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PRJEB1986: zebrafish developmental stages transcriptome

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Results for gsx2+pnx

Z-value: 1.01

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Transcription factors associated with gsx2+pnx

Gene Symbol Gene ID Gene Info
ENSDARG00000025899 posterior neuron-specific homeobox
ENSDARG00000043322 GS homeobox 2
ENSDARG00000116417 GS homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gsx2dr11_v1_chr20_-_22484621_22484621-0.725.6e-04Click!
pnxdr11_v1_chr10_+_2799285_2799285-0.671.7e-03Click!

Activity profile of gsx2+pnx motif

Sorted Z-values of gsx2+pnx motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22310919 7.22 ENSDART00000108719
crystallin, gamma M2d10
chr3_-_50443607 3.62 ENSDART00000074036
recoverin a
chr17_-_37395460 3.46 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr22_+_7738966 3.27 ENSDART00000147073
si:ch73-44m9.5
chr11_+_38280454 3.27 ENSDART00000171496
si:dkey-166c18.1
chr11_+_43043171 3.22 ENSDART00000180344

chr9_-_14683574 3.10 ENSDART00000144022
par-3 family cell polarity regulator beta b
chr5_+_51597677 3.05 ENSDART00000048210
ENSDART00000184797
creatine kinase, mitochondrial 2b (sarcomeric)
chr6_+_40354424 2.90 ENSDART00000047416
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr8_-_21372446 2.77 ENSDART00000061481
ENSDART00000079293
elastase 2 like
chr25_-_36827491 2.70 ENSDART00000170941

chr25_+_29160102 2.66 ENSDART00000162854
pyruvate kinase M1/2b
chr25_+_31277415 2.60 ENSDART00000036275
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr6_-_39344259 2.58 ENSDART00000104074
zgc:158846
chr10_-_44508249 2.53 ENSDART00000160018
dual specificity phosphatase 26
chr7_-_71758307 2.49 ENSDART00000161067
ENSDART00000165253
myomesin 1b
chr18_+_9615147 2.49 ENSDART00000160284
piccolo presynaptic cytomatrix protein b
chr24_+_3307857 2.44 ENSDART00000106527
glycogenin 1b
chr23_+_40460333 2.38 ENSDART00000184658
SOGA family member 3b
chr8_+_53423408 2.33 ENSDART00000164792
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr3_-_61218272 2.30 ENSDART00000133091
ENSDART00000055068
parvalbumin 5
chr19_+_1831911 2.19 ENSDART00000166653
protein tyrosine kinase 2aa
chr3_-_61217753 2.15 ENSDART00000182630
parvalbumin 5
chr11_-_472547 2.13 ENSDART00000005923
zgc:77375
chr1_-_50859053 2.10 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr19_+_9295244 2.05 ENSDART00000132255
ENSDART00000144299
si:ch73-15n24.1
chr21_-_37790727 2.05 ENSDART00000162907
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr3_-_60827402 2.03 ENSDART00000053494
ankyrin repeat and sterile alpha motif domain containing 4B
chr8_-_23780334 2.03 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr21_+_3244146 1.99 ENSDART00000127740
CBP80/20-dependent translation initiation factor
chr22_-_21897203 1.99 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr18_+_5137241 1.94 ENSDART00000159601
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr3_-_30625219 1.85 ENSDART00000151698
synaptotagmin III
chr19_-_657439 1.78 ENSDART00000167100
solute carrier family 6 (neutral amino acid transporter), member 18
chr16_-_13818061 1.77 ENSDART00000132982
ENSDART00000144856
leukocyte receptor cluster (LRC) member 9
chr18_+_11506561 1.76 ENSDART00000121647
protein arginine methyltransferase 8
chr4_+_21129752 1.75 ENSDART00000169764
synaptotagmin Ia
chr25_+_31276842 1.74 ENSDART00000187238
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr15_+_44366556 1.73 ENSDART00000133449
guanylate cyclase 1 soluble subunit alpha 2
chr21_+_1381276 1.71 ENSDART00000192907
transcription factor 4
chr2_+_55982300 1.69 ENSDART00000183903
nicotinamide riboside kinase 2
chr21_-_42097736 1.69 ENSDART00000100000
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr13_+_15190677 1.65 ENSDART00000142240
ENSDART00000129045
mitochondrial antiviral signaling protein
chr9_-_6372535 1.61 ENSDART00000149189
esophageal cancer related gene 4a
chr20_-_1378514 1.59 ENSDART00000181830
scavenger receptor class A, member 5 (putative)
chr1_+_14283692 1.58 ENSDART00000017679
protein phosphatase 2, regulatory subunit B, gamma a
chr7_-_27685365 1.55 ENSDART00000188342
calcitonin/calcitonin-related polypeptide, alpha
chr12_+_47446158 1.54 ENSDART00000152857
formin 2b
chr2_+_56937548 1.48 ENSDART00000189308

