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PRJEB1986: zebrafish developmental stages transcriptome

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Results for alx1

Z-value: 1.65

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Transcription factors associated with alx1

Gene Symbol Gene ID Gene Info
ENSDARG00000062824 ALX homeobox 1
ENSDARG00000110530 ALX homeobox 1
ENSDARG00000115230 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
alx1dr11_v1_chr18_+_16246806_162468060.625.0e-03Click!

Activity profile of alx1 motif

Sorted Z-values of alx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_31276842 19.81 ENSDART00000187238
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr1_-_43905252 9.62 ENSDART00000135477
ENSDART00000132089
si:dkey-22i16.3
chr4_-_13580348 7.86 ENSDART00000067160
opsin 1 (cone pigments), short-wave-sensitive 1
chr3_-_31079186 5.85 ENSDART00000145636
ENSDART00000140569
elongin B
elongin B
chr10_-_11385155 5.55 ENSDART00000064214
placenta-specific 8, tandem duplicate 1
chr20_-_40755614 5.38 ENSDART00000061247
connexin 32.3
chr19_+_10339538 4.98 ENSDART00000151808
ENSDART00000151235
recoverin 3
chr5_+_51594209 4.95 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
creatine kinase, mitochondrial 2b (sarcomeric)
chr25_+_31227747 4.62 ENSDART00000033872
troponin I type 2a (skeletal, fast), tandem duplicate 1
chr2_+_50608099 4.57 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr2_-_51794472 4.47 ENSDART00000186652

chr25_+_31277415 4.42 ENSDART00000036275
troponin I type 2a (skeletal, fast), tandem duplicate 4
chr17_-_37395460 4.41 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr9_+_34641237 4.31 ENSDART00000133996
short stature homeobox
chr23_-_27571667 4.30 ENSDART00000008174
phosphofructokinase, muscle a
chr23_+_40460333 4.25 ENSDART00000184658
SOGA family member 3b
chr16_+_5774977 4.24 ENSDART00000134202
cholecystokinin a
chr15_+_47903864 4.00 ENSDART00000063835
orthodenticle homolog 5
chr24_-_31452875 3.91 ENSDART00000187381
ENSDART00000185128
cyclic nucleotide gated channel beta 3, tandem duplicate 2
chr20_-_52902693 3.89 ENSDART00000166115
ENSDART00000161050
cathepsin Bb
chr6_-_46861676 3.83 ENSDART00000188712
ENSDART00000190148
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr14_-_2933185 3.82 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
chr21_+_42226113 3.76 ENSDART00000170362
gamma-aminobutyric acid type A receptor beta2 subunit
chr19_-_5103141 3.76 ENSDART00000150952
triosephosphate isomerase 1a
chr18_-_16801033 3.70 ENSDART00000100100
adrenomedullin b
chr15_-_34408777 3.64 ENSDART00000139934
alkylglycerol monooxygenase
chr23_+_20563779 3.60 ENSDART00000146008
CaM kinase-like vesicle-associated, like
chr24_-_7697274 3.54 ENSDART00000186077
synaptotagmin Vb
chr20_+_4060839 3.35 ENSDART00000178565
tripartite motif containing 67
chr15_-_16098531 3.35 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr18_+_15644559 3.31 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr5_-_23280098 3.25 ENSDART00000126540
ENSDART00000051533
proteolipid protein 1b
chr1_-_50859053 3.23 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
chr21_-_14251306 3.19 ENSDART00000114715
ENSDART00000181380
mannosidase, alpha, class 1B, member 1a
chr4_+_12612723 3.18 ENSDART00000133767
LIM domain only 3
chr13_+_29462249 3.12 ENSDART00000147903
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1a
chr16_-_28658341 3.10 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr21_+_10739846 3.03 ENSDART00000084011
complexin 4a
chr23_-_39666519 3.03 ENSDART00000110868
ENSDART00000190961
von Willebrand factor A domain containing 1
chr23_+_45584223 3.00 ENSDART00000149367
si:ch73-290k24.5
chr22_-_10486477 2.96 ENSDART00000184366
asporin (LRR class 1)
chr5_-_41494831 2.95 ENSDART00000051081
eukaryotic translation elongation factor 2, like 2
chr7_+_71547981 2.85 ENSDART00000012070
adenylate cyclase activating polypeptide 1a
chr6_-_50203682 2.80 ENSDART00000083999
ENSDART00000143050
RALY heterogeneous nuclear ribonucleoprotein
chr7_-_24699985 2.73 ENSDART00000052802
calbindin 2b
chr14_+_45675306 2.68 ENSDART00000105461
retinal outer segment membrane protein 1b
chr25_+_7504314 2.68 ENSDART00000163231
interferon induced transmembrane protein 5
chr21_-_22737228 2.64 ENSDART00000151366
F-box protein 40, tandem duplicate 2
chr20_-_39271844 2.62 ENSDART00000192708
clusterin
chr22_+_20427170 2.59 ENSDART00000136744
forkhead box Q2
chr7_+_73397283 2.56 ENSDART00000174390

chr15_-_46779934 2.56 ENSDART00000085136
chloride channel 2c
chr12_+_2522642 2.55 ENSDART00000152567
FERM and PDZ domain containing 2
chr19_-_5103313 2.53 ENSDART00000037007
triosephosphate isomerase 1a
chr20_-_9436521 2.51 ENSDART00000133000
zgc:101840
chr6_+_9175886 2.51 ENSDART00000165333
si:ch211-207l14.1
chr8_-_14126646 2.48 ENSDART00000027225
biglycan a
chr2_+_20332044 2.48 ENSDART00000112131
phospholipid phosphatase related 4a
chr23_-_19230627 2.43 ENSDART00000007122
guanylate cyclase activator 1B
chr6_+_9870192 2.42 ENSDART00000150894
si:ch211-222n4.6
chr4_+_21129752 2.39 ENSDART00000169764
synaptotagmin Ia
chr10_-_7756865 2.39 ENSDART00000114373
ENSDART00000125407
ENSDART00000016317
lysyl oxidase a
chr17_-_16965809 2.38 ENSDART00000153697
neurexin 3a
chr10_+_29698467 2.35 ENSDART00000163402
discs, large homolog 2 (Drosophila)
chr1_+_8601935 2.34 ENSDART00000152367
si:ch211-160d14.6
chr20_+_18551657 2.33 ENSDART00000147001
si:dkeyp-72h1.1
chr16_-_45058919 2.30 ENSDART00000177134
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr21_+_13366353 2.28 ENSDART00000151630
si:ch73-62l21.1
chr8_-_46525092 2.28 ENSDART00000030482
sulfotransferase family 1, cytosolic sulfotransferase 2
chr2_+_37227011 2.27 ENSDART00000126587
ENSDART00000084958
sterile alpha motif domain containing 7
chr4_+_8797197 2.26 ENSDART00000158671
sulfotransferase family 4A, member 1
chr7_+_71547747 2.26 ENSDART00000180869
adenylate cyclase activating polypeptide 1a
chr10_-_27049170 2.25 ENSDART00000143451
cornichon family AMPA receptor auxiliary protein 2
chr25_-_12937727 2.22 ENSDART00000172643
chemokine (C-C motif) ligand 39, duplicate 6
chr7_+_48761875 2.21 ENSDART00000003690
aggrecan a
chr5_+_37068223 2.19 ENSDART00000164279
si:dkeyp-110c7.4
chr1_-_10647484 2.19 ENSDART00000164541
ENSDART00000188958
ENSDART00000190904
si:dkey-31e10.1
chr2_+_3986083 2.18 ENSDART00000188979
mohawk homeobox b
chr8_+_43053519 2.17 ENSDART00000147178
prion protein a
chr21_+_28958471 2.15 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr13_+_38430466 2.15 ENSDART00000132691
adhesion G protein-coupled receptor B3
chr25_-_25384045 2.15 ENSDART00000150631
zgc:123278
chr25_+_3327071 2.13 ENSDART00000136131
ENSDART00000133243
lactate dehydrogenase Bb
chr9_-_14683574 2.12 ENSDART00000144022
par-3 family cell polarity regulator beta b
chr21_-_22827548 2.11 ENSDART00000079161
angiopoietin-like 5
chr7_-_27685365 2.11 ENSDART00000188342
calcitonin/calcitonin-related polypeptide, alpha
chr25_+_33849647 2.09 ENSDART00000121449
RAR-related orphan receptor A, paralog a
chr21_-_18993110 2.08 ENSDART00000144086
si:ch211-222n4.6
chr21_+_39705483 2.06 ENSDART00000147718
ENSDART00000168996
PITP-less RdgB-like protein
chr24_+_5208171 2.05 ENSDART00000155926
ENSDART00000154464
si:ch73-206p6.1
chr16_+_31804590 2.05 ENSDART00000167321
wingless-type MMTV integration site family, member 4b
chr3_+_25154078 2.02 ENSDART00000156973
si:ch211-256m1.8
chr25_-_27564205 2.02 ENSDART00000157319
hyaluronoglucosaminidase 4
chr1_+_31110817 2.02 ENSDART00000137863
eukaryotic translation elongation factor 1 alpha 1b
chr11_-_19694334 1.99 ENSDART00000054735
si:dkey-30j16.3
chr6_-_35439406 1.99 ENSDART00000073784
regulator of G protein signaling 5a
chr3_-_61162750 1.97 ENSDART00000055064
parvalbumin 8
chr2_+_6963296 1.97 ENSDART00000147146
discoidin domain receptor tyrosine kinase 2b
chr21_-_16632808 1.96 ENSDART00000172645
unc-5 netrin receptor Da
chr13_+_45709380 1.96 ENSDART00000192862
si:ch211-62a1.3
chr6_-_30839763 1.95 ENSDART00000154228
SH3-domain GRB2-like (endophilin) interacting protein 1a
chr19_+_19976990 1.94 ENSDART00000052627
neuropeptide VF precursor
chr12_+_24342303 1.94 ENSDART00000111239
neurexin 1a
chr15_-_22074315 1.93 ENSDART00000149830
dopamine receptor D2a
chr17_-_200316 1.92 ENSDART00000190561

chr6_-_38419318 1.91 ENSDART00000138026
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr21_-_41873584 1.90 ENSDART00000188089
endonuclease, polyU-specific 2
chr19_-_27261102 1.90 ENSDART00000143919
gamma-aminobutyric acid (GABA) B receptor, 1b
chr9_-_49493305 1.87 ENSDART00000148707
ENSDART00000148561
xin actin binding repeat containing 2b
chr11_-_24191928 1.87 ENSDART00000136827
SRY (sex determining region Y)-box 12
chr16_+_2820340 1.86 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
chr21_+_44857293 1.86 ENSDART00000134365
ENSDART00000168217
ENSDART00000065083
follistatin-like 4
chr14_+_25817628 1.85 ENSDART00000047680
glycine receptor, alpha 1
chr1_-_59287410 1.84 ENSDART00000158011
ENSDART00000170580
collagen, type V, alpha 3b
chr16_+_39159752 1.82 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr2_+_28672152 1.81 ENSDART00000157410
ENSDART00000169614
NAD synthetase 1
chr24_-_24282427 1.81 ENSDART00000123299
pyruvate dehydrogenase E1 alpha 1 subunit b
chr20_-_45062514 1.80 ENSDART00000183529
ENSDART00000182955
kelch-like family member 29
chr5_+_37903790 1.80 ENSDART00000162470
transmembrane protease, serine 4b
chr15_-_6247775 1.80 ENSDART00000148350
Down syndrome cell adhesion molecule b
chr18_+_14564085 1.79 ENSDART00000009363
ENSDART00000141813
ENSDART00000136120
si:dkey-246g23.4
chr8_+_635704 1.79 ENSDART00000130358
chondroitin sulfate N-acetylgalactosaminyltransferase 1b
chr1_+_135903 1.78 ENSDART00000124837
coagulation factor X
chr1_+_33969015 1.78 ENSDART00000042984
ENSDART00000146530
eph receptor A6
chr20_-_45060241 1.77 ENSDART00000185227
kelch-like family member 29
chr4_-_14315855 1.75 ENSDART00000133325
neural EGFL like 2b
chr20_+_32523576 1.74 ENSDART00000147319
Scm polycomb group protein like 4
chr13_+_4225173 1.74 ENSDART00000058242
ENSDART00000143456
male-enhanced antigen 1
chr19_-_5805923 1.72 ENSDART00000134340
si:ch211-264f5.8
chr6_+_51773873 1.71 ENSDART00000156516
transmembrane protein 74B
chr20_-_1151265 1.70 ENSDART00000012376
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr11_+_12052791 1.68 ENSDART00000158479
si:ch211-156l18.8
chr6_+_55032439 1.68 ENSDART00000164232
ENSDART00000158845
ENSDART00000157584
ENSDART00000026359
ENSDART00000122794
ENSDART00000183742
myosin binding protein Hb
chr18_+_1703984 1.68 ENSDART00000114010
SLIT and NTRK-like family, member 3a
chr10_-_26744131 1.68 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr21_+_3093419 1.67 ENSDART00000162520
SHC adaptor protein 3
chr4_+_11384891 1.67 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
piccolo presynaptic cytomatrix protein a
chr12_-_19007834 1.67 ENSDART00000153248
chondroadherin-like b
chr23_-_32157865 1.66 ENSDART00000000876
nuclear receptor subfamily 4, group A, member 1
chr8_+_3820134 1.65 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr3_-_25268751 1.63 ENSDART00000139423
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a
chr24_-_38110779 1.62 ENSDART00000147783
c-reactive protein, pentraxin-related
chr3_+_32553714 1.62 ENSDART00000165638
paired box 10
chr12_+_45677293 1.61 ENSDART00000152850
ENSDART00000153047
si:ch73-111m19.2
chr19_-_13808630 1.59 ENSDART00000166895
ENSDART00000187670
connective tissue growth factor b
chr16_+_34531486 1.59 ENSDART00000043291
progestin and adipoQ receptor family member VII, b
chr17_-_28198099 1.58 ENSDART00000156143
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr23_-_20051369 1.58 ENSDART00000049836
biglycan b
chr3_+_33341640 1.58 ENSDART00000186352
peptide YYa
chr10_-_35103208 1.54 ENSDART00000192734
zgc:110006
chr15_+_44366556 1.53 ENSDART00000133449
guanylate cyclase 1 soluble subunit alpha 2
chr15_-_29598679 1.53 ENSDART00000155153
si:ch211-207n23.2
chr12_+_41697664 1.52 ENSDART00000162302
BCL2 interacting protein 3
chr1_+_52392511 1.51 ENSDART00000144025
si:ch211-217k17.8
chr5_-_23999777 1.51 ENSDART00000085969
MAP7 domain containing 2a
chr22_-_10121880 1.50 ENSDART00000002348
retinol dehydrogenase 5 (11-cis/9-cis)
chr13_+_28701233 1.50 ENSDART00000135931
si:ch211-67n3.9
chr1_-_5455498 1.49 ENSDART00000040368
ENSDART00000114035
motor neuron and pancreas homeobox 2b
chr6_+_41038757 1.49 ENSDART00000011245
ectonucleoside triphosphate diphosphohydrolase 8
chr4_-_16334362 1.48 ENSDART00000101461
epiphycan
chr25_+_31267268 1.48 ENSDART00000181239
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr7_-_28148310 1.48 ENSDART00000044208
LIM domain only 1
chr17_-_7861219 1.46 ENSDART00000148604
spectrin repeat containing, nuclear envelope 1b
chr20_+_42565049 1.46 ENSDART00000061101
insulin-like growth factor 2 receptor
chr5_+_64732036 1.46 ENSDART00000073950
olfactomedin 1a
chr20_-_9273669 1.46 ENSDART00000175069
synaptotagmin XIVb
chr21_-_25722834 1.46 ENSDART00000101208
abhydrolase domain containing 11
chr5_-_28915130 1.46 ENSDART00000078592
neural proliferation, differentiation and control, 1b
chr23_-_32162810 1.44 ENSDART00000155905
nuclear receptor subfamily 4, group A, member 1
chr16_+_13883872 1.44 ENSDART00000101304
ENSDART00000136005
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr17_+_43032529 1.42 ENSDART00000055611
ENSDART00000154863
iron-sulfur cluster assembly 2
chr9_+_24159280 1.42 ENSDART00000184624
ENSDART00000178422
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr15_-_21877726 1.40 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr7_-_38792543 1.40 ENSDART00000157416
si:dkey-23n7.10
chr13_-_29420885 1.39 ENSDART00000024225
choline O-acetyltransferase a
chr22_+_18477934 1.39 ENSDART00000132684
cartilage intermediate layer protein 2
chr19_-_5865766 1.38 ENSDART00000191007

chr17_-_30666037 1.37 ENSDART00000156509
ALK and LTK ligand 2b
chr7_-_38658411 1.37 ENSDART00000109463
ENSDART00000017155
nephrosin
chr6_+_13730522 1.37 ENSDART00000153524
wingless-type MMTV integration site family, member 6a
chr21_-_21089781 1.37 ENSDART00000144361
ankyrin 1, erythrocytic b
chr25_-_13381854 1.36 ENSDART00000164621
ENSDART00000169129
NDRG family member 4
chr21_-_37790727 1.36 ENSDART00000162907
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr20_-_44496245 1.36 ENSDART00000012229
FK506 binding protein 1b
chr11_+_38280454 1.35 ENSDART00000171496
si:dkey-166c18.1
chr1_+_10118455 1.35 ENSDART00000152432
lecithin retinol acyltransferase b, tandem duplicate 2
chr15_-_44601331 1.35 ENSDART00000161514
zgc:165508
chr5_+_61301525 1.34 ENSDART00000128773
double C2-like domains, beta
chr10_+_21786656 1.34 ENSDART00000185851
ENSDART00000167219
protocadherin 1 gamma 26
chr18_-_1185772 1.34 ENSDART00000143245
neuroplastin b
chr19_-_32710922 1.33 ENSDART00000004034
hippocalcin
chr1_+_12766351 1.32 ENSDART00000165785
protocadherin 10a
chr22_-_12160283 1.32 ENSDART00000146785
ENSDART00000128176
transmembrane protein 163b
chr9_-_22821901 1.31 ENSDART00000101711
nebulin
chr4_+_14900042 1.31 ENSDART00000018261
aldo-keto reductase family 1, member B1 (aldose reductase)
chr16_+_47207691 1.31 ENSDART00000062507
islet cell autoantigen 1
chr3_+_28953274 1.30 ENSDART00000133528
ENSDART00000103602
lectin, galactoside-binding, soluble, 2a
chr3_+_17537352 1.30 ENSDART00000104549
hypocretin (orexin) neuropeptide precursor
chr1_-_15797663 1.29 ENSDART00000177122
sarcoglycan zeta
chr18_+_9637744 1.29 ENSDART00000190171
piccolo presynaptic cytomatrix protein b

Network of associatons between targets according to the STRING database.

First level regulatory network of alx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
1.5 4.4 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.8 3.1 GO:0045938 positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.7 3.6 GO:0046485 ether lipid metabolic process(GO:0046485)
0.7 2.7 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.6 1.3 GO:0022410 circadian sleep/wake cycle process(GO:0022410) circadian sleep/wake cycle(GO:0042745)
0.6 1.8 GO:0071361 cellular response to ethanol(GO:0071361)
0.6 31.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.6 3.4 GO:0003151 outflow tract morphogenesis(GO:0003151)
0.6 3.3 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.5 2.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.5 1.9 GO:0035095 behavioral response to nicotine(GO:0035095)
0.5 1.4 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.5 1.4 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.5 1.8 GO:0060074 synapse maturation(GO:0060074)
0.5 5.0 GO:0036368 cone photoresponse recovery(GO:0036368)
0.4 2.2 GO:0016322 neuron remodeling(GO:0016322)
0.4 1.7 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.4 1.2 GO:0072592 oxygen metabolic process(GO:0072592) regulation of oxygen metabolic process(GO:2000374) positive regulation of oxygen metabolic process(GO:2000376)
0.4 3.6 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.4 4.3 GO:0061718 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.4 5.0 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.3 7.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3 1.0 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.3 1.8 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.3 3.0 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.3 3.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.3 1.4 GO:0010872 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.3 1.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.3 0.8 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.3 3.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 2.3 GO:0008210 estrogen metabolic process(GO:0008210)
0.3 1.5 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.2 2.0 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.2 1.2 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 1.4 GO:0070375 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.2 0.7 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.2 1.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.2 0.7 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.2 0.9 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 2.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 0.4 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.2 6.4 GO:0030073 insulin secretion(GO:0030073)
0.2 3.3 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.2 1.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 1.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 1.0 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.2 0.8 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.2 2.7 GO:1901642 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.2 1.6 GO:0050795 regulation of behavior(GO:0050795)
0.2 1.9 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.2 1.5 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.2 1.3 GO:0090303 positive regulation of wound healing(GO:0090303)
0.2 1.5 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.2 0.6 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.2 0.5 GO:0032637 interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757)
0.2 0.5 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 1.5 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 2.8 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 2.4 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.1 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.0 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.1 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.0 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 1.9 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.8 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1 1.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 3.8 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 6.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.4 GO:0016540 protein autoprocessing(GO:0016540)
0.1 1.8 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 1.1 GO:0048532 anatomical structure arrangement(GO:0048532)
0.1 1.0 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 3.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 1.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.0 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 0.6 GO:2000389 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.1 2.6 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.5 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1 1.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 1.3 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 2.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 5.3 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 2.5 GO:0007631 feeding behavior(GO:0007631)
0.1 2.3 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 0.8 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 3.6 GO:0007586 digestion(GO:0007586)
0.1 1.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 1.0 GO:0046386 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
0.1 1.6 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 5.7 GO:0006414 translational elongation(GO:0006414)
0.1 2.8 GO:0009636 response to toxic substance(GO:0009636)
0.1 3.6 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 1.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.1 0.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.4 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 1.8 GO:0001556 oocyte maturation(GO:0001556)
0.1 2.3 GO:0051923 sulfation(GO:0051923)
0.1 1.3 GO:0097324 melanocyte migration(GO:0097324)
0.1 0.2 GO:1900158 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.1 3.3 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 1.0 GO:0033198 response to purine-containing compound(GO:0014074) response to ATP(GO:0033198) response to organophosphorus(GO:0046683)
0.1 0.2 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.1 15.0 GO:0050953 sensory perception of light stimulus(GO:0050953)
0.1 0.4 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 2.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 1.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 2.9 GO:0030282 bone mineralization(GO:0030282)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 1.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.3 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 1.1 GO:0033344 cholesterol efflux(GO:0033344)
0.1 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 1.5 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 1.2 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 1.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.1 1.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1 1.1 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.1 2.2 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 0.5 GO:2000251 regulation of actin cytoskeleton reorganization(GO:2000249) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 1.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.6 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 1.7 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.3 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 2.3 GO:0021575 hindbrain morphogenesis(GO:0021575)
0.0 3.6 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 1.0 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.6 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.0 GO:0070296 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) sarcoplasmic reticulum calcium ion transport(GO:0070296) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0 0.8 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.0 2.3 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.9 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 2.0 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 1.5 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 1.4 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 1.6 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.6 GO:1901214 regulation of neuron death(GO:1901214)
0.0 1.2 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.3 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 1.9 GO:0007596 blood coagulation(GO:0007596)
0.0 2.1 GO:0007254 JNK cascade(GO:0007254)
0.0 1.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.4 GO:0006825 copper ion transport(GO:0006825)
0.0 0.5 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 2.3 GO:0010506 regulation of autophagy(GO:0010506)
0.0 3.2 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.6 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 1.3 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0 1.7 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 1.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 1.4 GO:0099518 vesicle cytoskeletal trafficking(GO:0099518)
0.0 0.4 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.8 GO:0030641 regulation of pH(GO:0006885) regulation of cellular pH(GO:0030641)
0.0 0.6 GO:0032456 endocytic recycling(GO:0032456)
0.0 1.1 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.1 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.3 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.3 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.2 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 2.2 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.0 GO:0060347 trabecula formation(GO:0060343) heart trabecula formation(GO:0060347)
0.0 2.0 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.5 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.4 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.0 0.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0033628 regulation of cell adhesion mediated by integrin(GO:0033628)
0.0 0.3 GO:0007041 lysosomal transport(GO:0007041)
0.0 0.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.3 GO:0030891 VCB complex(GO:0030891)
0.7 31.5 GO:0005861 troponin complex(GO:0005861)
0.5 3.5 GO:0031045 dense core granule(GO:0031045)
0.5 5.0 GO:0042583 chromaffin granule(GO:0042583)
0.4 4.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.4 2.2 GO:0005955 calcineurin complex(GO:0005955)
0.4 2.2 GO:0043083 synaptic cleft(GO:0043083)
0.3 2.6 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.3 1.8 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 3.0 GO:0098982 GABA-ergic synapse(GO:0098982)
0.3 1.4 GO:0030314 junctional membrane complex(GO:0030314)
0.3 5.8 GO:0043195 terminal bouton(GO:0043195)
0.2 9.3 GO:0043204 perikaryon(GO:0043204)
0.2 3.2 GO:0043209 myelin sheath(GO:0043209)
0.2 1.9 GO:0044295 axonal growth cone(GO:0044295)
0.2 0.5 GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556)
0.1 3.1 GO:0032420 stereocilium(GO:0032420)
0.1 5.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 6.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.8 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 1.4 GO:0042627 chylomicron(GO:0042627)
0.1 1.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.7 GO:0030904 retromer complex(GO:0030904)
0.1 1.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.9 GO:0098978 glutamatergic synapse(GO:0098978)
0.1 1.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.5 GO:0016586 RSC complex(GO:0016586)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 10.8 GO:0030424 axon(GO:0030424)
0.0 1.0 GO:0005921 gap junction(GO:0005921)
0.0 0.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 3.7 GO:0016459 myosin complex(GO:0016459)
0.0 1.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.5 GO:0030018 Z disc(GO:0030018)
0.0 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 27.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 5.2 GO:0030425 dendrite(GO:0030425)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.9 GO:0043005 neuron projection(GO:0043005)
0.0 2.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.5 GO:0031968 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.3 GO:0043235 receptor complex(GO:0043235)
0.0 0.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 11.0 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
1.3 5.1 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
1.0 3.1 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.7 2.1 GO:0031716 calcitonin receptor binding(GO:0031716)
0.6 3.3 GO:0032052 bile acid binding(GO:0032052)
0.5 2.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5 2.7 GO:0031843 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.4 4.0 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.4 1.3 GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity(GO:0047173)
0.4 3.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 2.0 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.4 1.2 GO:0033819 lipoyl(octanoyl) transferase activity(GO:0033819)
0.4 5.1 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.4 4.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.4 5.0 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.4 1.8 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.4 2.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 2.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 3.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 3.2 GO:0005042 netrin receptor activity(GO:0005042)
0.3 2.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.3 2.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.3 2.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.3 2.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 2.3 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.3 1.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.3 1.4 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 2.6 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 1.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.3 0.8 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.3 2.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 1.9 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 1.4 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.2 2.0 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.2 2.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 3.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 1.8 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 1.8 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.8 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 0.8 GO:0048531 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.2 5.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 2.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 3.0 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.2 0.8 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 5.0 GO:0016917 GABA receptor activity(GO:0016917)
0.1 1.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.6 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 1.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.5 GO:0051139 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.1 2.2 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 1.3 GO:0016936 galactoside binding(GO:0016936)
0.1 0.5 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.1 5.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 6.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 4.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 3.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 3.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 2.0 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 1.4 GO:0030507 spectrin binding(GO:0030507)
0.1 3.0 GO:0005518 collagen binding(GO:0005518)
0.1 1.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 4.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 1.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.7 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 2.6 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.6 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.4 GO:0050699 WW domain binding(GO:0050699)
0.1 1.5 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 0.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.5 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 1.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 1.8 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0005231 excitatory extracellular ligand-gated ion channel activity(GO:0005231)
0.1 0.5 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.6 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.9 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.5 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.6 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 1.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.2 GO:0031005 filamin binding(GO:0031005)
0.1 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0005537 mannose binding(GO:0005537)
0.1 0.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 4.5 GO:0019905 syntaxin binding(GO:0019905)
0.1 2.6 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.7 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.7 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.0 0.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 1.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.0 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.9 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.0 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.2 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.0 0.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.7 GO:0005501 retinoid binding(GO:0005501) isoprenoid binding(GO:0019840)
0.0 1.3 GO:0030145 manganese ion binding(GO:0030145)
0.0 1.6 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.9 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.9 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 2.2 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 0.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.9 GO:0099589 serotonin receptor activity(GO:0099589)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 1.1 GO:0044325 ion channel binding(GO:0044325)
0.0 0.9 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 1.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.5 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.2 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 1.4 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.2 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.0 1.9 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 6.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 3.9 PID CONE PATHWAY Visual signal transduction: Cones
0.2 2.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 6.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 1.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.0 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 1.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 5.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 3.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.1 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 3.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 2.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.0 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 1.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 1.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 2.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1