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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for vsx2
Z-value: 1.37
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Transcription factors associated with vsx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| vsx2 | dr11_v1_chr17_-_31659670_31659670 | 0.84 | 1.8e-26 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_21129752 Show fit | 31.42 |
ENSDART00000169764
|
synaptotagmin Ia |
|
| chr23_+_28731379 Show fit | 30.69 |
ENSDART00000047378
|
cortistatin |
|
| chr16_+_46111849 Show fit | 27.21 |
ENSDART00000172232
|
synaptic vesicle glycoprotein 2A |
|
| chr15_-_16098531 Show fit | 26.60 |
ENSDART00000080377
|
aldolase C, fructose-bisphosphate, a |
|
| chr20_+_35382482 Show fit | 25.85 |
ENSDART00000135284
|
visinin-like 1a |
|
| chr18_-_1185772 Show fit | 23.90 |
ENSDART00000143245
|
neuroplastin b |
|
| chr21_+_28958471 Show fit | 18.74 |
ENSDART00000144331
ENSDART00000005929 |
protein phosphatase 3, catalytic subunit, alpha isozyme |
|
| chr3_-_43356082 Show fit | 18.07 |
ENSDART00000171213
|
UNC homeobox |
|
| chr9_+_11532025 Show fit | 17.70 |
ENSDART00000109037
|
cyclin-dependent kinase 5, regulatory subunit 2b (p39) |
|
| chr24_-_21923930 Show fit | 15.93 |
ENSDART00000131944
|
transgelin 3b |
Network of associatons between targets according to the STRING database.
First level regulatory network of vsx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 31.4 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 1.1 | 26.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.8 | 23.9 | GO:0070593 | dendrite self-avoidance(GO:0070593) |
| 2.3 | 22.6 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) |
| 0.2 | 22.4 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.1 | 21.0 | GO:0030334 | regulation of cell migration(GO:0030334) |
| 1.2 | 18.7 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.3 | 15.4 | GO:0035195 | gene silencing by miRNA(GO:0035195) |
| 0.0 | 13.7 | GO:0006486 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 1.1 | 13.5 | GO:0042044 | fluid transport(GO:0042044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 31.4 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.4 | 27.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 24.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 23.9 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 22.1 | GO:1990904 | ribonucleoprotein complex(GO:1990904) |
| 0.0 | 21.4 | GO:0030054 | cell junction(GO:0030054) |
| 3.1 | 18.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 3.5 | 17.7 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 13.5 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 12.5 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 42.9 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.7 | 31.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.3 | 27.4 | GO:0005254 | chloride channel activity(GO:0005254) |
| 3.3 | 26.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 25.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.7 | 23.9 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.0 | 23.5 | GO:0003723 | RNA binding(GO:0003723) |
| 3.1 | 18.7 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 18.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.4 | 17.7 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 17.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.3 | 12.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 7.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 18.7 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.4 | 13.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.7 | 11.6 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.5 | 7.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 6.9 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |