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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hoxa13a+hoxa13b

Z-value: 1.28

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Transcription factors associated with hoxa13a+hoxa13b

Gene Symbol Gene ID Gene Info
ENSDARG00000036254 homeobox A13b
ENSDARG00000100312 homeobox A13a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa13bdr11_v1_chr16_+_20895904_20895904-0.532.1e-02Click!
hoxa13adr11_v1_chr19_+_19729506_197295060.474.4e-02Click!

Activity profile of hoxa13a+hoxa13b motif

Sorted Z-values of hoxa13a+hoxa13b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_47571456 3.47 ENSDART00000158071
ENSDART00000165841
ribonucleotide reductase M2 polypeptide
chr20_-_29499363 3.35 ENSDART00000152889
ENSDART00000153252
ENSDART00000170972
ENSDART00000166420
ENSDART00000163079
ribonucleotide reductase M2 polypeptide
chr19_-_47571797 2.95 ENSDART00000166180
ENSDART00000168134
ribonucleotide reductase M2 polypeptide
chr18_+_619619 2.63 ENSDART00000159846
protogenin homolog a (Gallus gallus)
chr13_-_50614639 2.57 ENSDART00000170527
ventral expressed homeobox
chr16_+_29509133 2.39 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr16_-_45917322 2.18 ENSDART00000060822
antifreeze protein type IV
chr9_-_32300783 2.09 ENSDART00000078596
heat shock 60 protein 1
chr10_-_21545091 1.93 ENSDART00000029122
ENSDART00000132207
zgc:165539
chr16_-_7793457 1.86 ENSDART00000113483
tripartite motif containing 71, E3 ubiquitin protein ligase
chr9_-_32300611 1.83 ENSDART00000127938
heat shock 60 protein 1
chr7_-_26076970 1.79 ENSDART00000101120
zgc:92664
chr21_-_34844316 1.76 ENSDART00000029708
zgc:56585
chr14_+_15495088 1.76 ENSDART00000165765
ENSDART00000188577
si:dkey-203a12.6
chr19_-_14191592 1.76 ENSDART00000164594
T-box transcription factor Ta
chr3_+_24275766 1.76 ENSDART00000055607
platelet-derived growth factor beta polypeptide b
chr5_+_68807170 1.72 ENSDART00000017849
hairy and enhancer of split related-7
chr17_-_43031763 1.64 ENSDART00000132754
ENSDART00000050399
Niemann-Pick disease, type C2
chr1_-_23268013 1.57 ENSDART00000146575
replication factor C (activator 1) 1
chr13_+_28690355 1.56 ENSDART00000137475
ENSDART00000128246
polymerase (RNA) I polypeptide C
chr14_+_34495216 1.54 ENSDART00000147756
wingless-type MMTV integration site family, member 8a
chr7_-_69025306 1.51 ENSDART00000180796

chr13_+_7442023 1.51 ENSDART00000080975
tumor necrosis factor, alpha-induced protein 2b
chr4_+_12031958 1.51 ENSDART00000044154
troponin T2c, cardiac
chr23_+_10146542 1.46 ENSDART00000048073
zgc:171775
chr10_+_32066537 1.42 ENSDART00000124166
si:dkey-250d21.1
chr2_+_42260021 1.40 ENSDART00000124702
ENSDART00000140203
ENSDART00000184079
ENSDART00000193349
finTRIM family, member 4
chr9_+_426392 1.37 ENSDART00000172515
basic leucine zipper and W2 domains 1b
chr4_-_30249792 1.37 ENSDART00000151833
ENSDART00000137564
ENSDART00000168249
si:dkey-265e15.2
chr6_-_19683406 1.34 ENSDART00000158041
cilia and flagella associated protein 52
chr4_-_61651223 1.33 ENSDART00000172688
si:dkey-26i24.1
chr19_-_1948236 1.32 ENSDART00000163344
zinc and ring finger 2a
chr7_+_67429185 1.32 ENSDART00000162553
ENSDART00000178646
lysyl-tRNA synthetase
chr6_+_13039951 1.32 ENSDART00000091700
ciliogenesis associated TTC17 interacting protein
chr15_-_5901514 1.31 ENSDART00000155252
si:ch73-281n10.2
chr6_+_40629066 1.31 ENSDART00000103757
solute carrier family 6 (neurotransmitter transporter), member 11a
chr18_-_14677936 1.31 ENSDART00000111995
si:dkey-238o13.4
chr9_+_38158570 1.30 ENSDART00000059549
ENSDART00000133060
nucleolar protein interacting with the FHA domain of MKI67
chr1_-_35924495 1.29 ENSDART00000184424
SMAD family member 1
chr23_-_43718067 1.28 ENSDART00000015777
ATP-binding cassette, sub-family E (OABP), member 1
chr11_+_19603251 1.28 ENSDART00000005639
THO complex 7
chr12_+_19199735 1.27 ENSDART00000066393
pdgfa associated protein 1a
chr8_+_23382568 1.27 ENSDART00000129167
microtubule-associated protein, RP/EB family, member 1a
chr23_+_22200467 1.27 ENSDART00000025414
solute carrier family 2 (facilitated glucose transporter), member 1a
chr19_+_40322912 1.24 ENSDART00000146893
cyclin-dependent kinase 6
chr17_+_21295132 1.22 ENSDART00000103845
enolase family member 4
chr20_-_26491567 1.21 ENSDART00000147154
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr1_+_47486104 1.21 ENSDART00000114746
leucine rich repeat containing 58a
chr7_+_2455344 1.21 ENSDART00000172942
si:dkey-125e8.4
chr12_+_27231607 1.20 ENSDART00000066270
transmembrane protein 106A
chr2_-_20715094 1.20 ENSDART00000155439
dual specificity phosphatase 12
chr18_-_10713230 1.19 ENSDART00000183646
RNA binding motif protein 28
chr2_-_24962820 1.16 ENSDART00000182767
helicase-like transcription factor
chr1_-_33647138 1.15 ENSDART00000142111
ENSDART00000015547
claudin g
chr8_-_13985032 1.15 ENSDART00000140576
insulin-like growth factor 3
chr18_+_26422124 1.14 ENSDART00000060245
cathepsin H
chr5_+_30520249 1.13 ENSDART00000013431
hydroxymethylbilane synthase a
chr9_+_32301017 1.12 ENSDART00000127916
ENSDART00000183298
ENSDART00000143103
heat shock 10 protein 1
chr23_-_21446985 1.12 ENSDART00000044080
hairy-related 12
chr6_-_33916756 1.09 ENSDART00000137447
ENSDART00000138488
nuclear autoantigenic sperm protein (histone-binding)
chr18_+_20034023 1.09 ENSDART00000139441
mortality factor 4 like 1
chr6_-_45869127 1.08 ENSDART00000062459
ENSDART00000180563
RNA binding motif protein 19
chr10_+_22775253 1.07 ENSDART00000190141
transmembrane protein 88 a
chr14_+_26437891 1.07 ENSDART00000175459
G protein-coupled receptor 137
chr19_+_20778011 1.06 ENSDART00000024208
nuclear transport factor 2, like
chr23_+_39606108 1.06 ENSDART00000109464
G0/G1 switch 2
chr22_+_1911269 1.06 ENSDART00000164158
ENSDART00000168205
zinc finger protein 1156
chr1_+_56463494 1.05 ENSDART00000097964
zgc:171452
chr2_+_19195841 1.05 ENSDART00000163137
ENSDART00000161095
ELOVL fatty acid elongase 1a
chr17_+_51906053 1.04 ENSDART00000159072
ENSDART00000056869
feline leukemia virus subgroup C cellular receptor family, member 2a
chr6_-_52348562 1.04 ENSDART00000142565
ENSDART00000145369
ENSDART00000016890
eukaryotic translation initiation factor 6
chr2_+_35595454 1.04 ENSDART00000098734
calcyclin binding protein
chr2_-_27385934 1.04 ENSDART00000139886
target of EGR1, exonuclease
chr15_+_32419303 1.03 ENSDART00000162663
si:dkey-285b23.3
chr7_+_24393678 1.02 ENSDART00000188690
HAUS augmin-like complex, subunit 3
chr21_-_27195256 1.02 ENSDART00000133152
ENSDART00000065401
zgc:110782
chr5_-_41307550 1.01 ENSDART00000143446
natriuretic peptide receptor 3
chr21_-_3007412 1.01 ENSDART00000190839
zgc:86839
chr22_+_2409175 1.01 ENSDART00000141776
zgc:113220
chr8_-_44298964 1.00 ENSDART00000098520
frizzled class receptor 10
chr2_-_10877765 1.00 ENSDART00000100607
cell division cycle 7 homolog (S. cerevisiae)
chr6_-_9695294 0.99 ENSDART00000162728
NOP58 ribonucleoprotein homolog (yeast)
chr2_+_30032303 0.99 ENSDART00000151841
RNA binding motif protein 33b
chr11_-_25418856 0.99 ENSDART00000013714
GATA binding protein 1a
chr19_-_1002959 0.99 ENSDART00000168138
euchromatic histone-lysine N-methyltransferase 2
chr5_-_33281046 0.99 ENSDART00000051344
ENSDART00000138116
surfeit 6
chr13_-_35892243 0.98 ENSDART00000002750
ENSDART00000122810
ENSDART00000162399
transforming, acidic coiled-coil containing protein 3
chr18_-_35407695 0.98 ENSDART00000191845
ENSDART00000141703
small nuclear ribonucleoprotein polypeptide A
chr4_-_1776352 0.98 ENSDART00000123089
DnaJ (Hsp40) homolog, subfamily C, member 2
chr13_-_11986754 0.98 ENSDART00000164214
nucleophosmin/nucleoplasmin, 3
chr19_-_24555623 0.98 ENSDART00000176022
polymerase (RNA) III (DNA directed) polypeptide G like a
chr9_-_48370645 0.97 ENSDART00000140185
collagen, type XXVIII, alpha 2a
chr6_-_12644563 0.97 ENSDART00000153797
dedicator of cytokinesis 9b
chr23_+_43718115 0.97 ENSDART00000149266
ENSDART00000149503
anaphase promoting complex subunit 10
chr19_+_7835025 0.96 ENSDART00000026276
CDC28 protein kinase regulatory subunit 1B
chr7_+_41314862 0.96 ENSDART00000185198
zgc:165532
chr12_-_17698669 0.96 ENSDART00000191384
parvalbumin 9
chr14_-_26425416 0.96 ENSDART00000088690
lectin, mannose-binding 2
chr4_-_18850799 0.96 ENSDART00000151844
malonyl CoA:ACP acyltransferase (mitochondrial)
chr2_+_21855036 0.95 ENSDART00000140012
carbonic anhydrase VIII
chr1_-_19648227 0.95 ENSDART00000054574
polymerase (RNA) I polypeptide E
chr21_-_30111134 0.94 ENSDART00000014223
solute carrier family 23 (ascorbic acid transporter), member 1
chr13_-_37474989 0.94 ENSDART00000114136
WD repeat domain 89
chr8_-_20914829 0.94 ENSDART00000025356
HAUS augmin-like complex, subunit 5
chr2_+_21048661 0.93 ENSDART00000156876
ras responsive element binding protein 1b
chr7_-_59159253 0.93 ENSDART00000159285
HAUS augmin-like complex, subunit 6
chr9_-_2892250 0.93 ENSDART00000140695
cell division cycle associated 7a
chr20_-_14012859 0.93 ENSDART00000152429
si:ch211-22i13.2
chr1_+_26626824 0.93 ENSDART00000158193
coronin, actin binding protein, 2A
chr15_+_11814969 0.92 ENSDART00000127248

chr2_+_10147029 0.92 ENSDART00000139064
ENSDART00000053426
ENSDART00000153678
profilin 2 like
chr14_-_34513103 0.92 ENSDART00000136306
zgc:194246
chr22_+_25590391 0.92 ENSDART00000178133
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr7_+_51805525 0.92 ENSDART00000026571
solute carrier family 38, member 7
chr24_+_39105051 0.92 ENSDART00000115297
MSS51 mitochondrial translational activator
chr21_+_11503212 0.91 ENSDART00000146701
si:dkey-184p9.7
chr18_-_8380090 0.91 ENSDART00000141581
ENSDART00000081143
selenophosphate synthetase 1
chr5_-_12223434 0.91 ENSDART00000161706
nitric oxide synthase 1 (neuronal)
chr6_+_16468776 0.90 ENSDART00000109151
ENSDART00000114667
zgc:161969
chr13_-_33256667 0.90 ENSDART00000003314
nucleolar and spindle associated protein 1
chr8_+_19668654 0.90 ENSDART00000091436
forkhead box E3
chr1_+_51827046 0.90 ENSDART00000052992
DAN domain family, member 5
chr23_+_19813677 0.90 ENSDART00000139192
ENSDART00000142308
emerin (Emery-Dreifuss muscular dystrophy)
chr4_+_13428993 0.89 ENSDART00000067151
si:dkey-39a18.1
chr17_-_31695217 0.89 ENSDART00000104332
ENSDART00000143090
lin-52 DREAM MuvB core complex component
chr14_+_22498757 0.89 ENSDART00000021657
SMYD family member 5
chr4_-_43280244 0.89 ENSDART00000150762
si:dkeyp-53e4.1
chr4_-_30440116 0.89 ENSDART00000159935
si:dkey-199m13.5
chr21_-_20328375 0.89 ENSDART00000079593
solute carrier family 26 (anion exchanger), member 1
chr17_+_8799661 0.89 ENSDART00000105326
tonsoku-like, DNA repair protein
chr4_-_2380173 0.88 ENSDART00000177727
nucleosome assembly protein 1-like 1
chr17_-_2690083 0.88 ENSDART00000135374
protein tyrosine phosphatase, non-receptor type 21
chr13_+_28495983 0.88 ENSDART00000144968
fibroblast growth factor 8a
chr12_-_10476448 0.88 ENSDART00000106172
Rac family small GTPase 1a
chr3_+_13600714 0.88 ENSDART00000162124
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr7_-_24364536 0.87 ENSDART00000064789
thioredoxin
chr7_+_32693890 0.86 ENSDART00000121972
solute carrier family 39 (zinc transporter), member 13
chr8_+_8927870 0.85 ENSDART00000081985
Pim-2 proto-oncogene, serine/threonine kinase
chr6_-_59505589 0.85 ENSDART00000170685
GLI family zinc finger 1
chr9_+_3519191 0.83 ENSDART00000008606
methyltransferase like 8
chr10_+_32066355 0.83 ENSDART00000062311
si:dkey-250d21.1
chr23_+_7379728 0.83 ENSDART00000012194
GATA binding protein 5
chr2_+_16781015 0.83 ENSDART00000155147
ENSDART00000003845
transferrin-a
chr9_-_53666031 0.82 ENSDART00000126314
protocadherin 8
chr1_-_59124505 0.82 ENSDART00000186257

chr19_-_18418763 0.82 ENSDART00000167271
zgc:112966
chr8_+_28593707 0.82 ENSDART00000097213
transcription factor 15
chr1_-_15329277 0.82 ENSDART00000109970
DLC1 Rho GTPase activating protein
chr7_+_59169081 0.82 ENSDART00000167980
oligosaccharyltransferase complex subunit
chr1_+_54683655 0.82 ENSDART00000132785
lysine-rich nucleolar protein 1
chr4_-_56898328 0.82 ENSDART00000169189
si:dkey-269o24.6
chr17_-_50022827 0.81 ENSDART00000161008
filamin A interacting protein 1a
chr14_+_45596583 0.81 ENSDART00000110429
zgc:194285
chr2_-_44777592 0.81 ENSDART00000113351
ENSDART00000169310
non-SMC condensin I complex, subunit D2
chr6_-_39893501 0.81 ENSDART00000141611
ENSDART00000135631
ENSDART00000077662
ENSDART00000130613
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr11_+_18175893 0.81 ENSDART00000177625
zgc:173545
chr16_-_21785261 0.81 ENSDART00000078858
si:ch73-86n18.1
chr20_+_32501748 0.81 ENSDART00000152944
ENSDART00000021035
SEC63 homolog, protein translocation regulator
chr15_-_7337537 0.80 ENSDART00000161613
high affinity cationic amino acid transporter 1
chr9_+_22782027 0.80 ENSDART00000090816
replication timing regulatory factor 1
chr18_+_3572314 0.80 ENSDART00000169814
ENSDART00000157819
stress-associated endoplasmic reticulum protein 1
chr2_-_50225411 0.80 ENSDART00000147117
ENSDART00000000042
MCM6 minichromosome maintenance deficient 6, like
chr13_-_23612324 0.80 ENSDART00000136406
ENSDART00000005004
DNA primase subunit 2
chr8_+_23381892 0.80 ENSDART00000180950
ENSDART00000063010
ENSDART00000074241
ENSDART00000142783
microtubule-associated protein, RP/EB family, member 1a
chr12_+_13118540 0.79 ENSDART00000077840
ENSDART00000127870
calymmin
chr16_-_27543024 0.79 ENSDART00000147737
ENSDART00000078283
testis expressed 10
chr9_+_32301456 0.79 ENSDART00000078608
ENSDART00000185153
ENSDART00000144947
heat shock 10 protein 1
chr25_+_9013342 0.78 ENSDART00000154207
ENSDART00000153705
im:7145024
chr21_-_11970199 0.78 ENSDART00000114524
NOP56 ribonucleoprotein homolog
chr6_-_57485411 0.78 ENSDART00000011663
small nuclear ribonucleoprotein polypeptides B and B1
chr5_+_32845759 0.78 ENSDART00000136552
si:ch211-208h16.4
chr17_+_28611746 0.78 ENSDART00000156711
ENSDART00000113300
MIS18 binding protein 1
chr3_-_23574622 0.78 ENSDART00000176012
insulin-like growth factor 2 mRNA binding protein 1
chr7_+_51816321 0.78 ENSDART00000073846
si:ch211-122f10.4
chr5_+_1493767 0.77 ENSDART00000022132
HAUS augmin-like complex, subunit 4
chr20_+_42537768 0.77 ENSDART00000134066
ENSDART00000153434
si:dkeyp-93d12.1
chr12_+_27117609 0.77 ENSDART00000076154
homeobox B8b
chr10_-_34889053 0.77 ENSDART00000136966
coiled-coil domain containing 169
chr20_-_15090862 0.77 ENSDART00000063892
ENSDART00000122592
si:dkey-239i20.2
chr12_+_8074343 0.77 ENSDART00000124084
ciliary associated calcium binding coiled-coil 1
chr20_+_25586099 0.77 ENSDART00000063122
ENSDART00000134047
cytochrome P450, family 2, subfamily P, polypeptide 10
chr5_-_36328688 0.76 ENSDART00000011399
ephrin-B1
chr21_-_20341836 0.76 ENSDART00000176689
retinol binding protein 4, like
chr8_+_32747612 0.76 ENSDART00000142824
hemicentin 2
chr2_+_24374305 0.76 ENSDART00000022379
nuclear receptor subfamily 2, group F, member 6a
chr20_+_32478151 0.76 ENSDART00000145269
osteopetrosis associated transmembrane protein 1
chr23_+_32499916 0.76 ENSDART00000134811
si:dkey-261h17.1
chr7_+_36470159 0.76 ENSDART00000188703
akt interacting protein
chr14_-_4170654 0.75 ENSDART00000188347
si:dkey-185e18.7
chr12_+_13908418 0.75 ENSDART00000066367
FK506 binding protein 10b
chr5_-_40510397 0.75 ENSDART00000146237
ENSDART00000051065
follistatin a
chr17_-_49481672 0.74 ENSDART00000166394
FCF1 rRNA-processing protein
chr6_-_6423885 0.74 ENSDART00000092257
si:ch211-194e18.2
chr6_+_35362225 0.74 ENSDART00000133783
ENSDART00000102483
regulator of G protein signaling 4
chr22_+_15343953 0.73 ENSDART00000045682
ribosomal RNA processing 36
chr14_+_14608099 0.73 ENSDART00000165099
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
chr2_+_16780643 0.73 ENSDART00000125647
ENSDART00000108611
ENSDART00000181245
ENSDART00000163194
transferrin-a
chr14_+_4276394 0.72 ENSDART00000038301
glucosamine-6-phosphate deaminase 2
chr8_+_19489854 0.72 ENSDART00000184671
ENSDART00000011258
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr21_+_18910502 0.72 ENSDART00000147567
sphingomyelin phosphodiesterase 4

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa13a+hoxa13b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.9 9.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.8 2.4 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.7 2.1 GO:0021512 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.4 1.8 GO:0072045 convergent extension involved in nephron morphogenesis(GO:0072045)
0.4 1.7 GO:0097037 heme export(GO:0097037)
0.4 0.4 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.4 1.9 GO:0010586 miRNA metabolic process(GO:0010586)
0.4 1.1 GO:0015882 L-ascorbic acid transport(GO:0015882)
0.4 1.1 GO:2000726 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.4 1.4 GO:0021742 abducens nucleus development(GO:0021742)
0.3 1.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.3 0.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.3 0.9 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
0.3 0.9 GO:1902746 negative regulation of epithelial cell differentiation(GO:0030857) regulation of lens fiber cell differentiation(GO:1902746)
0.3 0.9 GO:0065001 specification of axis polarity(GO:0065001)
0.3 2.6 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.3 1.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.3 1.6 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.3 1.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 1.0 GO:0030224 monocyte differentiation(GO:0030224)
0.2 0.7 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.2 0.7 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 0.7 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.2 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 0.9 GO:0019532 oxalate transport(GO:0019532)
0.2 0.9 GO:0021571 rhombomere 5 development(GO:0021571) rhombomere 6 development(GO:0021572)
0.2 2.6 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.2 0.8 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 1.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 0.6 GO:0005997 xylulose metabolic process(GO:0005997)
0.2 0.8 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.2 1.4 GO:0090497 mesenchymal cell migration(GO:0090497)
0.2 0.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 0.4 GO:0071634 regulation of transforming growth factor beta production(GO:0071634) negative regulation of transforming growth factor beta production(GO:0071635)
0.2 0.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 1.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.2 0.9 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 1.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.2 0.6 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.2 0.5 GO:0032814 regulation of natural killer cell activation(GO:0032814) positive regulation of natural killer cell activation(GO:0032816) TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.2 0.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.2 0.5 GO:0003250 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793)
0.2 0.7 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.2 1.0 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.2 0.7 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.2 0.6 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 1.0 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.2 0.6 GO:1990697 protein depalmitoleylation(GO:1990697)
0.2 1.3 GO:0046323 glucose import(GO:0046323)
0.2 0.6 GO:0015871 choline transport(GO:0015871)
0.2 1.2 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.2 0.9 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 1.5 GO:0051601 exocyst localization(GO:0051601)
0.1 0.4 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.4 GO:0014857 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.1 1.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.7 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.6 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.1 1.2 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.6 GO:0009957 epidermal cell fate specification(GO:0009957)
0.1 0.5 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.5 GO:0050955 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.1 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.7 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.5 GO:0045730 respiratory burst(GO:0045730)
0.1 0.5 GO:1900120 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.1 0.5 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 0.4 GO:0046824 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 0.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.6 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.5 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.8 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.7 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.6 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.1 0.9 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.8 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 0.6 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.6 GO:0044241 lipid digestion(GO:0044241)
0.1 1.8 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.3 GO:0007571 age-dependent general metabolic decline(GO:0007571)
0.1 0.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.6 GO:0044209 AMP salvage(GO:0044209)
0.1 0.9 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.1 0.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.4 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.6 GO:0071800 podosome assembly(GO:0071800)
0.1 1.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 1.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 0.8 GO:1990402 embryonic liver development(GO:1990402)
0.1 0.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 0.8 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.4 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 1.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.5 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.3 GO:0036076 ligamentous ossification(GO:0036076)
0.1 0.6 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 1.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 1.1 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.1 0.9 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 2.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.2 GO:0035108 limb morphogenesis(GO:0035108)
0.1 1.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 2.6 GO:0006458 'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 2.4 GO:0060030 dorsal convergence(GO:0060030)
0.1 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.6 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 0.2 GO:0008344 adult locomotory behavior(GO:0008344)
0.1 0.3 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.1 0.4 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.3 GO:0016074 snoRNA metabolic process(GO:0016074)
0.1 0.4 GO:0007289 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.3 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 1.3 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.1 1.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.7 GO:0043486 histone exchange(GO:0043486)
0.1 0.5 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.1 0.1 GO:0003348 cardiac endothelial cell differentiation(GO:0003348) endocardial cell differentiation(GO:0060956)
0.1 0.3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 0.6 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.2 GO:0030237 female sex determination(GO:0030237)
0.1 1.7 GO:0007379 somite specification(GO:0001757) segment specification(GO:0007379)
0.1 0.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.3 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 0.4 GO:0061511 centriole elongation(GO:0061511)
0.1 0.7 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 0.4 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 1.5 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.7 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.1 0.2 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.1 0.3 GO:0008334 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) histone mRNA metabolic process(GO:0008334)
0.1 0.7 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.3 GO:1902914 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.4 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1 1.0 GO:0014855 striated muscle cell proliferation(GO:0014855) cardiac muscle cell proliferation(GO:0060038)
0.1 1.3 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.3 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.3 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 1.4 GO:0006949 syncytium formation by plasma membrane fusion(GO:0000768) syncytium formation(GO:0006949)
0.1 0.2 GO:0034154 toll-like receptor 3 signaling pathway(GO:0034138) toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.3 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.3 GO:1902369 negative regulation of RNA catabolic process(GO:1902369)
0.1 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.9 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1 1.8 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.8 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 0.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:0003352 regulation of cilium movement(GO:0003352)
0.1 0.4 GO:2001271 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 3.2 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.2 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.7 GO:0036065 fucosylation(GO:0036065)
0.0 0.2 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.0 0.5 GO:0061647 histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0 1.0 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.2 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 0.5 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.9 GO:0031297 replication fork processing(GO:0031297)
0.0 0.8 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.3 GO:0032231 regulation of actin filament bundle assembly(GO:0032231)
0.0 0.4 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.9 GO:0006298 mismatch repair(GO:0006298)
0.0 0.3 GO:0060036 notochord cell vacuolation(GO:0060036)
0.0 0.4 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.4 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.2 GO:0032218 riboflavin transport(GO:0032218)
0.0 1.8 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.2 GO:0006499 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.0 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.5 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0055071 manganese ion homeostasis(GO:0055071)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 3.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.0 GO:0048538 thymus development(GO:0048538)
0.0 0.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:0090342 regulation of cell aging(GO:0090342)
0.0 0.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.4 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.2 GO:0015809 arginine transport(GO:0015809)
0.0 0.4 GO:0051121 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.5 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.2 GO:0042138 meiotic DNA double-strand break processing(GO:0000706) meiotic DNA double-strand break formation(GO:0042138)
0.0 0.3 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.8 GO:0007632 visual behavior(GO:0007632)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.0 0.3 GO:0034434 steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0 0.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0030325 adrenal gland development(GO:0030325)
0.0 2.6 GO:0001756 somitogenesis(GO:0001756)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.9 GO:0001878 response to yeast(GO:0001878)
0.0 0.7 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.5 GO:0001510 RNA methylation(GO:0001510)
0.0 0.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.6 GO:0009411 response to UV(GO:0009411)
0.0 0.5 GO:0014812 muscle cell migration(GO:0014812)
0.0 0.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 1.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 2.5 GO:0050768 negative regulation of neurogenesis(GO:0050768)
0.0 0.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.4 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 1.1 GO:0032200 telomere maintenance(GO:0000723) telomere organization(GO:0032200)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0009081 branched-chain amino acid metabolic process(GO:0009081)
0.0 0.3 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 0.8 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.6 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.2 GO:0042554 superoxide anion generation(GO:0042554)
0.0 4.2 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.0 GO:0001839 neural plate morphogenesis(GO:0001839)
0.0 1.3 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.4 GO:0070672 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.0 0.5 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0039021 pronephric glomerulus development(GO:0039021)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199) commissural neuron axon guidance(GO:0071679)
0.0 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.8 GO:0061053 somite development(GO:0061053)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.3 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.1 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.2 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.4 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.7 GO:0001764 neuron migration(GO:0001764)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.7 GO:0021549 cerebellum development(GO:0021549)
0.0 0.1 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 4.3 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.0 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.6 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 1.4 GO:0009615 response to virus(GO:0009615)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.6 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.2 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.1 GO:0035308 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.5 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.3 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.7 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.3 GO:0010669 epithelial structure maintenance(GO:0010669)
0.0 1.0 GO:0061515 myeloid cell development(GO:0061515)
0.0 0.1 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.5 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.6 GO:0003205 cardiac chamber development(GO:0003205)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.1 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.2 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.3 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0 0.1 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.5 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:1903321 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.0 1.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.9 GO:0090504 epiboly(GO:0090504)
0.0 0.3 GO:0042073 intraciliary transport(GO:0042073)
0.0 0.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0016072 rRNA metabolic process(GO:0016072)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0097189 apoptotic body(GO:0097189)
0.4 3.7 GO:0070652 HAUS complex(GO:0070652)
0.3 1.8 GO:0016589 NURF complex(GO:0016589)
0.3 1.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 1.1 GO:0033186 CAF-1 complex(GO:0033186)
0.3 0.8 GO:1990077 primosome complex(GO:1990077)
0.3 1.8 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 0.9 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.2 0.6 GO:1990745 EARP complex(GO:1990745)
0.2 2.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.2 2.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.5 GO:0031251 PAN complex(GO:0031251)
0.2 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.6 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.1 GO:0060091 kinocilium(GO:0060091)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.8 GO:0070695 FHF complex(GO:0070695)
0.1 0.4 GO:0042382 paraspeckles(GO:0042382)
0.1 1.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.3 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.4 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 1.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.6 GO:0030891 VCB complex(GO:0030891)
0.1 1.2 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 1.6 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 2.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.7 GO:0071797 LUBAC complex(GO:0071797)
0.1 1.3 GO:0042555 MCM complex(GO:0042555)
0.1 0.5 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.8 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 1.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.0 GO:0070187 telosome(GO:0070187)
0.1 0.2 GO:0031213 RSF complex(GO:0031213)
0.1 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.3 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 1.0 GO:0015030 Cajal body(GO:0015030)
0.1 0.3 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.5 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 1.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.5 GO:0000145 exocyst(GO:0000145)
0.1 0.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.2 GO:0097519 DNA recombinase complex(GO:0097519)
0.1 0.6 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.0 0.2 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 1.0 GO:0090568 nuclear transcriptional repressor complex(GO:0090568)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.5 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 6.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.2 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 1.5 GO:0030684 preribosome(GO:0030684)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 2.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0032021 NELF complex(GO:0032021)
0.0 0.4 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:0097268 cytoophidium(GO:0097268)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 3.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.0 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0042627 chylomicron(GO:0042627)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.5 GO:0005657 replication fork(GO:0005657)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0030904 retromer complex(GO:0030904)
0.0 4.6 GO:0000785 chromatin(GO:0000785)
0.0 1.3 GO:0055037 recycling endosome(GO:0055037)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.2 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.5 GO:0005764 lysosome(GO:0005764)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.3 GO:0043186 P granule(GO:0043186)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.8 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.3 0.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 2.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.3 1.0 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.7 GO:0003919 FMN adenylyltransferase activity(GO:0003919)
0.2 0.7 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 1.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.2 1.7 GO:0015232 heme transporter activity(GO:0015232)
0.2 0.8 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.2 0.6 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.2 1.0 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.2 0.6 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.6 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2 1.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.2 1.9 GO:0035198 miRNA binding(GO:0035198)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.2 1.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 5.7 GO:0051087 chaperone binding(GO:0051087)
0.2 1.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 0.5 GO:0017050 ceramide kinase activity(GO:0001729) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 1.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 1.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 2.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 0.5 GO:0031701 angiotensin receptor binding(GO:0031701)
0.2 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.2 1.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.6 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.2 0.8 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.2 0.6 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 2.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.4 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.1 0.6 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.1 1.5 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.1 0.5 GO:0001096 TFIIF-class transcription factor binding(GO:0001096)
0.1 0.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.6 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 1.0 GO:0030619 U1 snRNA binding(GO:0030619)
0.1 0.5 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 2.1 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.5 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.1 0.5 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.1 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.9 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.8 GO:0034632 retinol transporter activity(GO:0034632)
0.1 2.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 1.0 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.4 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 1.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 1.1 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 2.5 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 0.5 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.6 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.2 GO:0000035 acyl binding(GO:0000035)
0.1 2.0 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 0.5 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.3 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.1 0.2 GO:0000996 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
0.1 0.4 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 2.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.3 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.3 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 1.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.4 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.2 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 0.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.0 GO:0002039 p53 binding(GO:0002039)
0.1 0.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.4 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.1 0.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 0.4 GO:0034584 piRNA binding(GO:0034584)
0.1 1.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.5 GO:0032977 membrane insertase activity(GO:0032977)
0.1 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.2 GO:1990238 double-stranded DNA endodeoxyribonuclease activity(GO:1990238)
0.1 2.1 GO:0005109 frizzled binding(GO:0005109)
0.1 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.3 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324) fatty acid transporter activity(GO:0015245)
0.0 0.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.2 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.5 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.4 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 1.4 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0043295 glutathione binding(GO:0043295)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.4 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.2 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.0 0.3 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 0.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.8 GO:0048185 activin binding(GO:0048185)
0.0 0.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.4 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0034061 DNA polymerase activity(GO:0034061)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.8 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.6 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.0 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.6 GO:0048038 quinone binding(GO:0048038)
0.0 0.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.0 0.2 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.1 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.2 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0 1.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0097617 annealing activity(GO:0097617)
0.0 0.1 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 3.7 GO:0042393 histone binding(GO:0042393)
0.0 0.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.4 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.4 GO:0019894 kinesin binding(GO:0019894)
0.0 0.0 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0015278 calcium-release channel activity(GO:0015278)
0.0 0.0 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0019202 amino acid kinase activity(GO:0019202)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0001047 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.2 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 7.9 PID E2F PATHWAY E2F transcription factor network
0.1 1.3 PID ALK2 PATHWAY ALK2 signaling events
0.1 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 0.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.7 PID AURORA A PATHWAY Aurora A signaling
0.1 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.9 ST GA13 PATHWAY G alpha 13 Pathway
0.0 1.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 1.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 2.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.6 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.7 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.1 4.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.8 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.0 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 0.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 1.0 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 1.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.4 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.3 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.1 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor