ISMARA results: yy1a+yy1b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for yy1a+yy1b

Z-value: 3.37

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Transcription factors associated with yy1a+yy1b

Gene Symbol	Gene ID	Gene Info
yy1b NCBI UniProt	ENSDARG00000027978	YY1 transcription factor b
yy1a NCBI UniProt	ENSDARG00000042796	YY1 transcription factor a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
yy1b	dr11_v1_chr20_-_54435287_54435287	0.74	2.0e-17	Click!
yy1a	dr11_v1_chr17_-_30863252_30863252	0.51	1.9e-07	Click!

Activity profile of yy1a+yy1b motif

Sorted Z-values of yy1a+yy1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_-_4915118 Show fit	38.49	ENSDART00000060714	atp6ap1a NCBI UniProt Show fit	ATPase H+ transporting accessory protein 1a
chr24_-_6158933 Show fit	37.91	ENSDART00000021609	gad2 NCBI UniProt Show fit	glutamate decarboxylase 2
chr5_-_29643381 Show fit	34.34	ENSDART00000034849	grin1b NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr21_+_11468934 Show fit	32.22	ENSDART00000126045 ENSDART00000129744 ENSDART00000102368	grin1a NCBI UniProt Show fit	glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr10_-_31782616 Show fit	31.22	ENSDART00000128839	fez1 NCBI UniProt Show fit	fasciculation and elongation protein zeta 1 (zygin I)
chr15_+_28685892 Show fit	29.65	ENSDART00000155815 ENSDART00000060244	nova2 NCBI UniProt Show fit	neuro-oncological ventral antigen 2
chr7_+_32722227 Show fit	28.32	ENSDART00000126565	si:ch211-150g13.3 NCBI UniProt Show fit	si:ch211-150g13.3
chr4_-_7212875 Show fit	26.89	ENSDART00000161297	lrrn3b NCBI UniProt Show fit	leucine rich repeat neuronal 3b
chr12_+_9817440 Show fit	25.57	ENSDART00000137081 ENSDART00000123712	rundc3ab NCBI UniProt Show fit	RUN domain containing 3Ab
chr12_-_14922955 Show fit	25.19	ENSDART00000002078	neurod2 NCBI UniProt Show fit	neurogenic differentiation 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of yy1a+yy1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	105.2	GO:0006470	protein dephosphorylation(GO:0006470)
4.9	88.8	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1	86.2	GO:0030182	neuron differentiation(GO:0030182)
1.6	72.5	GO:0007019	microtubule depolymerization(GO:0007019)
0.7	66.6	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3	61.0	GO:0006813	potassium ion transport(GO:0006813)
0.2	48.3	GO:0000377	RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.8	42.9	GO:0048813	dendrite morphogenesis(GO:0048813)
1.8	41.6	GO:0042551	neuron maturation(GO:0042551)
1.1	41.5	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)

Showing 1 to 10 of 477 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	355.3	GO:0005634	nucleus(GO:0005634)
0.5	212.8	GO:0043005	neuron projection(GO:0043005)
0.5	91.1	GO:0030424	axon(GO:0030424)
0.6	74.6	GO:0008021	synaptic vesicle(GO:0008021)
4.9	72.9	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
1.6	68.4	GO:0099634	postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
1.4	58.7	GO:0032590	neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.6	57.7	GO:0043025	neuronal cell body(GO:0043025)
1.8	50.2	GO:0030125	clathrin vesicle coat(GO:0030125)
0.7	48.5	GO:0005891	voltage-gated calcium channel complex(GO:0005891)

Showing 1 to 10 of 205 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	128.6	GO:0015631	tubulin binding(GO:0015631)
1.0	84.0	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.8	71.8	GO:0030276	clathrin binding(GO:0030276)
3.6	71.5	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.2	66.2	GO:0003924	GTPase activity(GO:0003924)
1.2	59.4	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.4	55.8	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.3	51.5	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.9	40.2	GO:0022851	benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
1.0	39.8	GO:0017075	syntaxin-1 binding(GO:0017075)

Showing 1 to 10 of 341 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	43.9	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.5	32.7	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.2	27.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.5	26.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.7	25.4	PID BMP PATHWAY	BMP receptor signaling
2.0	23.4	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.6	21.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
1.0	20.2	PID ARF 3PATHWAY	Arf1 pathway
0.8	15.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.7	12.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	40.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
2.0	33.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.3	31.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
7.5	30.0	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.9	27.7	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
1.1	24.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
1.8	24.0	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.9	22.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.9	21.4	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.3	20.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Showing 1 to 10 of 86 entries

Results for yy1a+yy1b

Z-value: 3.37

Motif logo

Transcription factors associated with yy1a+yy1b

Activity-expression correlation:

Activity profile of yy1a+yy1b motif

Sorted Z-values of yy1a+yy1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of yy1a+yy1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: