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PRJEB1986: zebrafish developmental stages transcriptome

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Results for creb1a+creb1b+crema+cremb

Z-value: 8.02

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Transcription factors associated with creb1a+creb1b+crema+cremb

Gene Symbol Gene ID Gene Info
ENSDARG00000023217 cAMP responsive element modulator a
ENSDARG00000053586 cAMP responsive element binding protein 1a
ENSDARG00000093420 cAMP responsive element binding protein 1b
ENSDARG00000102899 cAMP responsive element modulator b
ENSDARG00000109505 cAMP responsive element modulator b
ENSDARG00000116064 cAMP responsive element modulator b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cremadr11_v1_chr2_-_43168292_43168292-0.972.5e-12Click!
crembdr11_v1_chr24_+_31361407_313614070.888.3e-07Click!
creb1adr11_v1_chr1_-_33557915_335579150.771.0e-04Click!
creb1bdr11_v1_chr9_-_28275600_282756000.361.4e-01Click!

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_42556555 20.74 ENSDART00000168536
zinc finger protein 1053
chr4_-_56898328 18.15 ENSDART00000169189
si:dkey-269o24.6
chr4_-_57001458 17.68 ENSDART00000158660
si:ch211-161m3.1
chr15_+_23722620 17.10 ENSDART00000011447
SUMO1 activating enzyme subunit 1
chr19_-_3056235 16.77 ENSDART00000137020
block of proliferation 1
chr4_-_61651223 16.71 ENSDART00000172688
si:dkey-26i24.1
chr4_-_50544015 16.70 ENSDART00000155155
zgc:174704
chr10_-_23099809 16.66 ENSDART00000148333
ENSDART00000079703
ENSDART00000162444
notchless homolog 1 (Drosophila)
chr4_-_32180155 15.75 ENSDART00000164151
si:dkey-72l17.6
chr4_+_45504471 15.70 ENSDART00000150399
si:dkey-256i11.2
chr4_-_56068511 15.67 ENSDART00000168345
zinc finger protein 1133
chr4_+_33461796 15.65 ENSDART00000150445
si:dkey-247i3.1
chr4_+_30454496 15.50 ENSDART00000164555
si:dkey-199m13.4
chr4_-_43280244 15.39 ENSDART00000150762
si:dkeyp-53e4.1
chr4_-_49952636 15.22 ENSDART00000157941
si:dkey-156k2.3
chr3_-_62194512 14.87 ENSDART00000074174
transducin (beta)-like 3
chr4_-_33331681 14.85 ENSDART00000150319
zinc finger protein 1000
chr4_-_61650771 14.84 ENSDART00000168593
si:dkey-26i24.1
chr19_-_27339670 14.81 ENSDART00000139323
zinc ribbon domain containing 1
chr20_+_47143900 14.48 ENSDART00000153360
si:dkeyp-104f11.6
chr4_+_62184754 14.31 ENSDART00000168844
si:dkeyp-35e5.9
chr20_-_36679233 14.27 ENSDART00000062908
ribosomal protein L7-like 1
chr4_-_57530817 14.25 ENSDART00000158435
zgc:173702
chr4_+_49073583 14.24 ENSDART00000170022
zgc:173705
chr4_-_69615167 14.23 ENSDART00000171108
si:ch211-120c15.3
chr3_+_32651697 14.17 ENSDART00000055338
THO complex 6
chr22_-_17606575 14.11 ENSDART00000183951
glutathione peroxidase 4a
chr4_-_55459037 14.10 ENSDART00000172184
zinc finger protein 569, like
chr4_-_45301719 13.81 ENSDART00000150282
si:ch211-162i8.2
chr6_+_3716666 13.79 ENSDART00000041627
Sjogren syndrome antigen B (autoantigen La)
chr18_-_5850683 13.56 ENSDART00000082087
NIP7, nucleolar pre-rRNA processing protein
chr5_+_50869091 13.39 ENSDART00000083294
nucleolar protein 6 (RNA-associated)
chr4_+_69823638 13.31 ENSDART00000165786
zinc finger protein 1087
chr4_+_59320243 13.29 ENSDART00000150611
zinc finger protein 1084
chr6_-_9236309 13.20 ENSDART00000160397
ENSDART00000164603
IQ motif containing B1
chr4_-_42294516 13.16 ENSDART00000133558
si:dkey-4e4.1
chr4_-_49720964 13.14 ENSDART00000156103
zinc finger protein 1057
chr4_+_64577406 13.07 ENSDART00000159754
si:ch211-223a21.4
chr4_-_70488123 12.94 ENSDART00000169266
si:dkeyp-44b5.5
chr2_-_58374842 12.92 ENSDART00000111651

chr4_+_58576146 12.89 ENSDART00000164911
si:ch211-212k5.4
chr4_+_59711338 12.77 ENSDART00000150849
si:dkey-149m13.4
chr4_+_38103421 12.77 ENSDART00000164164
zinc finger protein 1016
chr4_-_32471434 12.71 ENSDART00000152013
ENSDART00000183621
zinc finger protein 1085
chr4_-_52621665 12.64 ENSDART00000137064
si:dkeyp-104f11.6
chr4_-_45301250 12.31 ENSDART00000181753
si:ch211-162i8.2
chr3_-_16413606 12.26 ENSDART00000127309
ENSDART00000017172
ENSDART00000136465
elongation factor Tu GTP binding domain containing 2
chr8_+_13064750 12.25 ENSDART00000039878
SAP30 binding protein
chr15_+_823437 12.13 ENSDART00000155608
si:dkey-7i4.7
chr19_-_8536474 12.03 ENSDART00000139715
dolichyl-phosphate mannosyltransferase polypeptide 3
chr12_-_30043809 11.89 ENSDART00000150220
ENSDART00000075889
ENSDART00000148847
TruB pseudouridine (psi) synthase family member 1
chr23_-_43424510 11.76 ENSDART00000055564
regulation of nuclear pre-mRNA domain containing 1B
chr4_+_63818718 11.76 ENSDART00000161177
si:dkey-30f3.2
chr4_-_64142389 11.48 ENSDART00000172126

chr13_-_36141486 11.47 ENSDART00000044115
mediator complex subunit 6
chr4_+_58016732 11.42 ENSDART00000165777

chr4_+_59234719 11.38 ENSDART00000170724
ENSDART00000192143
ENSDART00000109914
zinc finger protein 1086
chr4_-_30712160 11.37 ENSDART00000141715
si:dkey-16p19.5
chr19_-_27339844 11.34 ENSDART00000052358
ENSDART00000148238
ENSDART00000147661
ENSDART00000137346
zinc ribbon domain containing 1
chr4_+_58057168 11.29 ENSDART00000161097
si:dkey-57k17.1
chr1_+_19083501 11.23 ENSDART00000002886
ENSDART00000131948
exosome component 9
chr4_-_36144500 11.20 ENSDART00000170896
zinc finger protein 992
chr5_-_26199505 11.19 ENSDART00000132950
RAD17 checkpoint clamp loader component
chr4_-_52621232 11.19 ENSDART00000124451
si:dkeyp-104f11.6
chr17_-_49481672 11.16 ENSDART00000166394
FCF1 rRNA-processing protein
chr4_+_45504938 11.14 ENSDART00000145958
si:dkey-256i11.2
chr8_-_32354677 11.13 ENSDART00000138268
ENSDART00000133245
ENSDART00000179677
ENSDART00000174450
importin 11
chr4_+_33373100 10.87 ENSDART00000150417
zinc finger protein 1090
chr4_+_54798291 10.85 ENSDART00000165113
ENSDART00000109624
si:dkeyp-82b4.6
chr4_-_59159690 10.82 ENSDART00000164706
zinc finger protein 1149
chr9_+_145093 10.76 ENSDART00000162764
ribosomal RNA processing 1
chr4_+_59748607 10.76 ENSDART00000108499
zinc finger protein 1068
chr4_-_50722304 10.73 ENSDART00000150480
zinc finger protein 1110
chr4_+_71819777 10.70 ENSDART00000171070
zinc finger protein 1017
chr4_+_63769987 10.63 ENSDART00000168878
zinc finger protein 1048
chr4_+_56315530 10.62 ENSDART00000169288
zgc:174275
chr8_-_28274251 10.58 ENSDART00000050671
RAP1A, member of RAS oncogene family a
chr4_-_64336954 10.50 ENSDART00000157986
zinc finger protein 1147
chr7_-_40657831 10.50 ENSDART00000084153
nucleolar protein with MIF4G domain 1
chr4_+_63818212 10.44 ENSDART00000164929
si:dkey-30f3.2
chr4_-_69917450 10.41 ENSDART00000168915
zinc finger protein 1076
chr4_-_57994891 10.35 ENSDART00000168657
zinc finger protein 1097
chr4_+_69510337 10.34 ENSDART00000165995
zinc finger protein 1025
chr4_-_69127091 10.31 ENSDART00000136092
si:ch211-209j12.3
chr4_+_61865790 10.30 ENSDART00000166793
si:dkey-146c18.5
chr4_+_43408004 10.30 ENSDART00000150476
si:dkeyp-53e4.2
chr10_+_28306749 10.23 ENSDART00000142016
peptidyl-tRNA hydrolase 2
chr4_-_77218637 10.19 ENSDART00000174325
proteasome subunit beta 10
chr5_+_72194444 10.19 ENSDART00000165436
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
chr4_+_64577910 10.11 ENSDART00000128164
si:ch211-223a21.4
chr4_-_73488406 10.11 ENSDART00000115002
si:ch73-266f23.1
chr4_-_35900331 10.10 ENSDART00000164413
zgc:174653
chr4_-_50158550 10.00 ENSDART00000121664

chr16_+_25074029 9.97 ENSDART00000155465
si:dkeyp-84f3.9
chr4_+_62262253 9.93 ENSDART00000166022
si:dkeyp-35e5.10
chr4_-_43279775 9.90 ENSDART00000183160
si:dkeyp-53e4.1
chr4_+_69863019 9.90 ENSDART00000168400
zinc finger protein 1117
chr4_-_51045333 9.84 ENSDART00000150560
zinc finger protein 1026
chr23_-_17450746 9.80 ENSDART00000145399
ENSDART00000136457
ENSDART00000133125
ENSDART00000145719
ENSDART00000147524
ENSDART00000005366
ENSDART00000104680
tumor protein D52-like 2b
chr11_-_12802123 9.75 ENSDART00000104143
taxilin gamma
chr4_+_28962774 9.73 ENSDART00000150629
si:dkey-23a23.3
chr4_-_25515154 9.73 ENSDART00000186524
RNA binding motif protein 17
chr4_+_41528590 9.71 ENSDART00000164004
zinc finger protein 1094
chr4_-_65090543 9.67 ENSDART00000167888
si:ch211-194h1.2
chr13_-_31370184 9.66 ENSDART00000034829
ribosomal RNA processing 12 homolog
chr4_+_64147241 9.61 ENSDART00000163509
zinc finger protein 1089
chr9_+_22929675 9.56 ENSDART00000061299
translin
chr4_-_44673017 9.56 ENSDART00000156670
si:dkey-7j22.4
chr4_-_59057046 9.42 ENSDART00000150249
zinc finger protein 1132
chr4_-_44872722 9.41 ENSDART00000150621

chr4_+_29909870 9.39 ENSDART00000150324
zinc finger protein 1111
chr14_-_21932403 9.33 ENSDART00000054420
RAD9 checkpoint clamp component A
chr4_-_50788075 9.33 ENSDART00000150302
zinc finger protein 1045
chr4_-_43185261 9.28 ENSDART00000150380
si:dkey-16p6.2
chr4_+_28418829 9.14 ENSDART00000111603
zinc finger protein 1041
chr4_-_67143082 9.14 ENSDART00000162586

chr4_+_53183373 9.04 ENSDART00000176617
zinc finger protein 1037
chr8_+_49065348 9.03 ENSDART00000032277
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr13_-_31687925 8.95 ENSDART00000085989
TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae)
chr4_+_69559692 8.93 ENSDART00000164383
zinc finger protein 993
chr23_+_43424518 8.92 ENSDART00000022498
TELO2 interacting protein 1
chr4_-_42074960 8.92 ENSDART00000164406
zgc:174696
chr4_-_45115963 8.82 ENSDART00000137248
si:dkey-51d8.6
chr8_-_28274552 8.77 ENSDART00000131580
RAP1A, member of RAS oncogene family a
chr4_-_63769147 8.76 ENSDART00000189919
zinc finger protein 1098
chr4_+_29344957 8.73 ENSDART00000185164

chr3_+_9588705 8.71 ENSDART00000172543
ENSDART00000104875
TNF receptor-associated protein 1
chr4_+_60381608 8.69 ENSDART00000167351
zinc finger protein 1130
chr8_+_12118097 8.66 ENSDART00000081819
endonuclease G
chr11_-_45433419 8.65 ENSDART00000163923
ENSDART00000075612
replication factor C (activator 1) 4
chr4_+_64102312 8.64 ENSDART00000157859
zinc finger protein 1103
chr10_+_1681518 8.63 ENSDART00000018532
TP53 regulated inhibitor of apoptosis 1
chr15_+_846768 8.47 ENSDART00000155633
ENSDART00000191235
si:dkey-7i4.5
si:dkey-77f5.8
chr7_-_7797654 8.47 ENSDART00000084503
ENSDART00000192779
ENSDART00000173079
tRNA methyltransferase 10B
chr17_+_13007307 8.45 ENSDART00000064554
protein phosphatase 2, regulatory subunit B'', gamma
chr5_+_56277866 8.42 ENSDART00000170610
ENSDART00000028854
ENSDART00000148749
apoptosis antagonizing transcription factor
chr3_+_25990052 8.42 ENSDART00000007398
glycine C-acetyltransferase
chr4_-_69787943 8.34 ENSDART00000166487
zinc finger protein 1081
chr4_+_65332578 8.33 ENSDART00000170824
zinc finger protein 1108
chr4_+_48769555 8.20 ENSDART00000150725
zinc finger protein 1020
chr10_+_23099890 8.18 ENSDART00000135890
si:dkey-175g6.5
chr4_-_28958601 8.13 ENSDART00000111294
zgc:174315
chr4_-_32888436 8.04 ENSDART00000176728

chr13_+_30035253 8.03 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr4_+_69375564 8.02 ENSDART00000150334
si:dkey-246j6.1
chr1_-_23268569 8.01 ENSDART00000143948
replication factor C (activator 1) 1
chr19_+_27339848 8.00 ENSDART00000052355
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr4_+_36150332 8.00 ENSDART00000161697
zinc finger protein 1116
chr4_-_63980140 7.85 ENSDART00000160818
zinc finger protein 1091
chr8_+_471342 7.83 ENSDART00000167205
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr4_-_33189070 7.83 ENSDART00000150444

chr4_-_40883162 7.82 ENSDART00000151978
zinc finger protein 1102
chr15_+_847077 7.76 ENSDART00000188586
si:dkey-7i4.5
chr4_-_64542903 7.75 ENSDART00000143176

chr4_-_30712588 7.74 ENSDART00000142393
si:dkey-16p19.5
chr12_-_25201576 7.72 ENSDART00000077188
cytochrome c oxidase subunit VIIa polypeptide 3
chr12_+_36109507 7.65 ENSDART00000175409
mitogen-activated protein kinase kinase 6
chr4_-_43056627 7.64 ENSDART00000150269
si:dkey-54j5.2
chr21_-_11199366 7.59 ENSDART00000167666
DnaJ (Hsp40) homolog, subfamily C, member 21
chr4_-_60356042 7.58 ENSDART00000125171
zinc finger protein 1121
chr4_+_64608808 7.54 ENSDART00000143989
si:ch211-223a21.6
chr1_+_29862074 7.51 ENSDART00000133905
ENSDART00000136786
ENSDART00000135252
propionyl CoA carboxylase, alpha polypeptide
chr15_+_841383 7.49 ENSDART00000115077
zgc:174573
chr4_-_32179699 7.47 ENSDART00000124106
ENSDART00000158835
si:dkey-72l17.6
chr4_-_43071336 7.38 ENSDART00000150773
zinc finger protein 1072
chr5_+_54555567 7.36 ENSDART00000171159
anaphase promoting complex subunit 2
chr4_+_73651053 7.35 ENSDART00000150532
ENSDART00000172536
zinc finger protein 989
chr7_-_52949944 7.26 ENSDART00000174289
tubulin, gamma complex associated protein 4
chr4_+_63992019 7.23 ENSDART00000158645

chr4_-_64482414 7.22 ENSDART00000159000
zinc finger protein 1105
chr3_-_60027255 7.21 ENSDART00000189252
ENSDART00000154684
RecQ helicase-like 5
chr4_-_61920018 7.17 ENSDART00000164832
zinc finger protein 1056
chr4_-_41825115 7.16 ENSDART00000160196
si:dkey-237m9.1
chr19_-_32914227 7.16 ENSDART00000186115
ENSDART00000124246
metadherin a
chr4_-_64918854 7.15 ENSDART00000132409
si:ch211-234c11.2
chr4_+_47385355 7.13 ENSDART00000163413
zinc finger protein 1122
chr19_+_2876106 7.13 ENSDART00000189309
HGH1 homolog (S. cerevisiae)
chr11_+_12744575 7.11 ENSDART00000131059
ENSDART00000081335
ENSDART00000142481
retinoblastoma binding protein 4, like
chr4_-_43640507 7.10 ENSDART00000150700
si:dkey-29p23.2
chr4_+_65271779 7.09 ENSDART00000134257
zinc finger protein 1027
chr4_+_45195202 6.97 ENSDART00000150838
ENSDART00000187011
zinc finger protein 1021

chr4_-_42171503 6.89 ENSDART00000163798
zinc finger protein 1148
chr4_-_44573692 6.89 ENSDART00000153885
si:dkey-7j22.1
chr5_+_1089600 6.83 ENSDART00000183128

chr4_+_61810270 6.83 ENSDART00000158840

chr4_-_33405483 6.74 ENSDART00000150625

chr4_+_60001731 6.73 ENSDART00000150615
zinc finger protein 1109
chr4_+_42295479 6.72 ENSDART00000162279
zinc finger protein 1118
chr4_+_69409331 6.71 ENSDART00000159440
si:dkey-246j6.3
chr4_+_69190524 6.70 ENSDART00000168009
zinc finger protein 1075
chr4_+_44577872 6.68 ENSDART00000157214
si:dkey-7j22.2
chr4_+_68456852 6.66 ENSDART00000165623
zinc finger protein 1146
chr4_-_55178568 6.66 ENSDART00000165288
zinc finger protein 1039
chr3_+_40284598 6.62 ENSDART00000009411
BUD31 homolog (S. cerevisiae)
chr4_+_43679421 6.61 ENSDART00000132945
zgc:173705
chr4_-_53168673 6.58 ENSDART00000168891
zinc finger protein 1053
chr4_-_55322519 6.58 ENSDART00000143067
zinc finger protein 998
chr19_-_26923273 6.57 ENSDART00000089609
SKI2 homolog, superkiller viralicidic activity 2-like
chr4_+_50970601 6.54 ENSDART00000150374
si:dkey-156j15.1
chr4_+_38424204 6.47 ENSDART00000168884
zinc finger protein 994

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.5 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
5.0 14.9 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
4.5 13.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
3.9 19.3 GO:0071320 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
2.9 14.6 GO:0090646 mitochondrial tRNA processing(GO:0090646)
2.8 8.4 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
2.6 7.8 GO:0072526 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
2.4 11.9 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
2.2 9.0 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
2.1 6.2 GO:0048478 replication fork protection(GO:0048478)
2.0 36.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
2.0 6.0 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
1.9 13.6 GO:0060221 retinal rod cell differentiation(GO:0060221)
1.7 13.2 GO:0036372 opsin transport(GO:0036372)
1.6 4.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
1.6 17.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
1.5 20.5 GO:0000076 DNA replication checkpoint(GO:0000076)
1.4 4.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
1.3 3.9 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
1.2 5.0 GO:0006404 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
1.2 8.7 GO:0030262 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
1.2 3.6 GO:1904158 axonemal central apparatus assembly(GO:1904158)
1.0 7.2 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.0 10.0 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.9 8.4 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.9 3.7 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.9 5.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.8 19.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.8 3.3 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.8 3.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.8 3.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.7 3.6 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.6 10.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.6 10.5 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.6 4.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.6 2.2 GO:0032790 ribosome disassembly(GO:0032790)
0.6 3.3 GO:0000479 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.5 4.4 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 3.8 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.5 17.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.5 4.9 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.4 50.8 GO:0006364 rRNA processing(GO:0006364)
0.4 12.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.4 28.1 GO:0051028 mRNA transport(GO:0051028)
0.4 2.6 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.4 4.5 GO:0006382 adenosine to inosine editing(GO:0006382)
0.4 1448.1 GO:0006355 regulation of transcription, DNA-templated(GO:0006355)
0.3 8.0 GO:0051788 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.3 3.5 GO:0006611 protein export from nucleus(GO:0006611)
0.3 10.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 2.0 GO:0048660 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.3 6.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 11.1 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.3 13.1 GO:0000187 activation of MAPK activity(GO:0000187)
0.3 3.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 11.8 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.2 1.2 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.2 4.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 6.5 GO:0034968 histone lysine methylation(GO:0034968)
0.2 3.2 GO:0016926 protein desumoylation(GO:0016926)
0.2 2.0 GO:0045117 azole transport(GO:0045117)
0.2 2.6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.2 8.7 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.2 3.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 2.0 GO:0030330 DNA damage response, signal transduction by p53 class mediator(GO:0030330)
0.1 5.4 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 3.9 GO:0003146 heart jogging(GO:0003146)
0.1 4.5 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 14.1 GO:0006979 response to oxidative stress(GO:0006979)
0.1 3.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 16.9 GO:0006260 DNA replication(GO:0006260)
0.1 7.1 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 3.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 10.2 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 10.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 23.4 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1 6.0 GO:0001666 response to hypoxia(GO:0001666)
0.1 4.3 GO:0006400 tRNA modification(GO:0006400)
0.1 13.8 GO:0006396 RNA processing(GO:0006396)
0.0 13.0 GO:0016070 RNA metabolic process(GO:0016070)
0.0 3.5 GO:0060027 convergent extension involved in gastrulation(GO:0060027)
0.0 12.2 GO:0006412 translation(GO:0006412)
0.0 0.1 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.0 7.5 GO:0016042 lipid catabolic process(GO:0016042)
0.0 9.7 GO:0051726 regulation of cell cycle(GO:0051726)
0.0 7.4 GO:0051301 cell division(GO:0051301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:0070545 PeBoW complex(GO:0070545)
4.5 13.4 GO:0032545 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
4.3 17.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
4.0 12.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
3.1 9.3 GO:0030896 checkpoint clamp complex(GO:0030896)
2.2 8.9 GO:0070209 ASTRA complex(GO:0070209)
2.0 10.0 GO:0055087 Ski complex(GO:0055087)
1.7 19.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.7 13.6 GO:0000923 equatorial microtubule organizing center(GO:0000923)
1.6 11.5 GO:0070847 core mediator complex(GO:0070847)
1.5 16.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
1.5 6.0 GO:0000974 Prp19 complex(GO:0000974)
1.4 9.8 GO:0005663 DNA replication factor C complex(GO:0005663)
1.2 3.7 GO:0005960 glycine cleavage complex(GO:0005960)
1.1 4.4 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.9 12.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.8 3.3 GO:0035339 SPOTS complex(GO:0035339)
0.8 29.2 GO:0032040 small-subunit processome(GO:0032040)
0.7 13.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.6 4.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.6 4.9 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.6 5.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.5 6.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.5 2.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.5 7.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 4.0 GO:0035060 brahma complex(GO:0035060)
0.5 10.9 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.5 5.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.4 10.2 GO:0005839 proteasome core complex(GO:0005839)
0.3 5.9 GO:0015030 Cajal body(GO:0015030)
0.3 79.0 GO:0005730 nucleolus(GO:0005730)
0.2 5.1 GO:0005686 U2 snRNP(GO:0005686)
0.2 15.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 2.1 GO:0032021 NELF complex(GO:0032021)
0.2 3.0 GO:0017119 Golgi transport complex(GO:0017119)
0.2 18.6 GO:0016607 nuclear speck(GO:0016607)
0.1 11.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 6.0 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 2.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 879.4 GO:0005634 nucleus(GO:0005634)
0.1 4.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.0 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.1 3.6 GO:0044447 axoneme part(GO:0044447)
0.1 9.3 GO:0031201 SNARE complex(GO:0031201)
0.1 3.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 38.7 GO:0005739 mitochondrion(GO:0005739)
0.0 6.3 GO:0005929 cilium(GO:0005929)
0.0 10.6 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.1 GO:0008022 protein C-terminus binding(GO:0008022)
4.5 18.2 GO:0034511 U3 snoRNA binding(GO:0034511)
4.1 12.3 GO:0030623 U5 snRNA binding(GO:0030623)
3.6 10.9 GO:0071532 ankyrin repeat binding(GO:0071532)
3.5 17.4 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
2.8 14.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
2.1 8.4 GO:0016453 C-acetyltransferase activity(GO:0016453)
2.0 6.1 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
1.9 21.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.7 5.1 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
1.6 7.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
1.5 9.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
1.5 32.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
1.5 4.5 GO:0036310 annealing helicase activity(GO:0036310)
1.5 10.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.4 8.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.0 3.1 GO:0000996 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
1.0 7.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.9 7.5 GO:0016421 CoA carboxylase activity(GO:0016421)
0.9 13.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.8 16.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.7 4.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.7 5.6 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.6 4.9 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 3 promoter sequence-specific DNA binding(GO:0001006) RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.6 1419.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.5 10.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 8.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.5 2.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.5 11.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.5 5.9 GO:0004017 adenylate kinase activity(GO:0004017)
0.4 35.8 GO:0003724 RNA helicase activity(GO:0003724)
0.4 4.5 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.3 23.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.3 3.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.3 5.0 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.2 2.0 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.2 3.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.2 3.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 5.2 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 4.0 GO:0051087 chaperone binding(GO:0051087)
0.2 6.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 2.8 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 14.8 GO:0051082 unfolded protein binding(GO:0051082)
0.2 9.6 GO:0004521 endoribonuclease activity(GO:0004521)
0.2 9.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 3.9 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 9.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.2 GO:0032977 membrane insertase activity(GO:0032977)
0.1 9.7 GO:0019905 syntaxin binding(GO:0019905)
0.1 6.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 7.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 107.5 GO:0003723 RNA binding(GO:0003723)
0.1 12.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 15.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 13.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 11.9 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 1.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 7.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 1.7 GO:0015297 antiporter activity(GO:0015297)
0.0 4.9 GO:0005543 phospholipid binding(GO:0005543)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 13.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.7 34.8 PID ATR PATHWAY ATR signaling pathway
0.6 10.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 9.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 10.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 8.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 8.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 8.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.7 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 16.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.8 10.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.8 13.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.6 30.3 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.6 10.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.6 13.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.5 4.9 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.5 7.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4 10.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 4.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.4 7.4 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 12.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 6.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2 10.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 5.9 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 8.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 4.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 11.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 5.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 3.1 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 10.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation