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PRJEB1986: zebrafish developmental stages transcriptome

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Results for bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Z-value: 1.01

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Transcription factors associated with bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

Gene Symbol Gene ID Gene Info
bhlha15
ENSDARG00000045166 basic helix-loop-helix family, member a15
bhlhe23
ENSDARG00000037588 basic helix-loop-helix family, member e23
si_ch211-196c10.13
ENSDARG00000096756 si_ch211-196c10.13
bhlhe22
ENSDARG00000058039 basic helix-loop-helix family, member e22

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe23dr11_v1_chr23_-_17657348_176573480.901.4e-07Click!
bhlhe22dr11_v1_chr24_+_24461341_244613410.803.2e-05Click!
si:ch211-196c10.13dr11_v1_chr8_+_23142946_231429460.752.0e-04Click!
bhlha15dr11_v1_chr12_+_17754859_17754859-0.009.9e-01Click!

Activity profile of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Sorted Z-values of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_43712120 6.00 ENSDART00000074600
SLC9B2
si:dkey-162b23.4
chr23_+_21544227 5.10 ENSDART00000140253
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr21_+_11468642 4.97 ENSDART00000041869
grin1a
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr15_+_36457888 4.49 ENSDART00000155100
si:dkey-262k9.2
si:dkey-262k9.2
chr2_-_27774783 4.38 ENSDART00000161864
XKR4
zgc:123035
chr14_+_25817246 4.29 ENSDART00000136733
glra1
glycine receptor, alpha 1
chr12_-_14922955 4.06 ENSDART00000002078
neurod2
neurogenic differentiation 2
chr14_+_25816874 3.95 ENSDART00000005499
glra1
glycine receptor, alpha 1
chr14_-_4682114 3.46 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr4_-_8882572 3.45 ENSDART00000190060
mpped1
metallophosphoesterase domain containing 1
chr2_-_27775236 3.30 ENSDART00000187983
XKR4
zgc:123035
chr14_-_4556896 3.05 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr3_-_61205711 2.82 ENSDART00000055062
pvalb1
parvalbumin 1
chr7_-_15413019 2.38 ENSDART00000172147
si:ch211-106j24.1
si:ch211-106j24.1
chr20_-_33462961 2.36 ENSDART00000135927
si:dkey-65b13.1
si:dkey-65b13.1
chr3_+_28953274 2.30 ENSDART00000133528
ENSDART00000103602
lgals2a
lectin, galactoside-binding, soluble, 2a
chr10_+_22012389 2.29 ENSDART00000035188
kcnip1b
Kv channel interacting protein 1 b
chr17_-_20558961 2.09 ENSDART00000155993
sh3pxd2ab
SH3 and PX domains 2Ab
chr2_-_5074812 1.87 ENSDART00000163728
dlg1l
discs, large (Drosophila) homolog 1, like
chr19_-_7406933 1.77 ENSDART00000151137
oxr1b
oxidation resistance 1b
chr5_+_45138934 1.77 ENSDART00000041412
ENSDART00000136002
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr24_-_7777389 1.63 ENSDART00000138541
rpgrip1
RPGR interacting protein 1
chr20_+_18994059 1.60 ENSDART00000152380
tdh
L-threonine dehydrogenase
chr25_+_4787431 1.56 ENSDART00000170640
myo5c
myosin VC
chr5_-_25576462 1.48 ENSDART00000165147
si:dkey-229d2.4
si:dkey-229d2.4
chr8_-_3773374 1.47 ENSDART00000115036
bicdl1
BICD family like cargo adaptor 1
chr2_-_39036604 1.39 ENSDART00000129963
rbp1
retinol binding protein 1b, cellular
chr12_+_24562667 1.39 ENSDART00000056256
nrxn1a
neurexin 1a
chr3_+_47322494 1.33 ENSDART00000102202
ppap2d
phosphatidic acid phosphatase type 2D
chr7_-_15413188 1.29 ENSDART00000185980
si:ch211-106j24.1
si:ch211-106j24.1
chr8_-_39952727 1.22 ENSDART00000181310
cabp1a
calcium binding protein 1a
chr8_-_22660678 1.20 ENSDART00000181258
iqsec2a
IQ motif and Sec7 domain 2a
chr22_-_17052381 1.18 ENSDART00000138382
nfia
nuclear factor I/A
chr23_+_26491931 1.11 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
si:ch73-206d17.1
chr4_+_12617108 1.07 ENSDART00000134362
ENSDART00000112860
lmo3
LIM domain only 3
chr20_+_18994465 1.07 ENSDART00000152778
tdh
L-threonine dehydrogenase
chr5_+_45139196 1.03 ENSDART00000113738
smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_-_23358357 1.00 ENSDART00000135475
cadm2a
cell adhesion molecule 2a
chr3_+_50310684 0.99 ENSDART00000112152
gas7a
growth arrest-specific 7a
chr20_+_6773790 0.98 ENSDART00000169966
igfbp3
insulin-like growth factor binding protein 3
chr22_-_18116635 0.97 ENSDART00000005724
ncanb
neurocan b
chr22_-_23067859 0.94 ENSDART00000137873
ptprc
protein tyrosine phosphatase, receptor type, C
chr12_-_3753131 0.91 ENSDART00000129668
fam57bb
family with sequence similarity 57, member Bb
chr7_-_31938938 0.85 ENSDART00000132353
bdnf
brain-derived neurotrophic factor
chr21_-_40174647 0.81 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
slco2b1
solute carrier organic anion transporter family, member 2B1
chr20_+_39283849 0.77 ENSDART00000002481
ENSDART00000146683
scara3
scavenger receptor class A, member 3
chr5_-_24245218 0.75 ENSDART00000042481
phf23a
PHD finger protein 23a
chr20_-_8365244 0.72 ENSDART00000167102
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr11_+_6684968 0.72 ENSDART00000139454
pde4cb
phosphodiesterase 4C, cAMP-specific b
chr23_-_4019699 0.71 ENSDART00000159780
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr13_+_31285660 0.70 ENSDART00000148352
gdf10a
growth differentiation factor 10a
chr4_-_16354292 0.70 ENSDART00000139919
lum
lumican
chr18_+_12147971 0.69 ENSDART00000162067
ENSDART00000168386
fgd4a
FYVE, RhoGEF and PH domain containing 4a
chr22_-_188102 0.68 ENSDART00000125391
ENSDART00000170463
CABZ01052268.1

chr3_+_40809011 0.67 ENSDART00000033713
arpc1b
actin related protein 2/3 complex, subunit 1B
chr9_-_42989297 0.67 ENSDART00000126871
ttn.2
titin, tandem duplicate 2
chr18_-_25645680 0.66 ENSDART00000135874
si:ch211-13k12.2
si:ch211-13k12.2
chr5_-_27994679 0.63 ENSDART00000132740
ppp3cca
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr4_+_20318127 0.60 ENSDART00000028856
ENSDART00000132909
cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr19_-_12212692 0.60 ENSDART00000142077
ENSDART00000151599
ENSDART00000140834
ENSDART00000078781
znf706
zinc finger protein 706
chr1_+_42874410 0.59 ENSDART00000153506
ctnna2
catenin (cadherin-associated protein), alpha 2
chr18_+_50687702 0.59 ENSDART00000159877
p2ry1
purinergic receptor P2Y1
chr20_-_34028967 0.58 ENSDART00000153408
ENSDART00000033817
scyl3
SCY1-like, kinase-like 3
chr14_-_12071447 0.58 ENSDART00000166116
tmsb1
thymosin beta 1
chr21_-_13751535 0.58 ENSDART00000111666
npdc1a
neural proliferation, differentiation and control, 1a
chr20_-_4031475 0.54 ENSDART00000112053
fam89a
family with sequence similarity 89, member A
chr2_-_32551178 0.54 ENSDART00000145603
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr17_+_20174812 0.52 ENSDART00000186628
si:ch211-248a14.8
si:ch211-248a14.8
chr2_-_42558549 0.52 ENSDART00000025997
dip2cb
disco-interacting protein 2 homolog Cb
chr19_+_1184878 0.50 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr6_-_10963887 0.49 ENSDART00000151102
notum2
notum pectinacetylesterase 2
chr3_-_57779801 0.46 ENSDART00000074285
syngr2a
synaptogyrin 2a
chr14_+_36521553 0.44 ENSDART00000136233
TENM3
si:dkey-237h12.3
chr22_-_14475927 0.44 ENSDART00000135768
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr1_-_16394814 0.42 ENSDART00000013024
fgf20a
fibroblast growth factor 20a
chr19_+_32456974 0.42 ENSDART00000088265
atxn1a
ataxin 1a
chr12_-_35095414 0.41 ENSDART00000153229
si:dkey-21e13.3
si:dkey-21e13.3
chr13_+_28821841 0.41 ENSDART00000179900
CU639469.1

chr17_+_28882977 0.41 ENSDART00000153937
prkd1
protein kinase D1
chr3_-_24909245 0.37 ENSDART00000178321
SHISA8
shisa family member 8
chr25_+_4787607 0.37 ENSDART00000159422
myo5c
myosin VC
chr14_+_23874062 0.36 ENSDART00000172149
sh3rf2
SH3 domain containing ring finger 2
chr9_+_29994439 0.36 ENSDART00000012447
tmem30c
transmembrane protein 30C
chr13_-_31441042 0.35 ENSDART00000076571
rtn1a
reticulon 1a
chr6_+_54142311 0.34 ENSDART00000154115
hmga1b
high mobility group AT-hook 1b
chr10_-_31015535 0.34 ENSDART00000146116
panx3
pannexin 3
chr11_-_34521342 0.34 ENSDART00000114004
pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr14_-_46117345 0.33 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr10_+_24445698 0.32 ENSDART00000146370
slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr9_-_34121839 0.32 ENSDART00000000004
slc35a5
solute carrier family 35, member A5
chr23_+_25832689 0.31 ENSDART00000138907
hnf4a
hepatocyte nuclear factor 4, alpha
chr12_+_15487834 0.30 ENSDART00000181138
arhgap23b
Rho GTPase activating protein 23b
chr19_+_32822269 0.27 ENSDART00000052097
ENSDART00000052096
ENSDART00000188012
rida
reactive intermediate imine deaminase A homolog
chr18_+_39327010 0.26 ENSDART00000012164
tmod2
tropomodulin 2
chr15_+_15856178 0.26 ENSDART00000080338
dusp14
dual specificity phosphatase 14
chr22_+_11857356 0.25 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr10_-_7347311 0.22 ENSDART00000168885
nrg1
neuregulin 1
chr16_-_45225520 0.22 ENSDART00000158855
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr13_-_41908583 0.20 ENSDART00000136515
ipmka
inositol polyphosphate multikinase a
chr10_+_43088270 0.20 ENSDART00000191221
xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr6_-_36182115 0.19 ENSDART00000154639
brinp3a.2
bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
chr23_-_6982966 0.19 ENSDART00000033774
ENSDART00000169965
edem2
ER degradation enhancer, mannosidase alpha-like 2
chr15_-_4314042 0.18 ENSDART00000173311
ENSDART00000170562
ECE2
si:ch211-117a13.2
chr8_-_51507144 0.18 ENSDART00000024882
ENSDART00000135166
fgfr1a
fibroblast growth factor receptor 1a
chr4_+_5796761 0.18 ENSDART00000164854
si:ch73-352p4.8
si:ch73-352p4.8
chr3_-_26109322 0.17 ENSDART00000113780
zgc:162612
zgc:162612
chr2_+_7075220 0.17 ENSDART00000022963
cdc14aa
cell division cycle 14Aa
chr22_+_3238474 0.16 ENSDART00000157954
si:ch1073-178p5.3
si:ch1073-178p5.3
chr19_-_8798178 0.16 ENSDART00000188232
cers2a
ceramide synthase 2a
chr19_+_30990815 0.14 ENSDART00000134645
sync
syncoilin, intermediate filament protein
chr6_-_10964083 0.14 ENSDART00000181583
notum2
notum pectinacetylesterase 2
chr10_-_36220061 0.14 ENSDART00000160392
or109-7
odorant receptor, family D, subfamily 109, member 7
chr11_-_24532988 0.13 ENSDART00000067078
plekhg5a
pleckstrin homology domain containing, family G (with RhoGef domain) member 5a
chr18_+_33171765 0.13 ENSDART00000064153
si:ch73-125k17.2
si:ch73-125k17.2
chr1_-_16507812 0.13 ENSDART00000169081
mtmr7b
myotubularin related protein 7b
chr17_-_51260476 0.13 ENSDART00000084348
trappc12
trafficking protein particle complex 12
chr15_+_32297441 0.12 ENSDART00000153657
trim3a
tripartite motif containing 3a
chr19_+_31904836 0.12 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tpd52
tumor protein D52
chr19_-_22568203 0.12 ENSDART00000182888
pleca
plectin a
chr20_-_456998 0.12 ENSDART00000149973
frk
fyn-related Src family tyrosine kinase
chr17_+_33453689 0.11 ENSDART00000156894
rin3
Ras and Rab interactor 3
chr5_+_37379825 0.11 ENSDART00000171826
klhl13
kelch-like family member 13
chr19_+_14113886 0.10 ENSDART00000169343
kdf1b
keratinocyte differentiation factor 1b
chr15_+_4988189 0.10 ENSDART00000142995
ENSDART00000062852
spcs2
signal peptidase complex subunit 2
chr13_+_30421472 0.10 ENSDART00000143569
zmiz1a
zinc finger, MIZ-type containing 1a
chr6_-_60020385 0.09 ENSDART00000169990
ENSDART00000167740
ENSDART00000098247
wbp4
WW domain binding protein 4
chr15_+_14145346 0.09 ENSDART00000047531
clca5.2
chloride channel accessory 5, tandem duplicate 2
chr3_+_57779673 0.07 ENSDART00000101839
tmc6a
transmembrane channel-like 6a
chr13_-_17723417 0.06 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr14_-_12071679 0.05 ENSDART00000165581
tmsb1
thymosin beta 1
chr19_-_10771558 0.05 ENSDART00000085165
slc9a3.2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3, tandem duplicate 2
chr15_-_14486534 0.03 ENSDART00000179368
numbl
numb homolog (Drosophila)-like
chr2_+_33383227 0.03 ENSDART00000183068
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr20_+_3997684 0.02 ENSDART00000113184
arv1
ARV1 homolog, fatty acid homeostasis modulator
chr9_-_8895130 0.01 ENSDART00000144673
ENSDART00000138527
rab20
RAB20, member RAS oncogene family
chr13_+_31286076 0.01 ENSDART00000142725
gdf10a
growth differentiation factor 10a
chr20_+_36730049 0.00 ENSDART00000045948
ncoa1
nuclear receptor coactivator 1

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlha15_bhlhe23+si:ch211-196c10.13_bhlhe22

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0071361 cellular response to ethanol(GO:0071361)
1.0 4.1 GO:0060074 synapse maturation(GO:0060074)
0.5 2.8 GO:0031507 heterochromatin assembly(GO:0031507)
0.4 5.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.4 1.5 GO:0055107 Golgi to secretory granule transport(GO:0055107)
0.3 2.7 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.3 5.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 2.3 GO:0090303 positive regulation of wound healing(GO:0090303)
0.2 0.6 GO:1990697 protein depalmitoleylation(GO:1990697)
0.2 3.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 0.6 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 1.6 GO:0046548 retinal rod cell development(GO:0046548)
0.1 3.7 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.6 GO:0014896 muscle hypertrophy(GO:0014896)
0.1 0.7 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.7 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 1.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.9 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.6 GO:0090075 relaxation of muscle(GO:0090075)
0.1 2.1 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.2 GO:0036135 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.4 GO:0089700 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
0.1 0.6 GO:0042989 sequestering of actin monomers(GO:0042989)
0.1 0.5 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.2 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.1 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.0 0.4 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 0.7 GO:0048769 sarcomerogenesis(GO:0048769)
0.0 0.2 GO:0006266 DNA ligation(GO:0006266) immunoglobulin V(D)J recombination(GO:0033152) DNA ligation involved in DNA repair(GO:0051103)
0.0 1.9 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.7 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 1.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.3 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.3 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.1 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.9 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 1.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 1.8 GO:0006979 response to oxidative stress(GO:0006979)
0.0 0.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.7 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 8.2 GO:0043204 perikaryon(GO:0043204)
0.1 1.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 3.5 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 3.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.3 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.3 GO:0005921 gap junction(GO:0005921)
0.0 1.7 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.5 2.7 GO:0008743 L-threonine 3-dehydrogenase activity(GO:0008743)
0.2 5.0 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 3.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2 2.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 2.0 GO:0016936 galactoside binding(GO:0016936)
0.2 1.5 GO:0034452 dynactin binding(GO:0034452)
0.2 0.6 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.1 3.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.0 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 0.8 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.8 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 1.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 2.8 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.9 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.2 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 5.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.4 GO:0022829 wide pore channel activity(GO:0022829)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 1.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway
0.0 0.7 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 14.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 0.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 0.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle