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PRJEB1986: zebrafish developmental stages transcriptome

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Results for irx6a

Z-value: 0.33

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Transcription factors associated with irx6a

Gene Symbol Gene ID Gene Info
irx6a
ENSDARG00000034420 iroquois homeobox 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx6adr11_v1_chr7_-_35516251_35516251-0.175.0e-01Click!

Activity profile of irx6a motif

Sorted Z-values of irx6a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_910992 0.44 ENSDART00000161206
ENSDART00000167229
pkma
pyruvate kinase M1/2a
chr8_+_29986265 0.30 ENSDART00000148258
ptch1
patched 1
chr23_-_32944796 0.29 ENSDART00000190388
plxna2
plexin A2
chr1_-_59287410 0.28 ENSDART00000158011
ENSDART00000170580
col5a3b
collagen, type V, alpha 3b
chr21_-_45871866 0.26 ENSDART00000161716
larp1
La ribonucleoprotein domain family, member 1
chr5_-_33460959 0.26 ENSDART00000085636
si:ch211-182d3.1
si:ch211-182d3.1
chr9_-_2945008 0.25 ENSDART00000183452
zak
sterile alpha motif and leucine zipper containing kinase AZK
chr16_+_22649855 0.22 ENSDART00000143043
chrnb2b
cholinergic receptor, nicotinic, beta 2b
chr22_+_2431585 0.21 ENSDART00000167758
zgc:171435
zgc:171435
chr22_+_2492397 0.21 ENSDART00000181596
CU570894.2

chr20_-_13774826 0.21 ENSDART00000063831
opn8c
opsin 8, group member c
chr14_-_33177935 0.20 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr4_+_22613625 0.20 ENSDART00000131161
sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr20_-_27190393 0.20 ENSDART00000149024
btbd7
BTB (POZ) domain containing 7
chr4_-_75175407 0.19 ENSDART00000180125
CABZ01043953.1

chr16_-_45398408 0.19 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr11_+_13224281 0.19 ENSDART00000102557
ENSDART00000178706
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr18_+_5549672 0.19 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr11_+_14284866 0.19 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr16_+_1803462 0.19 ENSDART00000183974
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr10_-_28117740 0.18 ENSDART00000134491
med13a
mediator complex subunit 13a
chr13_+_23677949 0.18 ENSDART00000144215
pcnxl2
pecanex-like 2 (Drosophila)
chr14_-_47963115 0.18 ENSDART00000003826
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr15_-_9419472 0.17 ENSDART00000122117
sacs
sacsin molecular chaperone
chr20_+_35382482 0.16 ENSDART00000135284
vsnl1a
visinin-like 1a
chr18_+_19990412 0.16 ENSDART00000155054
ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr8_-_11832771 0.16 ENSDART00000193412
ENSDART00000184720
ENSDART00000139947
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a
chr8_-_1219815 0.15 ENSDART00000016800
ENSDART00000149969
znf367
zinc finger protein 367
chr24_-_15263142 0.15 ENSDART00000183176
ENSDART00000006930
rttn
rotatin
chr8_-_6943155 0.15 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr20_+_23440632 0.15 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr9_+_24088062 0.14 ENSDART00000126198
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr14_+_10567104 0.14 ENSDART00000160723
gpr174
G protein-coupled receptor 174
chr23_-_3721444 0.14 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr6_-_131401 0.14 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr25_+_7671640 0.14 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr22_+_2937485 0.13 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr4_+_9028819 0.13 ENSDART00000102893
aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr21_+_40498628 0.12 ENSDART00000163454
coro6
coronin 6
chr13_-_34683370 0.12 ENSDART00000113661
kif16bb
kinesin family member 16Bb
chr6_+_3827751 0.12 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr15_-_3976035 0.11 ENSDART00000168061
si:ch73-309g22.1
si:ch73-309g22.1
chr2_+_54804385 0.10 ENSDART00000172309
twsg1a
twisted gastrulation BMP signaling modulator 1a
chr20_-_38610360 0.10 ENSDART00000168783
ENSDART00000164638
slc30a2
solute carrier family 30 (zinc transporter), member 2
chr20_-_7072487 0.09 ENSDART00000145954
si:ch211-121a2.2
si:ch211-121a2.2
chr5_+_66170479 0.09 ENSDART00000172117
gldc
glycine dehydrogenase (decarboxylating)
chr23_-_7594723 0.08 ENSDART00000115298
plagl2
pleiomorphic adenoma gene-like 2
chr5_-_24238733 0.08 ENSDART00000138170
plscr3a
phospholipid scramblase 3a
chr16_+_25316973 0.08 ENSDART00000086409
dync1i1
dynein, cytoplasmic 1, intermediate chain 1
chr15_-_5178899 0.08 ENSDART00000132148
or126-4
odorant receptor, family E, subfamily 126, member 4
chr17_-_26719821 0.08 ENSDART00000186813
calm1a
calmodulin 1a
chr15_-_23522653 0.08 ENSDART00000144685
hmbsb
hydroxymethylbilane synthase, b
chr19_-_17526735 0.08 ENSDART00000189391
thrb
thyroid hormone receptor beta
chr24_-_26981848 0.07 ENSDART00000183198
stag1b
stromal antigen 1b
chr7_+_10701770 0.07 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr15_-_2857961 0.06 ENSDART00000033263
ankrd49
ankyrin repeat domain 49
chr9_-_52598343 0.06 ENSDART00000167922
xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr20_-_23440955 0.05 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr22_+_31207226 0.05 ENSDART00000180016
grip2b
glutamate receptor interacting protein 2b
chr12_+_4222854 0.04 ENSDART00000144881
mapk7
mitogen-activated protein kinase 7
chr1_-_7951002 0.04 ENSDART00000138187
si:dkey-79f11.8
si:dkey-79f11.8
chr6_-_43262400 0.04 ENSDART00000156267
frmd4ba
FERM domain containing 4Ba
chr9_+_23748133 0.03 ENSDART00000180758
faima
Fas apoptotic inhibitory molecule a
chr19_-_26923273 0.03 ENSDART00000089609
skiv2l
SKI2 homolog, superkiller viralicidic activity 2-like
chr19_-_26923957 0.03 ENSDART00000182390
skiv2l
SKI2 homolog, superkiller viralicidic activity 2-like
chr7_-_44672095 0.03 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr5_+_37517800 0.02 ENSDART00000048107
FP102018.1
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr15_-_14375452 0.02 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
dpf1
D4, zinc and double PHD fingers family 1
chr4_-_18841071 0.01 ENSDART00000140722
cbll1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr21_+_21702623 0.01 ENSDART00000136840
or125-2
odorant receptor, family E, subfamily 125, member 2
chr6_+_27304503 0.01 ENSDART00000154759
espnla
espin like a
chr17_-_27266053 0.01 ENSDART00000110903
E2F2
si:ch211-160f23.5
chr5_-_48268049 0.01 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr21_+_20549395 0.01 ENSDART00000181633
efna5a
ephrin-A5a
chr18_+_8346920 0.01 ENSDART00000083421
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr6_+_6802582 0.01 ENSDART00000189422
dtd1
D-tyrosyl-tRNA deacylase 1
chr5_-_58996324 0.00 ENSDART00000033923
mis12
MIS12 kinetochore complex component
chr13_+_12389849 0.00 ENSDART00000086525
atp10d
ATPase phospholipid transporting 10D

Network of associatons between targets according to the STRING database.

First level regulatory network of irx6a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003403 optic vesicle formation(GO:0003403)
0.0 0.2 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0009397 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.3 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.1 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.1 GO:0043703 retinal cone cell fate determination(GO:0042671) eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate determination(GO:0043703) retinal cone cell fate commitment(GO:0046551) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 0.1 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.1 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 0.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.2 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors