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PRJEB1986: zebrafish developmental stages transcriptome

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Results for SPDEF

Z-value: 1.70

Motif logo

Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
ENSDARG00000029930 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFdr11_v1_chr6_-_54290227_542902270.634.2e-03Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_22749553 3.42 ENSDART00000040033
nucleoporin 107
chr23_-_33775145 3.34 ENSDART00000132147
ENSDART00000027959
ENSDART00000160116
Rac GTPase activating protein 1
chr20_+_39344889 3.30 ENSDART00000009164
establishment of sister chromatid cohesion N-acetyltransferase 2
chr20_+_13141408 3.22 ENSDART00000034098
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr8_+_23726708 3.17 ENSDART00000142395
makorin, ring finger protein, 4
chr18_+_29898955 3.08 ENSDART00000064080
centromere protein N
chr6_-_34860574 3.02 ENSDART00000073957
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1a
chr1_+_49435017 2.96 ENSDART00000124833
programmed cell death 11
chr21_-_36619599 2.86 ENSDART00000065208
NOP16 nucleolar protein homolog (yeast)
chr18_-_3552414 2.70 ENSDART00000163762
ENSDART00000165434
ENSDART00000161197
ENSDART00000166841
ENSDART00000170260
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
chr19_+_34742706 2.64 ENSDART00000103276
family with sequence similarity 206, member A
chr15_-_43625549 2.63 ENSDART00000168589
cathepsin C
chr3_-_3398383 2.62 ENSDART00000047865
si:dkey-46g23.2
chr17_-_12966907 2.60 ENSDART00000022874
proteasome subunit alpha 6a
chr18_-_26797723 2.56 ENSDART00000008013
SEC11 homolog A, signal peptidase complex subunit
chr25_-_3347418 2.54 ENSDART00000082385
golgi transport 1Bb
chr3_-_34136778 2.52 ENSDART00000131951
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr14_-_23684814 2.51 ENSDART00000024604
methionyl-tRNA synthetase 2, mitochondrial
chr9_-_24218367 2.49 ENSDART00000135356
nucleic acid binding protein 1a
chr7_-_57637779 2.48 ENSDART00000028017
MAD2 mitotic arrest deficient-like 1 (yeast)
chr19_-_34742440 2.47 ENSDART00000122625
ENSDART00000175621
elongator acetyltransferase complex subunit 2
chr9_+_56232548 2.46 ENSDART00000099276
CCR4-NOT transcription complex, subunit 11
chr11_+_2202987 2.45 ENSDART00000190008
ENSDART00000173139
homeobox C6b
chr25_+_27405738 2.45 ENSDART00000183266
ENSDART00000115139
protection of telomeres 1 homolog
chr5_+_44806374 2.44 ENSDART00000184237
cathepsin La
chr5_+_28497956 2.44 ENSDART00000191935
notochord formation related
chr6_-_18531349 2.43 ENSDART00000160693
ENSDART00000169780
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr18_-_22735002 2.42 ENSDART00000023721
nudix hydrolase 21
chr1_-_51720633 2.37 ENSDART00000045894
ribonuclease H2, subunit A
chr3_-_27065477 2.34 ENSDART00000185660
activating transcription factor 7 interacting protein 2
chr3_-_24681404 2.33 ENSDART00000161612

chr2_+_3044992 2.33 ENSDART00000020463
zgc:63882
chr19_+_9455218 2.32 ENSDART00000139385
si:ch211-288g17.3
chr16_+_33938227 2.29 ENSDART00000166254
GPN-loop GTPase 2
chr21_+_5080789 2.26 ENSDART00000024199
ATP synthase F1 subunit alpha
chr19_-_34089205 2.25 ENSDART00000163618
ENSDART00000161666
RP9, pre-mRNA splicing factor
chr8_+_28593707 2.24 ENSDART00000097213
transcription factor 15
chr11_-_16115804 2.24 ENSDART00000143436
ENSDART00000157928
ribosome production factor 1 homolog
chr5_+_64856666 2.23 ENSDART00000050863
zgc:101858
chr8_+_23726244 2.22 ENSDART00000132734
makorin, ring finger protein, 4
chr3_-_40276057 2.18 ENSDART00000132225
ENSDART00000074737
serine hydroxymethyltransferase 1 (soluble)
chr3_-_27066451 2.18 ENSDART00000156228
ENSDART00000156311
activating transcription factor 7 interacting protein 2
chr2_+_30182431 2.12 ENSDART00000004903
retinol dehydrogenase 10b
chr4_-_1824836 2.12 ENSDART00000111858
mitochondrial ribosomal protein L42
chr12_+_6465557 2.11 ENSDART00000066477
ENSDART00000122271
dickkopf WNT signaling pathway inhibitor 1b
chr21_+_26539157 2.11 ENSDART00000021121
syntaxin 5A, like
chr7_+_1505507 2.10 ENSDART00000161015
NOP10 ribonucleoprotein homolog (yeast)
chr1_+_24557414 2.10 ENSDART00000076519
dCTP pyrophosphatase 1
chr7_-_30177691 2.09 ENSDART00000046689
transmembrane p24 trafficking protein 3
chr3_-_34136368 2.09 ENSDART00000136900
ENSDART00000186125
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr11_-_15296805 2.07 ENSDART00000124968
ribophorin II
chr8_-_1267247 2.03 ENSDART00000150064
cell division cycle 14B
chr6_+_3334710 2.03 ENSDART00000132848
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr1_-_28950366 2.02 ENSDART00000110270
PWP2 periodic tryptophan protein homolog (yeast)
chr13_-_33700461 2.01 ENSDART00000160520
MAD2L1 binding protein
chr16_-_31824525 2.00 ENSDART00000058737
cell division cycle 42, like
chr5_-_29780752 2.00 ENSDART00000137400
ENSDART00000145021
cilia and flagella associated protein 77
chr3_+_19665319 1.99 ENSDART00000007857
ENSDART00000193509
methyltransferase like 2A
chr20_+_39685572 1.99 ENSDART00000050729
HD domain containing 2
chr12_-_31724198 1.97 ENSDART00000153056
ENSDART00000165299
ENSDART00000137464
ENSDART00000080173
serine/arginine-rich splicing factor 2a
chr21_-_40938382 1.96 ENSDART00000008593
Yip1 domain family, member 5
chr18_-_18584839 1.96 ENSDART00000159274
splicing factor 3b, subunit 3
chr4_+_5506952 1.96 ENSDART00000032857
ENSDART00000160222
mitogen-activated protein kinase 11
chr14_-_10617923 1.95 ENSDART00000133723
ENSDART00000131939
ENSDART00000136649
si:dkey-92i17.2
chr24_+_19522094 1.95 ENSDART00000191042
ENSDART00000184714
ENSDART00000180782
sulfatase 1
chr22_-_10752471 1.93 ENSDART00000081191
SAS-6 centriolar assembly protein
chr15_-_15230264 1.92 ENSDART00000155400
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr5_+_41477954 1.91 ENSDART00000185871
protein inhibitor of activated STAT, 2
chr4_+_13931578 1.88 ENSDART00000142466
periphilin 1
chr12_-_28363111 1.87 ENSDART00000016283
ENSDART00000164156
proteasome 26S subunit, non-ATPase 11b
chr14_+_712115 1.86 ENSDART00000157494
ENSDART00000166516
ENSDART00000082017
ENSDART00000122374
ENSDART00000170203
integrator complex subunit 10
chr2_+_48303142 1.85 ENSDART00000023040
hes family bHLH transcription factor 6
chr8_+_47683539 1.84 ENSDART00000190701
dipeptidyl-peptidase 9
chr13_+_33655404 1.83 ENSDART00000023379
mitochondrial genome maintenance exonuclease 1
chr9_-_28255029 1.82 ENSDART00000160387
cyclin Y-like 1
chr14_+_4276394 1.82 ENSDART00000038301
glucosamine-6-phosphate deaminase 2
chr16_-_44673851 1.82 ENSDART00000015139
ddb1 and cul4 associated factor 13
chr5_+_51833132 1.80 ENSDART00000167491
PAP associated domain containing 4
chr6_-_29159888 1.77 ENSDART00000110288
zinc finger and BTB domain containing 11
chr1_+_12335816 1.77 ENSDART00000067086
N-acetylneuraminic acid synthase a
chr24_-_7826489 1.77 ENSDART00000112777
si:dkey-197c15.6
chr22_+_10752787 1.75 ENSDART00000186542
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr2_+_16798923 1.74 ENSDART00000181603
ENSDART00000179816
ENSDART00000087107
ENSDART00000187009
eukaryotic translation initiation factor 4 gamma, 1a
chr22_+_10752511 1.73 ENSDART00000081188
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr5_+_25084385 1.72 ENSDART00000134526
ENSDART00000111863
PAXX, non-homologous end joining factor
chr8_-_17184482 1.72 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr8_-_14080534 1.71 ENSDART00000042867
death effector domain containing
chr7_-_13906409 1.70 ENSDART00000062257
solute carrier family 39 (zinc transporter), member 1
chr7_+_38809241 1.66 ENSDART00000190979
harbinger transposase derived 1
chr24_-_13349464 1.66 ENSDART00000134482
ENSDART00000139212
telomeric repeat binding factor (NIMA-interacting) 1
chr7_-_66693712 1.63 ENSDART00000021317
CTR9 homolog, Paf1/RNA polymerase II complex component
chr5_-_52010122 1.63 ENSDART00000073627
ENSDART00000163898
ENSDART00000051003
cyclin-dependent kinase 7
chr22_-_5663354 1.62 ENSDART00000081774
coiled-coil domain containing 51
chr5_+_44346691 1.61 ENSDART00000034523
threonyl-tRNA synthetase
chr14_-_5407555 1.61 ENSDART00000001424
polycomb group ring finger 1
chr22_+_5663529 1.59 ENSDART00000106141
translation machinery associated 7 homolog
chr1_-_31657644 1.59 ENSDART00000142296
deleted in primary ciliary dyskinesia homolog (mouse)
chr4_+_9536860 1.56 ENSDART00000130083
LSM8 homolog, U6 small nuclear RNA associated
chr9_-_41090048 1.54 ENSDART00000131681
ENSDART00000182552
asparagine synthetase domain containing 1
chr20_-_48898560 1.54 ENSDART00000163071
5'-3' exoribonuclease 2
chr6_-_18531760 1.54 ENSDART00000167167
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr13_+_9559461 1.54 ENSDART00000047740
WD repeat domain 32
chr23_-_24234371 1.53 ENSDART00000124539
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr5_+_42064144 1.53 ENSDART00000035235
si:ch211-202a12.4
chr18_-_40884087 1.53 ENSDART00000059194
small nuclear ribonucleoprotein D2 polypeptide
chr8_-_41279326 1.53 ENSDART00000075491
POP5 homolog, ribonuclease P/MRP subunit
chr14_-_30897177 1.52 ENSDART00000087918
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3b
chr7_+_756942 1.51 ENSDART00000152224
zgc:63470
chr14_-_43616572 1.49 ENSDART00000111189
GAR1 homolog, ribonucleoprotein
chr19_+_43004408 1.48 ENSDART00000038230
small nuclear ribonucleoprotein 40 (U5)
chr1_+_41596099 1.47 ENSDART00000111367
si:dkey-56e3.3
chr19_+_3842891 1.47 ENSDART00000159043
LSM10, U7 small nuclear RNA associated
chr11_+_6374448 1.47 ENSDART00000135906

chr17_+_6452511 1.46 ENSDART00000064694
Danio rerio TatD DNase domain containing 3-like (LOC571912), mRNA.
chr23_+_16928506 1.46 ENSDART00000162292
ENSDART00000080625
si:dkey-147f3.4
chr16_+_33931032 1.46 ENSDART00000167240
Smad nuclear interacting protein
chr17_-_31579715 1.44 ENSDART00000110167
ENSDART00000191092
RNA polymerase II associated protein 1
chr7_-_71384391 1.43 ENSDART00000112841
coiled-coil domain containing 149a
chr5_+_47863153 1.43 ENSDART00000051518
RAS p21 protein activator (GTPase activating protein) 1a
chr2_+_32846602 1.41 ENSDART00000056649
transmembrane protein 53
chr4_-_20108833 1.40 ENSDART00000100867
family with sequence similarity 3, member C
chr21_-_30994577 1.40 ENSDART00000065503
post-GPI attachment to proteins 2
chr18_+_6638726 1.40 ENSDART00000142755
ENSDART00000167781
C2 calcium-dependent domain containing 5
chr15_-_43284021 1.39 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr12_+_46543572 1.39 ENSDART00000167510
HID1 domain containing b
chr13_-_33654931 1.37 ENSDART00000020350
sorting nexin 5
chr15_+_17343319 1.37 ENSDART00000018461
vacuole membrane protein 1
chr5_-_28041715 1.36 ENSDART00000078660
zgc:113436
chr5_-_25084318 1.36 ENSDART00000089339
diphthamide biosynthesis 7
chr3_+_59880317 1.34 ENSDART00000166922
ENSDART00000108647
Aly/REF export factor
chr6_-_54444929 1.32 ENSDART00000154121
Sys1 golgi trafficking protein
chr23_+_4260458 1.31 ENSDART00000103747
serine/arginine-rich splicing factor 6a
chr1_-_44581937 1.30 ENSDART00000009858
thioredoxin-related transmembrane protein 2b
chr9_+_25853052 1.30 ENSDART00000127135
glycosyltransferase-like domain containing 1
chr15_-_34668485 1.30 ENSDART00000186605
BCL2 associated athanogene 6
chr2_-_45510699 1.29 ENSDART00000024034
ENSDART00000145634
G protein signaling modulator 2
chr6_-_2222707 1.28 ENSDART00000022179
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr20_-_5369105 1.28 ENSDART00000114316
serine palmitoyltransferase, long chain base subunit 2b
chr12_-_14211293 1.28 ENSDART00000158399
AVL9 homolog (S. cerevisiase)
chr17_+_24684778 1.27 ENSDART00000146309
ENSDART00000082237
zinc finger protein 593
chr10_+_15970 1.27 ENSDART00000040240
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr24_-_13349802 1.26 ENSDART00000164729
telomeric repeat binding factor (NIMA-interacting) 1
chr18_+_6638974 1.25 ENSDART00000162398
C2 calcium-dependent domain containing 5
chr22_-_16494406 1.25 ENSDART00000062727
syntaxin 6
chr7_-_34062301 1.25 ENSDART00000052404
mitogen-activated protein kinase kinase 5
chr6_-_54433995 1.24 ENSDART00000017230
small nuclear ribonucleoprotein polypeptide C
chr5_+_29714786 1.24 ENSDART00000148314
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr6_+_3334392 1.23 ENSDART00000133707
ENSDART00000130879
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr3_-_36419641 1.23 ENSDART00000173545
component of oligomeric golgi complex 1
chr2_-_3044947 1.21 ENSDART00000192642
guanylate kinase 1a
chr25_+_3347461 1.21 ENSDART00000104888
solute carrier family 35, member B4
chr6_+_41808673 1.20 ENSDART00000038163
RAD18 E3 ubiquitin protein ligase
chr9_+_2333927 1.18 ENSDART00000123340
ATP synthase membrane subunit c locus 3a
chr5_+_32490238 1.17 ENSDART00000191839
NADPH dependent diflavin oxidoreductase 1
chr21_-_22892124 1.17 ENSDART00000065563
coiled-coil domain containing 90B
chr9_+_40874194 1.17 ENSDART00000141548
3-hydroxyisobutyryl-CoA hydrolase
chr16_+_38337783 1.15 ENSDART00000135008
GA binding protein transcription factor, beta subunit 2b
chr14_+_28438947 1.14 ENSDART00000006489
acyl-CoA synthetase long chain family member 4a
chr5_+_51833305 1.13 ENSDART00000165276
ENSDART00000166443
PAP associated domain containing 4
chr17_+_8754020 1.13 ENSDART00000105322
erythroid differentiation regulatory factor 1
chr7_-_29356084 1.13 ENSDART00000075757
general transcription factor IIA, 2
chr1_+_46598764 1.13 ENSDART00000053240
calcium binding protein 39-like
chr15_+_7064819 1.12 ENSDART00000155268
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr3_-_30153242 1.12 ENSDART00000077089
nucleobindin 1
chr11_+_24348425 1.12 ENSDART00000089747
NFS1 cysteine desulfurase
chr1_-_23294753 1.10 ENSDART00000013263
UDP-glucose 6-dehydrogenase
chr23_-_4225606 1.10 ENSDART00000014152
ENSDART00000133341
AAR2 splicing factor homolog (S. cerevisiae)
chr25_+_8921425 1.10 ENSDART00000128591
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
chr2_+_2772447 1.09 ENSDART00000124882
THO complex 1
chr5_-_67292690 1.07 ENSDART00000062366
arginine/serine-rich coiled-coil 2
chr20_-_16906623 1.06 ENSDART00000012859
ENSDART00000171628
proteasome subunit alpha 6b
chr11_+_44622472 1.06 ENSDART00000159068
ENSDART00000166323
ENSDART00000187753
RNA binding motif protein 34
chr17_+_20237727 1.06 ENSDART00000180115
survival motor neuron domain containing 1
chr5_+_64397454 1.06 ENSDART00000015940
endothelial differentiation-related factor 1
chr13_-_5569562 1.05 ENSDART00000102576
Meis homeobox 1 b
chr8_-_1266181 1.05 ENSDART00000148654
ENSDART00000149924
cell division cycle 14B
chr9_-_41090343 1.04 ENSDART00000187769
ENSDART00000180078
ENSDART00000166785
asparagine synthetase domain containing 1
chr5_+_54555567 1.04 ENSDART00000171159
anaphase promoting complex subunit 2
chr20_-_23254876 1.03 ENSDART00000141510
OCIA domain containing 1
chr5_-_26893310 1.02 ENSDART00000126669
lectin, mannose-binding 2-like b
chr20_-_10487951 1.02 ENSDART00000064112
glutaredoxin 5 homolog (S. cerevisiae)
chr23_+_36115541 1.02 ENSDART00000130090
homeobox C6a
chr15_+_38299385 1.01 ENSDART00000142403
si:dkey-24p1.6
chr20_+_27087539 1.01 ENSDART00000062094
transmembrane protein 251
chr8_+_24740013 1.01 ENSDART00000126897
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr19_+_37118547 0.97 ENSDART00000103163
connexin 30.9
chr7_+_35193832 0.95 ENSDART00000189002
zinc finger, DHHC-type containing 1
chr9_-_40873934 0.95 ENSDART00000066424
protein O-fucosyltransferase 2
chr7_+_29177191 0.94 ENSDART00000008096
APH1B gamma secretase subunit
chr22_-_10826 0.94 ENSDART00000125700
mitochondrial ribosomal protein L20
chr15_-_29114449 0.94 ENSDART00000145748
ENSDART00000109482
ENSDART00000179123
zgc:162698
chr2_-_42173834 0.94 ENSDART00000098357
ENSDART00000144707
solute carrier family 39 (zinc transporter), member 6
chr15_-_2519640 0.93 ENSDART00000047013
signal recognition particle receptor, B subunit
chr4_+_13931733 0.93 ENSDART00000141742
ENSDART00000067175
periphilin 1
chr3_-_30152836 0.92 ENSDART00000165920
nucleobindin 1
chr5_+_29715040 0.92 ENSDART00000192563
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr20_+_52492192 0.91 ENSDART00000057986
zgc:100864
chr17_-_24684687 0.91 ENSDART00000105457
MORN repeat containing 2
chr7_-_38861741 0.90 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
PHD finger protein 21Aa
chr1_-_44048798 0.90 ENSDART00000073746
si:ch73-109d9.2

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.1 3.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.8 2.4 GO:1990120 messenger ribonucleoprotein complex assembly(GO:1990120)
0.7 2.2 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.7 2.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.7 2.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.6 2.6 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.6 1.8 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.6 1.8 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.6 2.8 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.5 2.7 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.5 2.5 GO:0051972 regulation of telomerase activity(GO:0051972)
0.5 1.4 GO:0015074 DNA integration(GO:0015074)
0.4 2.1 GO:0061011 hepatic duct development(GO:0061011)
0.4 3.2 GO:0072422 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.4 2.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.4 1.8 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.3 5.8 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.3 1.9 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.3 1.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 2.6 GO:0006465 signal peptide processing(GO:0006465)
0.3 0.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.3 1.9 GO:0040016 embryonic cleavage(GO:0040016)
0.3 8.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 1.5 GO:0090467 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.2 2.0 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.2 1.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 2.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 3.2 GO:0045116 protein neddylation(GO:0045116)
0.2 1.5 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.2 1.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 1.2 GO:0006574 valine catabolic process(GO:0006574)
0.2 0.8 GO:0021742 abducens nucleus development(GO:0021742)
0.2 3.1 GO:0051382 kinetochore assembly(GO:0051382)
0.2 1.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 1.1 GO:1900744 regulation of p38MAPK cascade(GO:1900744)
0.2 0.6 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.2 0.7 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 2.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 4.6 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.2 1.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 2.1 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.7 GO:0060043 regulation of cardiac muscle tissue growth(GO:0055021) regulation of cardiac muscle cell proliferation(GO:0060043)
0.2 0.9 GO:0006004 fucose metabolic process(GO:0006004)
0.2 1.1 GO:0003190 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.2 3.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 3.1 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 0.4 GO:0015808 L-alanine transport(GO:0015808) proline transport(GO:0015824)
0.1 0.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 1.9 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.6 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 2.5 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.5 GO:1903232 melanosome assembly(GO:1903232)
0.1 3.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 0.8 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.9 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 2.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 2.5 GO:0031577 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.1 1.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 1.3 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 3.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.8 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.1 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 1.6 GO:0031060 regulation of histone methylation(GO:0031060)
0.1 1.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 2.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.9 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.5 GO:0016572 histone phosphorylation(GO:0016572)
0.1 2.8 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 2.5 GO:0016180 snRNA processing(GO:0016180)
0.1 0.6 GO:0019563 glycerol catabolic process(GO:0019563)
0.1 1.7 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.1 0.4 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.8 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 2.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.0 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 2.2 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.1 1.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 2.0 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 3.3 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 1.4 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 0.7 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 1.7 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.9 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 1.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.2 GO:0006513 postreplication repair(GO:0006301) protein monoubiquitination(GO:0006513)
0.1 0.9 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 4.6 GO:0006364 rRNA processing(GO:0006364)
0.1 0.7 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.4 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 2.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 2.5 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 0.2 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.0 1.0 GO:0007020 microtubule nucleation(GO:0007020)
0.0 1.7 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.9 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.4 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.4 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.5 GO:0003209 cardiac atrium morphogenesis(GO:0003209)
0.0 3.6 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 1.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 2.2 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 3.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.1 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.5 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 2.7 GO:0048278 vesicle docking(GO:0048278)
0.0 1.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 1.2 GO:0008643 carbohydrate transport(GO:0008643)
0.0 2.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.7 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 1.6 GO:0030217 T cell differentiation(GO:0030217)
0.0 1.2 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 1.0 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.2 GO:0032048 cardiolipin metabolic process(GO:0032048) phosphatidylglycerol metabolic process(GO:0046471)
0.0 2.0 GO:0008033 tRNA processing(GO:0008033)
0.0 0.3 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 1.8 GO:0016051 carbohydrate biosynthetic process(GO:0016051)
0.0 0.2 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.8 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.3 GO:0046660 female sex differentiation(GO:0046660)
0.0 4.7 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 0.4 GO:0019835 cytolysis(GO:0019835)
0.0 0.4 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.5 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.3 GO:0050821 protein stabilization(GO:0050821)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.9 3.6 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.9 6.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.8 2.4 GO:0042382 paraspeckles(GO:0042382)
0.6 1.9 GO:0098536 deuterosome(GO:0098536)
0.6 2.6 GO:0005787 signal peptidase complex(GO:0005787)
0.6 2.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 5.0 GO:0005688 U6 snRNP(GO:0005688)
0.4 2.5 GO:0070876 SOSS complex(GO:0070876)
0.4 1.9 GO:0033553 rDNA heterochromatin(GO:0033553)
0.4 1.5 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.3 1.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 3.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 2.3 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 3.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 1.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.3 1.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 3.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 2.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 2.0 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.2 1.7 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 1.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 0.8 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.2 1.3 GO:0071818 BAT3 complex(GO:0071818)
0.2 4.1 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.2 2.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 1.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 1.0 GO:0071986 Ragulator complex(GO:0071986)
0.2 2.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 1.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 0.6 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.2 4.8 GO:0032040 small-subunit processome(GO:0032040)
0.1 1.6 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 0.7 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 3.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.5 GO:0031085 BLOC-3 complex(GO:0031085)
0.1 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 2.5 GO:0032039 integrator complex(GO:0032039)
0.1 0.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.4 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 1.5 GO:0000243 commitment complex(GO:0000243)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 2.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.7 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.9 GO:0070449 elongin complex(GO:0070449)
0.1 2.3 GO:0030684 preribosome(GO:0030684)
0.1 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 3.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 3.3 GO:0005811 lipid particle(GO:0005811)
0.1 0.4 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 3.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.8 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 2.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0030496 midbody(GO:0030496)
0.0 2.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 2.5 GO:0000776 kinetochore(GO:0000776)
0.0 2.0 GO:0005795 Golgi stack(GO:0005795)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.4 GO:0055037 recycling endosome(GO:0055037)
0.0 4.3 GO:0005730 nucleolus(GO:0005730)
0.0 0.7 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.2 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.6 GO:0005769 early endosome(GO:0005769)
0.0 0.5 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.5 GO:0000785 chromatin(GO:0000785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
1.0 2.9 GO:0071532 ankyrin repeat binding(GO:0071532)
0.7 2.2 GO:0070905 glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905)
0.6 2.6 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.6 2.5 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.6 1.8 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.6 2.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.6 2.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.5 2.6 GO:0030620 U2 snRNA binding(GO:0030620)
0.5 4.6 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.5 2.0 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.5 3.3 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.4 2.1 GO:0039706 co-receptor binding(GO:0039706)
0.4 1.5 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.4 2.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 2.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 5.3 GO:0030515 snoRNA binding(GO:0030515)
0.3 1.5 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.3 1.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.3 1.1 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.2 1.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 2.4 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 1.8 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.2 1.5 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.2 2.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.2 GO:0030619 U1 snRNA binding(GO:0030619)
0.2 0.8 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.2 1.3 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 0.5 GO:0004969 histamine receptor activity(GO:0004969)
0.2 1.4 GO:0034452 dynactin binding(GO:0034452)
0.2 0.5 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.2 2.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.9 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.6 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 2.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.1 0.9 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.9 GO:0034057 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 3.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.5 GO:0070035 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142) purine NTP-dependent helicase activity(GO:0070035)
0.1 2.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 1.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.1 2.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 0.4 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 1.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.7 GO:0048039 ubiquinone binding(GO:0048039)
0.1 1.3 GO:0031386 protein tag(GO:0031386)
0.1 1.0 GO:0005537 mannose binding(GO:0005537)
0.1 2.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 1.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.1 3.2 GO:0019843 rRNA binding(GO:0019843)
0.1 0.2 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.1 0.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.3 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.1 0.9 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 2.0 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.2 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.3 GO:0016208 AMP binding(GO:0016208)
0.0 1.2 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 3.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 3.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 2.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 3.3 GO:0016407 acetyltransferase activity(GO:0016407)
0.0 0.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 2.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.0 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 1.7 GO:0004518 nuclease activity(GO:0004518)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 2.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 3.3 PID AURORA B PATHWAY Aurora B signaling
0.1 3.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 5.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.2 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 6.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.2 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.4 5.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.4 1.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 1.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 2.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 3.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 1.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 3.3 REACTOME KINESINS Genes involved in Kinesins
0.1 3.5 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 5.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.7 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 2.4 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 2.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 0.9 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 3.4 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 2.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 0.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.6 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 1.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 3.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 0.7 REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX Genes involved in Formation of RNA Pol II elongation complex
0.1 1.1 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.8 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.4 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.2 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane