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PRJEB1986: zebrafish developmental stages transcriptome

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Results for bhlhe40

Z-value: 0.65

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Transcription factors associated with bhlhe40

Gene Symbol Gene ID Gene Info
bhlhe40
ENSDARG00000004060 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe40dr11_v1_chr11_-_35763323_357633230.771.0e-04Click!

Activity profile of bhlhe40 motif

Sorted Z-values of bhlhe40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_54765262 1.55 ENSDART00000150362
si:ch211-197k17.3
si:ch211-197k17.3
chr7_+_48999723 1.52 ENSDART00000182699
ENSDART00000166329
si:ch211-288d18.1
si:ch211-288d18.1
chr25_-_35599887 1.40 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b
chr4_+_13696537 1.12 ENSDART00000109195
ENSDART00000122041
ENSDART00000192554
nrcama
neuronal cell adhesion molecule a
chr10_-_44027391 1.01 ENSDART00000145404
crybb1
crystallin, beta B1
chr10_-_6775271 0.79 ENSDART00000110735
zgc:194281
zgc:194281
chr16_+_26824691 0.70 ENSDART00000135053
zmp:0000001316
zmp:0000001316
chr21_+_43178831 0.63 ENSDART00000151512
aff4
AF4/FMR2 family, member 4
chr24_+_7631797 0.62 ENSDART00000187464
cavin1b
caveolae associated protein 1b
chr19_+_40379771 0.61 ENSDART00000017917
ENSDART00000110699
vps50
vps50
VPS50 EARP/GARPII complex subunit
VPS50 EARP/GARPII complex subunit
chr20_+_40766645 0.58 ENSDART00000144401
tbc1d32
TBC1 domain family, member 32
chr23_+_42131509 0.57 ENSDART00000184544
SHISAL2A
shisa like 2A
chr3_-_25420931 0.57 ENSDART00000109601
ENSDART00000182184
bptf
bromodomain PHD finger transcription factor
chr6_-_49547680 0.56 ENSDART00000169678
ppp4r1l
protein phosphatase 4, regulatory subunit 1-like
chr9_+_36946340 0.55 ENSDART00000135281
si:dkey-3d4.3
si:dkey-3d4.3
chr15_-_44077937 0.54 ENSDART00000110112
lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr17_+_10501647 0.52 ENSDART00000140391
tyro3
TYRO3 protein tyrosine kinase
chr13_+_19884631 0.51 ENSDART00000089533
atrnl1a
attractin-like 1a
chr24_-_42072886 0.49 ENSDART00000171389
CABZ01095370.1

chr9_-_1200187 0.49 ENSDART00000158760
ino80da
INO80 complex subunit Da
chr15_+_59417 0.49 ENSDART00000187260
AXL
AXL receptor tyrosine kinase
chr10_-_35108683 0.48 ENSDART00000049633
zgc:110006
zgc:110006
chr15_-_41290415 0.47 ENSDART00000152157
si:dkey-75b17.1
si:dkey-75b17.1
chr4_+_331351 0.46 ENSDART00000132625
tulp4a
tubby like protein 4a
chr20_+_46213553 0.45 ENSDART00000100532
stx7l
syntaxin 7-like
chr21_+_4540127 0.44 ENSDART00000043431
nup188
nucleoporin 188
chr20_+_13969414 0.43 ENSDART00000049864
rd3
retinal degeneration 3
chr12_-_3778848 0.41 ENSDART00000152128
si:ch211-166g5.4
si:ch211-166g5.4
chr3_-_39627412 0.39 ENSDART00000123292
si:dkey-27o4.1
si:dkey-27o4.1
chr21_-_4539899 0.39 ENSDART00000112460
dolk
dolichol kinase
chr8_+_17933475 0.39 ENSDART00000100651
erich3
glutamate-rich 3
chr7_-_67214972 0.38 ENSDART00000156861
swap70a
switching B cell complex subunit SWAP70a
chr12_-_7280551 0.38 ENSDART00000061633
zgc:171971
zgc:171971
chr22_-_16759151 0.36 ENSDART00000191880
patj
PATJ, crumbs cell polarity complex component
chr7_+_1442059 0.35 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr15_-_41807371 0.33 ENSDART00000156819
slc25a36b
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36b
chr14_-_25452503 0.33 ENSDART00000148652
slc26a2
solute carrier family 26 (anion exchanger), member 2
chr20_-_45040916 0.33 ENSDART00000190001
klhl29
kelch-like family member 29
chr3_-_25421504 0.33 ENSDART00000154200
bptf
bromodomain PHD finger transcription factor
chr17_-_37299394 0.32 ENSDART00000154414
ptgr2
prostaglandin reductase 2
chr12_+_47044707 0.31 ENSDART00000186506
zranb1a
zinc finger, RAN-binding domain containing 1a
chr12_+_13652361 0.31 ENSDART00000182757
ENSDART00000152689
oplah
5-oxoprolinase, ATP-hydrolysing
chr24_-_21498802 0.31 ENSDART00000181235
ENSDART00000153695
atp8a2
ATPase phospholipid transporting 8A2
chr1_+_50639416 0.31 ENSDART00000141977
herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr18_+_6479963 0.30 ENSDART00000092752
ENSDART00000136333
wash1
WAS protein family homolog 1
chr22_+_30184039 0.29 ENSDART00000049075
add3a
adducin 3 (gamma) a
chr10_+_26515946 0.28 ENSDART00000134276
synj1
synaptojanin 1
chr15_-_34418525 0.28 ENSDART00000147582
agmo
alkylglycerol monooxygenase
chr5_+_32009956 0.28 ENSDART00000188482
scai
suppressor of cancer cell invasion
chr22_-_16758973 0.27 ENSDART00000145208
patj
PATJ, crumbs cell polarity complex component
chr15_+_1534644 0.27 ENSDART00000130413
smc4
structural maintenance of chromosomes 4
chr12_+_13652747 0.27 ENSDART00000066359
oplah
5-oxoprolinase, ATP-hydrolysing
chr18_+_39074139 0.26 ENSDART00000142390
gnb5b
guanine nucleotide binding protein (G protein), beta 5b
chr3_+_13929860 0.25 ENSDART00000164179
syce2
synaptonemal complex central element protein 2
chr15_-_26570948 0.25 ENSDART00000156621
wdr81
WD repeat domain 81
chr12_+_17933775 0.24 ENSDART00000186047
ENSDART00000160586
trrap
transformation/transcription domain-associated protein
chr19_-_5103313 0.23 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr19_+_791538 0.23 ENSDART00000146554
ENSDART00000138406
tmem79a
transmembrane protein 79a
chr9_-_10805231 0.23 ENSDART00000193913
ENSDART00000078348
si:ch1073-416j23.1
si:ch1073-416j23.1
chr4_+_17655872 0.23 ENSDART00000066999
washc3
WASH complex subunit 3
chr7_-_14446512 0.22 ENSDART00000041577
kif7
kinesin family member 7
chr16_+_25296389 0.22 ENSDART00000114528
tbc1d31
TBC1 domain family, member 31
chr10_-_15644904 0.22 ENSDART00000138389
ENSDART00000101191
ENSDART00000186559
ENSDART00000122170
smc5
structural maintenance of chromosomes 5
chr12_+_45677293 0.22 ENSDART00000152850
ENSDART00000153047
si:ch73-111m19.2
si:ch73-111m19.2
chr17_-_44440832 0.22 ENSDART00000148786
exoc5
exocyst complex component 5
chr24_+_3307857 0.21 ENSDART00000106527
gyg1b
glycogenin 1b
chr9_-_34269066 0.21 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr16_+_5251768 0.20 ENSDART00000144558
plecb
plectin b
chr5_-_66798729 0.18 ENSDART00000113077
FERMT3 (1 of many)
im:7154036
chr12_-_44010532 0.18 ENSDART00000183875
si:ch211-182p11.1
si:ch211-182p11.1
chr15_+_1148074 0.18 ENSDART00000152638
ENSDART00000152466
ENSDART00000188011
mlf1
myeloid leukemia factor 1
chr18_-_7677208 0.16 ENSDART00000092456
shank3a
SH3 and multiple ankyrin repeat domains 3a
chr14_+_94946 0.16 ENSDART00000165766
ENSDART00000163778
mcm7
minichromosome maintenance complex component 7
chr7_+_65939098 0.16 ENSDART00000193599
RASSF10
Ras association domain family member 10
chr19_-_38830582 0.16 ENSDART00000189966
ENSDART00000183055
adgrb2
adhesion G protein-coupled receptor B2
chr8_-_6943155 0.15 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr23_-_2901167 0.15 ENSDART00000165955
ENSDART00000190616
zhx3
zinc fingers and homeoboxes 3
chr15_+_34939906 0.15 ENSDART00000131182
si:ch73-95l15.3
si:ch73-95l15.3
chr10_-_24724388 0.15 ENSDART00000148582
smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr11_-_44163164 0.15 ENSDART00000047126
clcn4
chloride channel, voltage-sensitive 4
chr17_+_32622933 0.14 ENSDART00000077418
ctsba
cathepsin Ba
chr23_-_31913231 0.13 ENSDART00000146852
ENSDART00000085054
mtfr2
mitochondrial fission regulator 2
chr16_+_19029297 0.12 ENSDART00000115263
ENSDART00000114954
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr21_+_45816030 0.12 ENSDART00000187056
pitx1
paired-like homeodomain 1
chr15_+_6652396 0.12 ENSDART00000192813
ENSDART00000157678
nop53
NOP53 ribosome biogenesis factor
chr25_-_1323623 0.11 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calml4b
calmodulin-like 4b
chr9_+_54686686 0.11 ENSDART00000066198
rab9a
RAB9A, member RAS oncogene family
chr20_-_51100669 0.11 ENSDART00000023488
atp6v1d
ATPase H+ transporting V1 subunit D
chr14_-_3071564 0.10 ENSDART00000166136
ENSDART00000167138
slc35a4
solute carrier family 35, member A4
chr20_-_211920 0.09 ENSDART00000104790
znf292b
zinc finger protein 292b
chr4_-_5831522 0.08 ENSDART00000008898
foxm1
forkhead box M1
chr3_+_12784460 0.08 ENSDART00000168382
cyp2k8
cytochrome P450, family 2, subfamily K, polypeptide 8
chr1_+_54766943 0.07 ENSDART00000144759
nlrc6
NLR family CARD domain containing 6
chr21_-_14251306 0.07 ENSDART00000114715
ENSDART00000181380
man1b1a
mannosidase, alpha, class 1B, member 1a
chr5_+_41476443 0.06 ENSDART00000145228
ENSDART00000137981
ENSDART00000142538
pias2
protein inhibitor of activated STAT, 2
chr11_-_236984 0.06 ENSDART00000170778
dusp7
dual specificity phosphatase 7
chr21_+_11916788 0.05 ENSDART00000136103
ubap2a
ubiquitin associated protein 2a
chr22_+_8800432 0.05 ENSDART00000139940
si:dkey-182g1.6
si:dkey-182g1.6
chr23_+_9035578 0.05 ENSDART00000140455
ccm2l
cerebral cavernous malformation 2-like
chr7_+_34620418 0.05 ENSDART00000081338
slc9a5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr1_-_38538284 0.04 ENSDART00000009777
glra3
glycine receptor, alpha 3
chr23_+_32028574 0.03 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
tpx2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr19_+_9111550 0.03 ENSDART00000088336
setdb1a
SET domain, bifurcated 1a
chr13_+_40692804 0.02 ENSDART00000109822
hps1
Hermansky-Pudlak syndrome 1
chr5_-_9540641 0.02 ENSDART00000124384
ENSDART00000160079
gak
cyclin G associated kinase
chr14_-_45595711 0.02 ENSDART00000074038
scyl1
SCY1-like, kinase-like 1
chr18_+_31280984 0.01 ENSDART00000170285
ENSDART00000150608
ENSDART00000159720
def8
differentially expressed in FDCP 8 homolog (mouse)
chr6_+_12968101 0.01 ENSDART00000013781
mcm6
minichromosome maintenance complex component 6
chr5_+_26204561 0.01 ENSDART00000137178
marveld2b
MARVEL domain containing 2b
chr13_+_12389849 0.01 ENSDART00000086525
atp10d
ATPase phospholipid transporting 10D

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlhe40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 0.4 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.1 0.3 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.2 GO:0035973 aggrephagy(GO:0035973)
0.1 0.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.2 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.6 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.5 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.3 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 1.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.5 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0070193 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.0 0.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.3 GO:0032474 sulfate transport(GO:0008272) otolith morphogenesis(GO:0032474)
0.0 0.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.2 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 1.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.6 GO:0035082 axoneme assembly(GO:0035082)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1990745 EARP complex(GO:1990745)
0.1 0.9 GO:0016589 NURF complex(GO:0016589)
0.1 0.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.5 GO:0071203 WASH complex(GO:0071203)
0.1 0.5 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.2 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.3 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.2 GO:0043621 protein self-association(GO:0043621)
0.1 0.2 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.0 0.2 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.6 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0034595 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596)
0.0 0.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.4 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling