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PRJEB1986: zebrafish developmental stages transcriptome
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Results for elf2a+elf2b
Z-value: 2.82
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Transcription factors associated with elf2a+elf2b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000019459 | E74-like factor 2a (ets domain transcription factor) | |
| ENSDARG00000079626 | E74-like factor 2b (ets domain transcription factor) | |
| ENSDARG00000117064 | E74-like factor 2b (ets domain transcription factor) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| elf2b | dr11_v1_chr1_-_13964284_13964284 | 0.89 | 2.7e-07 | Click! |
| elf2a | dr11_v1_chr14_-_46070802_46070802 | 0.44 | 5.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_26482096 Show fit | 12.71 |
ENSDART00000187280
|
SMAD family member 5 |
|
| chr23_-_21471022 Show fit | 7.91 |
ENSDART00000104206
|
hairy-related 4, tandem duplicate 2 |
|
| chr8_-_36554675 Show fit | 6.85 |
ENSDART00000132804
ENSDART00000078746 |
coiled-coil domain containing 157 |
|
| chr13_+_15941850 Show fit | 6.66 |
ENSDART00000016294
|
fidgetin-like 1 |
|
| chr4_+_12031958 Show fit | 6.62 |
ENSDART00000044154
|
troponin T2c, cardiac |
|
| chr15_+_24737599 Show fit | 5.53 |
ENSDART00000078024
|
v-crk avian sarcoma virus CT10 oncogene homolog |
|
| chr25_+_186583 Show fit | 5.22 |
ENSDART00000161504
|
PCNA clamp associated factor |
|
| chr19_-_47782916 Show fit | 5.08 |
ENSDART00000063337
|
cell division cycle associated 8 |
|
| chr1_+_25650917 Show fit | 4.88 |
ENSDART00000054235
|
pleiotropic regulator 1 |
|
| chr23_-_13840433 Show fit | 4.87 |
ENSDART00000104831
|
N(alpha)-acetyltransferase 10, NatA catalytic subunit |
Network of associatons between targets according to the STRING database.
First level regulatory network of elf2a+elf2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.6 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.2 | 19.5 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.8 | 16.3 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.1 | 13.8 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.6 | 13.6 | GO:0006301 | postreplication repair(GO:0006301) |
| 0.4 | 13.4 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.5 | 13.1 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.8 | 12.7 | GO:2000223 | regulation of BMP signaling pathway involved in heart jogging(GO:2000223) |
| 0.3 | 11.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.2 | 11.3 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 148.3 | GO:0005634 | nucleus(GO:0005634) |
| 0.1 | 25.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.7 | 19.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.2 | 17.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 16.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.6 | 12.7 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.7 | 11.9 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 10.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.6 | 9.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.9 | 9.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 67.4 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 56.4 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 20.3 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.1 | 13.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.6 | 12.7 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 1.1 | 12.0 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 3.4 | 10.2 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.1 | 10.2 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 9.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 9.1 | GO:0005112 | Notch binding(GO:0005112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 13.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.7 | 11.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 9.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 9.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 7.1 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.9 | 7.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.3 | 7.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 6.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 6.5 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 43.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.6 | 18.6 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.3 | 14.8 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.3 | 14.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 14.1 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 1.0 | 12.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.4 | 11.5 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.9 | 9.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.4 | 8.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.7 | 8.1 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |