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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 2.26

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Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Gene Symbol Gene ID Gene Info
ENSDARG00000054033 homeobox B1b
ENSDARG00000070337 homeobox C1a
ENSDARG00000104307 homeobox A1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb1bdr11_v1_chr12_+_27141140_27141140-0.752.4e-04Click!
hoxc1adr11_v1_chr23_+_36178104_36178104-0.561.2e-02Click!
hoxa1adr11_v1_chr19_+_19786117_19786213-0.551.4e-02Click!

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_27972474 27.85 ENSDART00000162753

chr25_-_36827491 21.30 ENSDART00000170941

chr17_+_40684 19.18 ENSDART00000164231

chr20_+_1088658 16.79 ENSDART00000162991

chr1_-_14258409 13.68 ENSDART00000079359
phosphodiesterase 5A, cGMP-specific, a
chr13_-_51065048 11.83 ENSDART00000168085

chr12_-_25916530 9.89 ENSDART00000186386
synuclein, gamma b (breast cancer-specific protein 1)
chr2_+_33541928 9.63 ENSDART00000162852

chr14_-_1565317 8.34 ENSDART00000169496

chr9_-_51370293 8.18 ENSDART00000084806
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr14_+_2478994 7.66 ENSDART00000170538

chr20_-_47550577 7.62 ENSDART00000187361

chr22_-_600016 7.35 ENSDART00000086434
transmembrane and coiled-coil domain family 2
chr19_+_42219165 7.14 ENSDART00000163192

chr17_+_20607487 6.58 ENSDART00000154123
si:ch73-288o11.5
chr6_-_55585423 6.12 ENSDART00000157129
solute carrier family 12 (potassium/chloride transporter), member 5a
chr21_-_43079161 5.35 ENSDART00000144151
janus kinase and microtubule interacting protein 2
chr7_+_56615554 5.11 ENSDART00000098430
dipeptidase 1
chr13_-_2189761 4.88 ENSDART00000166255
muscular LMNA-interacting protein
chr20_-_30369598 4.77 ENSDART00000144549
allantoicase
chr11_-_11458208 4.65 ENSDART00000005485
keratin 93
chr11_-_1131569 4.55 ENSDART00000173228
solute carrier family 6 (neurotransmitter transporter), member 11b
chr23_+_21067684 4.49 ENSDART00000132066
potassium voltage-gated channel, shaker-related subfamily, beta member 2 b
chr10_+_466926 4.42 ENSDART00000145220
ARVCF, delta catenin family member a
chr22_+_38778649 4.39 ENSDART00000075873
alkaline phosphatase, intestinal, tandem duplicate 2
chr4_+_11384891 4.36 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr14_-_7888748 4.29 ENSDART00000166293
protein phosphatase 3, catalytic subunit, beta isozyme
chr10_+_439692 4.19 ENSDART00000147740
zinc finger, DHHC-type containing 8a
chr6_+_2174082 4.18 ENSDART00000073936
activin A receptor type 1Bb
chr2_-_45630823 4.10 ENSDART00000183553

chr7_+_30371893 4.02 ENSDART00000075513
aquaporin 9b
chr20_-_53624645 3.94 ENSDART00000083427
ENSDART00000152920
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
chr22_+_38778854 3.86 ENSDART00000182926
ENSDART00000125466
alkaline phosphatase, intestinal, tandem duplicate 2
chr11_+_30817943 3.80 ENSDART00000150130
ENSDART00000159997
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr18_-_42785469 3.76 ENSDART00000024768
tetratricopeptide repeat domain 36
chr16_-_13730152 3.58 ENSDART00000138772
tweety family member 1
chr23_-_12014931 3.55 ENSDART00000134652
si:dkey-178k16.1
chr15_+_42933236 3.52 ENSDART00000167763
solute carrier family 8 (sodium/calcium exchanger), member 2b
chr25_+_20215964 3.24 ENSDART00000139235
troponin T2d, cardiac
chr12_+_39685485 3.23 ENSDART00000163403

chr6_+_3640381 3.18 ENSDART00000172078
collagen, type XXVIII, alpha 2b
chr25_+_336503 3.12 ENSDART00000160395

chr21_+_30194904 3.04 ENSDART00000137023
ENSDART00000078403
si:ch211-59d17.3
chr6_-_16561536 2.96 ENSDART00000167295
unc-80 homolog (C. elegans)
chr5_-_55600689 2.95 ENSDART00000013229
guanine nucleotide binding protein (G protein), q polypeptide
chr17_+_8183393 2.95 ENSDART00000155957
tubby like protein 4b
chr20_+_27691307 2.90 ENSDART00000153299
si:dkey-1h6.8
chr17_-_53282539 2.89 ENSDART00000164953

chr2_+_45354747 2.89 ENSDART00000083957
ENSDART00000135582
ENSDART00000160867
calmodulin regulated spectrin-associated protein family, member 2b
chr23_-_12015139 2.83 ENSDART00000110627
ENSDART00000193988
ENSDART00000184528
si:dkey-178k16.1
chr20_+_29587995 2.79 ENSDART00000153339
ADAM metallopeptidase domain 17b
chr13_-_41908583 2.74 ENSDART00000136515
inositol polyphosphate multikinase a
chr15_-_33304133 2.68 ENSDART00000186092
neurobeachin b
chr16_+_46869010 2.64 ENSDART00000153619
thrombospondin, type I, domain containing 7Ab
chr16_+_46111849 2.63 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr3_+_46628885 2.59 ENSDART00000006602
phosphodiesterase 4A, cAMP-specific
chr22_+_3232925 2.52 ENSDART00000166754

chr17_-_6399920 2.51 ENSDART00000022010
human immunodeficiency virus type I enhancer binding protein 2b
chr17_-_26604946 2.50 ENSDART00000087062
family with sequence similarity 149, member B1
chr21_-_3844322 2.43 ENSDART00000166652
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr25_+_20216159 2.40 ENSDART00000048642
troponin T2d, cardiac
chr9_-_23217196 2.34 ENSDART00000083567
kinesin family member 5C
chr4_+_21129752 2.27 ENSDART00000169764
synaptotagmin Ia
chr8_-_44015210 2.26 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
RIMS binding protein 2
RIMS binding protein 2
chr5_+_61301525 2.20 ENSDART00000128773
double C2-like domains, beta
chr5_+_6617401 2.20 ENSDART00000060532
zgc:110796
chr9_+_11202552 2.18 ENSDART00000151931
acid-sensing (proton-gated) ion channel family member 4a
chr16_+_6735015 2.18 ENSDART00000148479
zinc finger protein 407
chr3_+_37824268 2.14 ENSDART00000137038
acid-sensing (proton-gated) ion channel 2
chr3_+_29714775 2.14 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr2_+_17451656 2.14 ENSDART00000163620

chr17_-_20394566 2.13 ENSDART00000154667
sortilin related VPS10 domain containing receptor 3b
chr4_+_74226447 2.08 ENSDART00000174336
ENSDART00000191455
ENSDART00000180062
protein tyrosine phosphatase, receptor type, r
chr5_-_7199998 2.07 ENSDART00000167316

chr19_-_9648542 1.97 ENSDART00000172628
chloride channel, voltage-sensitive 1a
chr11_+_33628104 1.96 ENSDART00000165318
thrombospondin, type I, domain containing 7Bb
chr8_-_22698651 1.90 ENSDART00000181411
IQ motif and Sec7 domain 2a
chr7_-_72067475 1.89 ENSDART00000017763

chr4_-_14926637 1.89 ENSDART00000110199
PR domain containing 4
chr6_+_4255319 1.88 ENSDART00000170351
neurobeachin-like 1
chr23_+_27782071 1.86 ENSDART00000131379
lysine (K)-specific methyltransferase 2D
chr6_+_23752593 1.86 ENSDART00000164366
zgc:158654
chr17_-_26604549 1.83 ENSDART00000174773
family with sequence similarity 149, member B1
chr23_+_40951443 1.82 ENSDART00000115161
RALBP1 associated Eps domain containing 2
chr24_+_30521619 1.76 ENSDART00000162903
dihydropyrimidine dehydrogenase a, tandem duplicate 3
chr17_-_7436766 1.72 ENSDART00000162002
glutamate receptor, metabotropic 1b
chr16_-_13004166 1.71 ENSDART00000133735
calcium channel, voltage-dependent, gamma subunit 7b
chr10_-_2527342 1.68 ENSDART00000184168

chr17_+_51764310 1.67 ENSDART00000157171
si:ch211-168d23.3
chr7_+_31074636 1.65 ENSDART00000173805
tight junction protein 1a
chr7_+_25036188 1.64 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr2_-_31754292 1.63 ENSDART00000192498
RALY RNA binding protein like
chr22_+_35089031 1.62 ENSDART00000076040
serum response factor a
chr19_-_43226124 1.60 ENSDART00000168965
gonadotropin releasing hormone receptor 1
chr24_+_26039464 1.59 ENSDART00000131017
tyrosine kinase, non-receptor, 2a
chr25_+_2668892 1.54 ENSDART00000122929
Bardet-Biedl syndrome 4
chr5_+_65492183 1.52 ENSDART00000162804
si:dkey-21e5.1
chr1_+_10221568 1.47 ENSDART00000152424
neuropeptide Y receptor Y2, like
chr17_-_28749640 1.45 ENSDART00000000948
coagulation factor C homolog, cochlin (Limulus polyphemus)
chr12_+_41510492 1.44 ENSDART00000170976
ENSDART00000176164
kinesin family member 5B, b
chr14_+_19258702 1.43 ENSDART00000187087
ENSDART00000005738
SLIT and NTRK-like family, member 2
chr1_+_20069535 1.39 ENSDART00000088653
protease, serine, 12 (neurotrypsin, motopsin)
chr17_-_6202816 1.38 ENSDART00000151908
protein tyrosine kinase 2 beta, a
chr18_-_16392448 1.37 ENSDART00000180253
mgat4 family, member C
chr1_-_47431453 1.35 ENSDART00000101104
gap junction protein, alpha 5b
chr7_+_7151832 1.32 ENSDART00000109485
galactose-3-O-sulfotransferase 3
chr11_-_11471857 1.31 ENSDART00000030103
keratin 94
chr4_-_14926106 1.25 ENSDART00000147629
PR domain containing 4
chr16_+_25196572 1.24 ENSDART00000141956
TYRO protein tyrosine kinase binding protein
chr8_-_39739056 1.23 ENSDART00000147992
si:ch211-170d8.5
chr13_-_39736938 1.22 ENSDART00000141645
zgc:171482
chr10_-_26766780 1.22 ENSDART00000146666
MCF.2 cell line derived transforming sequence b
chr5_-_3960161 1.21 ENSDART00000111453
myosin XIX
chr17_+_31914877 1.19 ENSDART00000177801
family with sequence similarity 196 member A
chr5_-_22544151 1.19 ENSDART00000006474
glycine receptor, alpha 4b
chr3_-_214709 1.18 ENSDART00000098311

chr15_-_16704417 1.16 ENSDART00000155163
calneuron 1
chr12_-_36268723 1.15 ENSDART00000113740
potassium inwardly-rectifying channel, subfamily J, member 16
chr15_+_8335600 1.09 ENSDART00000190066
ENSDART00000152603
egl-9 family hypoxia-inducible factor 2
chr24_+_119680 1.05 ENSDART00000061973
transforming growth factor, beta receptor 1 b
chr20_-_9462433 0.99 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr25_+_7461624 0.95 ENSDART00000170569
synaptotagmin XII
chr17_-_45009782 0.94 ENSDART00000123971
family with sequence similarity 161, member B
chr13_-_32577386 0.85 ENSDART00000016535
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3a
chr16_+_46401576 0.85 ENSDART00000130264
rapunzel
chr16_-_31188715 0.82 ENSDART00000058829
scratch family zinc finger 1b
chr21_+_43561650 0.82 ENSDART00000085071
G protein-coupled receptor 185 a
chr24_+_34806822 0.81 ENSDART00000148407
ENSDART00000188328
melanin-concentrating hormone receptor 2
chr19_+_4463389 0.81 ENSDART00000168805
potassium channel, subfamily K, member 9
chr15_+_15456910 0.77 ENSDART00000155708
zgc:174895
chr19_-_27542433 0.73 ENSDART00000136414
si:ch211-152p11.4
chr7_-_18617187 0.69 ENSDART00000172419
si:ch211-119e14.1
chr23_-_333457 0.67 ENSDART00000114486
UHRF1 binding protein 1
chr2_+_42872661 0.64 ENSDART00000036979
EFR3 homolog A (S. cerevisiae)
chr7_+_17861489 0.61 ENSDART00000173860
echinoderm microtubule associated protein like 3
chr13_+_35745572 0.61 ENSDART00000159690
G protein-coupled receptor 75
chr8_+_6410933 0.51 ENSDART00000168789
leucine rich repeat transmembrane neuronal 4 like 2
chr22_+_635813 0.49 ENSDART00000179067

chr12_+_48581588 0.46 ENSDART00000114996

chr6_+_52064304 0.45 ENSDART00000153468
actin binding Rho activating protein a
chr1_-_49505449 0.44 ENSDART00000187294
ENSDART00000132171
si:dkeyp-80c12.5
chr25_-_24074500 0.43 ENSDART00000040410
tyrosine hydroxylase
chr3_-_1283247 0.43 ENSDART00000149814
transcription factor 20
chr7_-_7810348 0.43 ENSDART00000171984
chemokine (C-X-C motif) ligand 19
chr14_+_34547554 0.42 ENSDART00000074819
gamma-aminobutyric acid (GABA) A receptor, pi
chr4_-_17642168 0.42 ENSDART00000007030
kelch-like family, member 42
chr14_+_24215046 0.39 ENSDART00000079215
stanniocalcin 2a
chr7_+_29952719 0.35 ENSDART00000173737
alpha-tropomyosin
chr4_-_13255700 0.30 ENSDART00000162277
ENSDART00000026593
glutamate receptor interacting protein 1
chr23_-_11870962 0.28 ENSDART00000143481
si:dkey-178k16.1
chr1_-_10577945 0.27 ENSDART00000179237
ENSDART00000040502
ENSDART00000186876
transient receptor potential cation channel, subfamily C, member 5a
chr13_+_37273010 0.27 ENSDART00000144387
glycoprotein hormone beta 5
chr7_+_4386753 0.27 ENSDART00000172915
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr19_+_13994563 0.26 ENSDART00000164696
transmembrane protein 222b
chr10_-_27741793 0.24 ENSDART00000129369
ENSDART00000192440
ENSDART00000189808
ENSDART00000138149
autism susceptibility candidate 2a
si:dkey-33o22.1
chr2_+_23731194 0.24 ENSDART00000155747
solute carrier family 22 member 13a
chr13_-_36184476 0.22 ENSDART00000057185
mitogen-activated protein kinase kinase kinase 9
chr16_+_14707960 0.22 ENSDART00000137912
collagen, type XIV, alpha 1a
chr11_+_22109887 0.22 ENSDART00000122136
si:dkey-91m3.1
chr2_-_16217344 0.21 ENSDART00000152031
Rho guanine nucleotide exchange factor (GEF) 4
chr1_-_56717813 0.20 ENSDART00000159196

chr5_-_52921532 0.20 ENSDART00000160566

chr10_+_39692241 0.19 ENSDART00000113414
kirre like nephrin family adhesion molecule 3a
chr8_-_51930826 0.15 ENSDART00000109785
calcineurin binding protein 1
chr2_+_6303639 0.13 ENSDART00000132859
otolin 1a
chr20_-_25369767 0.12 ENSDART00000180278
intersectin 2a
chr23_-_2037566 0.09 ENSDART00000191312
ENSDART00000127443
PR domain containing 5
chr17_+_19626479 0.02 ENSDART00000044993
ENSDART00000131863
regulator of G protein signaling 7a
chr25_-_29987839 0.02 ENSDART00000154088
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5b

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0000256 allantoin catabolic process(GO:0000256)
1.0 3.9 GO:0006844 acyl carnitine transport(GO:0006844)
0.7 4.5 GO:0051969 regulation of transmission of nerve impulse(GO:0051969)
0.5 4.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.4 4.4 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.4 1.2 GO:0032816 regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.4 9.9 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.4 1.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.4 8.2 GO:0015701 bicarbonate transport(GO:0015701)
0.4 1.8 GO:0019483 uracil catabolic process(GO:0006212) beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483) uracil metabolic process(GO:0019860) 'de novo' UMP biosynthetic process(GO:0044205)
0.3 2.3 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.3 4.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.3 6.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.2 2.9 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.2 6.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.2 1.9 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.2 3.8 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.2 2.2 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.2 2.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 3.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.6 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.4 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.1 2.7 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 3.8 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 2.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 4.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.4 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 2.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 4.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 5.2 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.1 5.6 GO:0006937 regulation of muscle contraction(GO:0006937)
0.1 3.0 GO:0001508 action potential(GO:0001508)
0.1 1.2 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 2.8 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 1.3 GO:0030534 adult behavior(GO:0030534)
0.1 0.3 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.1 5.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.1 GO:0045299 otolith mineralization(GO:0045299)
0.1 8.9 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.1 6.0 GO:0006821 chloride transport(GO:0006821)
0.1 1.1 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 1.4 GO:0060349 bone morphogenesis(GO:0060349)
0.0 1.6 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.0 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.2 GO:1990573 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 1.3 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 1.4 GO:0031638 zymogen activation(GO:0031638)
0.0 10.3 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.3 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 2.6 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.4 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0071219 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 1.4 GO:0021782 glial cell development(GO:0021782)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 GO:0005955 calcineurin complex(GO:0005955)
0.5 3.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.5 2.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.4 4.4 GO:0098982 GABA-ergic synapse(GO:0098982)
0.4 5.2 GO:0048179 activin receptor complex(GO:0048179)
0.3 4.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 11.3 GO:0043679 axon terminus(GO:0043679)
0.3 2.9 GO:0036449 microtubule minus-end(GO:0036449)
0.1 5.6 GO:0005861 troponin complex(GO:0005861)
0.1 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 1.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 8.4 GO:0042383 sarcolemma(GO:0042383)
0.1 8.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 3.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 6.0 GO:0005882 intermediate filament(GO:0005882)
0.0 5.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 2.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.1 GO:0034703 cation channel complex(GO:0034703)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.8 GO:0005871 kinesin complex(GO:0005871)
0.0 2.4 GO:0045177 apical part of cell(GO:0045177)
0.0 0.4 GO:0043204 perikaryon(GO:0043204)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:1903136 cuprous ion binding(GO:1903136)
1.2 4.9 GO:0005521 lamin binding(GO:0005521)
1.1 13.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
1.0 3.1 GO:1990226 histone methyltransferase binding(GO:1990226)
1.0 8.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.0 5.1 GO:0070573 metallodipeptidase activity(GO:0070573)
1.0 4.0 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
1.0 3.9 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.9 2.7 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.9 5.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.7 4.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.6 8.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.5 4.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.5 5.6 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.4 1.8 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.4 1.6 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.4 3.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 4.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.3 4.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.3 3.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.3 2.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.3 4.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.3 3.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 1.3 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.3 6.4 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.2 1.7 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.2 4.4 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 0.7 GO:0003999 adenine phosphoribosyltransferase activity(GO:0003999)
0.2 2.9 GO:0030507 spectrin binding(GO:0030507)
0.2 4.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 1.3 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 1.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 3.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 2.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.5 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.1 1.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 3.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 3.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.1 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 1.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 2.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.4 GO:0045296 cadherin binding(GO:0045296)
0.0 9.9 GO:0019900 kinase binding(GO:0019900)
0.0 3.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 1.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 1.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 4.5 GO:0005261 cation channel activity(GO:0005261)
0.0 1.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 8.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.3 4.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.3 3.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 2.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 4.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.2 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.8 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors