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PRJEB1986: zebrafish developmental stages transcriptome

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Results for klf15+si:ch211-117k10.3

Z-value: 0.76

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Transcription factors associated with klf15+si:ch211-117k10.3

Gene Symbol Gene ID Gene Info
si_ch211-117k10.3
ENSDARG00000090914 si_ch211-117k10.3
klf15
ENSDARG00000091127 Kruppel-like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-117k10.3dr11_v1_chr11_-_38513978_38513978-0.871.1e-06Click!
klf15dr11_v1_chr23_-_35195908_35195908-0.861.8e-06Click!

Activity profile of klf15+si:ch211-117k10.3 motif

Sorted Z-values of klf15+si:ch211-117k10.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_16289826 2.64 ENSDART00000131972
bckdhbl
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr5_+_22067570 2.37 ENSDART00000045574
shisa2a
shisa family member 2a
chr23_+_31245395 2.31 ENSDART00000053588
irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr14_-_9522364 2.24 ENSDART00000054689
atoh8
atonal bHLH transcription factor 8
chr11_-_30138299 1.92 ENSDART00000172106
scml2
Scm polycomb group protein like 2
chr5_+_27525477 1.88 ENSDART00000051491
sfrp1a
secreted frizzled-related protein 1a
chr21_-_43117327 1.81 ENSDART00000122352
p4ha2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr7_+_19552381 1.72 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr14_+_34495216 1.60 ENSDART00000147756
wnt8a
wingless-type MMTV integration site family, member 8a
chr7_+_1449999 1.59 ENSDART00000173864
si:cabz01101003.1
si:cabz01101003.1
chr10_-_43113731 1.54 ENSDART00000138099
tmem167a
transmembrane protein 167A
chr6_-_53326421 1.52 ENSDART00000191740
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr20_+_35279968 1.51 ENSDART00000168216
ENSDART00000153332
fam49a
family with sequence similarity 49, member A
chr13_-_45523026 1.51 ENSDART00000020663
rhd
Rh blood group, D antigen
chr3_+_23703704 1.51 ENSDART00000024256
hoxb6a
homeobox B6a
chr24_-_4450238 1.49 ENSDART00000066835
fzd8a
frizzled class receptor 8a
chr22_-_20403194 1.48 ENSDART00000010048
map2k2a
mitogen-activated protein kinase kinase 2a
chr5_-_35264517 1.45 ENSDART00000114981
ptcd2
pentatricopeptide repeat domain 2
chr14_+_45596583 1.45 ENSDART00000110429
zgc:194285
zgc:194285
chr18_-_26715156 1.22 ENSDART00000142043
malt3
MALT paracaspase 3
chr25_+_150570 1.17 ENSDART00000170892
adam10b
ADAM metallopeptidase domain 10b
chr6_+_36821621 1.17 ENSDART00000104157
tmem45a
transmembrane protein 45a
chr12_+_10443785 1.10 ENSDART00000029133
snu13b
SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5)
chr8_-_23776399 1.08 ENSDART00000114800
INAVA
si:ch211-163l21.4
chr2_-_7246338 1.07 ENSDART00000186735
zgc:153115
zgc:153115
chr9_-_8314028 1.06 ENSDART00000102739
si:ch211-145c1.1
si:ch211-145c1.1
chr21_+_15601100 1.06 ENSDART00000180558
ENSDART00000145454
smarcb1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr9_-_39968820 1.06 ENSDART00000100311
IKZF2
si:zfos-1425h8.1
chr4_+_9057427 1.02 ENSDART00000113867
slc41a2b
solute carrier family 41 (magnesium transporter), member 2b
chr7_+_29167744 0.92 ENSDART00000076345
slc38a8b
solute carrier family 38, member 8b
chr24_+_42131564 0.89 ENSDART00000153854
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr7_+_44445595 0.89 ENSDART00000108766
cdh5
cadherin 5
chr11_+_6010177 0.89 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
gtpbp3
GTP binding protein 3, mitochondrial
chr19_-_2707048 0.85 ENSDART00000166112
il6
interleukin 6 (interferon, beta 2)
chr2_+_44977889 0.83 ENSDART00000144024
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr11_+_11719575 0.80 ENSDART00000003891
jupa
junction plakoglobin a
chr14_-_32089117 0.80 ENSDART00000158014
si:ch211-69b22.5
si:ch211-69b22.5
chr25_-_34284144 0.79 ENSDART00000188109
gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr18_+_46151505 0.78 ENSDART00000015034
ENSDART00000141287
blvrb
biliverdin reductase B
chr3_-_36690348 0.77 ENSDART00000192513
myh11b
myosin, heavy chain 11b, smooth muscle
chr16_+_7991274 0.76 ENSDART00000179704
ano10a
anoctamin 10a
chr10_-_40333319 0.76 ENSDART00000150479
taar20a
trace amine associated receptor 20a
chr10_-_24961310 0.75 ENSDART00000037303
si:ch211-214k5.3
si:ch211-214k5.3
chr14_-_15154695 0.73 ENSDART00000160677
uvssa
UV-stimulated scaffold protein A
chr22_-_24285432 0.71 ENSDART00000164083
si:ch211-117l17.4
si:ch211-117l17.4
chr22_-_24284961 0.70 ENSDART00000141230
si:ch211-117l17.4
si:ch211-117l17.4
chr19_+_48117995 0.68 ENSDART00000170865
nme2b.1
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
chr5_-_28606916 0.68 ENSDART00000026107
ENSDART00000137717
tnc
tenascin C
chr14_+_48960078 0.65 ENSDART00000165514
mif
macrophage migration inhibitory factor
chr1_-_39943596 0.63 ENSDART00000149730
stox2a
storkhead box 2a
chr17_+_53418445 0.62 ENSDART00000097631
slc9a1b
solute carrier family 9 member A1b
chr3_+_35611625 0.61 ENSDART00000190995
traf7
TNF receptor-associated factor 7
chr22_-_4872418 0.60 ENSDART00000132360
si:ch73-256j6.6
si:ch73-256j6.6
chr20_-_7080427 0.59 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
si:ch211-121a2.2
chr11_-_3334248 0.57 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr18_-_26715655 0.57 ENSDART00000181497
malt3
MALT paracaspase 3
chr12_-_14211293 0.57 ENSDART00000158399
avl9
AVL9 homolog (S. cerevisiase)
chr5_-_36916790 0.56 ENSDART00000143827
kptn
kaptin (actin binding protein)
chr24_+_28525507 0.55 ENSDART00000191121
arhgap29a
Rho GTPase activating protein 29a
chr15_-_23376541 0.54 ENSDART00000078570
c1qtnf5
C1q and TNF related 5
chr12_-_15002563 0.52 ENSDART00000108852
ENSDART00000141909
pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
chr18_+_32780450 0.50 ENSDART00000168399
olfcg7
olfactory receptor C family, g7
chr2_-_23479714 0.49 ENSDART00000167291
si:ch211-14p21.3
si:ch211-14p21.3
chr22_-_5918670 0.48 ENSDART00000141373
si:rp71-36a1.1
si:rp71-36a1.1
chr23_+_36308717 0.48 ENSDART00000131711
hnrnpa1b
heterogeneous nuclear ribonucleoprotein A1b
chr11_-_23322182 0.48 ENSDART00000111289
kiss1
KiSS-1 metastasis-suppressor
chr7_-_71331499 0.48 ENSDART00000081245
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr17_-_4395373 0.47 ENSDART00000015923
klhl10a
kelch-like family member 10a
chr2_+_24781026 0.47 ENSDART00000145692
pde4ca
phosphodiesterase 4C, cAMP-specific a
chr10_-_25657506 0.47 ENSDART00000110751
tiam1a
T cell lymphoma invasion and metastasis 1a
chr6_-_42003780 0.46 ENSDART00000032527
cav3
caveolin 3
chr13_+_18663600 0.44 ENSDART00000141647
selenou1a
selenoprotein U 1a
chr6_+_23712911 0.43 ENSDART00000167795
zgc:158654
zgc:158654
chr22_+_413349 0.42 ENSDART00000082453
celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr8_-_52938439 0.42 ENSDART00000168185
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr18_+_33725576 0.41 ENSDART00000146816
si:dkey-145c18.5
si:dkey-145c18.5
chr7_-_5711197 0.41 ENSDART00000134367
si:dkey-10h3.2
si:dkey-10h3.2
chr7_+_36898622 0.40 ENSDART00000190773
tox3
TOX high mobility group box family member 3
chr8_+_8947623 0.40 ENSDART00000131215
slc35a2
solute carrier family 35 (UDP-galactose transporter), member 2
chr20_-_46053720 0.40 ENSDART00000136254
taar12h
trace amine associated receptor 12h
chr24_-_40774028 0.40 ENSDART00000166578
CU633479.2

chr24_-_32582378 0.37 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr9_+_29323163 0.37 ENSDART00000184908
oxgr1b
oxoglutarate (alpha-ketoglutarate) receptor 1b
chr5_-_16351306 0.36 ENSDART00000168643
CABZ01088700.1

chr5_+_38886499 0.34 ENSDART00000076845
fras1
Fraser extracellular matrix complex subunit 1
chr16_-_31976269 0.33 ENSDART00000139664
styk1
serine/threonine/tyrosine kinase 1
chr15_-_18223769 0.31 ENSDART00000139966
or131-1
odorant receptor, family H, subfamily 131, member 1
chr5_-_69621227 0.30 ENSDART00000178543
aldh2.2
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr21_+_13389499 0.28 ENSDART00000151268
zgc:113162
zgc:113162
chr22_-_17474583 0.28 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr4_-_11064073 0.27 ENSDART00000150760
si:dkey-21h14.8
si:dkey-21h14.8
chr8_-_13722682 0.24 ENSDART00000142052
si:dkey-258f14.2
si:dkey-258f14.2
chr11_-_40504170 0.24 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr12_-_16990896 0.23 ENSDART00000152402
ifit12
interferon-induced protein with tetratricopeptide repeats 12
chr3_+_52467879 0.23 ENSDART00000156039
adgre5a
adhesion G protein-coupled receptor E5a
chr19_-_46037835 0.22 ENSDART00000163815
nup153
nucleoporin 153
chr1_-_44638058 0.21 ENSDART00000081835
slc43a1b
solute carrier family 43 (amino acid system L transporter), member 1b
chr22_+_12477996 0.19 ENSDART00000177704
CR847870.3

chr22_+_26703026 0.16 ENSDART00000158756
crebbpa
CREB binding protein a
chr13_+_28732101 0.16 ENSDART00000015773
ldb1a
LIM domain binding 1a
chr22_+_26853254 0.15 ENSDART00000182487
tmem186
transmembrane protein 186
chr14_+_24283915 0.14 ENSDART00000172868
klhl3
kelch-like family member 3
chr2_-_48512450 0.11 ENSDART00000160132
CR391991.1

chr16_-_12470034 0.11 ENSDART00000147483
ephb6
eph receptor B6
chr5_-_8636168 0.10 ENSDART00000134877
fyba
FYN binding protein a
chr20_-_48516765 0.09 ENSDART00000150200
si:zfos-223e1.2
si:zfos-223e1.2
chr11_-_19501439 0.08 ENSDART00000158328
ENSDART00000103983
slc2a9l1
solute carrier family 2 (facilitated glucose transporter), member 9-like 1
chr14_-_23799345 0.06 ENSDART00000124144
ENSDART00000181179
ENSDART00000124401
nr3c1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr7_-_71331690 0.05 ENSDART00000149682
dhx15
DEAH (Asp-Glu-Ala-His) box helicase 15
chr20_-_1560724 0.04 ENSDART00000179193
ENSDART00000092508
ENSDART00000133369
ptprk
protein tyrosine phosphatase, receptor type, K
chr6_-_29377092 0.03 ENSDART00000078665
tmem131
transmembrane protein 131
chr23_+_7518294 0.03 ENSDART00000081536
hck
HCK proto-oncogene, Src family tyrosine kinase
chr21_-_45086170 0.03 ENSDART00000188963
rapgef6
Rap guanine nucleotide exchange factor (GEF) 6
chr6_+_46697710 0.02 ENSDART00000154969
tespa1
thymocyte expressed, positive selection associated 1
chr9_-_50000144 0.00 ENSDART00000123416
scn1a
sodium channel, voltage-gated, type I, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15+si:ch211-117k10.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.5 1.6 GO:0021512 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.5 1.5 GO:0060898 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.2 0.7 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.2 0.9 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 1.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.8 GO:0002159 desmosome assembly(GO:0002159)
0.2 1.5 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.1 0.9 GO:0006953 acute-phase response(GO:0006953)
0.1 0.7 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.8 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 1.5 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.1 0.6 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.5 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.1 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.8 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.7 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 1.2 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.9 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.4 GO:0021754 facial nucleus development(GO:0021754)
0.0 1.1 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0033555 multicellular organismal response to stress(GO:0033555)
0.0 2.3 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.6 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.6 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0015804 neutral amino acid transport(GO:0015804)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0097189 apoptotic body(GO:0097189)
0.2 1.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.1 GO:0035060 brahma complex(GO:0035060)
0.0 1.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.7 GO:0016342 catenin complex(GO:0016342)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.2 0.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 2.6 GO:0033691 sialic acid binding(GO:0033691)
0.2 1.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 3.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.1 0.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.6 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 ST STAT3 PATHWAY STAT3 Pathway
0.1 0.9 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 0.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules