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PRJEB1986: zebrafish developmental stages transcriptome

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Results for egr4

Z-value: 0.68

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Transcription factors associated with egr4

Gene Symbol Gene ID Gene Info
egr4
ENSDARG00000077799 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr4dr11_v1_chr23_+_45579497_455794970.845.8e-06Click!

Activity profile of egr4 motif

Sorted Z-values of egr4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_44963154 1.76 ENSDART00000073735
rrad
Ras-related associated with diabetes
chr22_+_20720808 1.74 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr25_+_30298377 1.64 ENSDART00000153622
C11orf96
chromosome 11 open reading frame 96
chr14_+_15155684 1.42 ENSDART00000167966
zgc:158852
zgc:158852
chr6_+_40661703 1.29 ENSDART00000142492
eno1b
enolase 1b, (alpha)
chr2_-_31301929 1.18 ENSDART00000191992
ENSDART00000190723
adcyap1b
adenylate cyclase activating polypeptide 1b
chr8_+_23165749 1.12 ENSDART00000063057
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr25_+_13406069 1.05 ENSDART00000010495
znrf1
zinc and ring finger 1
chr17_+_27456804 1.05 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
ctsl.1
cathepsin L.1
chr23_+_41799748 1.01 ENSDART00000144257
pdyn
prodynorphin
chr12_+_14079097 0.95 ENSDART00000078033
si:ch211-217a12.1
si:ch211-217a12.1
chr21_+_33172526 0.81 ENSDART00000183532
arl3l1
ADP-ribosylation factor-like 3, like 1
chr25_-_207214 0.78 ENSDART00000193448
FP236318.3

chr4_+_842010 0.74 ENSDART00000067461
si:ch211-152c2.3
si:ch211-152c2.3
chr23_+_41800052 0.73 ENSDART00000141484
pdyn
prodynorphin
chr18_+_8901846 0.72 ENSDART00000132109
ENSDART00000144247
si:dkey-5i3.5
si:dkey-5i3.5
chr17_+_15297398 0.71 ENSDART00000156574
si:ch211-270g19.5
si:ch211-270g19.5
chr14_+_40641350 0.68 ENSDART00000074506
tnmd
tenomodulin
chr14_-_21218891 0.63 ENSDART00000158294
ppp2r2cb
protein phosphatase 2, regulatory subunit B, gamma b
chr11_-_277599 0.61 ENSDART00000187109
npffl
neuropeptide FF-amide peptide precursor like
chr2_+_38924975 0.59 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr3_+_16722014 0.56 ENSDART00000008711
gys1
glycogen synthase 1 (muscle)
chr10_+_19554604 0.56 ENSDART00000063806
atp6v1b2
ATPase H+ transporting V1 subunit B2
chr24_+_24831727 0.54 ENSDART00000080969
trim55b
tripartite motif containing 55b
chr19_+_342094 0.54 ENSDART00000151013
ENSDART00000187622
ensaa
endosulfine alpha a
chr6_+_42819337 0.50 ENSDART00000046498
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr14_+_29769336 0.48 ENSDART00000105898
si:dkey-34l15.1
si:dkey-34l15.1
chr8_+_22438398 0.46 ENSDART00000135145
zgc:153759
zgc:153759
chr15_+_9294620 0.46 ENSDART00000133588
ENSDART00000140009
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr5_+_64739762 0.45 ENSDART00000161112
ENSDART00000135610
ENSDART00000002908
olfm1a
olfactomedin 1a
chr20_+_9211237 0.42 ENSDART00000139527
si:ch211-59d15.4
si:ch211-59d15.4
chr13_-_31397987 0.42 ENSDART00000008287
pgam1a
phosphoglycerate mutase 1a
chr21_-_43398122 0.40 ENSDART00000050533
ccni2
cyclin I family, member 2
chr24_+_26895748 0.40 ENSDART00000089351
nceh1b.1
neutral cholesterol ester hydrolase 1b, tandem duplicate 1
chr23_+_40460333 0.40 ENSDART00000184658
soga3b
SOGA family member 3b
chr11_-_165288 0.38 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr17_-_15657029 0.35 ENSDART00000153925
fut9a
fucosyltransferase 9a
chr10_-_15919839 0.34 ENSDART00000065032
pip5k1ba
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr1_-_10473630 0.34 ENSDART00000040116
tnrc5
trinucleotide repeat containing 5
chr21_+_6212844 0.33 ENSDART00000150301
fnbp1b
formin binding protein 1b
chr5_-_14390445 0.32 ENSDART00000026120
ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr23_-_524780 0.32 ENSDART00000055139
col9a3
collagen, type IX, alpha 3
chr16_+_53519048 0.32 ENSDART00000124691
smpd5
sphingomyelin phosphodiesterase 5
chr18_-_45617146 0.31 ENSDART00000146543
wt1b
wilms tumor 1b
chr5_-_2689753 0.31 ENSDART00000172699
gng10
guanine nucleotide binding protein (G protein), gamma 10
chr23_+_44049509 0.30 ENSDART00000102003
txk
TXK tyrosine kinase
chr24_-_24146875 0.29 ENSDART00000173052
map7d2b
MAP7 domain containing 2b
chr7_-_41014773 0.29 ENSDART00000013785
insig1
insulin induced gene 1
chr17_-_10025234 0.28 ENSDART00000008355
cfl2
cofilin 2 (muscle)
chr5_-_23696926 0.28 ENSDART00000021462
rnf128a
ring finger protein 128a
chr16_-_12784373 0.27 ENSDART00000080396
foxj2
forkhead box J2
chr9_+_21146862 0.26 ENSDART00000136365
hao2
hydroxyacid oxidase 2 (long chain)
chr23_+_9067131 0.24 ENSDART00000144533
ccm2l
cerebral cavernous malformation 2-like
chr22_-_20720427 0.23 ENSDART00000105532
oaz1a
ornithine decarboxylase antizyme 1a
chr25_-_36827491 0.23 ENSDART00000170941
CU929365.1

chr6_+_2271559 0.22 ENSDART00000165223
pbx1b
pre-B-cell leukemia homeobox 1b
chr6_+_42818963 0.22 ENSDART00000184833
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr5_-_49012569 0.22 ENSDART00000184690
si:dkey-172m14.2
si:dkey-172m14.2
chr21_-_43398457 0.22 ENSDART00000166530
ccni2
cyclin I family, member 2
chr12_+_5215795 0.20 ENSDART00000170270
SLC35G1
si:ch211-197g18.2
chr14_+_918287 0.20 ENSDART00000167066
CU462913.1

chr17_+_20639180 0.20 ENSDART00000063624
npy4r
neuropeptide Y receptor Y4
chr21_-_26114886 0.16 ENSDART00000139320
nipal4
NIPA-like domain containing 4
chr3_+_24537023 0.16 ENSDART00000077702
sp100.1
SP110 nuclear body protein, tandem duplicate 1
chr5_+_51443009 0.16 ENSDART00000083350
rasgrf2b
Ras protein-specific guanine nucleotide-releasing factor 2b
chr22_+_6757741 0.15 ENSDART00000140815
CT583625.1

chr22_-_16180849 0.15 ENSDART00000090390
vcam1b
vascular cell adhesion molecule 1b
chr13_+_35925490 0.13 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr16_-_54405976 0.13 ENSDART00000055395
osr2
odd-skipped related transciption factor 2
chr22_-_5054773 0.12 ENSDART00000184207
matk
megakaryocyte-associated tyrosine kinase
chr5_+_42136359 0.11 ENSDART00000083731
trpv1
transient receptor potential cation channel, subfamily V, member 1
chr1_-_7917062 0.11 ENSDART00000177068
mmd2b
monocyte to macrophage differentiation-associated 2b
chr19_+_390298 0.08 ENSDART00000136361
sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr3_+_29469283 0.08 ENSDART00000103592
fam83fa
family with sequence similarity 83, member Fa
chr11_-_236766 0.07 ENSDART00000163978
dusp7
dual specificity phosphatase 7
chr14_+_36220479 0.07 ENSDART00000148319
pitx2
paired-like homeodomain 2
chr19_-_1920613 0.06 ENSDART00000186176
si:ch211-149a19.3
si:ch211-149a19.3
chr11_-_236984 0.05 ENSDART00000170778
dusp7
dual specificity phosphatase 7
chr4_+_63484571 0.05 ENSDART00000169518
ENSDART00000168681
si:dkey-11d20.1
si:dkey-11d20.1
chr21_-_31238244 0.04 ENSDART00000159678
tpst1l
tyrosylprotein sulfotransferase 1, like
chr22_-_14309817 0.03 ENSDART00000171625
si:ch73-338d8.5
si:ch73-338d8.5
chr22_-_3182965 0.02 ENSDART00000158009
lonp1
lon peptidase 1, mitochondrial
chr19_-_11237125 0.02 ENSDART00000163921
ssr2
signal sequence receptor, beta
chr22_-_34872533 0.01 ENSDART00000167176
slit1b
slit homolog 1b (Drosophila)
chr11_+_3308656 0.01 ENSDART00000082458
sarnp
SAP domain containing ribonucleoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 1.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1 0.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:0036315 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.3 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.4 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.0 0.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.7 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 0.5 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 3.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 1.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.5 GO:0035308 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.4 GO:0036065 fucosylation(GO:0036065)
0.0 1.5 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.0 0.2 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.1 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.3 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.6 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.6 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 1.7 GO:0043679 axon terminus(GO:0043679)
0.0 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.2 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.7 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.6 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 1.7 GO:0031628 opioid receptor binding(GO:0031628)
0.1 2.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.4 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.5 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.9 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 0.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism