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PRJEB1986: zebrafish developmental stages transcriptome

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Results for alx4a+alx4b

Z-value: 0.36

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Transcription factors associated with alx4a+alx4b

Gene Symbol Gene ID Gene Info
ENSDARG00000074442 ALX homeobox 4b
ENSDARG00000088332 ALX homeobox 4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
alx4adr11_v1_chr7_-_26924903_26924903-0.243.2e-01Click!
alx4bdr11_v1_chr18_+_38321039_383210390.223.6e-01Click!

Activity profile of alx4a+alx4b motif

Sorted Z-values of alx4a+alx4b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_22099536 1.85 ENSDART00000101923

chr22_+_7738966 1.26 ENSDART00000147073
si:ch73-44m9.5
chr17_-_37395460 1.11 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr3_-_31079186 1.07 ENSDART00000145636
ENSDART00000140569
elongin B
elongin B
chr25_+_29161609 0.94 ENSDART00000180752
pyruvate kinase M1/2b
chr9_-_22129788 0.85 ENSDART00000124272
ENSDART00000175417
crystallin, gamma M2d8
chr15_+_45640906 0.80 ENSDART00000149361
ENSDART00000149079
S-antigen; retina and pineal gland (arrestin) b
chr1_-_43915423 0.78 ENSDART00000181915
ENSDART00000113673
secretory calcium-binding phosphoprotein 5
chr3_+_24361096 0.74 ENSDART00000132387
parvalbumin 6
chr8_+_34731982 0.72 ENSDART00000066050
4-hydroxyphenylpyruvate dioxygenase b
chr6_-_607063 0.66 ENSDART00000189900
lectin, galactoside-binding, soluble, 2b
chr2_-_38000276 0.66 ENSDART00000034790
Purkinje cell protein 4 like 1
chr16_-_11798994 0.65 ENSDART00000135408
cornifelin
chr17_-_12336987 0.61 ENSDART00000172001
synaptosomal-associated protein, 25b
chr9_+_2574122 0.58 ENSDART00000166326
ENSDART00000191822
si:ch73-167c12.2
chr14_-_49063157 0.58 ENSDART00000021260
septin 8b
chr24_-_7697274 0.56 ENSDART00000186077
synaptotagmin Vb
chr16_-_28658341 0.56 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr21_+_21195487 0.54 ENSDART00000181746
ENSDART00000184832
RPTOR independent companion of MTOR, complex 2b
chr16_-_12173554 0.54 ENSDART00000110567
ENSDART00000155935
calsyntenin 3
chr5_+_2815021 0.52 ENSDART00000020472
4-hydroxyphenylpyruvate dioxygenase a
chr25_+_10811551 0.51 ENSDART00000167730
alanyl (membrane) aminopeptidase b
chr15_-_5815006 0.50 ENSDART00000102459
retinol binding protein 2a, cellular
chr3_+_62000822 0.49 ENSDART00000106680
retinoic acid induced 1
chr25_+_31276842 0.47 ENSDART00000187238
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr5_-_23280098 0.44 ENSDART00000126540
ENSDART00000051533
proteolipid protein 1b
chr25_+_5821910 0.43 ENSDART00000161035
chromosome 12 open reading frame 75
chr25_+_14087045 0.42 ENSDART00000155770
actin, alpha, cardiac muscle 1c
chr1_-_50438247 0.42 ENSDART00000114098
dickkopf WNT signaling pathway inhibitor 2
chr7_-_73752955 0.42 ENSDART00000171254
ENSDART00000009888
calsequestrin 1b
chr7_-_66868543 0.41 ENSDART00000149680
adenosine monophosphate deaminase 3a
chr21_-_20939488 0.41 ENSDART00000039043
regulator of G protein signaling 7 binding protein b
chr2_+_50608099 0.41 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr13_-_22862133 0.41 ENSDART00000138563
phenazine biosynthesis-like protein domain containing 2
chr5_-_41494831 0.41 ENSDART00000051081
eukaryotic translation elongation factor 2, like 2
chr2_-_27329667 0.40 ENSDART00000187490
thioredoxin related transmembrane protein 3a
chr11_+_42474694 0.40 ENSDART00000056048
ENSDART00000184710
si:ch1073-165f9.2
chr18_-_48983690 0.40 ENSDART00000182359

chr15_-_12258851 0.39 ENSDART00000180656
si:dkey-36i7.3
chr18_+_21408794 0.39 ENSDART00000140161
N-terminal EF-hand calcium binding protein 2
chr16_+_2820340 0.39 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
chr21_+_31150438 0.39 ENSDART00000065366
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_-_26869103 0.38 ENSDART00000089699
proline-rich transmembrane protein 1
chr8_+_43053519 0.38 ENSDART00000147178
prion protein a
chr16_-_12173399 0.37 ENSDART00000142574
calsyntenin 3
chr5_+_37068223 0.37 ENSDART00000164279
si:dkeyp-110c7.4
chr9_+_1139378 0.37 ENSDART00000170033
solute carrier family 15 (oligopeptide transporter), member 1a
chr6_+_39905021 0.37 ENSDART00000064904
endonuclease, polyU-specific
chr17_+_15433518 0.37 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr1_-_43948826 0.36 ENSDART00000132038
si:dkey-22i16.7
chr17_-_200316 0.36 ENSDART00000190561

chr16_-_28856112 0.36 ENSDART00000078543
synaptotagmin XIb
chr22_-_20011476 0.36 ENSDART00000093312
ENSDART00000093310
cugbp, Elav-like family member 5a
chr23_-_3681026 0.36 ENSDART00000192128
ENSDART00000040086
protein kinase C and casein kinase substrate in neurons 1a
chr21_+_28958471 0.35 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr20_+_18661624 0.35 ENSDART00000152136
ENSDART00000126959
tumor necrosis factor, alpha-induced protein 2a
chr25_+_8356707 0.35 ENSDART00000153708
mucin 5.1, oligomeric mucus/gel-forming
chr12_-_26153101 0.34 ENSDART00000076051
opsin 4b
chr21_+_45841731 0.34 ENSDART00000038657
fatty acid hydroxylase domain containing 2
chr4_+_21129752 0.34 ENSDART00000169764
synaptotagmin Ia
chr2_+_2223837 0.34 ENSDART00000101038
ENSDART00000129354
transmembrane inner ear
chr17_+_15433671 0.34 ENSDART00000149568
fatty acid binding protein 7, brain, a
chr3_+_26813058 0.34 ENSDART00000055537
suppressor of cytokine signaling 1a
chr14_+_40874608 0.33 ENSDART00000168448
si:ch211-106m9.1
chr9_-_35334642 0.33 ENSDART00000157195
neural cell adhesion molecule 2
chr19_+_43297546 0.32 ENSDART00000168002
lysosomal protein transmembrane 5
chr6_+_612594 0.32 ENSDART00000150903
kynureninase
chr2_+_44571200 0.32 ENSDART00000098132
kelch-like family member 24a
chr20_+_9128256 0.31 ENSDART00000163883
ENSDART00000183072
ENSDART00000187276
bisphosphate nucleotidase 1
chr3_-_21280373 0.31 ENSDART00000003939
synaptogyrin 1a
chr12_+_31713239 0.31 ENSDART00000122379
hyaluronan binding protein 2
chr6_-_43677125 0.31 ENSDART00000150128
forkhead box P1b
chr1_+_59293873 0.30 ENSDART00000168036
retinol dehydrogenase 8b
chr24_-_29586082 0.30 ENSDART00000136763
vav 3 guanine nucleotide exchange factor a
chr10_-_42519773 0.30 ENSDART00000039187
membrane-associated ring finger (C3HC4) 5, like
chr7_+_34620418 0.30 ENSDART00000081338
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr21_+_31150773 0.30 ENSDART00000126205
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr13_-_37229245 0.30 ENSDART00000140923
si:dkeyp-77c8.5
chr16_-_12316979 0.30 ENSDART00000182392
transient receptor potential cation channel, subfamily V, member 6
chr22_-_10482253 0.29 ENSDART00000143164
asporin (LRR class 1)
chr14_-_14659023 0.29 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr3_+_26814030 0.29 ENSDART00000180128
suppressor of cytokine signaling 1a
chr23_-_24483311 0.29 ENSDART00000185793
ENSDART00000109248
spen family transcriptional repressor
chr7_+_39634873 0.29 ENSDART00000114774
protein tyrosine phosphatase, non-receptor type 5
chr11_+_30057762 0.29 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr1_-_15797663 0.29 ENSDART00000177122
sarcoglycan zeta
chr13_-_29420885 0.29 ENSDART00000024225
choline O-acetyltransferase a
chr12_+_48634927 0.28 ENSDART00000168441
zgc:165653
chr15_-_46779934 0.28 ENSDART00000085136
chloride channel 2c
chr16_-_38118003 0.27 ENSDART00000058667
si:dkey-23o4.6
chr13_+_6342410 0.27 ENSDART00000065228
CUB and Sushi multiple domains 1a
chr10_+_17776981 0.27 ENSDART00000141693
chemokine (C-C motif) ligand 19b
chr10_-_35236949 0.26 ENSDART00000145804
yippee-like 2a
chr10_-_27049170 0.26 ENSDART00000143451
cornichon family AMPA receptor auxiliary protein 2
chr15_-_1941042 0.26 ENSDART00000112946
ENSDART00000155504
dedicator of cytokinesis 10
chr3_+_25154078 0.26 ENSDART00000156973
si:ch211-256m1.8
chr2_+_53204750 0.26 ENSDART00000163644
zgc:165603
chr25_-_19420949 0.26 ENSDART00000181338
microtubule-associated protein 1Ab
chr9_+_29643036 0.26 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr16_+_13818500 0.26 ENSDART00000135245
folliculin
chr7_+_23515966 0.26 ENSDART00000186893
ENSDART00000186189
zgc:109889
chr4_+_22480169 0.26 ENSDART00000146272
ENSDART00000066904
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
chr21_-_40174647 0.26 ENSDART00000183738
ENSDART00000076840
ENSDART00000145109
solute carrier organic anion transporter family, member 2B1
chr19_+_823945 0.25 ENSDART00000142287
protein phosphatase 1, regulatory subunit 18
chr9_+_54039006 0.25 ENSDART00000112441
toll-like receptor 7
chr14_-_4556896 0.25 ENSDART00000044678
ENSDART00000192863
gamma-aminobutyric acid type A receptor alpha2 subunit
chr15_-_12011390 0.25 ENSDART00000187403
si:dkey-202l22.6
chr11_+_44356707 0.25 ENSDART00000165219
serine/arginine-rich splicing factor 7b
chr15_-_33925851 0.25 ENSDART00000187807
ENSDART00000187780
myelin associated glycoprotein
chr15_-_462783 0.25 ENSDART00000161049
Danio rerio uncharacterized LOC100002960 (LOC100002960), mRNA.
chr6_+_24420523 0.25 ENSDART00000185461
transforming growth factor, beta receptor III
chr1_-_49250490 0.25 ENSDART00000150386
si:ch73-6k14.2
chr10_-_31015535 0.24 ENSDART00000146116
pannexin 3
chr24_+_7800486 0.24 ENSDART00000145504
protein tyrosine phosphatase, receptor type, h
chr21_-_22635245 0.24 ENSDART00000115224
ENSDART00000101782
nectin cell adhesion molecule 1a
chr3_-_59297532 0.24 ENSDART00000187991

chr1_+_55755304 0.24 ENSDART00000144983
trans-2,3-enoyl-CoA reductase b
chr6_+_11250033 0.24 ENSDART00000065411
ENSDART00000132677
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr6_+_11249706 0.24 ENSDART00000186547
ENSDART00000193287
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr16_+_34531486 0.23 ENSDART00000043291
progestin and adipoQ receptor family member VII, b
chr9_-_46399611 0.23 ENSDART00000164914
ENSDART00000145931
lactase
si:dkey-79p17.3
chr19_+_5480327 0.23 ENSDART00000148794
junction plakoglobin b
chr11_-_2838699 0.23 ENSDART00000066189
LHFPL tetraspan subfamily member 5a
chr14_-_858985 0.23 ENSDART00000148687
ENSDART00000149375
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr4_-_2219705 0.23 ENSDART00000131046
si:ch73-278m9.1
chr23_+_238893 0.23 ENSDART00000138198
si:ch73-162j3.4
chr11_+_44356504 0.23 ENSDART00000160678
serine/arginine-rich splicing factor 7b
chr5_+_64739762 0.23 ENSDART00000161112
ENSDART00000135610
ENSDART00000002908
olfactomedin 1a
chr19_-_27858033 0.23 ENSDART00000103898
ENSDART00000144884
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr7_+_24573721 0.23 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr13_-_20381485 0.23 ENSDART00000131351
si:ch211-270n8.1
chr8_-_13184989 0.22 ENSDART00000135738
zgc:194990
chr7_-_71829649 0.22 ENSDART00000160449
calcium channel, voltage-dependent, beta 2a
chr4_+_9669717 0.22 ENSDART00000004604
si:dkey-153k10.9
chr23_-_20051369 0.22 ENSDART00000049836
biglycan b
chr2_+_366429 0.22 ENSDART00000111746
si:dkey-33c14.6
chr10_-_13343831 0.22 ENSDART00000135941
interleukin 11 receptor, alpha
chr18_+_23218980 0.22 ENSDART00000185014
myocyte enhancer factor 2aa
chr12_-_41684729 0.22 ENSDART00000184461
Janus kinase and microtubule interacting protein 3
chr7_-_72261721 0.22 ENSDART00000172229
RAS guanyl releasing protein 2
chr21_-_275377 0.22 ENSDART00000157509
relaxin 1
chr2_-_48153945 0.22 ENSDART00000146553
phosphofructokinase, platelet b
chr12_+_18578597 0.22 ENSDART00000134944
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b
chr19_-_15397946 0.21 ENSDART00000143480
human immunodeficiency virus type I enhancer binding protein 3a
chr6_-_39489190 0.21 ENSDART00000151299
sodium channel, voltage gated, type VIII, alpha subunit b
chr21_+_8276989 0.21 ENSDART00000028265
nuclear receptor subfamily 5, group A, member 1b
chr9_-_43538328 0.21 ENSDART00000140526
zinc finger protein 385B
chr11_-_669558 0.21 ENSDART00000173450
peroxisome proliferator-activated receptor gamma
chr8_-_45838277 0.21 ENSDART00000046064
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr1_+_9966384 0.21 ENSDART00000132607
si:dkeyp-75b4.8
chr21_+_23108420 0.21 ENSDART00000192394
ENSDART00000088459
5-hydroxytryptamine (serotonin) receptor 3B
chr15_-_1885247 0.21 ENSDART00000149703
P450 (cytochrome) oxidoreductase b
chr13_+_7292061 0.21 ENSDART00000179504
Danio rerio neuroblast differentiation-associated protein AHNAK-like (LOC795051), mRNA.
chr20_-_9436521 0.21 ENSDART00000133000
zgc:101840
chr17_+_51627209 0.21 ENSDART00000056886
zgc:113142
chr2_+_55916911 0.21 ENSDART00000189483
ENSDART00000183647
ENSDART00000083470
ataxia, cerebellar, Cayman type b
chr6_+_25282671 0.21 ENSDART00000157575
si:ch211-180m24.3
chr15_-_44601331 0.20 ENSDART00000161514
zgc:165508
chr2_+_3986083 0.20 ENSDART00000188979
mohawk homeobox b
chr3_+_28953274 0.20 ENSDART00000133528
ENSDART00000103602
lectin, galactoside-binding, soluble, 2a
chr19_-_5103313 0.20 ENSDART00000037007
triosephosphate isomerase 1a
chr19_-_20113696 0.20 ENSDART00000188813
neuropeptide Y
chr15_+_34592215 0.19 ENSDART00000099776
tetraspanin 13a
chr5_-_16218777 0.19 ENSDART00000141698
kringle containing transmembrane protein 1
chr17_-_36896560 0.19 ENSDART00000045287
microtubule-associated protein, RP/EB family, member 3a
chr8_+_7359294 0.19 ENSDART00000121708
proprotein convertase subtilisin/kexin type 1 inhibitor, like
chr12_-_41662327 0.19 ENSDART00000191602
ENSDART00000170423
Janus kinase and microtubule interacting protein 3
chr23_-_16692312 0.19 ENSDART00000046784
FK506 binding protein 1Ab
chr3_-_32818607 0.19 ENSDART00000075465
myosin light chain, phosphorylatable, fast skeletal muscle a
chr11_-_2131280 0.19 ENSDART00000008409
calcium binding and coiled-coil domain 1b
chr8_+_52637507 0.19 ENSDART00000163830
si:dkey-90l8.3
chr20_+_591505 0.19 ENSDART00000046438
potassium channel, subfamily K, member 2b
chr10_-_2524297 0.19 ENSDART00000192475

chr18_+_39487486 0.19 ENSDART00000126978
acyl-CoA dehydrogenase long chain
chr25_-_35136267 0.19 ENSDART00000109751
zgc:173585
chr5_+_37903790 0.19 ENSDART00000162470
transmembrane protease, serine 4b
chr22_-_12160283 0.19 ENSDART00000146785
ENSDART00000128176
transmembrane protein 163b
chr20_+_3108597 0.19 ENSDART00000133435
si:ch73-212j7.1
chr6_+_11250316 0.18 ENSDART00000137122
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr16_-_31622777 0.18 ENSDART00000137311
ENSDART00000002930
PHD finger protein 20 like 1
chr9_+_34127005 0.18 ENSDART00000167384
ENSDART00000078065
coagulation factor V
chr22_+_1556948 0.18 ENSDART00000159050
si:ch211-255f4.8
chr7_-_66877058 0.18 ENSDART00000155954
adrenomedullin a
chr3_+_33341640 0.18 ENSDART00000186352
peptide YYa
chr7_-_71531846 0.18 ENSDART00000111797
alkaline ceramidase 2
chr13_+_1089942 0.18 ENSDART00000054322
cannabinoid receptor interacting protein 1b
chr13_-_18695289 0.18 ENSDART00000176809
sideroflexin 3
chr6_+_27151940 0.18 ENSDART00000088364
kinesin family member 1Aa
chr20_+_66857 0.18 ENSDART00000114999
leucine rich repeat and fibronectin type III domain containing 2b
chr12_-_6880694 0.18 ENSDART00000171846
protocadherin-related 15b
chr17_+_38476300 0.18 ENSDART00000123298
StAR-related lipid transfer (START) domain containing 9
chr14_-_34276574 0.18 ENSDART00000021437
glutamate receptor, ionotropic, AMPA 1a
chr10_-_11261565 0.18 ENSDART00000146727
polypyrimidine tract binding protein 3
chr12_+_31735159 0.18 ENSDART00000185442
si:dkey-49c17.3
chr2_+_48073972 0.18 ENSDART00000186442
Kruppel-like factor 6b
chr10_+_15255198 0.18 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr15_-_22074315 0.17 ENSDART00000149830
dopamine receptor D2a
chr20_+_32552912 0.17 ENSDART00000009691
Scm polycomb group protein like 4
chr13_-_2010191 0.17 ENSDART00000161021
ENSDART00000124134
GDNF family receptor alpha like
chr6_-_37468971 0.17 ENSDART00000126379
phosphatidylinositol-specific phospholipase C, X domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of alx4a+alx4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.2 1.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.4 GO:0014809 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.7 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.3 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.1 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.4 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.1 0.3 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 0.3 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.2 GO:0044406 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 0.2 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.3 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.1 0.3 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.8 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.1 0.1 GO:0051963 regulation of synapse assembly(GO:0051963)
0.1 0.7 GO:0044805 late nucleophagy(GO:0044805)
0.1 0.4 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.2 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.0 0.2 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 0.5 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.0 0.6 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.4 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.1 GO:0002407 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0060546 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.0 0.2 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.0 0.1 GO:0044038 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.4 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0070169 positive regulation of bone mineralization(GO:0030501) positive regulation of osteoblast differentiation(GO:0045669) positive regulation of ossification(GO:0045778) positive regulation of biomineral tissue development(GO:0070169)
0.0 0.3 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.0 0.1 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.7 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.0 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.1 GO:0051876 pigment granule dispersal(GO:0051876)
0.0 0.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.2 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.1 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.0 0.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.2 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0006007 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.9 GO:0006096 glycolytic process(GO:0006096)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.6 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.4 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 0.3 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:1900186 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.2 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.2 GO:0090303 positive regulation of wound healing(GO:0090303)
0.0 0.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.1 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 0.0 GO:0002369 T cell cytokine production(GO:0002369)
0.0 0.1 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.0 0.3 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.2 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.7 GO:0007599 hemostasis(GO:0007599)
0.0 0.1 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.0 0.6 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.1 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.5 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.2 GO:0001556 oocyte maturation(GO:0001556)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0030891 VCB complex(GO:0030891)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.1 0.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.0 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0044545 NSL complex(GO:0044545)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.2 0.6 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.2 0.9 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.2 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.3 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.4 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.1 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.8 GO:0016936 galactoside binding(GO:0016936)
0.1 0.3 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.2 GO:0035671 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 0.4 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 0.2 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.3 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.2 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.2 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.3 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0080132 fatty acid alpha-hydroxylase activity(GO:0080132)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.2 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.3 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 0.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine