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PRJEB1986: zebrafish developmental stages transcriptome

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Results for klf5l+klf6a+klf6b

Z-value: 0.46

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Transcription factors associated with klf5l+klf6a+klf6b

Gene Symbol Gene ID Gene Info
klf5l
ENSDARG00000018757 Kruppel-like factor 5 like
klf6a
ENSDARG00000029072 Kruppel-like factor 6a
klf6b
ENSDARG00000038561 Kruppel-like factor 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf6bdr11_v1_chr2_+_48074243_480742430.724.9e-04Click!
klf6adr11_v1_chr24_-_4148914_4148915-0.455.6e-02Click!
klf5ldr11_v1_chr21_-_38153824_381538240.107.0e-01Click!

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_44026369 1.72 ENSDART00000185456
crybb1
crystallin, beta B1
chr8_+_43056153 1.64 ENSDART00000186377
prnpa
prion protein a
chr20_+_9355912 1.29 ENSDART00000142337
si:dkey-174m14.3
si:dkey-174m14.3
chr3_+_32526263 1.27 ENSDART00000150897
si:ch73-367p23.2
si:ch73-367p23.2
chr6_-_13891727 1.13 ENSDART00000065356
desmb
desmin b
chr6_-_60104628 1.06 ENSDART00000057463
ENSDART00000169188
pmepa1
prostate transmembrane protein, androgen induced 1
chr24_+_36452927 0.70 ENSDART00000168181
zgc:114120
zgc:114120
chr18_+_660578 0.69 ENSDART00000161203
CELF6
si:dkey-205h23.2
chr3_+_1223824 0.66 ENSDART00000065922
wbp2nl
WBP2 N-terminal like
chr15_-_25613114 0.65 ENSDART00000182431
ENSDART00000187405
taok1a
TAO kinase 1a
chr20_-_7176809 0.65 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr21_+_45733871 0.63 ENSDART00000187285
ENSDART00000193018
zgc:77058
zgc:77058
chr20_+_4392687 0.63 ENSDART00000187271
im:7142702
im:7142702
chr2_+_59015878 0.59 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr2_-_32501501 0.57 ENSDART00000181309
faim2a
Fas apoptotic inhibitory molecule 2a
chr2_+_24867534 0.54 ENSDART00000158050
rab3aa
RAB3A, member RAS oncogene family, a
chr22_+_12366516 0.51 ENSDART00000157802
r3hdm1
R3H domain containing 1
chr25_+_2229301 0.50 ENSDART00000180198
pparab
peroxisome proliferator-activated receptor alpha b
chr3_-_62380146 0.49 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr21_+_43253538 0.49 ENSDART00000179940
ENSDART00000164806
ENSDART00000147026
shroom1
shroom family member 1
chr24_-_28381404 0.47 ENSDART00000148406
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr21_-_24865454 0.44 ENSDART00000142907
igsf9bb
immunoglobulin superfamily, member 9Bb
chr15_-_47956388 0.43 ENSDART00000116506
si:ch1073-111c8.3
si:ch1073-111c8.3
chr2_+_24868010 0.40 ENSDART00000078838
rab3aa
RAB3A, member RAS oncogene family, a
chr8_-_4100365 0.39 ENSDART00000142846
cux2b
cut-like homeobox 2b
chr15_+_20543770 0.37 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr1_-_10647484 0.37 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
si:dkey-31e10.1
chr22_+_1006573 0.34 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr4_+_3438510 0.34 ENSDART00000155320
atxn7l1
ataxin 7-like 1
chr20_-_1268863 0.33 ENSDART00000109321
ENSDART00000027119
lats1
large tumor suppressor kinase 1
chr21_-_37733571 0.33 ENSDART00000176214
mpp1
membrane protein, palmitoylated 1
chr13_+_23093743 0.30 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr12_-_47648538 0.29 ENSDART00000108477
fh
fumarate hydratase
chr21_-_24865217 0.29 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr2_+_33335911 0.28 ENSDART00000126135
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr4_+_57093908 0.28 ENSDART00000170198
si:ch211-238e22.5
si:ch211-238e22.5
chr15_-_45538773 0.27 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr10_-_38456382 0.25 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr10_+_21650828 0.25 ENSDART00000160754
pcdh1g1
protocadherin 1 gamma 1
chr9_+_44722205 0.25 ENSDART00000086176
ENSDART00000145271
ENSDART00000132696
nckap1
NCK-associated protein 1
chr21_+_6613772 0.25 ENSDART00000159645
col5a1
procollagen, type V, alpha 1
chr10_+_41549819 0.24 ENSDART00000114210
CABZ01049847.1

chr9_+_17787864 0.24 ENSDART00000013111
dgkh
diacylglycerol kinase, eta
chr13_-_50200042 0.23 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains
chr16_-_563235 0.23 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr25_-_6629281 0.22 ENSDART00000112782
cspg4
chondroitin sulfate proteoglycan 4
chr17_+_37253706 0.22 ENSDART00000076004
tmem62
transmembrane protein 62
chr1_-_10647307 0.21 ENSDART00000103548
si:dkey-31e10.1
si:dkey-31e10.1
chr13_-_7767548 0.20 ENSDART00000158720
ENSDART00000121952
h2afy2
H2A histone family, member Y2
chr8_+_36621598 0.20 ENSDART00000180389
magixb
MAGI family member, X-linked b
chr23_+_42338325 0.19 ENSDART00000169660
cyp2aa7
cytochrome P450, family 2, subfamily AA, polypeptide 7
chr13_+_33688474 0.18 ENSDART00000161465
CABZ01087953.1

chr22_+_396840 0.18 ENSDART00000163198
capzb
capping protein (actin filament) muscle Z-line, beta
chr9_+_13999620 0.17 ENSDART00000143229
cd28l
cd28-like molecule
chr19_-_20106486 0.17 ENSDART00000043924
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr20_-_49889111 0.16 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr21_-_5056812 0.16 ENSDART00000139713
ENSDART00000140859
zgc:77838
zgc:77838
chr21_-_37733287 0.16 ENSDART00000157826
mpp1
membrane protein, palmitoylated 1
chr4_+_53119675 0.16 ENSDART00000167470
si:dkey-8o9.2
si:dkey-8o9.2
chr17_+_6793001 0.15 ENSDART00000030773
foxo3a
forkhead box O3A
chr8_+_8298439 0.14 ENSDART00000170566
srpk3
SRSF protein kinase 3
chr9_+_38427572 0.14 ENSDART00000108860
CYP27A1 (1 of many)
zgc:136333
chr22_+_344763 0.13 ENSDART00000181934
CU914780.1

chr9_-_8454060 0.10 ENSDART00000110158
irs2b
insulin receptor substrate 2b
chr22_+_35089031 0.10 ENSDART00000076040
srfa
serum response factor a
chr22_-_26558166 0.10 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr23_-_524780 0.09 ENSDART00000055139
col9a3
collagen, type IX, alpha 3
chr6_+_12503849 0.07 ENSDART00000149529
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr3_-_30909487 0.05 ENSDART00000025046
ppp1caa
protein phosphatase 1, catalytic subunit, alpha isozyme a
chr15_-_38202630 0.04 ENSDART00000183772
rhoga
ras homolog family member Ga
chr7_-_23768234 0.04 ENSDART00000173981
si:ch211-200p22.4
si:ch211-200p22.4
chr5_-_37252111 0.03 ENSDART00000185110
lrch2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr6_-_10788065 0.02 ENSDART00000190968
wipf1b
WAS/WASL interacting protein family, member 1b
chr25_+_27493444 0.01 ENSDART00000112299
gpr37a
G protein-coupled receptor 37a
chr22_+_30496360 0.01 ENSDART00000189145
BX649490.4

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 0.5 GO:0070417 cellular response to cold(GO:0070417)
0.2 1.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.7 GO:0007343 egg activation(GO:0007343)
0.1 1.3 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 0.3 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.0 0.3 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.7 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.2 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.3 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.3 GO:0003139 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.0 0.6 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.2 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 1.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070062 extracellular exosome(GO:0070062)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.6 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.7 GO:0050699 WW domain binding(GO:0050699)
0.1 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.5 GO:0016208 AMP binding(GO:0016208)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)