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PRJEB1986: zebrafish developmental stages transcriptome

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Results for e4f1+si:dkeyp-79b7.12

Z-value: 0.42

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Transcription factors associated with e4f1+si:dkeyp-79b7.12

Gene Symbol Gene ID Gene Info
ENSDARG00000038243 E4F transcription factor 1
ENSDARG00000105305 si_dkeyp-79b7.12

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e4f1dr11_v1_chr3_-_18737126_18737126-0.652.6e-03Click!
si:dkeyp-79b7.12dr11_v1_chr22_+_2207502_22075020.253.1e-01Click!

Activity profile of e4f1+si:dkeyp-79b7.12 motif

Sorted Z-values of e4f1+si:dkeyp-79b7.12 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_22616212 1.35 ENSDART00000052844
claudin 7a
chr24_-_7632187 0.96 ENSDART00000041714
ATPase H+ transporting V0 subunit a1b
chr20_-_44576949 0.81 ENSDART00000148639
UBX domain protein 2A
chr15_-_163586 0.75 ENSDART00000163597
septin-4
chr16_-_45069882 0.73 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr16_-_32649929 0.71 ENSDART00000136161
failed axon connections homolog b
chr10_+_44903676 0.70 ENSDART00000158553
zgc:114173
chr23_-_32157865 0.70 ENSDART00000000876
nuclear receptor subfamily 4, group A, member 1
chr23_-_30764319 0.69 ENSDART00000075918
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr23_+_31405497 0.66 ENSDART00000053546
SH3 domain binding glutamate-rich protein like 2
chr23_+_17220986 0.60 ENSDART00000054761
nucleolar protein 4-like b
chr11_+_40649412 0.58 ENSDART00000043016
ENSDART00000134560
solute carrier family 45, member 1
chr21_-_43606502 0.56 ENSDART00000151030
si:ch73-362m14.4
chr2_+_9821757 0.56 ENSDART00000018408
ENSDART00000141227
ENSDART00000144681
ENSDART00000148227
annexin A13, like
chr1_-_51606552 0.53 ENSDART00000130828
cannabinoid receptor interacting protein 1a
chr20_+_29743904 0.50 ENSDART00000146366
ENSDART00000153154
kinase D-interacting substrate 220b
chr6_+_112579 0.45 ENSDART00000034505
adaptor-related protein complex 1, mu 2 subunit
chr6_-_49873020 0.44 ENSDART00000148511
GNAS complex locus
chr17_+_8184649 0.44 ENSDART00000091818
tubby like protein 4b
chr16_+_32995882 0.41 ENSDART00000170157
protease, serine, 35
chr3_-_11624694 0.41 ENSDART00000127157
hepatic leukemia factor a
chr7_+_29133321 0.41 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr13_-_17464362 0.39 ENSDART00000145499
leucine rich melanocyte differentiation associated
chr10_-_26744131 0.38 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr6_+_12462079 0.38 ENSDART00000192029
ENSDART00000065385
nuclear receptor subfamily 4, group A, member 2b
chr8_+_40628926 0.38 ENSDART00000163598
dual specificity phosphatase 2
chr8_-_410199 0.35 ENSDART00000091177
ENSDART00000122979
ENSDART00000151331
ENSDART00000151155
tripartite motif containing 36
chr4_+_9669717 0.35 ENSDART00000004604
si:dkey-153k10.9
chr21_-_45613564 0.34 ENSDART00000160324

chr2_-_42415902 0.34 ENSDART00000142489
solute carrier organic anion transporter family member 5A1b
chr13_+_32446169 0.33 ENSDART00000143325
5'-nucleotidase, cytosolic IB a
chr1_-_46632948 0.31 ENSDART00000148893
ENSDART00000053232
cytidine and dCMP deaminase domain containing 1
chr20_-_51727860 0.31 ENSDART00000147044
BRO1 domain and CAAX motif containing
chr23_-_29668286 0.30 ENSDART00000129248
calsyntenin 1
chr13_+_23843712 0.29 ENSDART00000057611
opioid receptor, mu 1
chr19_+_42660158 0.29 ENSDART00000018328
F-box and leucine-rich repeat protein 2
chr8_-_410728 0.29 ENSDART00000151255
tripartite motif containing 36
chr6_+_52350443 0.28 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
chr19_-_7225060 0.28 ENSDART00000133179
ENSDART00000151138
ENSDART00000104799
ENSDART00000128331
collagen, type XI, alpha 2
chr6_-_48311 0.28 ENSDART00000131010
zgc:114175
chr4_-_149334 0.27 ENSDART00000163280
TANK-binding kinase 1
chr22_+_33362552 0.27 ENSDART00000101580
nicolin 1
chr18_-_7539166 0.27 ENSDART00000133541
si:dkey-30c15.2
chr20_-_18915376 0.26 ENSDART00000063725
XK, Kell blood group complex subunit-related family, member 6b
chr20_+_9211237 0.26 ENSDART00000139527
si:ch211-59d15.4
chr19_-_3821678 0.26 ENSDART00000169639
si:dkey-206d17.12
chr23_-_27505825 0.26 ENSDART00000137229
ENSDART00000013797
ankyrin repeat and SOCS box containing 8
chr5_+_26921033 0.26 ENSDART00000051483
TM2 domain containing 2
chr21_+_43171013 0.25 ENSDART00000151362
zinc finger, CCHC domain containing 10
chr4_+_73051901 0.25 ENSDART00000174219
zgc:152938
chr24_-_12689571 0.25 ENSDART00000015517
programmed cell death 6
chr20_-_37629084 0.24 ENSDART00000141734
human immunodeficiency virus type I enhancer binding protein 2a
chr16_-_13613475 0.23 ENSDART00000139102
D site albumin promoter binding protein b
chr13_+_17702853 0.23 ENSDART00000145438
si:dkey-27m7.4
chr10_+_44940693 0.22 ENSDART00000157515
cyclin and CBS domain divalent metal cation transport mediator 4a
chr9_+_219124 0.22 ENSDART00000161484
mitogen-activated protein kinase kinase kinase 12
chr3_-_18373425 0.22 ENSDART00000178522
sperm associated antigen 9a
chr3_-_18373604 0.21 ENSDART00000148132
sperm associated antigen 9a
chr2_+_30103131 0.21 ENSDART00000185119
DnaJ (Hsp40) homolog, subfamily B, member 6a
chr15_-_34845414 0.20 ENSDART00000009892
gamma-aminobutyric acid (GABA) B receptor, 1a
chr8_-_50346246 0.20 ENSDART00000025008
stanniocalcin 1
chr23_-_35694171 0.20 ENSDART00000077539
tubulin, alpha 1c
chr25_-_23052707 0.19 ENSDART00000024633
dual specificity phosphatase 8a
chr23_+_33963619 0.19 ENSDART00000140666
ENSDART00000084792
pyridoxal phosphate binding protein
chr25_-_36248053 0.19 ENSDART00000134928
nuclear factor of activated T cells 3b
chr10_+_6496185 0.19 ENSDART00000164770
receptor accessory protein 5
chr10_-_9089545 0.19 ENSDART00000080781
ADP-ribosylation factor-like 15b
chr2_-_4032732 0.18 ENSDART00000158335
RAB18B, member RAS oncogene family
chr9_-_13963078 0.18 ENSDART00000193398
ENSDART00000061156
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr3_-_21137362 0.17 ENSDART00000104051
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr7_-_12909352 0.17 ENSDART00000172901
SH3-domain GRB2-like 3a
chr23_-_27506161 0.17 ENSDART00000145007
ankyrin repeat and SOCS box containing 8
chr11_-_2478374 0.17 ENSDART00000173205
si:ch73-267c23.10
chr18_-_7539469 0.17 ENSDART00000101296
si:dkey-30c15.2
chr17_+_16873417 0.17 ENSDART00000146276
iodothyronine deiodinase 2
chr25_-_13659249 0.17 ENSDART00000045488
casein kinase 2, alpha prime polypeptide b
chr9_-_42418470 0.16 ENSDART00000144353
calcitonin receptor-like a
chr18_-_5598958 0.16 ENSDART00000161538
cytochrome P450, family 1, subfamily A
chr21_-_43474012 0.16 ENSDART00000065104
transmembrane protein 185
chr13_-_38792061 0.16 ENSDART00000162858
LMBR1 domain containing 1
chr3_+_26019426 0.16 ENSDART00000135389
ENSDART00000182411
FAD-dependent oxidoreductase domain containing 2
chr8_-_45838277 0.15 ENSDART00000046064
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr19_-_44054930 0.15 ENSDART00000151084
ENSDART00000150991
ENSDART00000005191
ubiquinol-cytochrome c reductase binding protein
chr5_+_36439405 0.15 ENSDART00000102973
ectodysplasin A
chr8_+_44714336 0.15 ENSDART00000145801
ELMO/CED-12 domain containing 3
chr25_-_36044583 0.14 ENSDART00000073432
retinoblastoma-like 2 (p130)
chr20_+_19512727 0.14 ENSDART00000063696
all-trans retinoic acid-induced differentiation factor
chr20_+_25911342 0.14 ENSDART00000146004
tau tubulin kinase 2b
chr13_+_17702522 0.14 ENSDART00000057913
si:dkey-27m7.4
chr5_-_25576462 0.14 ENSDART00000165147
si:dkey-229d2.4
chr22_-_547748 0.14 ENSDART00000037455
ENSDART00000140101
cyclin D3
chr18_-_19103929 0.14 ENSDART00000188370
ENSDART00000177621
DENN/MADD domain containing 4A
chr11_+_769623 0.13 ENSDART00000172972
vestigial-like family member 4b
chr4_+_77076645 0.13 ENSDART00000174346

chr9_-_54840124 0.13 ENSDART00000137214
ENSDART00000085693
glycoprotein M6Bb
chr16_+_24681177 0.13 ENSDART00000058956
ENSDART00000189335
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr24_+_7631797 0.12 ENSDART00000187464
caveolae associated protein 1b
chr3_+_20156956 0.11 ENSDART00000125281
nerve growth factor receptor a (TNFR superfamily, member 16)
chr25_-_34845302 0.11 ENSDART00000039485
GABA(A) receptor-associated protein like 2
chr3_-_40284744 0.10 ENSDART00000018626
pdgfa associated protein 1b
chr20_-_36671660 0.10 ENSDART00000134819
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6a
chr17_-_13007484 0.10 ENSDART00000156812
si:dkeyp-33b5.4
chr9_-_52386733 0.10 ENSDART00000171721
death associated protein 1b
chr8_-_9118958 0.10 ENSDART00000037922
solute carrier family 6 (neurotransmitter transporter), member 8
chr23_-_17509656 0.10 ENSDART00000148423
DnaJ (Hsp40) homolog, subfamily C, member 5ab
chr25_+_18711804 0.09 ENSDART00000011149
family with sequence similarity 185, member A
chr17_+_23554932 0.09 ENSDART00000135814
pantothenate kinase 1a
chr1_-_23596391 0.09 ENSDART00000155184
ligand dependent nuclear receptor corepressor-like
chr4_+_40953320 0.08 ENSDART00000151912
zinc finger protein 1136
chr4_+_9011825 0.08 ENSDART00000058007
sorting and assembly machinery component 50 homolog, like
chr9_-_11655031 0.08 ENSDART00000044314
integrin, alpha V
chr19_-_20106486 0.07 ENSDART00000043924
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr8_-_19266325 0.06 ENSDART00000036148
ENSDART00000137994
zgc:77486
chr12_-_30760971 0.06 ENSDART00000066257
ectonucleoside triphosphate diphosphohydrolase 1
chr19_+_46222428 0.06 ENSDART00000183984
vacuolar protein sorting 28 (yeast)
chr15_-_1843831 0.06 ENSDART00000156718
ENSDART00000154175
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_-_14488472 0.05 ENSDART00000101298
ENSDART00000138161
galactose-1-phosphate uridylyltransferase
chr6_+_58832323 0.05 ENSDART00000042595
dynactin 2 (p50)
chr8_-_45838481 0.04 ENSDART00000148206
ENSDART00000170485
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr1_-_44037843 0.04 ENSDART00000160276
si:ch73-109d9.3
chr16_+_21242491 0.04 ENSDART00000145886
oxysterol binding protein-like 3b
chr23_-_35694461 0.04 ENSDART00000185884
tubulin, alpha 1c
chr5_-_1047222 0.03 ENSDART00000181112
methyl-CpG binding domain protein 2
chr12_+_33320504 0.03 ENSDART00000021491
casein kinase 1, delta b
chr23_-_41824460 0.03 ENSDART00000131235
si:ch73-302a13.2
chr8_+_48965767 0.03 ENSDART00000008058
AP2 associated kinase 1a
chr24_-_37326236 0.03 ENSDART00000003789
3-phosphoinositide dependent protein kinase 1b
chr19_-_32888758 0.02 ENSDART00000052080
lysosomal protein transmembrane 4 beta
chr10_+_39091716 0.02 ENSDART00000193072
si:ch73-1a9.4
chr10_-_42882215 0.02 ENSDART00000180580
ENSDART00000187374

chr6_+_58832155 0.02 ENSDART00000144842
dynactin 2 (p50)
chr6_-_1514767 0.02 ENSDART00000067586
coiled-coil-helix-coiled-coil-helix domain containing 6b
chr20_+_16639848 0.01 ENSDART00000063944
ENSDART00000152359
transmembrane protein 30Ab
chr13_+_35856463 0.01 ENSDART00000171056
ENSDART00000017202
potassium channel, subfamily K, member 1b
chr18_+_29402623 0.01 ENSDART00000014703
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
chr24_-_41657005 0.01 ENSDART00000159109

chr5_+_22510639 0.01 ENSDART00000080919
ribosomal protein L36A
chr14_+_16093889 0.01 ENSDART00000159181
inner membrane protein, mitochondrial (mitofilin)
chr19_+_14113886 0.01 ENSDART00000169343
keratinocyte differentiation factor 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of e4f1+si:dkeyp-79b7.12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.0 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.5 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.1 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792)
0.0 0.2 GO:0071788 endoplasmic reticulum tubular network maintenance(GO:0071788)
0.0 0.6 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.7 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 1.4 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 0.1 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.7 GO:0006096 glycolytic process(GO:0006096)
0.0 0.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0019388 hexose catabolic process(GO:0019320) galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.6 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.8 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.3 GO:0038046 enkephalin receptor activity(GO:0038046)
0.1 0.4 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.6 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.0 GO:0051117 ATPase binding(GO:0051117)
0.1 0.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0001635 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.1 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.2 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0005035 death receptor activity(GO:0005035)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.7 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway