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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hoxb5a+hoxb5b

Z-value: 0.72

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Transcription factors associated with hoxb5a+hoxb5b

Gene Symbol Gene ID Gene Info
hoxb5a
ENSDARG00000013057 homeobox B5a
hoxb5b
ENSDARG00000054030 homeobox B5b
hoxb5b
ENSDARG00000113174 homeobox B5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb5adr11_v1_chr3_+_23707691_23707691-0.821.7e-05Click!
hoxb5bdr11_v1_chr12_+_27129659_27129659-0.571.1e-02Click!

Activity profile of hoxb5a+hoxb5b motif

Sorted Z-values of hoxb5a+hoxb5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_48755638 1.78 ENSDART00000047401
abcb11a
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr13_+_534453 1.57 ENSDART00000147909
wu:fc17b08
wu:fc17b08
chr12_+_7865470 1.51 ENSDART00000161683
BX548028.1

chr19_+_17642356 1.32 ENSDART00000176431
CR382334.1

chr12_-_7710563 1.24 ENSDART00000187382
CABZ01050062.1

chr4_-_77551860 1.10 ENSDART00000188176
AL935186.6

chr16_-_29387215 1.08 ENSDART00000148787
s100a1
S100 calcium binding protein A1
chr4_-_77563411 1.06 ENSDART00000186841
AL935186.8

chr21_-_9769500 1.05 ENSDART00000170710
arhgap24
Rho GTPase activating protein 24
chr8_-_36554675 1.04 ENSDART00000132804
ENSDART00000078746
ccdc157
coiled-coil domain containing 157
chr19_+_15441022 0.98 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr6_+_54888493 0.94 ENSDART00000113331
nav1b
neuron navigator 1b
chr25_+_35212919 0.72 ENSDART00000180127
ano5a
anoctamin 5a
chr17_+_53156530 0.71 ENSDART00000126277
ENSDART00000156774
dph6
diphthamine biosynthesis 6
chr9_-_12034444 0.64 ENSDART00000038651
znf804a
zinc finger protein 804A
chr6_+_4255319 0.63 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr17_+_15041647 0.61 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr15_-_29556757 0.61 ENSDART00000060049
hspa13
heat shock protein 70 family, member 13
chr5_-_16791223 0.56 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr11_+_24957858 0.56 ENSDART00000145647
sulf2a
sulfatase 2a
chr13_-_44819254 0.53 ENSDART00000131673
si:dkeyp-2e4.8
si:dkeyp-2e4.8
chr3_-_5413018 0.53 ENSDART00000063138
vmo1a
vitelline membrane outer layer 1 homolog a
chr7_+_56889879 0.52 ENSDART00000039810
myo9aa
myosin IXAa
chr18_+_33580391 0.49 ENSDART00000189300
si:dkey-47k20.4
si:dkey-47k20.4
chr14_+_33723309 0.48 ENSDART00000132488
apln
apelin
chr19_+_48060464 0.48 ENSDART00000123163
zgc:85936
zgc:85936
chr4_-_25812329 0.47 ENSDART00000146658
tmcc3
transmembrane and coiled-coil domain family 3
chr12_+_17436904 0.46 ENSDART00000079130
atad1b
ATPase family, AAA domain containing 1b
chr19_-_27827744 0.45 ENSDART00000181620
papd7
PAP associated domain containing 7
chr1_-_56596701 0.43 ENSDART00000133693
LO018605.1

chr3_-_4911989 0.43 ENSDART00000158197
si:dkey-73p2.2
si:dkey-73p2.2
chr22_-_4812755 0.42 ENSDART00000191739
CU570881.2

chr1_+_55080797 0.42 ENSDART00000077390
lgalsla
lectin, galactoside-binding-like a
chr20_+_33708318 0.40 ENSDART00000135845
ak9
adenylate kinase 9
chr5_-_71838520 0.40 ENSDART00000174396
CU927890.1

chr8_-_43847138 0.39 ENSDART00000148358
adgrd1
adhesion G protein-coupled receptor D1
chr15_-_25099679 0.38 ENSDART00000154628
rflnb
refilin B
chr13_-_36134317 0.37 ENSDART00000015664
ENSDART00000188301
ENSDART00000191073
ENSDART00000184192
ENSDART00000139593
pcnx
pecanex homolog (Drosophila)
chr15_-_684911 0.32 ENSDART00000161685
zgc:171901
zgc:171901
chr9_+_6082793 0.31 ENSDART00000192045
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr6_+_41191482 0.31 ENSDART00000000877
opn1mw3
opsin 1 (cone pigments), medium-wave-sensitive, 3
chr5_-_33769211 0.31 ENSDART00000133504
dab2ipb
DAB2 interacting protein b
chr19_+_46259619 0.30 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr25_+_36316280 0.30 ENSDART00000152735
si:ch211-113a14.11
si:ch211-113a14.11
chr3_-_1520657 0.30 ENSDART00000053201
polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr14_-_31893996 0.30 ENSDART00000173222
gpr101
G protein-coupled receptor 101
chr20_+_51730658 0.29 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr23_+_22293682 0.28 ENSDART00000187304
CR354612.1

chr17_+_49081828 0.26 ENSDART00000156492
tiam2a
T cell lymphoma invasion and metastasis 2a
chr5_-_9625459 0.26 ENSDART00000143347
sh2b3
SH2B adaptor protein 3
chr6_-_15603675 0.26 ENSDART00000143502
lrrfip1b
leucine rich repeat (in FLII) interacting protein 1b
chr1_-_59126139 0.25 ENSDART00000156105
si:ch1073-110a20.7
si:ch1073-110a20.7
chr11_-_2297832 0.25 ENSDART00000158266
znf740a
zinc finger protein 740a
chr1_-_51157454 0.25 ENSDART00000047851
jag1a
jagged 1a
chr18_-_506082 0.25 ENSDART00000169974
sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
chr3_+_54776117 0.24 ENSDART00000189047
ENSDART00000115076
si:ch211-74m13.1
si:ch211-74m13.1
chr2_-_3038904 0.22 ENSDART00000186795
guk1a
guanylate kinase 1a
chr6_-_18992896 0.22 ENSDART00000170228
sept9b
septin 9b
chr15_-_23814330 0.22 ENSDART00000153843
si:ch211-167j9.5
si:ch211-167j9.5
chr5_+_59392183 0.21 ENSDART00000082983
ENSDART00000180882
clip2
CAP-GLY domain containing linker protein 2
chr3_+_54776475 0.19 ENSDART00000142710
si:ch211-74m13.1
si:ch211-74m13.1
chr10_+_35439952 0.19 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr4_+_41789497 0.18 ENSDART00000126634
si:dkey-237m9.2
si:dkey-237m9.2
chr19_-_40175800 0.18 ENSDART00000102904
illr4
immune-related, lectin-like receptor 4
chr11_-_6070192 0.16 ENSDART00000162776
babam1
BRISC and BRCA1 A complex member 1
chr2_+_24317465 0.15 ENSDART00000139339
ENSDART00000136284
mrpl34
mitochondrial ribosomal protein L34
chr7_-_51102479 0.15 ENSDART00000174023
col4a6
collagen, type IV, alpha 6
chr19_+_23298037 0.15 ENSDART00000183948
irgf1
immunity-related GTPase family, f1
chr7_+_33314925 0.14 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr16_+_16826504 0.14 ENSDART00000108691
kcnj14
potassium inwardly-rectifying channel, subfamily J, member 14
chr10_+_2684958 0.14 ENSDART00000112019
setd9
SET domain containing 9
chr10_+_18557102 0.14 ENSDART00000160157
CR388008.1

chr4_-_59094319 0.12 ENSDART00000162560
si:dkey-28i19.1
si:dkey-28i19.1
chr22_+_17536989 0.12 ENSDART00000149531
hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr5_-_41142467 0.11 ENSDART00000129415
zfr
zinc finger RNA binding protein
chr13_-_86847 0.11 ENSDART00000158062
pole2
polymerase (DNA directed), epsilon 2
chr8_+_36554816 0.11 ENSDART00000126687
sf3a1
splicing factor 3a, subunit 1
chr10_+_26944418 0.09 ENSDART00000135493
frmd8
FERM domain containing 8
chr4_+_77966055 0.09 ENSDART00000174203
ENSDART00000130100
ENSDART00000080665
ENSDART00000174317
ENSDART00000190123
zgc:113921
zgc:113921
chr20_+_48543492 0.08 ENSDART00000175480
LO018254.1

chr14_-_43586150 0.07 ENSDART00000113697
eif4ea
eukaryotic translation initiation factor 4ea
chr20_+_43113465 0.07 ENSDART00000004842
dusp23a
dual specificity phosphatase 23a
chr8_+_25962833 0.07 ENSDART00000086583
si:dkey-72l14.4
si:dkey-72l14.4
chr4_+_38547203 0.06 ENSDART00000171349
si:ch211-209n20.1
si:ch211-209n20.1
chr1_-_49498116 0.06 ENSDART00000137357
zgc:175214
zgc:175214
chr14_+_8476769 0.06 ENSDART00000131773
dnajc4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr9_+_16854121 0.05 ENSDART00000110866
cln5
CLN5, intracellular trafficking protein
chr15_-_35031523 0.05 ENSDART00000154848
si:ch211-272b8.6
si:ch211-272b8.6
chr17_+_20569806 0.05 ENSDART00000113936
SAMD8
zgc:162183
chr7_+_36035432 0.05 ENSDART00000179004
irx3a
iroquois homeobox 3a
chr15_-_41458613 0.04 ENSDART00000141496
nlrc9
NLR family CARD domain containing 9
chr2_-_24317240 0.04 ENSDART00000078975
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr23_-_41965557 0.04 ENSDART00000144183
slc1a7b
solute carrier family 1 (glutamate transporter), member 7b
chr14_-_25078569 0.04 ENSDART00000172802
ENSDART00000173345
ENSDART00000135004
matr3l1.1
matrin 3-like 1.1
chr3_+_28831450 0.04 ENSDART00000055422
flr
fleer
chr7_-_72426484 0.04 ENSDART00000190063
rph3ab
rabphilin 3A homolog (mouse), b
chr21_-_43117327 0.03 ENSDART00000122352
p4ha2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr15_-_2803313 0.03 ENSDART00000060839
tgfb1a
transforming growth factor, beta 1a
chr9_-_41817712 0.02 ENSDART00000182657
si:dkeyp-30e7.2
si:dkeyp-30e7.2
chr22_+_12477996 0.02 ENSDART00000177704
CR847870.3

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb5a+hoxb5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.2 1.1 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 0.4 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.1 0.7 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.5 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.1 0.4 GO:0009202 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202) dGDP metabolic process(GO:0046066)
0.1 0.5 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.1 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.6 GO:0042026 protein refolding(GO:0042026)
0.0 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.3 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.0 0.1 GO:2000815 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.0 0.3 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.2 GO:0072425 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0 0.2 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.9 GO:0001764 neuron migration(GO:0001764)
0.0 0.2 GO:0030878 thyroid gland development(GO:0030878)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.1 GO:0008016 regulation of heart contraction(GO:0008016)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005845 mRNA cap binding complex(GO:0005845)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.2 0.5 GO:0031704 apelin receptor binding(GO:0031704)
0.1 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling