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PRJEB1986: zebrafish developmental stages transcriptome

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Results for hnf4a+hnf4b

Z-value: 2.56

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Transcription factors associated with hnf4a+hnf4b

Gene Symbol Gene ID Gene Info
ENSDARG00000021494 hepatocyte nuclear factor 4, alpha
ENSDARG00000104742 hepatic nuclear factor 4, beta
ENSDARG00000112985 hepatocyte nuclear factor 4, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf4adr11_v1_chr23_+_25832689_258326890.914.2e-08Click!
CABZ01057488.1dr11_v1_chr7_+_69019851_69019851-0.253.0e-01Click!

Activity profile of hnf4a+hnf4b motif

Sorted Z-values of hnf4a+hnf4b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_11385155 15.03 ENSDART00000064214
placenta-specific 8, tandem duplicate 1
chr7_-_26457208 10.29 ENSDART00000173519
zgc:172079
chr12_-_20362041 9.33 ENSDART00000184145
ENSDART00000105952
aquaporin 8a, tandem duplicate 2
chr13_-_303137 8.95 ENSDART00000099131
chitin synthase 1
chr13_+_50375800 8.00 ENSDART00000099537
cytochrome c oxidase subunit Vb 2
chr25_-_26758253 7.59 ENSDART00000123004
si:dkeyp-73b11.8
chr17_-_14613711 7.55 ENSDART00000157345
serine dehydratase-like
chr6_+_30091811 7.48 ENSDART00000088403
melanotransferrin
chr9_-_9977827 7.23 ENSDART00000187315
ENSDART00000010246
UDP glucuronosyltransferase 1 family a, b
chr7_+_73444325 7.08 ENSDART00000123016
si:ch211-142d6.2
chr8_-_37263524 6.95 ENSDART00000061327
Rh50-like protein
chr7_-_24520866 6.80 ENSDART00000077039
fatty acid amide hydrolase 2b
chr8_-_20838342 6.80 ENSDART00000141345
si:ch211-133l5.7
chr20_+_1412193 6.66 ENSDART00000064419
liver-enriched gene 1, tandem duplicate 1
chr23_-_45504991 6.49 ENSDART00000148761
collagen type XXIV alpha 1
chr9_-_9982696 6.46 ENSDART00000192548
ENSDART00000125852
UDP glucuronosyltransferase 1 family a, b
chr12_+_22607761 6.41 ENSDART00000153112
si:dkey-219e21.2
chr2_-_37960688 5.85 ENSDART00000055565
cerebellin 14
chr18_+_26829086 5.34 ENSDART00000098356
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr1_+_53374454 5.28 ENSDART00000038807
uncoupling protein 1
chr10_+_17026870 5.21 ENSDART00000184529
ENSDART00000157480

chr11_+_33284837 5.13 ENSDART00000166239
ENSDART00000111412
NTPase, KAP family P-loop domain containing 1
chr3_-_50443607 5.10 ENSDART00000074036
recoverin a
chr8_-_33154677 4.98 ENSDART00000133300
zinc finger and BTB domain containing 34
chr20_-_40754794 4.81 ENSDART00000187251
connexin 32.3
chr15_+_19797918 4.78 ENSDART00000113314
si:ch211-229d2.5
chr3_+_16762483 4.70 ENSDART00000132732
transmembrane protein 86B
chr6_-_49873020 4.66 ENSDART00000148511
GNAS complex locus
chr16_+_22345513 4.61 ENSDART00000078000
zgc:123238
chr12_-_31457301 4.55 ENSDART00000043887
ENSDART00000148603
acyl-CoA synthetase long chain family member 5
chr5_-_69940868 4.50 ENSDART00000185924
ENSDART00000097357
UDP glucuronosyltransferase 2 family, polypeptide A4
chr1_-_9641845 4.46 ENSDART00000121490
ENSDART00000159411
UDP glucuronosyltransferase 5 family, polypeptide B2
UDP glucuronosyltransferase 5 family, polypeptide B3
chr8_-_25329967 4.41 ENSDART00000139682
EPS8-like 3b
chr12_-_33706726 4.10 ENSDART00000153135
myosin XVB
chr22_-_31517300 4.06 ENSDART00000164799
solute carrier family 6 (neurotransmitter transporter), member 6b
chr18_+_26829362 3.95 ENSDART00000132728
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr6_+_27624023 3.81 ENSDART00000147789
solute carrier organic anion transporter family, member 2A1
chr3_+_30257582 3.61 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
myosin binding protein C, fast type a
chr18_+_36037223 3.55 ENSDART00000144410
transmembrane protein 91
chr7_-_33868903 3.53 ENSDART00000173500
ENSDART00000178746
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr21_-_27443995 3.51 ENSDART00000003508
complement component bfb
chr23_-_24493768 3.45 ENSDART00000135559
ENSDART00000046933
sulfotransferase family 1, cytosolic sulfotransferase 5
chr10_+_10738880 3.44 ENSDART00000004181
solute carrier family 27 (fatty acid transporter), member 4
chr15_-_24178893 3.40 ENSDART00000077980
pipecolic acid oxidase
chr10_+_45128375 3.37 ENSDART00000164805
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr23_+_2778813 3.36 ENSDART00000142621
DNA topoisomerase I
chr13_-_37254777 3.35 ENSDART00000139734
spectrin repeat containing, nuclear envelope 2b
chr21_-_22910520 3.34 ENSDART00000065567
ENSDART00000191792
guanylate cyclase activator 1d
chr7_+_25036188 3.29 ENSDART00000163957
ENSDART00000169749
sb:cb1058
chr17_+_20173882 3.27 ENSDART00000155379
si:ch211-248a14.8
chr23_-_43595956 3.20 ENSDART00000162186
itchy E3 ubiquitin protein ligase b
chr7_+_26100024 3.17 ENSDART00000173726
si:ch211-196f2.3
chr1_-_46862190 3.17 ENSDART00000145167
1-acylglycerol-3-phosphate O-acyltransferase 3
chr24_-_32150276 3.15 ENSDART00000166212
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_22927958 3.15 ENSDART00000141621
myosin VIIBb
chr15_-_1885247 3.13 ENSDART00000149703
P450 (cytochrome) oxidoreductase b
chr18_-_370286 3.09 ENSDART00000162633
si:ch211-79l17.1
chr1_+_17900306 3.06 ENSDART00000089480
cytochrome P450, family 4, subfamily V, polypeptide 8
chr17_+_20174044 2.99 ENSDART00000156028
si:ch211-248a14.8
chr9_-_470038 2.99 ENSDART00000170338
ENSDART00000162054
si:dkey-11f4.16
chr17_-_30702411 2.98 ENSDART00000114358
zgc:194392
chr14_+_9009600 2.90 ENSDART00000133904
si:ch211-274f20.2
chr4_+_11375894 2.88 ENSDART00000190471
ENSDART00000143963
piccolo presynaptic cytomatrix protein a
chr5_-_13076779 2.83 ENSDART00000192826
yippee-like 1
chr4_+_1283068 2.78 ENSDART00000167233
cholinergic receptor, muscarinic 2a
chr11_-_36957127 2.77 ENSDART00000168528
calcium channel, voltage-dependent, L type, alpha 1D subunit, a
chr19_-_25005609 2.76 ENSDART00000151129
XK, Kell blood group complex subunit-related family, member 8, tandem duplicate 2
chr2_-_22927581 2.72 ENSDART00000109515
myosin VIIBb
chr3_+_12744083 2.70 ENSDART00000158554
ENSDART00000169545
cytochrome P450, family 2, subfamily k, polypeptide 21
chr14_+_6429399 2.69 ENSDART00000149783
ENSDART00000148461
ATP-binding cassette, sub-family A (ABC1), member 1B
chr6_-_46474483 2.64 ENSDART00000155761
retinol dehydrogenase 20
chr5_-_23317477 2.58 ENSDART00000090171
neuroligin 3b
chr5_-_55981288 2.57 ENSDART00000146616
si:dkey-189h5.6
chr7_+_24520518 2.50 ENSDART00000173604
bloodthirsty-related gene family, member 9
chr20_+_1398564 2.49 ENSDART00000002242
liver-enriched gene 1, tandem duplicate 2
chr3_+_46628885 2.48 ENSDART00000006602
phosphodiesterase 4A, cAMP-specific
chr2_-_23778180 2.47 ENSDART00000136782
si:dkey-24c2.7
chr6_+_28051978 2.47 ENSDART00000143218
si:ch73-194h10.2
chr21_-_36571804 2.46 ENSDART00000138129
WW and C2 domain containing 1
chr22_+_15323930 2.46 ENSDART00000142416
si:dkey-236e20.3
chr23_+_46183410 2.46 ENSDART00000167596
ENSDART00000151149
ENSDART00000150896
bloodthirsty-related gene family, member 31
chr8_+_6576940 2.43 ENSDART00000138135
V-set and immunoglobulin domain containing 8b
chr22_-_16400484 2.43 ENSDART00000135987
laminin, alpha 3
chr17_+_450956 2.37 ENSDART00000183022
ENSDART00000171386
zgc:194887
chr12_-_36260532 2.33 ENSDART00000022533
potassium inwardly-rectifying channel, subfamily J, member 2a
chr12_-_6172154 2.27 ENSDART00000185434
apobec1 complementation factor
chr6_+_36807861 2.25 ENSDART00000161708
si:ch73-29l19.1
chr2_+_47249179 2.24 ENSDART00000144438
si:ch211-284d12.3
chr5_-_41638039 2.18 ENSDART00000144525
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr13_-_22843562 2.18 ENSDART00000142738
phenazine biosynthesis like protein domain containing
chr16_+_32029090 2.16 ENSDART00000041054
transmembrane channel-like 4
chr12_-_17897134 2.14 ENSDART00000066407
neuronal pentraxin IIb
chr8_+_7778770 2.12 ENSDART00000171325
transcription factor binding to IGHM enhancer 3a
chr22_-_11648094 2.10 ENSDART00000191791
dipeptidyl-peptidase 4
chr20_-_52338782 2.10 ENSDART00000109735
ENSDART00000132941
si:ch1073-287p18.1
chr23_+_9522781 2.08 ENSDART00000136486
oxysterol binding protein-like 2b
chr23_-_27702561 2.07 ENSDART00000053876
DnaJ (Hsp40) homolog, subfamily C, member 22
chr6_-_1768724 2.02 ENSDART00000162488
ENSDART00000163613
zgc:158417
chr18_-_12957451 2.02 ENSDART00000140403
SLIT-ROBO Rho GTPase activating protein 1a
chr20_+_43379029 1.98 ENSDART00000142486
ENSDART00000186486
unc-93 homolog A
chr19_+_31532043 1.98 ENSDART00000136289
transmembrane protein 64
chr8_-_65189 1.97 ENSDART00000168412
hydroxysteroid (17-beta) dehydrogenase 4
chr16_+_2840775 1.96 ENSDART00000108735
C-type lectin domain family 3, member Ba
chr7_-_60351876 1.95 ENSDART00000098563
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr6_-_40429411 1.94 ENSDART00000156005
ENSDART00000156357
si:dkey-28n18.9
chr2_-_38261272 1.89 ENSDART00000143743
si:ch211-14a17.10
chr18_+_27515640 1.88 ENSDART00000181593
tumor protein p53 inducible protein 11b
chr15_+_26603395 1.84 ENSDART00000188667
solute carrier family 47 (multidrug and toxin extrusion), member 3
chr2_-_24407933 1.83 ENSDART00000088584
si:dkey-208k22.6
chr22_+_29994093 1.80 ENSDART00000104778
si:dkey-286j15.3
chr7_-_5487593 1.77 ENSDART00000136594
Rho guanine nucleotide exchange factor (GEF) 11
chr10_-_322769 1.75 ENSDART00000165244
v-akt murine thymoma viral oncogene homolog 2, like
chr24_-_1341543 1.73 ENSDART00000169341
neuropilin 1a
chr4_-_67799941 1.72 ENSDART00000185830
si:ch211-66c13.1
chr8_+_36803415 1.72 ENSDART00000111680
IQ motif and Sec7 domain 2b
chr4_+_69619 1.71 ENSDART00000164425
MANSC domain containing 1
chr24_-_26369185 1.71 ENSDART00000080039
leucine rich repeat containing 31
chr2_+_11670270 1.70 ENSDART00000100524
finTRIM family, member 1
chr2_-_37967368 1.69 ENSDART00000050345
cerebellin 9
chr22_+_37888249 1.67 ENSDART00000076082
fetuin B
chr22_+_15331214 1.66 ENSDART00000136566
sulfotransferase family 3, cytosolic sulfotransferase 4
chr1_-_37383741 1.63 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
secretory calcium-binding phosphoprotein 1
chr18_-_7400075 1.55 ENSDART00000101250
si:dkey-30c15.13
chr18_+_18861359 1.55 ENSDART00000144605
plasmolipin
chr2_+_3533458 1.50 ENSDART00000133007
glutamic pyruvate transaminase (alanine aminotransferase) 2, like
chr8_+_30699429 1.50 ENSDART00000005345
ureidopropionase, beta
chr2_-_47870649 1.49 ENSDART00000142854
finTRIM family, member 5
chr14_+_24934736 1.48 ENSDART00000191821
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr15_-_20412286 1.46 ENSDART00000008589
calcineurin-like EF-hand protein 2
chr1_-_37383539 1.45 ENSDART00000127579
secretory calcium-binding phosphoprotein 1
chr11_+_6764207 1.44 ENSDART00000104292
phosphodiesterase 4C, cAMP-specific b
chr11_+_39672874 1.44 ENSDART00000046663
ENSDART00000157659
calmodulin binding transcription activator 1b
chr3_-_45848257 1.37 ENSDART00000147198
insulin-like growth factor binding protein, acid labile subunit
chr24_-_17047918 1.32 ENSDART00000020204
methionine sulfoxide reductase B2
chr12_-_44199316 1.31 ENSDART00000170378
si:ch73-329n5.1
chr6_+_18367388 1.31 ENSDART00000163394
diacylglycerol kinase, epsilon
chr5_-_3885727 1.29 ENSDART00000143250
MLX interacting protein like
chr19_-_30524952 1.27 ENSDART00000103506
hippocalcin like 4
chr15_-_26552652 1.27 ENSDART00000152336
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr19_-_8604429 1.27 ENSDART00000151165
tripartite motif containing 46b
chr7_+_52135791 1.21 ENSDART00000098705
cytochrome P450, family 2, subfamily X, polypeptide 12
chr18_+_31410652 1.19 ENSDART00000098504
differentially expressed in FDCP 8 homolog (mouse)
chr5_+_8919698 1.18 ENSDART00000046440
1-acylglycerol-3-phosphate O-acyltransferase 9, like
chr5_-_24112175 1.17 ENSDART00000131595
si:ch211-114c12.5
chr2_-_24407732 1.17 ENSDART00000180612
ENSDART00000153688
ENSDART00000179913
si:dkey-208k22.6
chr3_-_36440705 1.15 ENSDART00000162875
rogdi homolog (Drosophila)
chr22_-_20126230 1.15 ENSDART00000138688
cAMP responsive element binding protein 3-like 3a
chr2_+_22659787 1.12 ENSDART00000043956
zgc:161973
chr11_+_11152214 1.11 ENSDART00000148030
lymphocyte antigen 75
chr22_+_24645325 1.11 ENSDART00000159531
lysophosphatidic acid receptor 3
chr1_-_47431453 1.10 ENSDART00000101104
gap junction protein, alpha 5b
chr20_-_3087162 1.09 ENSDART00000152495
mitogen-activated protein kinase kinase kinase 5
chr18_+_27926839 1.03 ENSDART00000191835
homeodomain interacting protein kinase 3b
chr16_-_25233515 1.03 ENSDART00000058943
zgc:110182
chr22_+_30502555 1.02 ENSDART00000139128
ENSDART00000104747
zgc:171679
chr5_-_62317496 1.01 ENSDART00000180089
zgc:85789
chr15_+_15403560 1.00 ENSDART00000049831
dehydrogenase/reductase (SDR family) member 11b
chr21_+_41743493 0.99 ENSDART00000192669
protein phosphatase 2, regulatory subunit B, beta b
chr23_+_9522942 0.99 ENSDART00000137751
oxysterol binding protein-like 2b
chr6_+_27339962 0.98 ENSDART00000193726
kelch-like family member 30
chr5_+_52039067 0.98 ENSDART00000143276
SET binding protein 1
chr13_+_8696825 0.97 ENSDART00000109059
tetratricopeptide repeat domain 7A
chr15_+_40074923 0.95 ENSDART00000111018
neuronal guanine nucleotide exchange factor
chr3_-_3496738 0.95 ENSDART00000186849

chr16_-_25606889 0.95 ENSDART00000077447
ENSDART00000131528
zgc:110410
chr10_-_15919839 0.94 ENSDART00000065032
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr14_-_16379843 0.92 ENSDART00000090711
leukotriene C4 synthase
chr8_+_1766206 0.90 ENSDART00000021820
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr22_-_10774735 0.89 ENSDART00000081156
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr23_-_21758253 0.89 ENSDART00000046613
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr7_+_24115082 0.87 ENSDART00000182718
mitochondrial ribosomal protein L52
chr19_+_9277327 0.86 ENSDART00000104623
ENSDART00000151164
si:rp71-15k1.1
chr6_-_40722480 0.85 ENSDART00000188187
kelch repeat and BTB (POZ) domain containing 12
chr23_+_33718602 0.84 ENSDART00000024695
DAZ associated protein 2
chr7_+_24114694 0.78 ENSDART00000127177
mitochondrial ribosomal protein L52
chr16_-_25607266 0.75 ENSDART00000192602
zgc:110410
chr12_+_2455429 0.74 ENSDART00000182929
si:dkey-191m6.4
chr7_+_65398161 0.73 ENSDART00000166109
ENSDART00000157399
ubiquitin specific peptidase 47
chr20_-_25669813 0.73 ENSDART00000153118
si:dkeyp-117h8.2
chr17_-_17948587 0.72 ENSDART00000090447
HHIP-like 1
chr2_-_5728843 0.71 ENSDART00000014020
somatostatin 2
chr2_-_56655769 0.70 ENSDART00000113589
glutathione peroxidase 4b
chr6_+_40952031 0.70 ENSDART00000189219
POZ (BTB) and AT hook containing zinc finger 1
chr10_-_21953643 0.69 ENSDART00000188921
ENSDART00000193569

chr22_-_21392748 0.66 ENSDART00000144648
ankyrin repeat domain 24
chr23_-_44786844 0.65 ENSDART00000148669
si:ch73-269m23.5
chr2_+_30916188 0.64 ENSDART00000137012
myomesin 1a (skelemin)
chr8_+_47099033 0.63 ENSDART00000142979
Rho guanine nucleotide exchange factor (GEF) 16
chr15_-_30857350 0.58 ENSDART00000138988
A kinase (PRKA) anchor protein 1b
chr18_+_32615075 0.58 ENSDART00000166937

chr14_+_33329420 0.54 ENSDART00000171090
ENSDART00000164062
sosondowah ankyrin repeat domain family d
chr2_-_44199722 0.52 ENSDART00000140633
ENSDART00000145728
succinate dehydrogenase complex, subunit C, integral membrane protein
chr5_-_30984010 0.52 ENSDART00000182367
spinster homolog 3 (Drosophila)
chr6_-_49078702 0.51 ENSDART00000135185
solute carrier family 5 (iodide transporter), member 8-like
chr19_-_27564980 0.50 ENSDART00000171967
si:dkeyp-46h3.8
chr12_+_2446837 0.47 ENSDART00000112032
si:dkey-191m6.4
chr18_+_45200043 0.46 ENSDART00000015786
LARGE xylosyl- and glucuronyltransferase 2
chr16_-_32013913 0.45 ENSDART00000030282
ENSDART00000138701
glutathione S-transferase kappa 1
chr11_+_11201096 0.44 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myomesin 2a
chr10_+_26747755 0.44 ENSDART00000100329
coagulation factor IXb

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf4a+hnf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
1.8 9.0 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
1.5 4.6 GO:0010747 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
1.2 3.5 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.1 6.5 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
1.0 3.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.9 4.7 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.9 7.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.9 3.4 GO:0006554 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.7 4.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.7 2.8 GO:0010459 cardiac conduction system development(GO:0003161) negative regulation of heart rate(GO:0010459)
0.7 6.7 GO:1990402 embryonic liver development(GO:1990402)
0.7 5.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.6 9.3 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.6 8.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 3.4 GO:0044539 long-chain fatty acid import(GO:0044539)
0.5 5.1 GO:0036368 cone photoresponse recovery(GO:0036368)
0.4 1.1 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.4 2.5 GO:0032475 otolith formation(GO:0032475)
0.3 1.7 GO:0002164 larval development(GO:0002164) larval heart development(GO:0007508) angiogenesis involved in wound healing(GO:0060055)
0.3 1.3 GO:0030091 protein repair(GO:0030091)
0.3 1.5 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.3 2.9 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.3 2.7 GO:0033700 phospholipid efflux(GO:0033700)
0.3 2.8 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.2 2.6 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 7.5 GO:0006826 iron ion transport(GO:0006826)
0.2 2.2 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 3.4 GO:0006265 DNA topological change(GO:0006265)
0.2 3.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 0.9 GO:0019370 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.2 5.1 GO:0051923 sulfation(GO:0051923)
0.2 0.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 2.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.2 2.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.2 2.3 GO:0016556 mRNA modification(GO:0016556)
0.2 2.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.9 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 2.0 GO:0090279 regulation of calcium ion import(GO:0090279)
0.1 4.2 GO:0072348 sulfur compound transport(GO:0072348)
0.1 1.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.5 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 1.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.4 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 3.2 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 4.0 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 3.4 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.1 2.1 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.1 0.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 1.1 GO:0030534 adult behavior(GO:0030534)
0.1 5.5 GO:0007605 sensory perception of sound(GO:0007605)
0.1 0.4 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.4 GO:0016572 histone phosphorylation(GO:0016572)
0.1 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 3.5 GO:0006956 complement activation(GO:0006956)
0.0 1.8 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.6 GO:0032543 mitochondrial translation(GO:0032543)
0.0 3.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 1.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.0 GO:0030282 bone mineralization(GO:0030282)
0.0 0.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 1.5 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.6 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.9 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 2.3 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 2.0 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 1.5 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 2.3 GO:0016358 dendrite development(GO:0016358)
0.0 1.2 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 2.5 GO:0055123 digestive system development(GO:0055123)
0.0 10.3 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 8.4 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0005592 collagen type XI trimer(GO:0005592)
1.1 9.0 GO:0030428 cell septum(GO:0030428)
0.7 3.0 GO:0061689 tricellular tight junction(GO:0061689)
0.4 2.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 0.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 1.2 GO:0043291 RAVE complex(GO:0043291)
0.3 2.9 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 2.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.8 GO:0005902 microvillus(GO:0005902)
0.1 4.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.5 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 1.1 GO:0005922 connexon complex(GO:0005922)
0.1 7.5 GO:0055037 recycling endosome(GO:0055037)
0.1 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 5.9 GO:0016459 myosin complex(GO:0016459)
0.1 1.1 GO:0031430 M band(GO:0031430)
0.0 2.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 3.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 7.7 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 6.7 GO:0009986 cell surface(GO:0009986)
0.0 10.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 93.1 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0016841 ammonia-lyase activity(GO:0016841)
1.3 5.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.1 9.0 GO:0004100 chitin synthase activity(GO:0004100)
1.0 9.3 GO:0015250 water channel activity(GO:0015250)
0.9 4.7 GO:0031852 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.8 3.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.6 4.7 GO:0016803 ether hydrolase activity(GO:0016803)
0.6 3.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.5 2.7 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.5 3.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4 3.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.4 4.6 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.4 3.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.3 1.3 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.3 4.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 7.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 17.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 8.0 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 3.4 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.3 1.5 GO:0030331 estrogen receptor binding(GO:0030331)
0.3 12.9 GO:0015370 solute:sodium symporter activity(GO:0015370)
0.3 2.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 0.9 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 1.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.2 1.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.2 0.5 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.2 3.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 2.9 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 2.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 1.9 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.1 1.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.5 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.4 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.3 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.1 2.8 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.4 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 8.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 2.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 11.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 8.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.2 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.1 3.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 2.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 3.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 5.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 2.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.6 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 3.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 5.9 GO:0003774 motor activity(GO:0003774)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 2.7 GO:0004497 monooxygenase activity(GO:0004497)
0.0 8.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.6 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 2.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.9 ST GA13 PATHWAY G alpha 13 Pathway
0.1 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 16.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.6 4.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.5 2.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.3 2.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 4.7 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.2 3.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 2.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 1.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 6.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.2 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 5.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events