chr24_-_41320037 1.47 ENSDART00000129058
Ras homolog, mTORC1 binding
chr20_+_35382482 1.45 ENSDART00000135284
visinin-like 1a
chr5_-_30074332 1.44 ENSDART00000147963
beta-carotene oxygenase 2a
chr23_+_28582865 1.44 ENSDART00000020296
L1 cell adhesion molecule, paralog a
chr22_+_17205608 1.44 ENSDART00000181267
RAB3B, member RAS oncogene family
chr11_+_26476153 1.43 ENSDART00000103507
un-named sa1614
chr7_+_54642005 1.42 ENSDART00000171864
fibroblast growth factor 19
chr18_+_8833251 1.42 ENSDART00000143519
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr24_-_33276139 1.41 ENSDART00000128943
nuclear receptor binding protein 2b
chr6_+_3280939 1.40 ENSDART00000151359
lysine (K)-specific demethylase 4A, genome duplicate a
chr7_+_65261576 1.39 ENSDART00000169566
beta-carotene oxygenase 1
chr19_-_5805923 1.39 ENSDART00000134340
si:ch211-264f5.8
chr15_-_16098531 1.38 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr3_-_34084387 1.34 ENSDART00000155365
immunoglobulin heavy variable 4-3
chr2_-_28671139 1.33 ENSDART00000165272
ENSDART00000164657
7-dehydrocholesterol reductase
chr8_+_14855471 1.33 ENSDART00000134775
si:dkey-21p1.3
chr6_+_34511886 1.33 ENSDART00000179450
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr16_+_13818500 1.31 ENSDART00000135245
folliculin
chr3_-_61099004 1.30 ENSDART00000112043
calcium channel, voltage-dependent, gamma subunit 4b
chr4_+_76575585 1.29 ENSDART00000131588
membrane-spanning 4-domains, subfamily A, member 17A.11
chr9_-_813511 1.28 ENSDART00000082368
macrophage receptor with collagenous structure
chr12_+_45677293 1.27 ENSDART00000152850
ENSDART00000153047
si:ch73-111m19.2
chr15_-_12011202 1.24 ENSDART00000160427
ENSDART00000168715
si:dkey-202l22.6
chr18_+_10929661 1.22 ENSDART00000061838
ENSDART00000113146
tetratricopeptide repeat domain 38
chr6_-_30210378 1.22 ENSDART00000157359
ENSDART00000113924
leucine rich repeat containing 7
chr4_+_9450415 1.21 ENSDART00000189690
transmembrane and tetratricopeptide repeat containing 1
chr15_-_33925851 1.21 ENSDART00000187807
ENSDART00000187780
myelin associated glycoprotein
chr2_+_50608099 1.20 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr15_-_38154616 1.20 ENSDART00000099392
immunity-related GTPase family, q2
chr9_-_22834860 1.19 ENSDART00000146486
nebulin
chr21_+_45841731 1.19 ENSDART00000038657
fatty acid hydroxylase domain containing 2
chr23_+_4646194 1.16 ENSDART00000092344

chr10_+_35952532 1.16 ENSDART00000184730
reticulon 4 receptor-like 1a
chr18_-_43884044 1.16 ENSDART00000087382
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr7_+_67486807 1.14 ENSDART00000159989
copine VII
chr18_+_3332999 1.14 ENSDART00000160857
glycerophosphodiester phosphodiesterase domain containing 4a
chr23_-_1348933 1.14 ENSDART00000168981

chr1_-_14332283 1.14 ENSDART00000090025
Wolfram syndrome 1a (wolframin)
chr15_-_36533322 1.14 ENSDART00000156466
ENSDART00000121755
si:dkey-262k9.4
chr13_-_44630111 1.14 ENSDART00000110092
MAM domain containing glycosylphosphatidylinositol anchor 1
chr2_-_1569250 1.14 ENSDART00000167202
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr24_-_31425799 1.13 ENSDART00000157998
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr8_+_52637507 1.13 ENSDART00000163830
si:dkey-90l8.3
chr11_-_2131280 1.13 ENSDART00000008409
calcium binding and coiled-coil domain 1b
chr22_+_28337429 1.12 ENSDART00000166177
interphotoreceptor matrix proteoglycan 2b
chr19_-_2861444 1.12 ENSDART00000169053
C-type lectin domain family 3, member Bb
chr10_+_3049636 1.12 ENSDART00000081794
ENSDART00000183167
ENSDART00000191634
ENSDART00000183514
Ras protein-specific guanine nucleotide-releasing factor 2a
chr3_-_23407720 1.11 ENSDART00000155658
Rap guanine nucleotide exchange factor (GEF)-like 1
chr24_-_24282427 1.11 ENSDART00000123299
pyruvate dehydrogenase E1 alpha 1 subunit b
chr22_+_2254972 1.11 ENSDART00000144906
zinc finger protein 1157
chr19_-_5103313 1.10 ENSDART00000037007
triosephosphate isomerase 1a
chr15_-_12011390 1.09 ENSDART00000187403
si:dkey-202l22.6
chr25_+_31267268 1.09 ENSDART00000181239
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr24_-_29586082 1.08 ENSDART00000136763
vav 3 guanine nucleotide exchange factor a
chr18_-_2433011 1.04 ENSDART00000181922
ENSDART00000193276

chr14_-_9713549 1.01 ENSDART00000193356
ENSDART00000166739
si:zfos-2326c3.2
chr21_+_6751405 1.01 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr6_-_48473694 1.01 ENSDART00000154237
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr1_+_55755304 0.99 ENSDART00000144983
trans-2,3-enoyl-CoA reductase b
chr2_-_57076687 0.99 ENSDART00000161523
solute carrier family 25, member 42
chr20_-_46362606 0.99 ENSDART00000153087
BCL2 modifying factor 2
chr6_+_39279104 0.98 ENSDART00000023686
ankyrin repeat domain 33Ab
chr9_-_950004 0.98 ENSDART00000168917
secretin receptor
chr23_-_44219902 0.98 ENSDART00000185874
zgc:158659
chr21_-_20939488 0.97 ENSDART00000039043
regulator of G protein signaling 7 binding protein b
chr7_-_24046999 0.97 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dehydrogenase/reductase (SDR family) member 4
chr10_+_42690374 0.97 ENSDART00000123496
Rho-related BTB domain containing 2b
chr10_-_2524917 0.97 ENSDART00000188642

chr5_+_30624183 0.97 ENSDART00000141444
ATP-binding cassette, sub-family G (WHITE), member 4a
chr14_-_4145594 0.96 ENSDART00000077348
caspase 3, apoptosis-related cysteine peptidase b
chr11_+_45323455 0.96 ENSDART00000189249
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr1_-_59287410 0.96 ENSDART00000158011
ENSDART00000170580
collagen, type V, alpha 3b
chr20_-_14925281 0.93 ENSDART00000152641
dynamin 3a
chr18_+_1154189 0.93 ENSDART00000135090
si:ch1073-75f15.2
chr15_+_34592215 0.93 ENSDART00000099776
tetraspanin 13a
chr2_+_6963296 0.91 ENSDART00000147146
discoidin domain receptor tyrosine kinase 2b
chr19_-_46091497 0.90 ENSDART00000178772
ENSDART00000167255
phosphatidylserine synthase 1b
si:dkey-108k24.2
chr12_-_4532066 0.90 ENSDART00000092687
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr17_+_3379673 0.89 ENSDART00000176354
syntrophin, gamma 2
chr20_-_1635922 0.89 ENSDART00000181502

chr11_+_7264457 0.87 ENSDART00000154182
receptor accessory protein 6
chr8_-_45277370 0.87 ENSDART00000146364
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr10_-_5581487 0.86 ENSDART00000141943
spleen tyrosine kinase
chr6_+_6924637 0.86 ENSDART00000065551
ENSDART00000151393
sterile alpha motif and leucine zipper containing kinase AZK
chr22_-_8388678 0.86 ENSDART00000184389

chr1_-_58963395 0.86 ENSDART00000130415

chr19_+_5543072 0.84 ENSDART00000082080
junction plakoglobin b
chr17_-_37195354 0.83 ENSDART00000190963
additional sex combs like transcriptional regulator 2
chr2_-_14390627 0.82 ENSDART00000172367
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr4_+_9400012 0.82 ENSDART00000191960
transmembrane and tetratricopeptide repeat containing 1
chr8_+_52503340 0.81 ENSDART00000168838
si:ch1073-392o20.1
chr19_-_5103141 0.81 ENSDART00000150952
triosephosphate isomerase 1a
chr8_-_49908978 0.80 ENSDART00000172642
ATP/GTP binding protein 1
chr16_+_31804590 0.79 ENSDART00000167321
wingless-type MMTV integration site family, member 4b
chr23_-_46020226 0.79 ENSDART00000160010
synapse defective Rho GTPase homolog 2
chr8_+_7756893 0.78 ENSDART00000191894
FYVE, RhoGEF and PH domain containing 1
chr15_+_19646902 0.78 ENSDART00000179822
lens intrinsic membrane protein 2.3
chr8_+_36942262 0.78 ENSDART00000188173
IQ motif and Sec7 domain 2b
chr21_-_5205617 0.76 ENSDART00000145554
ENSDART00000045284
ribosomal protein L37
chr17_+_20174812 0.76 ENSDART00000186628
si:ch211-248a14.8
chr7_+_30787903 0.76 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr1_+_52392511 0.76 ENSDART00000144025
si:ch211-217k17.8
chr20_-_13774826 0.75 ENSDART00000063831
opsin 8, group member c
chr24_-_36680261 0.75 ENSDART00000059507
chemokine (C-C motif) receptor 10
chr11_-_42554290 0.75 ENSDART00000130573
ATPase H+ transporting accessory protein 1 like a
chr14_-_33824329 0.74 ENSDART00000189271
ENSDART00000180458
vimentin-related 2
chr16_-_25568512 0.74 ENSDART00000149411
ataxin 1b
chr25_+_2361721 0.74 ENSDART00000172905
zmp:0000000932
chr3_+_13637383 0.74 ENSDART00000166000
si:ch211-194b1.1
chr18_-_2727764 0.74 ENSDART00000160841
si:ch211-248g20.5
chr19_-_22541652 0.73 ENSDART00000188208
plectin a
chr22_-_30770751 0.73 ENSDART00000172115

chr15_-_22074315 0.73 ENSDART00000149830
dopamine receptor D2a
chr8_+_20776654 0.73 ENSDART00000135850
nuclear factor I/C
chr15_-_2726662 0.72 ENSDART00000108856
si:ch211-235m3.5
chr19_-_44064842 0.72 ENSDART00000151541
mitochondrial transcription termination factor 3
chr4_+_73085993 0.72 ENSDART00000165749
si:ch73-170d6.2
chr9_-_5263947 0.71 ENSDART00000088342
cytohesin 1 interacting protein
chr16_+_45424907 0.71 ENSDART00000134471
PHD finger protein 1
chr12_-_46112892 0.71 ENSDART00000187128
ENSDART00000114268
zgc:153932
chr2_+_33382648 0.70 ENSDART00000137207
ENSDART00000098831
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_-_22541284 0.70 ENSDART00000019505
plectin a
chr23_-_1658980 0.70 ENSDART00000186227

chr6_+_24420523 0.70 ENSDART00000185461
transforming growth factor, beta receptor III
chr25_-_13839743 0.70 ENSDART00000158780
mitogen-activated protein kinase 8 interacting protein 1a
chr5_+_19343880 0.68 ENSDART00000148130
acetyl-CoA carboxylase beta
chr2_+_8779164 0.68 ENSDART00000134308
zinc finger, ZZ-type containing 3
chr5_+_69747417 0.67 ENSDART00000153717
si:ch211-275j6.5
chr12_+_30265802 0.67 ENSDART00000182412
actin filament associated protein 1-like 2
chr10_+_37137464 0.66 ENSDART00000114909
CUE domain containing 1a
chr10_+_16188761 0.66 ENSDART00000193244
cortexin 3
chr13_-_25719628 0.66 ENSDART00000135383
si:dkey-192p21.6
chr20_-_18382708 0.64 ENSDART00000170864
ENSDART00000166762
ENSDART00000191333
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr19_-_31402429 0.64 ENSDART00000137292
transmembrane protein 106Bb
chr17_+_20204122 0.64 ENSDART00000078672
gonadotropin-releasing hormone 3
chr3_+_34919810 0.64 ENSDART00000055264
carbonic anhydrase Xb
chr6_-_30954268 0.64 ENSDART00000154523
phosphodiesterase 4B, cAMP-specific a
chr7_+_18106727 0.63 ENSDART00000190307
zRAB1B, member RAS oncogene family a
chr4_-_5019113 0.63 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr25_-_4713461 0.62 ENSDART00000155302
dopamine receptor D4a
chr10_-_5847655 0.62 ENSDART00000192773
ankyrin repeat domain 55
chr5_-_38063585 0.62 ENSDART00000164947
si:dkey-111e8.5
chr15_-_14552101 0.61 ENSDART00000171169
numb homolog (Drosophila)-like
chr2_+_30369116 0.60 ENSDART00000142137
peptidase inhibitor 15b
chr10_-_17083180 0.60 ENSDART00000170083
family with sequence similarity 166, member B
chr12_-_33354409 0.60 ENSDART00000178515
solute carrier family 16 (monocarboxylate transporter), member 3
chr21_+_6751760 0.59 ENSDART00000135914
olfactomedin 1b
chr18_+_19008560 0.59 ENSDART00000184217
ENSDART00000060735
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr11_+_2506516 0.59 ENSDART00000130886
ENSDART00000189767
si:ch73-190f16.2
chr16_-_41936932 0.59 ENSDART00000111956
GRAM domain containing 1A
chr10_+_21867307 0.58 ENSDART00000126629
cerebellin 17

Network of associatons between targets according to the STRING database.

First level regulatory network of gsx2+pnx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.8 3.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.5 1.6 GO:0070314 G1 to G0 transition(GO:0070314)
0.5 1.9 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 1.7 GO:0070208 protein heterotrimerization(GO:0070208)
0.3 1.7 GO:0098586 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.3 3.6 GO:0036368 cone photoresponse recovery(GO:0036368)
0.3 2.8 GO:0042214 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.3 0.9 GO:0002369 T cell cytokine production(GO:0002369)
0.3 0.9 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.2 2.5 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.2 3.1 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 1.6 GO:0070207 protein trimerization(GO:0070206) protein homotrimerization(GO:0070207)
0.2 0.7 GO:0032757 interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757)
0.2 0.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.2 1.2 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.2 0.6 GO:0060292 long term synaptic depression(GO:0060292)
0.2 1.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2 0.7 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.2 0.7 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.2 0.7 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.2 0.7 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 0.5 GO:2000374 oxygen metabolic process(GO:0072592) regulation of oxygen metabolic process(GO:2000374) positive regulation of oxygen metabolic process(GO:2000376)
0.2 0.8 GO:0002159 desmosome assembly(GO:0002159)
0.2 2.2 GO:0007172 signal complex assembly(GO:0007172)
0.2 1.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.2 3.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.2 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.4 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 1.1 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 1.0 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.9 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.4 GO:0035973 aggrephagy(GO:0035973)
0.1 2.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 5.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.9 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 1.2 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1 0.6 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.3 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 1.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.3 GO:0099590 postsynaptic neurotransmitter receptor internalization(GO:0098884) neurotransmitter receptor internalization(GO:0099590)
0.1 1.0 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 1.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 8.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 4.0 GO:0006096 glycolytic process(GO:0006096)
0.1 0.3 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 1.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.3 GO:0042446 hormone biosynthetic process(GO:0042446)
0.1 0.4 GO:0036268 swimming(GO:0036268)
0.1 2.4 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.5 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 0.6 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 1.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 1.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 1.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.6 GO:0032418 lysosome localization(GO:0032418)
0.0 0.6 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.4 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.8 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 2.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.2 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.0 0.8 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.5 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 3.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.1 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.7 GO:0006415 translational termination(GO:0006415)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.2 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.3 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 2.0 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 1.0 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.8 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 2.4 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.3 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.6 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 1.3 GO:0006909 phagocytosis(GO:0006909)
0.0 1.1 GO:0030282 bone mineralization(GO:0030282)
0.0 2.3 GO:0070509 calcium ion import(GO:0070509)
0.0 0.9 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.4 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.2 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.7 GO:1903844 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.8 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.6 GO:0036269 swimming behavior(GO:0036269)
0.0 1.8 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 1.8 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098)
0.0 0.5 GO:0003094 glomerular filtration(GO:0003094)
0.0 1.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.9 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.6 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 2.5 GO:0098982 GABA-ergic synapse(GO:0098982)
0.2 2.6 GO:0045095 keratin filament(GO:0045095)
0.2 1.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 5.8 GO:0005861 troponin complex(GO:0005861)
0.1 1.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.8 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 1.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.8 GO:0035517 PR-DUB complex(GO:0035517)
0.1 3.7 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.5 GO:0031430 M band(GO:0031430)
0.1 1.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 0.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.5 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 4.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 5.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.7 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.9 GO:0030018 Z disc(GO:0030018)
0.0 2.2 GO:0005925 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.7 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.1 GO:0070382 exocytic vesicle(GO:0070382)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:0030175 filopodium(GO:0030175)
0.0 15.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.6 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0031716 calcitonin receptor binding(GO:0031716)
0.5 1.9 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.4 2.7 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 1.0 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.3 2.8 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.3 1.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.7 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.2 1.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 3.1 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 1.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 2.0 GO:0008494 translation activator activity(GO:0008494)
0.2 2.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 0.6 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.2 2.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 0.7 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 0.5 GO:0033819 lipoyl(octanoyl) transferase activity(GO:0033819)
0.2 1.2 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.2 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 2.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 2.5 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.1 1.7 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.1 1.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 2.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 8.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.1 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 2.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 3.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.4 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.5 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.1 0.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.6 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 1.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0031779 melanocortin receptor binding(GO:0031779)
0.0 0.5 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.0 1.0 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 2.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.5 GO:0019003 GDP binding(GO:0019003)
0.0 1.2 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 6.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.4 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.1 GO:0070738 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.5 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 2.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.5 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.8 GO:0019843 rRNA binding(GO:0019843)
0.0 2.9 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.8 GO:0015293 symporter activity(GO:0015293)
0.0 0.9 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.3 PID REELIN PATHWAY Reelin signaling pathway
0.1 0.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 2.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.4 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 2.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 1.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 2.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 1.7 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.7 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 3.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 1.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion