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PRJEB1986: zebrafish developmental stages transcriptome

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Results for dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Z-value: 0.92

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Transcription factors associated with dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

Gene Symbol Gene ID Gene Info
ENSDARG00000017174 distal-less homeobox 2b
ENSDARG00000079964 distal-less homeobox 2a
ENSDARG00000116017 distal-less homeobox 2b
ENSDARG00000011956 distal-less homeobox 4a
ENSDARG00000042291 distal-less homeobox 6a
ENSDARG00000071560 distal-less homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
dlx4adr11_v1_chr3_+_34670076_346700760.752.3e-04Click!
dlx6adr11_v1_chr19_+_41464870_414648700.615.2e-03Click!
dlx4bdr11_v1_chr12_-_5728755_5728755-0.321.8e-01Click!
dlx2adr11_v1_chr9_-_3400727_3400729-0.312.0e-01Click!
dlx2bdr11_v1_chr1_-_30979707_309797070.019.5e-01Click!

Activity profile of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Sorted Z-values of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_30244356 5.48 ENSDART00000036050
ENSDART00000150080
retinoschisin 1a
chr25_+_29160102 4.15 ENSDART00000162854
pyruvate kinase M1/2b
chr1_-_43905252 4.06 ENSDART00000135477
ENSDART00000132089
si:dkey-22i16.3
chr16_+_5774977 3.65 ENSDART00000134202
cholecystokinin a
chr20_-_40755614 3.53 ENSDART00000061247
connexin 32.3
chr13_+_25449681 3.24 ENSDART00000101328
atonal bHLH transcription factor 7
chr19_+_10339538 2.85 ENSDART00000151808
ENSDART00000151235
recoverin 3
chr23_-_38497705 2.67 ENSDART00000109493
teashirt zinc finger homeobox 2
chr24_-_24849091 2.63 ENSDART00000133649
ENSDART00000038290
corticotropin releasing hormone b
chr12_+_24342303 2.56 ENSDART00000111239
neurexin 1a
chr10_+_29698467 2.41 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr2_-_33645411 2.31 ENSDART00000114663
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr1_-_50859053 2.16 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr2_+_37227011 2.15 ENSDART00000126587
ENSDART00000084958
sterile alpha motif domain containing 7
chr22_+_20427170 2.15 ENSDART00000136744
forkhead box Q2
chr15_-_6247775 2.13 ENSDART00000148350
Down syndrome cell adhesion molecule b
chr7_-_28148310 2.06 ENSDART00000044208
LIM domain only 1
chr16_+_31804590 2.03 ENSDART00000167321
wingless-type MMTV integration site family, member 4b
chr14_-_30587814 2.01 ENSDART00000144912
ENSDART00000149714
transmembrane protein 265
chr13_-_40401870 1.93 ENSDART00000128951
NK3 homeobox 3
chr6_-_41229787 1.88 ENSDART00000065013
synaptoporin
chr20_-_29420713 1.87 ENSDART00000147464
ryanodine receptor 3
chr13_+_38430466 1.85 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr20_-_9462433 1.83 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr8_-_46894362 1.62 ENSDART00000111124
acyl-CoA thioesterase 7
chr23_+_28731379 1.62 ENSDART00000047378
cortistatin
chr16_+_13818500 1.56 ENSDART00000135245
folliculin
chr4_+_12612723 1.52 ENSDART00000133767
LIM domain only 3
chr16_-_13921589 1.45 ENSDART00000023543
recoverin 2
chr16_+_17389116 1.45 ENSDART00000103750
ENSDART00000173448
family with sequence similarity 131, member Bb
chr4_+_7391110 1.44 ENSDART00000160708
ENSDART00000187823
troponin I4a
chr7_+_30787903 1.42 ENSDART00000174000
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr19_-_5103141 1.39 ENSDART00000150952
triosephosphate isomerase 1a
chr17_-_12389259 1.38 ENSDART00000185724
synaptosomal-associated protein, 25b
chr16_-_47483142 1.32 ENSDART00000147072
collagen triple helix repeat containing 1b
chr2_+_50608099 1.32 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr17_-_16965809 1.32 ENSDART00000153697
neurexin 3a
chr10_-_34871737 1.31 ENSDART00000138755
doublecortin-like kinase 1a
chr3_-_32337653 1.29 ENSDART00000156918
ENSDART00000156551
si:dkey-16p21.8
chr20_+_30445971 1.27 ENSDART00000153150
myelin transcription factor 1-like, a
chr19_-_7358184 1.26 ENSDART00000092379
oxidation resistance 1b
chr1_+_16397063 1.23 ENSDART00000159794
mitochondrial calcium uptake family, member 3a
chr23_-_29824146 1.22 ENSDART00000020616
zgc:194189
chr1_+_52929185 1.22 ENSDART00000147683
inositol polyphosphate-4-phosphatase type II B
chr20_-_28800999 1.20 ENSDART00000049462
RAB15, member RAS oncogene family
chr19_-_32804535 1.19 ENSDART00000175613
ENSDART00000052098
5'-nucleotidase, cytosolic IAa
chr4_+_11384891 1.15 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr1_+_16396870 1.12 ENSDART00000189245
ENSDART00000113266
mitochondrial calcium uptake family, member 3a
chr1_-_5455498 1.11 ENSDART00000040368
ENSDART00000114035
motor neuron and pancreas homeobox 2b
chr15_+_9053059 1.11 ENSDART00000012039
protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)
chr18_+_15644559 1.07 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr10_+_3049636 1.07 ENSDART00000081794
ENSDART00000183167
ENSDART00000191634
ENSDART00000183514
Ras protein-specific guanine nucleotide-releasing factor 2a
chr14_-_17622080 1.05 ENSDART00000112149
si:ch211-159i8.4
chr18_+_9637744 1.04 ENSDART00000190171
piccolo presynaptic cytomatrix protein b
chr6_-_14292307 1.03 ENSDART00000177852
ENSDART00000061745
inositol polyphosphate-4-phosphatase type I Ab
chr15_-_34408777 1.03 ENSDART00000139934
alkylglycerol monooxygenase
chr2_-_15324837 1.02 ENSDART00000015655
trans-2,3-enoyl-CoA reductase-like 2b
chr10_+_41765616 0.99 ENSDART00000170682
ring finger protein 34b
chr20_-_32270866 0.96 ENSDART00000153140
armadillo repeat containing 2
chr21_+_28958471 0.93 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr8_-_20230559 0.91 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr21_-_42100471 0.90 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_-_44701313 0.89 ENSDART00000193926
si:dkey-28b4.8
chr6_+_36807861 0.88 ENSDART00000161708
si:ch73-29l19.1
chr2_-_16380283 0.87 ENSDART00000149992
si:dkey-231j24.3
chr23_+_20689255 0.87 ENSDART00000182420
ubiquitin specific peptidase 21
chr4_+_26629368 0.86 ENSDART00000183575
IQ motif and Sec7 domain 3a
chr3_+_33341640 0.86 ENSDART00000186352
peptide YYa
chr23_+_20563779 0.86 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr17_-_20717845 0.85 ENSDART00000150037
ankyrin 3b
chr3_+_34919810 0.85 ENSDART00000055264
carbonic anhydrase Xb
chr19_-_205104 0.85 ENSDART00000011890
zinc finger and BTB domain containing 22a
chr20_-_45060241 0.84 ENSDART00000185227
kelch-like family member 29
chr1_-_22512063 0.83 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr22_-_11136625 0.81 ENSDART00000016873
ENSDART00000125561
ATPase H+ transporting accessory protein 2
chr1_+_11977426 0.81 ENSDART00000103399
tetraspanin 5b
chr16_+_20161805 0.80 ENSDART00000192146
chromosome 16 C2orf66 homolog
chr2_-_23004286 0.79 ENSDART00000134664
ENSDART00000110373
ENSDART00000185833
ENSDART00000187235
zinc finger protein 414
MLLT1, super elongation complex subunit b
chr12_-_19007834 0.79 ENSDART00000153248
chondroadherin-like b
chr22_+_28320792 0.78 ENSDART00000160562
ENSDART00000164138
interphotoreceptor matrix proteoglycan 2b
interphotoreceptor matrix proteoglycan 2b
chr22_+_35068046 0.78 ENSDART00000161660
ENSDART00000169573
si:ch73-173h19.3
chr10_+_42690374 0.75 ENSDART00000123496
Rho-related BTB domain containing 2b
chr11_-_37509001 0.74 ENSDART00000109753
bassoon (presynaptic cytomatrix protein) b
chr13_-_36911118 0.74 ENSDART00000048739
tripartite motif containing 9
chr11_-_37997419 0.73 ENSDART00000102870
solute carrier family 41 (magnesium transporter), member 1
chr20_-_38617766 0.72 ENSDART00000050474
solute carrier family 30 (zinc transporter), member 2
chr20_+_34933183 0.72 ENSDART00000062738
synaptosomal-associated protein, 25a
chr22_-_7129631 0.68 ENSDART00000171359
acid-sensing (proton-gated) ion channel 1b
chr20_-_46362606 0.67 ENSDART00000153087
BCL2 modifying factor 2
chr23_+_17387325 0.67 ENSDART00000083947
PTK6 protein tyrosine kinase 6b
chr15_-_21877726 0.66 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr23_+_33963619 0.65 ENSDART00000140666
ENSDART00000084792
pyridoxal phosphate binding protein
chr19_-_38830582 0.64 ENSDART00000189966
ENSDART00000183055
adhesion G protein-coupled receptor B2
chr18_-_48550426 0.64 ENSDART00000145189
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr20_+_4060839 0.64 ENSDART00000178565
tripartite motif containing 67
chr13_-_44630111 0.63 ENSDART00000110092
MAM domain containing glycosylphosphatidylinositol anchor 1
chr2_+_21229909 0.61 ENSDART00000046127
vasoactive intestinal peptide receptor 1a
chr22_-_20386982 0.59 ENSDART00000089015
zinc finger and BTB domain containing 7a
chr16_-_12953739 0.59 ENSDART00000103894
calcium channel, voltage-dependent, gamma subunit 8b
chr12_-_6880694 0.59 ENSDART00000171846
protocadherin-related 15b
chr16_-_19890303 0.58 ENSDART00000147161
ENSDART00000079159
histone deacetylase 9b
chr15_-_23376541 0.57 ENSDART00000078570
C1q and TNF related 5
chr12_+_20352400 0.57 ENSDART00000066383
hemoglobin, alpha embryonic 5
chr9_+_24008879 0.56 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
melanophilin b
chr22_-_10502780 0.55 ENSDART00000136961
extracellular matrix protein 2, female organ and adipocyte specific
chr24_+_38306010 0.54 ENSDART00000143184
myosin binding protein C, fast type b
chr5_+_45139196 0.54 ENSDART00000113738
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_45323400 0.52 ENSDART00000148906
ENSDART00000132366
epithelial membrane protein 1
chr18_-_1185772 0.52 ENSDART00000143245
neuroplastin b
chr21_-_10488379 0.52 ENSDART00000163878
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr4_+_12615836 0.51 ENSDART00000003583
LIM domain only 3
chr20_+_28861629 0.51 ENSDART00000187274
ENSDART00000047826
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr15_+_31806303 0.50 ENSDART00000155902
furry homolog a (Drosophila)
chr4_-_9891874 0.48 ENSDART00000067193
adrenomedullin 2a
chr1_-_54765262 0.48 ENSDART00000150362
si:ch211-197k17.3
chr22_+_5176693 0.48 ENSDART00000160927
ceramide synthase 1
chr18_+_1837668 0.48 ENSDART00000164210

chr23_-_306796 0.47 ENSDART00000143125
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr22_-_13649588 0.47 ENSDART00000131877
si:ch211-279g13.1
chr10_+_11282883 0.47 ENSDART00000135355
si:ch211-126i22.5
chr11_+_30057762 0.46 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr4_-_15420452 0.46 ENSDART00000016230
plexin A4
chr12_+_22580579 0.46 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr6_-_54826061 0.45 ENSDART00000149982
troponin I type 1b (skeletal, slow)
chr12_+_33395748 0.44 ENSDART00000129458
fatty acid synthase
chr15_-_22074315 0.44 ENSDART00000149830
dopamine receptor D2a
chr20_-_27711970 0.44 ENSDART00000139637
zinc finger and BTB domain containing 25
chr5_+_20147830 0.43 ENSDART00000098727
SV2 related protein a
chr22_+_18477934 0.43 ENSDART00000132684
cartilage intermediate layer protein 2
chr11_+_38280454 0.42 ENSDART00000171496
si:dkey-166c18.1
chr24_-_39518599 0.42 ENSDART00000145606
ENSDART00000031486
LYR motif containing 1
chr15_-_38154616 0.42 ENSDART00000099392
immunity-related GTPase family, q2
chr17_-_19963718 0.42 ENSDART00000154251
cholinergic receptor, muscarinic 3a
chr2_-_17235891 0.41 ENSDART00000144251
artemin b
chr11_-_8126223 0.40 ENSDART00000091617
ENSDART00000192391
ENSDART00000101561
tubulin tyrosine ligase-like family, member 7
chr10_-_35236949 0.40 ENSDART00000145804
yippee-like 2a
chr10_+_41765944 0.40 ENSDART00000171484
ring finger protein 34b
chr4_+_22343093 0.40 ENSDART00000023588
guanylate cyclase activator 1A
chr16_-_13623928 0.39 ENSDART00000164344
si:dkeyp-69b9.6
chr6_+_23887314 0.39 ENSDART00000163188
zinc finger protein 648
chr19_-_44955710 0.39 ENSDART00000165246
si:ch211-233f16.1
chr6_-_6487876 0.38 ENSDART00000137642
centrosomal protein 170Ab
chr5_+_19314574 0.37 ENSDART00000133247
RUN and SH3 domain containing 2
chr6_+_52804267 0.36 ENSDART00000065681
matrilin 4
chr18_-_43884044 0.36 ENSDART00000087382
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr16_-_17197546 0.36 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
glyceraldehyde-3-phosphate dehydrogenase
chr25_+_11456696 0.36 ENSDART00000171408
si:ch73-141f14.1
chr13_-_40141630 0.34 ENSDART00000181618
ENSDART00000171583
ENSDART00000192780
cartilage acidic protein 1b
chr15_+_22014029 0.33 ENSDART00000079504
ankyrin repeat and kinase domain containing 1
chr1_-_49947482 0.33 ENSDART00000143398
sphingomyelin synthase 2
chr17_-_44247707 0.32 ENSDART00000126097
orthodenticle homeobox 2b
chr6_+_39232245 0.31 ENSDART00000187351
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr11_+_12052791 0.30 ENSDART00000158479
si:ch211-156l18.8
chr15_+_31344472 0.30 ENSDART00000146695
ENSDART00000159182
ENSDART00000060125
odorant receptor, family D, subfamily 107, member 1
chr25_-_27621268 0.30 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr25_+_10410620 0.30 ENSDART00000151886
ets homologous factor
chr10_-_13343831 0.30 ENSDART00000135941
interleukin 11 receptor, alpha
chr1_-_44704261 0.29 ENSDART00000133210
si:dkey-28b4.8
chr20_+_19238382 0.29 ENSDART00000136757
fibronectin type III domain containing 4a
chr7_-_48263516 0.29 ENSDART00000006619
ENSDART00000142370
ENSDART00000148273
ENSDART00000147968
RNA binding protein with multiple splicing 2b
chr13_-_25720876 0.29 ENSDART00000142404
ENSDART00000146487
si:dkey-192p21.6
chr13_-_31435137 0.28 ENSDART00000057441
reticulon 1a
chr16_+_54263921 0.28 ENSDART00000002856
dopamine receptor D2 like
chr20_+_28861435 0.28 ENSDART00000142678
solute carrier family 10 (sodium/bile acid cotransporter), member 1
chr5_+_6954162 0.28 ENSDART00000086666
sperm-tail PG-rich repeat containing 2
chr3_-_34296361 0.27 ENSDART00000181485
ENSDART00000113726
trinucleotide repeat containing 6C1
chr1_+_52392511 0.27 ENSDART00000144025
si:ch211-217k17.8
chr21_-_15046065 0.25 ENSDART00000178507
matrix metallopeptidase 17a
chr8_+_26253252 0.25 ENSDART00000142031
solute carrier family 26, member 6
chrM_+_9052 0.25 ENSDART00000093612
ATP synthase 6, mitochondrial
chr6_+_3280939 0.24 ENSDART00000151359
lysine (K)-specific demethylase 4A, genome duplicate a
chrM_+_9735 0.24 ENSDART00000093613
cytochrome c oxidase III, mitochondrial
chr10_-_10969596 0.24 ENSDART00000092011
exonuclease 3'-5' domain containing 3
chr10_+_21867307 0.24 ENSDART00000126629
cerebellin 17
chr1_-_49947290 0.23 ENSDART00000141476
sphingomyelin synthase 2
chr22_-_23000815 0.23 ENSDART00000137111
protein tyrosine phosphatase, receptor type, C
chr15_-_2184638 0.23 ENSDART00000135460
short stature homeobox 2
chr10_-_10969444 0.23 ENSDART00000138041
exonuclease 3'-5' domain containing 3
chr10_+_16584382 0.22 ENSDART00000112039

chr19_-_19556778 0.22 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr10_-_33297864 0.20 ENSDART00000163360
PR/SET domain 15
chr13_+_2625150 0.19 ENSDART00000164177
phospholipid phosphatase 4
chr18_+_19006063 0.18 ENSDART00000135729
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr1_+_56755536 0.18 ENSDART00000157727

chr1_-_6028876 0.17 ENSDART00000168117
si:ch1073-345a8.1
chr15_+_15856178 0.17 ENSDART00000080338
dual specificity phosphatase 14
chr7_+_2236317 0.16 ENSDART00000075859
zgc:172065
chr5_-_28109416 0.16 ENSDART00000042002
si:ch211-48m9.1
chr9_-_51436377 0.15 ENSDART00000006612
T-box, brain, 1b
chr21_+_40417152 0.14 ENSDART00000171244
slingshot protein phosphatase 2b
chr9_+_17983463 0.14 ENSDART00000182150
A kinase (PRKA) anchor protein 11
chr25_-_18913336 0.13 ENSDART00000171010
parietopsin
chr23_-_17484555 0.13 ENSDART00000187181
DnaJ (Hsp40) homolog, subfamily C, member 5ab
chr22_-_20166660 0.12 ENSDART00000085913
ENSDART00000188241
BTB (POZ) domain containing 2a
chr13_+_38817871 0.10 ENSDART00000187708
collagen, type XIX, alpha 1
chr2_+_38147761 0.09 ENSDART00000135307
spalt-like transcription factor 2
chr19_-_12212692 0.09 ENSDART00000142077
ENSDART00000151599
ENSDART00000140834
ENSDART00000078781
zinc finger protein 706
chr8_-_19467011 0.09 ENSDART00000162010
zgc:92140
chr4_+_16885854 0.08 ENSDART00000017726
ethanolamine kinase 1
chr12_+_34953038 0.08 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
QKI, KH domain containing, RNA binding 2

Network of associatons between targets according to the STRING database.

First level regulatory network of dlx2a+dlx2b_dlx4a+dlx4b+dlx6a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0035902 response to immobilization stress(GO:0035902)
0.4 4.3 GO:0036368 cone photoresponse recovery(GO:0036368)
0.4 1.9 GO:0016322 neuron remodeling(GO:0016322)
0.3 1.4 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 2.9 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.2 1.5 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 1.0 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 1.4 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 0.9 GO:0070208 protein heterotrimerization(GO:0070208)
0.2 0.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.2 0.5 GO:0007414 axonal defasciculation(GO:0007414)
0.1 0.7 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.4 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.1 1.0 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.7 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1 2.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 2.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.7 GO:0070207 protein homotrimerization(GO:0070207)
0.1 2.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 0.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 3.6 GO:0007586 digestion(GO:0007586)
0.1 0.4 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 3.9 GO:0036269 swimming behavior(GO:0036269)
0.1 1.6 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 1.1 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 0.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 4.9 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.1 2.0 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 0.9 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.2 GO:0060292 long term synaptic depression(GO:0060292)
0.1 0.3 GO:0051145 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.1 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.7 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.6 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.5 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 1.1 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.3 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 1.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.0 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.9 GO:0007631 feeding behavior(GO:0007631)
0.0 0.8 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.6 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.7 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.1 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.7 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 1.9 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.6 GO:0060319 primitive erythrocyte differentiation(GO:0060319)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.0 0.6 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 0.4 GO:0050821 protein stabilization(GO:0050821)
0.0 0.3 GO:0010507 negative regulation of autophagy(GO:0010507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.3 1.9 GO:0043083 synaptic cleft(GO:0043083)
0.3 2.9 GO:0098982 GABA-ergic synapse(GO:0098982)
0.3 1.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 2.3 GO:1990246 uniplex complex(GO:1990246)
0.2 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.8 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.1 2.4 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.7 GO:0042627 chylomicron(GO:0042627)
0.1 0.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.9 GO:0005861 troponin complex(GO:0005861)
0.0 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.9 GO:0032590 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 1.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.7 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 5.7 GO:0030424 axon(GO:0030424)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.5 GO:0030427 site of polarized growth(GO:0030427)
0.0 1.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 1.9 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.3 1.4 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.3 2.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.3 0.8 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.3 1.3 GO:0016531 copper chaperone activity(GO:0016531)
0.2 1.6 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.1 GO:0032052 bile acid binding(GO:0032052)
0.2 0.9 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.2 2.9 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 0.9 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.6 GO:0070052 collagen V binding(GO:0070052)
0.1 0.7 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.7 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.0 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 3.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 4.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.4 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 2.3 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 2.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.9 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.6 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.6 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 3.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.1 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.4 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.5 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.0 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0017022 myosin binding(GO:0017022)
0.0 2.5 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 0.8 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis