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PRJEB1986: zebrafish developmental stages transcriptome

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Results for gcm2

Z-value: 1.14

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Transcription factors associated with gcm2

Gene Symbol Gene ID Gene Info
ENSDARG00000045413 glial cells missing transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gcm2dr11_v1_chr24_-_8831866_8831912-0.716.0e-04Click!

Activity profile of gcm2 motif

Sorted Z-values of gcm2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_43056153 2.90 ENSDART00000186377
prion protein a
chr17_+_45305645 2.66 ENSDART00000172488
calpain 3a, (p94)
chr19_-_8604429 1.97 ENSDART00000151165
tripartite motif containing 46b
chr24_+_39614853 1.80 ENSDART00000165138

chr24_-_6158933 1.56 ENSDART00000021609
glutamate decarboxylase 2
chr16_+_25407021 1.54 ENSDART00000187489
ENSDART00000086333
jumonji, AT rich interactive domain 2a
chr23_-_30960506 1.50 ENSDART00000142661
oxysterol binding protein-like 2a
chr13_-_44285793 1.48 ENSDART00000167383

chr10_+_7182423 1.43 ENSDART00000186788
pleckstrin and Sec7 domain containing 3, like
chr21_-_1799265 1.41 ENSDART00000066623
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr12_-_7824291 1.28 ENSDART00000148673
ENSDART00000149453
ankyrin 3b
chr19_+_7627070 1.18 ENSDART00000151078
ENSDART00000131324
pygopus homolog 2 (Drosophila)
chr16_+_3004422 1.15 ENSDART00000189969

chr1_-_53756851 1.14 ENSDART00000122445
v-akt murine thymoma viral oncogene homolog 3b
chr17_+_443264 1.12 ENSDART00000159086
zgc:195050
chr19_+_31183495 1.10 ENSDART00000088618
mesenchyme homeobox 2b
chr5_-_16274058 1.08 ENSDART00000090684
kringle containing transmembrane protein 1
chr5_-_21065094 1.02 ENSDART00000143785
si:dkey-13n15.2
chr17_+_23554932 1.01 ENSDART00000135814
pantothenate kinase 1a
chr10_+_7182168 1.01 ENSDART00000172766
pleckstrin and Sec7 domain containing 3, like
chr20_+_48100261 0.99 ENSDART00000158604
XK related 5a
chr6_+_46406565 0.99 ENSDART00000168440
ENSDART00000131203
ENSDART00000138567
ENSDART00000132845
polybromo 1, like
chr5_-_23317477 0.97 ENSDART00000090171
neuroligin 3b
chr16_-_383664 0.96 ENSDART00000051693
iroquois homeobox 4a
chr10_+_45071603 0.96 ENSDART00000186505
ENSDART00000157573
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr1_-_20928772 0.95 ENSDART00000078277
methylsterol monooxygenase 1
chr25_-_28443607 0.95 ENSDART00000157243
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr16_+_45571956 0.94 ENSDART00000143867
synaptic Ras GTPase activating protein 1b
chr21_+_349091 0.91 ENSDART00000183693
zinc finger protein 462
chr6_+_39499623 0.90 ENSDART00000036057
si:ch211-173n18.3
chr21_+_27278120 0.89 ENSDART00000193882
si:dkey-175m17.7
chr25_-_35599887 0.86 ENSDART00000153827
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr19_+_56351 0.86 ENSDART00000168334
collagen, type XIV, alpha 1b
chr6_-_55354004 0.86 ENSDART00000165911
PDX1 C-terminal inhibiting factor 1
chr4_-_760560 0.85 ENSDART00000103601
ATP/GTP binding protein-like 5
chr2_-_32505091 0.84 ENSDART00000141884
ENSDART00000056639
Fas apoptotic inhibitory molecule 2a
chr7_-_4036875 0.83 ENSDART00000165021
NDRG family member 2
chr8_+_23521974 0.83 ENSDART00000188130
ENSDART00000129378
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr14_-_2217285 0.83 ENSDART00000157949
ENSDART00000166150
ENSDART00000054891
ENSDART00000183268
protocadherin 2 alpha b2
protocadherin 2 alpha b2
chr13_-_25284379 0.83 ENSDART00000124167
vinculin a
chr10_-_302827 0.82 ENSDART00000157582
EMSY BRCA2-interacting transcriptional repressor
chr1_-_20911297 0.82 ENSDART00000078271
carboxypeptidase E
chr2_-_13886842 0.82 ENSDART00000187203

chr17_-_35361322 0.80 ENSDART00000019617
radical S-adenosyl methionine domain containing 2
chr9_+_51882534 0.78 ENSDART00000165493

chr25_-_21894317 0.76 ENSDART00000089642
F-box protein 31
chr12_+_49125510 0.76 ENSDART00000185804

chr3_+_39759130 0.75 ENSDART00000185202
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr3_+_46724528 0.72 ENSDART00000181358
phosphodiesterase 4A, cAMP-specific
chr1_+_17527342 0.71 ENSDART00000139702
ENSDART00000140076
ENSDART00000005593
caspase 3, apoptosis-related cysteine peptidase a
chr17_+_53250802 0.70 ENSDART00000143819
vasohibin 1
chr1_+_2112726 0.70 ENSDART00000131714
ENSDART00000138396
muscleblind-like splicing regulator 2
chr4_-_49582108 0.70 ENSDART00000154999
si:dkey-159n16.2
chr6_-_46403475 0.70 ENSDART00000154148
calcium/calmodulin-dependent protein kinase Ia
chr5_-_34185115 0.67 ENSDART00000192771
fibrinogen C domain containing 1
chr15_+_8335600 0.66 ENSDART00000190066
ENSDART00000152603
egl-9 family hypoxia-inducible factor 2
chr22_+_5176693 0.66 ENSDART00000160927
ceramide synthase 1
chr4_+_11384891 0.65 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr24_+_25069609 0.64 ENSDART00000115165
APC membrane recruitment protein 2
chr20_+_28434196 0.64 ENSDART00000034245
D4, zinc and double PHD fingers, family 3
chr12_+_16168342 0.63 ENSDART00000079326
ENSDART00000170024
low density lipoprotein receptor-related protein 2b
chr14_-_413273 0.63 ENSDART00000163976
ENSDART00000179907
FAT atypical cadherin 4
chr10_-_5053589 0.62 ENSDART00000193579
transmembrane protein 150C
chr15_-_28618502 0.61 ENSDART00000086902
solute carrier family 6 (neurotransmitter transporter), member 4a
chr12_+_29055143 0.60 ENSDART00000076322
gamma-aminobutyric acid (GABA) A receptor, zeta
chr4_+_19534833 0.60 ENSDART00000140028
leucine rich repeat containing 4.1
chr14_-_33177935 0.60 ENSDART00000180583
ENSDART00000078856
discs, large homolog 3 (Drosophila)
chr7_-_71829649 0.59 ENSDART00000160449
calcium channel, voltage-dependent, beta 2a
chr1_+_45323400 0.59 ENSDART00000148906
ENSDART00000132366
epithelial membrane protein 1
chr3_-_32299892 0.58 ENSDART00000181472
si:dkey-16p21.7
chr18_+_43183749 0.58 ENSDART00000151166
nectin cell adhesion molecule 1b
chr15_-_3976035 0.58 ENSDART00000168061
si:ch73-309g22.1
chr23_+_4646194 0.58 ENSDART00000092344

chr23_-_36823932 0.58 ENSDART00000142305
homeodomain interacting protein kinase 1a
chr7_-_69429561 0.57 ENSDART00000127351
ataxin 1-like
chr19_-_47452874 0.56 ENSDART00000025931
transcription factor AP-2 epsilon
chr9_+_36356740 0.54 ENSDART00000139033
low density lipoprotein receptor-related protein 1Bb
chr10_+_8534750 0.54 ENSDART00000183960
TBC1 domain family, member 10Ab
chr11_-_2277081 0.54 ENSDART00000109026
zinc finger protein 740a
chr17_+_8183393 0.54 ENSDART00000155957
tubby like protein 4b
chr13_+_2448251 0.53 ENSDART00000188361
ARFGEF family member 3
chr21_-_43398457 0.53 ENSDART00000166530
cyclin I family, member 2
chr22_+_5176255 0.52 ENSDART00000092647
ceramide synthase 1
chr23_-_32100106 0.51 ENSDART00000044658
LETM1 domain containing 1
chr14_-_27289042 0.50 ENSDART00000159727
protocadherin 11
chr11_+_23760470 0.50 ENSDART00000175688
ENSDART00000121874
ENSDART00000086720
neurofascin homolog (chicken) a
chr12_+_29054907 0.50 ENSDART00000152936
gamma-aminobutyric acid (GABA) A receptor, zeta
chr23_-_31266586 0.50 ENSDART00000139746
si:dkey-261l7.2
chr10_-_2960665 0.50 ENSDART00000006772
MARVEL domain containing 2a
chr18_-_7539469 0.50 ENSDART00000101296
si:dkey-30c15.2
chr16_+_4133519 0.50 ENSDART00000174521
ENSDART00000175718
metal-regulatory transcription factor 1
chr16_-_22006996 0.49 ENSDART00000116114
si:dkey-71b5.7
chr25_-_21894706 0.49 ENSDART00000189158
F-box protein 31
chr3_-_6768905 0.49 ENSDART00000193638
ENSDART00000123809
ENSDART00000189440
ENSDART00000188335
microtubule associated serine/threonine kinase 1b
chr21_+_5993188 0.48 ENSDART00000048399
solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
chr17_-_2685026 0.47 ENSDART00000191014
ENSDART00000179309
protein tyrosine phosphatase, non-receptor type 21
chr8_+_30797363 0.47 ENSDART00000077280
matrix metallopeptidase 11a
chr17_+_43629008 0.47 ENSDART00000184185
ENSDART00000181681
zinc finger protein 365
chr20_+_54333774 0.46 ENSDART00000144633
CLOCK-interacting pacemaker b
chr21_+_1380099 0.46 ENSDART00000184516
transcription factor 4
chr4_+_50261086 0.44 ENSDART00000140833
si:dkey-16p6.1
chr18_-_215698 0.44 ENSDART00000147430
threonyl-tRNA synthetase-like 2
chr4_+_7888047 0.44 ENSDART00000104676
calcium/calmodulin-dependent protein kinase 1Da
chr14_-_1963369 0.43 ENSDART00000125521
protocadherin 2 gamma 5
chr1_+_418869 0.41 ENSDART00000152173
tripeptidyl peptidase 2
chr18_+_20047374 0.41 ENSDART00000146957
uveal autoantigen with coiled-coil domains and ankyrin repeats a
chr7_-_6355459 0.40 ENSDART00000172898

chr8_-_28655338 0.39 ENSDART00000017440
melanocortin 3 receptor
chr18_+_8346920 0.39 ENSDART00000083421
carnitine palmitoyltransferase 1B (muscle)
chr10_+_4095917 0.39 ENSDART00000114533
meningioma 1a
chr3_-_45298487 0.39 ENSDART00000102245
3-phosphoinositide dependent protein kinase 1a
chr14_+_44860335 0.38 ENSDART00000091620
ENSDART00000173043
ENSDART00000091625
ATPase phospholipid transporting 8A1
chr6_+_9204099 0.37 ENSDART00000150167
ENSDART00000115394
T-box 19
chr17_+_13099476 0.37 ENSDART00000012670
pinin, desmosome associated protein
chr7_-_73846995 0.37 ENSDART00000188079

chr16_+_5678071 0.36 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
chr14_-_14746767 0.35 ENSDART00000183755
ENSDART00000190938
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr15_-_14469704 0.35 ENSDART00000185077
numb homolog (Drosophila)-like
chr21_-_3452683 0.35 ENSDART00000009740
SMAD family member 7
chr21_+_15312542 0.35 ENSDART00000144308
si:dkey-11o15.5
chr7_-_6368406 0.34 ENSDART00000172787
histone cluster 1 H2A family member 11
chr17_+_37310663 0.33 ENSDART00000157122
ELM2 and Myb/SANT-like domain containing 1b
chr17_+_38602602 0.33 ENSDART00000187996
coiled-coil domain containing 88C
chr4_-_71294485 0.33 ENSDART00000162174
si:ch211-205a14.1
chr4_+_76441823 0.33 ENSDART00000163932
si:dkey-16p6.1
chr12_+_35011899 0.32 ENSDART00000153007
ENSDART00000153020
QKI, KH domain containing, RNA binding 2
chr3_-_30061985 0.31 ENSDART00000189583
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr14_+_7699443 0.31 ENSDART00000123139
bromodomain containing 8
chr17_+_38602790 0.31 ENSDART00000062010
coiled-coil domain containing 88C
chr8_+_47683352 0.30 ENSDART00000187320
ENSDART00000192605
dipeptidyl-peptidase 9
chr6_+_39506043 0.29 ENSDART00000086260

chr20_-_32110882 0.29 ENSDART00000030324
glutamate receptor, metabotropic 1a
chr10_+_37145007 0.28 ENSDART00000131777
CUE domain containing 1a
chr3_-_9722603 0.28 ENSDART00000168234
CREB binding protein b
chr4_+_19127973 0.28 ENSDART00000136611
si:dkey-21o22.2
chr18_-_17399291 0.27 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zinc finger protein, FOG family member 1
chr5_+_70262153 0.26 ENSDART00000185309
zinc finger protein 618
chr24_-_25787501 0.26 ENSDART00000015628
kelch-like family member 24b
chr11_-_41130239 0.25 ENSDART00000173268
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr16_-_32671998 0.25 ENSDART00000161395
PNN-interacting serine/arginine-rich protein
chr14_-_5677979 0.25 ENSDART00000182156
T cell leukemia homeobox 2
chr13_+_15004398 0.24 ENSDART00000057810
empty spiracles homeobox 1
chr15_-_41749364 0.23 ENSDART00000155464
finTRIM family, member 73
chr10_-_25852517 0.22 ENSDART00000191551
transient receptor potential cation channel, subfamily C, member 4a
chr1_+_44941031 0.22 ENSDART00000141145
si:dkey-9i23.16
chr16_-_52646789 0.22 ENSDART00000035761
ubiquitin protein ligase E3 component n-recognin 5
chr25_-_21156678 0.22 ENSDART00000156257
WNK lysine deficient protein kinase 1a
chr13_-_214122 0.21 ENSDART00000169273
protein phosphatase 1, regulatory subunit 21
chr25_+_36336920 0.21 ENSDART00000073402
histone cluster 1 H2A family member1
chr6_-_13308813 0.21 ENSDART00000065372
potassium inwardly-rectifying channel, subfamily J, member 3b
chr7_-_74090168 0.21 ENSDART00000050528
tyrosinase-related protein 1a
chr19_-_81851 0.21 ENSDART00000172319
heterogeneous nuclear ribonucleoprotein R
chr10_+_24445698 0.20 ENSDART00000146370
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr8_+_10350122 0.20 ENSDART00000186650
ENSDART00000098009
TBC1 domain family, member 22B
chr22_+_26703026 0.19 ENSDART00000158756
CREB binding protein a
chr4_+_55758103 0.19 ENSDART00000185964

chr1_-_54425791 0.18 ENSDART00000039911
polycystic kidney disease 1a
chr18_-_21218851 0.16 ENSDART00000060160
calbindin 2a
chr1_-_26293203 0.15 ENSDART00000180140
CXXC finger 4
chr7_+_15266093 0.14 ENSDART00000124676
synaptic vesicle glycoprotein 2Ba
chr1_-_13989643 0.14 ENSDART00000191046
E74-like factor 2b (ets domain transcription factor)
chr22_+_10759113 0.14 ENSDART00000045303
transmembrane protease, serine 9
chr20_-_52271262 0.14 ENSDART00000135463
rhophilin, Rho GTPase binding protein 1
chr19_+_9790806 0.13 ENSDART00000155948
calcium channel, voltage-dependent, gamma subunit 6a
chr20_+_30725778 0.13 ENSDART00000062532
NHS-like 1b
chr22_+_26703518 0.12 ENSDART00000187997
ENSDART00000166775
CREB binding protein a
chr7_-_6431158 0.11 ENSDART00000173199
si:ch1073-153i20.5
chr1_+_54043563 0.10 ENSDART00000149760
TRIO and F-actin binding protein a
chr24_+_21346796 0.10 ENSDART00000126519
shisa family member 2b
chr2_+_8717155 0.10 ENSDART00000018114
ENSDART00000137872
ENSDART00000133037
ubiquitin specific peptidase 33
chr25_+_3328487 0.10 ENSDART00000181143
lactate dehydrogenase Bb
chr21_-_9562272 0.10 ENSDART00000162225
ENSDART00000163874
ENSDART00000168173
protein tyrosine phosphatase, non-receptor type 13
chr16_-_20312146 0.09 ENSDART00000134980
si:dkeyp-86h10.3
chr10_+_44956660 0.09 ENSDART00000169225
ENSDART00000189298
interleukin 1, beta
chr4_+_50260361 0.09 ENSDART00000166894
si:dkey-16p6.1
chr15_+_618081 0.09 ENSDART00000181518
si:ch211-210b2.1
chr13_-_9335891 0.08 ENSDART00000080637

chr12_-_33357655 0.08 ENSDART00000066233
ENSDART00000148165
solute carrier family 16 (monocarboxylate transporter), member 3
chr6_-_8407406 0.08 ENSDART00000151355
prostaglandin E receptor 1a (subtype EP1)
chr16_-_32671782 0.07 ENSDART00000123980
PNN-interacting serine/arginine-rich protein
chr1_-_51157454 0.06 ENSDART00000047851
jagged 1a
chr11_-_41132296 0.06 ENSDART00000162944
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr20_+_26947800 0.05 ENSDART00000062066
si:dkey-177p2.6
chr3_-_30909487 0.05 ENSDART00000025046
protein phosphatase 1, catalytic subunit, alpha isozyme a
chr17_-_27382826 0.05 ENSDART00000186657
ENSDART00000155986
ENSDART00000191060
ENSDART00000077608
si:ch1073-358c10.1
chr17_-_35278763 0.04 ENSDART00000063437
ADAM metallopeptidase domain 17a
chr21_+_15295685 0.04 ENSDART00000135603

chr18_-_3103827 0.04 ENSDART00000165048
adipogenesis associated, Mth938 domain containing
chr20_-_23842631 0.03 ENSDART00000153079
si:dkey-15j16.3
chr23_+_27652906 0.03 ENSDART00000077931
wingless-type MMTV integration site family, member 1
chr16_-_21903083 0.03 ENSDART00000165849
SET domain, bifurcated 1b
chr21_+_17301790 0.01 ENSDART00000145057
TSC complex subunit 1b
chr1_-_44940830 0.00 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
transmembrane protein 176
chr21_+_28535203 0.00 ENSDART00000184950

Network of associatons between targets according to the STRING database.

First level regulatory network of gcm2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 1.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.2 0.7 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.2 1.1 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.2 0.6 GO:0044406 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.2 0.9 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 0.9 GO:0035608 protein deglutamylation(GO:0035608)
0.2 1.4 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.2 0.6 GO:0006837 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
0.1 0.8 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.1 0.4 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 1.2 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 0.5 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.1 0.5 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 1.0 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 1.0 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 1.0 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.0 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 3.0 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.7 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.3 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.1 0.6 GO:0070252 actin-mediated cell contraction(GO:0070252)
0.0 0.2 GO:0044246 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.0 0.7 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 2.7 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.2 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.0 0.2 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.7 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.2 GO:0035777 pronephric distal tubule development(GO:0035777)
0.0 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.0 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.1 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 1.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.2 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.6 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.4 GO:0007398 ectoderm development(GO:0007398)
0.0 0.4 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 1.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.6 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.5 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.9 GO:0036269 swimming behavior(GO:0036269) brain morphogenesis(GO:0048854)
0.0 0.4 GO:1990798 pancreas regeneration(GO:1990798)
0.0 2.6 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.6 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.5 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.0 0.6 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.2 GO:1903286 positive regulation of sodium ion transport(GO:0010765) positive regulation of potassium ion transport(GO:0043268) positive regulation of potassium ion transmembrane transport(GO:1901381) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 1.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.4 GO:0006493 protein O-linked glycosylation(GO:0006493)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.0 GO:0016586 RSC complex(GO:0016586)
0.1 0.7 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.4 GO:0042383 sarcolemma(GO:0042383)
0.0 0.9 GO:0030496 midbody(GO:0030496)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.4 2.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.9 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.2 0.6 GO:0005335 serotonin:sodium symporter activity(GO:0005335) serotonin transmembrane transporter activity(GO:0015222)
0.2 1.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 0.5 GO:0030882 lipid antigen binding(GO:0030882)
0.2 1.5 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 1.0 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.2 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 2.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.4 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 0.4 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.7 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.7 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0004960 thromboxane receptor activity(GO:0004960)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) beta-catenin binding(GO:0008013)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle