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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for tlx1
Z-value: 1.19
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Transcription factors associated with tlx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tlx1 | dr11_v1_chr13_-_28272299_28272299 | -0.10 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_-_4146947 Show fit | 25.97 |
ENSDART00000129268
|
fatty acid desaturase 2 |
|
| chr20_+_10539293 Show fit | 19.55 |
ENSDART00000182265
|
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like |
|
| chr20_+_10545514 Show fit | 19.16 |
ENSDART00000153667
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
|
| chr20_+_25581627 Show fit | 13.81 |
ENSDART00000030229
|
cytochrome P450, family 2, subfamily P, polypeptide 9 |
|
| chr22_+_38229321 Show fit | 12.89 |
ENSDART00000132670
ENSDART00000104504 |
si:ch211-284e20.8 |
|
| chr12_+_33403694 Show fit | 11.08 |
ENSDART00000124083
|
fatty acid synthase |
|
| chr7_+_52122224 Show fit | 10.29 |
ENSDART00000174268
|
cytochrome P450, family 2, subfamily X, polypeptide 12 |
|
| chr13_-_9895564 Show fit | 9.85 |
ENSDART00000169831
ENSDART00000142629 |
si:ch211-117n7.6 |
|
| chr3_-_15081874 Show fit | 9.41 |
ENSDART00000192532
|
NME/NM23 nucleoside diphosphate kinase 4 |
|
| chr25_-_30394746 Show fit | 8.88 |
ENSDART00000185346
|
si:ch211-93f2.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tlx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 54.7 | GO:0042738 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.6 | 51.6 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.5 | 26.0 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.0 | 9.9 | GO:0048701 | embryonic cranial skeleton morphogenesis(GO:0048701) |
| 2.0 | 9.8 | GO:0046462 | phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
| 0.6 | 9.4 | GO:0046051 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 0.3 | 7.5 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.7 | 7.2 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 0.8 | 6.8 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.1 | 6.8 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 30.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 13.4 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 11.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.8 | 6.3 | GO:0071914 | prominosome(GO:0071914) |
| 0.1 | 4.6 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 3.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 3.1 | GO:0031970 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.0 | 3.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 3.1 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 54.7 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.3 | 38.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 16.5 | GO:0016491 | oxidoreductase activity(GO:0016491) |
| 0.3 | 12.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.8 | 9.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.3 | 9.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 7.7 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.4 | 7.5 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 7.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 7.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 21.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 11.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 6.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.4 | 4.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 3.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 1.8 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 1.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.1 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 26.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.3 | 21.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.9 | 11.1 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.5 | 10.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 9.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 5.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.8 | 4.8 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.3 | 3.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 3.0 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.4 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |