+_39137001 1.60 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
TBC1 domain family, member 24
chr6_+_2195625 1.59 ENSDART00000155659
activin A receptor type 1Bb
chr3_-_15264698 1.58 ENSDART00000111948
ENSDART00000142594
seizure related 6 homolog (mouse)-like 2
chr2_-_34555945 1.58 ENSDART00000056671
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr8_+_3820134 1.56 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr8_-_53198154 1.55 ENSDART00000083416
gamma-aminobutyric acid (GABA) A receptor, delta
chr11_+_30981777 1.50 ENSDART00000148949
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr5_+_27137473 1.48 ENSDART00000181833
unc-5 netrin receptor Db
chr14_+_17197132 1.48 ENSDART00000054598
reticulon 4 receptor-like 2b
chr4_-_17785120 1.48 ENSDART00000024775
myosin binding protein C, slow type
chr1_+_7546259 1.46 ENSDART00000015732
myosin, light polypeptide 3, skeletal muscle
chr18_+_7286788 1.39 ENSDART00000022998
si:ch73-86n2.1
chr3_-_32169754 1.37 ENSDART00000179010
troponin T type 1 (skeletal, slow)
chr14_-_33105434 1.36 ENSDART00000163795
discs, large homolog 3 (Drosophila)
chr9_+_49712868 1.30 ENSDART00000192969
ENSDART00000183310
cysteine and serine rich nuclear protein 3
chr5_-_22882210 1.21 ENSDART00000182232
si:ch211-26b3.4
chr3_+_25154078 1.19 ENSDART00000156973
si:ch211-256m1.8
chr17_-_2386569 1.19 ENSDART00000121614
phospholipase C beta 2
chr6_+_11250033 1.11 ENSDART00000065411
ENSDART00000132677
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr2_+_20332044 1.06 ENSDART00000112131
phospholipid phosphatase related 4a
chr18_+_9635178 1.06 ENSDART00000183486
piccolo presynaptic cytomatrix protein b
chr10_-_7974155 1.06 ENSDART00000147368
ENSDART00000075524
oxysterol binding protein 2
chr19_+_4139065 1.03 ENSDART00000172524
si:dkey-218f9.10
chr8_+_7737062 1.01 ENSDART00000166712
FYVE, RhoGEF and PH domain containing 1
chr20_-_51727860 1.01 ENSDART00000147044
BRO1 domain and CAAX motif containing
chr21_-_36972127 0.98 ENSDART00000100310
drebrin 1
chr6_+_11249706 0.98 ENSDART00000186547
ENSDART00000193287
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr22_+_1779401 0.96 ENSDART00000170126
zinc finger protein 1154
chr9_-_18568927 0.96 ENSDART00000084668
ecto-NOX disulfide-thiol exchanger 1
chr21_-_36571804 0.94 ENSDART00000138129
WW and C2 domain containing 1
chr20_-_39273505 0.92 ENSDART00000153114
clusterin
chr1_-_58064738 0.92 ENSDART00000073778
caspase b
chr23_-_21797517 0.91 ENSDART00000110041
leucine rich repeat containing 38a
chr8_+_25351863 0.91 ENSDART00000034092
deoxyribonuclease I-like 1-like
chr11_-_43200994 0.89 ENSDART00000164700
spectrin, beta, non-erythrocytic 1
chr21_-_13662237 0.89 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr6_-_57938043 0.88 ENSDART00000171073
TOX high mobility group box family member 2
chr11_+_21050326 0.88 ENSDART00000065984
zgc:113307
chr16_-_27749172 0.88 ENSDART00000145198
STEAP family member 4
chr6_+_11250316 0.87 ENSDART00000137122
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr2_+_20331445 0.86 ENSDART00000186880
phospholipid phosphatase related 4a
chr11_+_25276748 0.86 ENSDART00000126211
cylindromatosis (turban tumor syndrome), b
chr2_-_14387335 0.86 ENSDART00000189332
ENSDART00000164786
ENSDART00000188572
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr23_-_41965557 0.84 ENSDART00000144183
solute carrier family 1 (glutamate transporter), member 7b
chr21_+_26612777 0.84 ENSDART00000142667
estrogen-related receptor alpha
chr6_-_957830 0.84 ENSDART00000090019
ENSDART00000184286
zinc finger E-box binding homeobox 2b
chr16_-_12319822 0.84 ENSDART00000127453
ENSDART00000184526
transient receptor potential cation channel, subfamily V, member 6
chr20_-_38610360 0.83 ENSDART00000168783
ENSDART00000164638
solute carrier family 30 (zinc transporter), member 2
chr8_+_6967108 0.83 ENSDART00000004588
acid-sensing (proton-gated) ion channel 1a
chr3_+_15773991 0.81 ENSDART00000089923
zinc finger protein 652
chr21_-_10488379 0.81 ENSDART00000163878
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr7_+_26224211 0.80 ENSDART00000173999
VGF nerve growth factor inducible
chr2_-_20470125 0.80 ENSDART00000114899
ENSDART00000147806
ferric-chelate reductase 1a
chr19_-_6303099 0.78 ENSDART00000133371
POU class 2 homeobox 2a
chr4_-_287425 0.78 ENSDART00000159128
enoyl CoA hydratase domain containing 3
chr7_-_39378903 0.78 ENSDART00000173659
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr20_+_18551657 0.77 ENSDART00000147001
si:dkeyp-72h1.1
chr10_+_29199172 0.77 ENSDART00000148828
phosphatidylinositol binding clathrin assembly protein a
chr16_-_35329803 0.75 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
protein tyrosine phosphatase, receptor type, U, b
chr10_+_21804772 0.75 ENSDART00000162194
protocadherin 1 gamma 31
chr23_+_34321237 0.75 ENSDART00000173272
plexin A1a
chr22_-_15562933 0.74 ENSDART00000141528
ankyrin repeat and MYND domain containing 1
chr7_+_72469724 0.73 ENSDART00000187629
HECT domain E3 ubiquitin protein ligase 4
chr25_-_35147698 0.73 ENSDART00000121963
zgc:165555
chr9_+_6079528 0.72 ENSDART00000142167
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr20_+_42563618 0.71 ENSDART00000153441
insulin-like growth factor 2 receptor
chr15_+_25683069 0.71 ENSDART00000148190
hypermethylated in cancer 1
chr7_+_2228276 0.70 ENSDART00000064294
si:dkey-187j14.4
chr3_+_16724614 0.70 ENSDART00000182135
glycogen synthase 1 (muscle)
chr17_-_8173380 0.70 ENSDART00000148520
spectrin repeat containing, nuclear envelope 1b
chr14_+_19258702 0.69 ENSDART00000187087
ENSDART00000005738
SLIT and NTRK-like family, member 2
chr9_-_34986827 0.69 ENSDART00000137862
si:ch211-160b11.4
chr23_-_29668286 0.69 ENSDART00000129248
calsyntenin 1
chr2_+_45548890 0.69 ENSDART00000113994
fibronectin type III domain containing 7a
chr8_-_18316482 0.67 ENSDART00000190156
ring finger protein 220b
chr15_+_32268790 0.66 ENSDART00000154457
FH2 domain containing 4
chr3_+_49021079 0.66 ENSDART00000162012
zgc:163083
chr2_-_34483597 0.66 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr21_+_9997418 0.65 ENSDART00000181454
ENSDART00000171579
hect domain and RLD 7
chr20_-_39273987 0.64 ENSDART00000127173
clusterin
chr21_+_13861589 0.64 ENSDART00000015629
ENSDART00000171306
syntaxin binding protein 1a
chr1_-_23308225 0.64 ENSDART00000137567
ENSDART00000008201
small integral membrane protein 14
chr17_+_12138715 0.64 ENSDART00000112888
zgc:174379
chr18_+_31410652 0.63 ENSDART00000098504
differentially expressed in FDCP 8 homolog (mouse)
chr14_-_8625845 0.63 ENSDART00000054760
zgc:162144
chr18_-_7539166 0.63 ENSDART00000133541
si:dkey-30c15.2
chr4_-_12766418 0.62 ENSDART00000024312
deoxyribose-phosphate aldolase (putative)
chr3_-_55197881 0.61 ENSDART00000179903
KN motif and ankyrin repeat domains 2
chr3_-_30384353 0.61 ENSDART00000186832
leucine rich repeat containing 4Ba
chr9_-_52847881 0.61 ENSDART00000166407
transient receptor potential cation channel, subfamily M, member 2
chr18_+_8340886 0.60 ENSDART00000081132
carnitine palmitoyltransferase 1B (muscle)
chr2_-_32551178 0.60 ENSDART00000145603
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr10_-_7666810 0.60 ENSDART00000191479
prenylcysteine oxidase 1
chr1_-_2457546 0.58 ENSDART00000103795
gamma-glutamylamine cyclotransferase, tandem duplicate 1
chr19_+_20801486 0.58 ENSDART00000038202
carnosine dipeptidase 2
chr2_+_37227011 0.58 ENSDART00000126587
ENSDART00000084958
sterile alpha motif domain containing 7
chr20_+_23173710 0.57 ENSDART00000074172
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr11_-_891674 0.57 ENSDART00000172904
ATG7 autophagy related 7 homolog (S. cerevisiae)
chr22_+_38164486 0.57 ENSDART00000137521
transmembrane 4 L six family member 18
chr20_-_25436389 0.57 ENSDART00000153266
intersectin 2a
chr22_-_7129631 0.55 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr1_+_52929185 0.55 ENSDART00000147683
inositol polyphosphate-4-phosphatase type II B
chr23_+_4362463 0.55 ENSDART00000039829
zgc:112175
chr25_-_28768489 0.55 ENSDART00000088315
WASH complex subunit 4
chr15_-_45356635 0.53 ENSDART00000192000

chr4_+_612363 0.52 ENSDART00000049154
parathyroid hormone-like hormone a
chr6_-_12456077 0.52 ENSDART00000190107
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr21_-_26918901 0.52 ENSDART00000100685
leucine rich repeat and fibronectin type III domain containing 4a
chr5_+_51909740 0.52 ENSDART00000162541
thrombospondin 4a
chr24_+_36339242 0.51 ENSDART00000105686
ENSDART00000142264
granulin b
chr5_-_30080332 0.51 ENSDART00000140049
beta-carotene oxygenase 2a
chr20_+_28434196 0.50 ENSDART00000034245
D4, zinc and double PHD fingers, family 3
chr18_-_46957840 0.50 ENSDART00000182754
GRAM domain containing 1Bb
chr16_-_45209684 0.50 ENSDART00000184595
FXYD domain containing ion transport regulator 1 (phospholemman)
chr5_-_23749348 0.49 ENSDART00000140766
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 2
chr8_-_2289264 0.49 ENSDART00000189397
plasminogen activator, tissue
chr15_-_4094888 0.48 ENSDART00000166307
si:dkey-83h2.3
chr7_+_5959203 0.47 ENSDART00000110813
zgc:165555
chr9_-_16877456 0.47 ENSDART00000161105
ENSDART00000160869
F-box and leucine-rich repeat protein 3a
chr12_+_42574148 0.47 ENSDART00000157855
early B cell factor 3a
chr10_-_42131408 0.47 ENSDART00000076693
STAM binding protein a
chr15_-_25613114 0.46 ENSDART00000182431
ENSDART00000187405
TAO kinase 1a
chr11_-_10828539 0.46 ENSDART00000040180
T-box, brain, 1a
chr4_+_11479705 0.46 ENSDART00000019458
ENSDART00000150587
ENSDART00000139370
ENSDART00000135826
ankyrin repeat and SOCS box containing 13a, tandem duplicate 1
chr6_+_12865137 0.45 ENSDART00000090065
family with sequence similarity 117, member Ba
chr4_+_31405646 0.44 ENSDART00000128732
si:rp71-5o12.3
chr22_-_910926 0.44 ENSDART00000180075

chr21_-_33995710 0.44 ENSDART00000100508
ENSDART00000179622
early B cell factor 1b
chr13_-_33667922 0.43 ENSDART00000141631
si:dkey-76k16.5
chr22_-_23000815 0.43 ENSDART00000137111
protein tyrosine phosphatase, receptor type, C
chr2_-_3403020 0.43 ENSDART00000092741
synaptosomal-associated protein, 47
chr18_+_19120984 0.43 ENSDART00000141501
si:dkey-242h9.3
chr25_+_19238175 0.43 ENSDART00000110730
ENSDART00000193619
ENSDART00000154420
diphosphoinositol pentakisphosphate kinase 1b
chr1_+_10019653 0.43 ENSDART00000190227
tripartite motif containing 2b
chr9_-_4606463 0.43 ENSDART00000179110
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr25_-_27621268 0.42 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr16_+_4838808 0.42 ENSDART00000179363
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr22_-_29586608 0.41 ENSDART00000059869
adrenoceptor alpha 2A
chr20_-_49681850 0.41 ENSDART00000025926
collagen, type XII, alpha 1b
chr17_+_15559046 0.40 ENSDART00000187126
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr8_+_26254903 0.39 ENSDART00000113763
solute carrier family 26, member 6
chr3_-_24456451 0.38 ENSDART00000024480
ENSDART00000156814
BAI1-associated protein 2-like 2a
chr10_+_21656654 0.38 ENSDART00000160464
protocadherin 1 gamma 2
chr4_+_45458619 0.38 ENSDART00000124892
si:dkey-256i11.3
chr5_-_35888499 0.37 ENSDART00000193932
relaxin/insulin-like family peptide receptor 2, like
chr2_+_49644803 0.37 ENSDART00000160342
si:ch211-209f23.7
chr7_-_51727760 0.37 ENSDART00000174180
histone deacetylase 8
chr6_+_9289802 0.36 ENSDART00000188650
kalirin RhoGEF kinase b
chr16_-_35427060 0.36 ENSDART00000172294
CTP synthase 1b
chr3_+_464127 0.36 ENSDART00000169510
ENSDART00000144886
diverse immunoglobulin domain-containing protein 1.1
chr4_+_42878556 0.36 ENSDART00000171047
si:zfos-451d2.2
chr23_+_21278948 0.36 ENSDART00000156701
ENSDART00000033970
ubiquitin protein ligase E3 component n-recognin 4
chr7_-_1101694 0.36 ENSDART00000183017
ENSDART00000182681
dynactin 1a
chr13_+_17702522 0.35 ENSDART00000057913
si:dkey-27m7.4
chr13_-_1085961 0.35 ENSDART00000171872
ENSDART00000166598
pleckstrin
chr13_-_8892514 0.35 ENSDART00000144553
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr16_+_25535993 0.35 ENSDART00000077436
myosin regulatory light chain interacting protein b
chr4_+_15605844 0.34 ENSDART00000101619
ENSDART00000021384
exocyst complex component 4
chr22_-_23706771 0.34 ENSDART00000159771
complement factor H like 1
chr7_+_27253063 0.34 ENSDART00000191138
SRY (sex determining region Y)-box 6
chr1_+_7414318 0.34 ENSDART00000127426
si:ch73-383l1.1
chr18_-_7539469 0.34 ENSDART00000101296
si:dkey-30c15.2
chr4_-_4751981 0.33 ENSDART00000147436
ENSDART00000092984
ENSDART00000158466
cAMP responsive element binding protein 3-like 2
chr16_+_49088698 0.33 ENSDART00000182037
phospholipase C like 2
chr25_+_28893615 0.32 ENSDART00000156994
ENSDART00000075151
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr22_+_9069081 0.32 ENSDART00000187842

chr22_-_8720794 0.31 ENSDART00000191236
ENSDART00000185738
si:ch73-27e22.1
si:ch73-27e22.8
chr6_-_16456093 0.31 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr22_+_6254194 0.31 ENSDART00000112388
ENSDART00000135176
ribonuclease like 4
chr4_+_65614183 0.31 ENSDART00000180387
si:dkey-205i10.1
chr24_+_12945803 0.30 ENSDART00000005105
proteasome activator subunit 1
chr22_+_31295791 0.29 ENSDART00000092447
glutamate receptor interacting protein 2b
chr1_-_59077650 0.29 ENSDART00000043516
si:zfos-2330d3.1
chr22_-_9694433 0.29 ENSDART00000180101
si:dkey-286j17.4
chr15_-_23645810 0.28 ENSDART00000168845
creatine kinase, muscle b
chr1_-_40086978 0.28 ENSDART00000136990
si:dkey-117m1.4

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx8a+lhx8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.4 3.9 GO:0036368 cone photoresponse recovery(GO:0036368)
0.4 3.5 GO:0044805 late nucleophagy(GO:0044805)
0.3 2.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.2 1.8 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.2 2.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 0.9 GO:0015677 copper ion import(GO:0015677)
0.2 0.8 GO:0070317 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.2 1.4 GO:0070207 protein homotrimerization(GO:0070207)
0.2 1.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.2 1.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 1.0 GO:0007624 ultradian rhythm(GO:0007624)
0.2 2.1 GO:0006020 inositol metabolic process(GO:0006020)
0.2 0.5 GO:0002076 osteoblast development(GO:0002076)
0.2 0.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 0.8 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 1.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.9 GO:0032475 otolith formation(GO:0032475)
0.1 0.6 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 0.5 GO:0014909 smooth muscle cell migration(GO:0014909)
0.1 0.6 GO:0030329 prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.1 2.1 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 0.3 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 1.1 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.4 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 0.9 GO:0070266 necroptotic process(GO:0070266)
0.1 1.2 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.4 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.1 0.5 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.8 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 1.5 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.6 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.4 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 2.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.0 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.1 2.3 GO:0030199 collagen fibril organization(GO:0030199)
0.1 0.5 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 3.0 GO:0006096 glycolytic process(GO:0006096)
0.1 0.6 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
0.0 0.1 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 5.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.5 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 1.1 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.2 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.0 0.3 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 1.2 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.5 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 2.2 GO:0006956 complement activation(GO:0006956)
0.0 1.6 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.6 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.7 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 1.4 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.5 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.8 GO:0001757 somite specification(GO:0001757)
0.0 0.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.6 GO:0007032 endosome organization(GO:0007032)
0.0 0.3 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 1.1 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 1.0 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.6 GO:0051289 protein homotetramerization(GO:0051289)
0.0 1.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 1.6 GO:1901214 regulation of neuron death(GO:1901214)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.4 GO:0070672 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.4 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.6 GO:0007041 lysosomal transport(GO:0007041)
0.0 0.5 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.5 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.3 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.7 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.7 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.5 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.3 GO:0010950 positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.3 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 1.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 3.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0006942 regulation of striated muscle contraction(GO:0006942)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 GO:0001772 immunological synapse(GO:0001772)
0.3 2.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.9 GO:0061702 inflammasome complex(GO:0061702)
0.2 0.9 GO:0008091 spectrin(GO:0008091)
0.2 1.6 GO:0042583 chromaffin granule(GO:0042583)
0.1 3.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.7 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.6 GO:0071203 WASH complex(GO:0071203)
0.1 1.1 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.4 GO:0097268 cytoophidium(GO:0097268)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.8 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 1.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.1 GO:0071565 nBAF complex(GO:0071565)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.8 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.1 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.4 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0043195 terminal bouton(GO:0043195)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0052834 inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.5 2.7 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.5 3.0 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 1.7 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.3 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.7 GO:0016361 activin receptor activity, type I(GO:0016361)
0.3 1.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.2 1.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 0.9 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.8 GO:0004359 glutaminase activity(GO:0004359)
0.2 0.7 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.2 0.6 GO:0072571 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.1 1.5 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.4 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.6 GO:0001735 prenylcysteine oxidase activity(GO:0001735)
0.1 0.6 GO:0070573 metallodipeptidase activity(GO:0070573)
0.1 0.6 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.1 0.4 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 1.0 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.4 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.6 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.6 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 6.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.9 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.4 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.1 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 1.6 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.5 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.7 GO:0005537 mannose binding(GO:0005537)
0.1 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 1.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.8 GO:0030552 cAMP binding(GO:0030552)
0.0 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 1.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.8 GO:0045296 cadherin binding(GO:0045296)
0.0 2.9 GO:0061135 endopeptidase inhibitor activity(GO:0004866) endopeptidase regulator activity(GO:0061135)
0.0 0.9 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.1 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation