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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for tefa+tefb

Z-value: 1.25

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Transcription factors associated with tefa+tefb

Gene Symbol Gene ID Gene Info
tefa
ENSDARG00000039117 TEF transcription factor, PAR bZIP family member a
tefb
ENSDARG00000098103 TEF transcription factor, PAR bZIP family member b
tefa
ENSDARG00000109532 TEF transcription factor, PAR bZIP family member a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tefbdr11_v1_chr3_-_5067585_50675850.771.3e-19Click!
tefadr11_v1_chr12_-_19151708_191517080.622.7e-11Click!

Activity profile of tefa+tefb motif

Sorted Z-values of tefa+tefb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_31112436 27.86 ENSDART00000075340
eef1a1b
eukaryotic translation elongation factor 1 alpha 1b
chr16_+_34523515 27.15 ENSDART00000041007
stmn1b
stathmin 1b
chr17_-_43466317 26.37 ENSDART00000155313
hspa4l
heat shock protein 4 like
chr4_-_5302866 25.59 ENSDART00000138590
SNAP91 (1 of many)
si:ch211-214j24.9
chr25_+_15354095 23.79 ENSDART00000090397
kiaa1549la
KIAA1549-like a
chr3_-_46818001 22.91 ENSDART00000166505
elavl3
ELAV like neuron-specific RNA binding protein 3
chr16_+_46111849 21.81 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr17_-_20979077 18.66 ENSDART00000006676
phyhipla
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr10_-_24371312 17.91 ENSDART00000149362
pitpnab
phosphatidylinositol transfer protein, alpha b
chr4_-_5302162 17.66 ENSDART00000177099
SNAP91 (1 of many)
si:ch211-214j24.9
chr16_+_39146696 17.53 ENSDART00000121756
ENSDART00000084381
sybu
syntabulin (syntaxin-interacting)
chr7_+_38717624 16.11 ENSDART00000132522
syt13
synaptotagmin XIII
chr20_-_45661049 15.96 ENSDART00000124582
ENSDART00000131251
napbb
N-ethylmaleimide-sensitive factor attachment protein, beta b
chr11_-_10770053 15.02 ENSDART00000179213
slc4a10a
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr5_-_21970881 14.81 ENSDART00000182907
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr25_-_11088839 14.68 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr2_+_24177190 14.51 ENSDART00000099546
map4l
microtubule associated protein 4 like
chr12_-_26383242 14.15 ENSDART00000152941
usp54b
ubiquitin specific peptidase 54b
chr3_-_28665291 13.69 ENSDART00000151670
fbxl16
F-box and leucine-rich repeat protein 16
chr21_-_42202792 13.68 ENSDART00000124708
gabra6b
gamma-aminobutyric acid (GABA) A receptor, alpha 6b
chr9_+_17862858 11.88 ENSDART00000166566
dgkh
diacylglycerol kinase, eta
chr5_-_22001003 11.00 ENSDART00000134393
ENSDART00000143878
arhgef9a
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr16_-_45069882 10.73 ENSDART00000058384
gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr5_+_1278092 10.49 ENSDART00000147972
ENSDART00000159783
dnm1a
dynamin 1a
chr18_-_1228688 10.31 ENSDART00000064403
nptnb
neuroplastin b
chr22_-_18491813 9.94 ENSDART00000105419
si:ch211-212d10.2
si:ch211-212d10.2
chr9_+_46644633 9.23 ENSDART00000160285
slc4a3
solute carrier family 4 (anion exchanger), member 3
chr20_-_40717900 9.21 ENSDART00000181663
cx43
connexin 43
chr14_+_36628131 8.72 ENSDART00000188625
ENSDART00000125345
TENM3
si:dkey-237h12.3
chr20_+_1121458 8.36 ENSDART00000064472
pnrc1
proline-rich nuclear receptor coactivator 1
chr19_+_7549854 8.34 ENSDART00000138866
ENSDART00000151758
pbxip1a
pre-B-cell leukemia homeobox interacting protein 1a
chr7_+_38278860 8.27 ENSDART00000016265
lrp3
low density lipoprotein receptor-related protein 3
chr3_-_21348478 7.85 ENSDART00000114906
fam171a2a
family with sequence similarity 171, member A2a
chr11_+_6819050 7.74 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr7_+_17716601 7.37 ENSDART00000173792
ENSDART00000080825
rtn3
reticulon 3
chr10_-_26729930 7.36 ENSDART00000145532
fgf13b
fibroblast growth factor 13b
chr6_-_29612269 7.23 ENSDART00000104293
pex5la
peroxisomal biogenesis factor 5-like a
chr23_+_19590006 7.19 ENSDART00000021231
slmapb
sarcolemma associated protein b
chr7_-_32833153 6.97 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr8_+_8712446 6.78 ENSDART00000158674
elk1
ELK1, member of ETS oncogene family
chr10_+_33895315 6.64 ENSDART00000142881
fryb
furry homolog b (Drosophila)
chr12_+_36416173 6.54 ENSDART00000190278
unk
unkempt family zinc finger
chr11_-_7078392 6.47 ENSDART00000112156
ENSDART00000188556
si:ch211-253b8.5
si:ch211-253b8.5
chr15_-_16121496 6.42 ENSDART00000128624
sgk494a
uncharacterized serine/threonine-protein kinase SgK494a
chr7_+_4162994 6.25 ENSDART00000172800
si:ch211-63p21.1
si:ch211-63p21.1
chr20_-_44576949 6.08 ENSDART00000148639
ubxn2a
UBX domain protein 2A
chr9_+_33788626 5.76 ENSDART00000088469
kdm6a
lysine (K)-specific demethylase 6A
chr5_-_21030934 5.74 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr20_+_38201644 5.63 ENSDART00000022694
ehd3
EH-domain containing 3
chr9_+_33788389 5.59 ENSDART00000144623
kdm6a
lysine (K)-specific demethylase 6A
chr18_-_39288894 5.25 ENSDART00000186216
mapk6
mitogen-activated protein kinase 6
chr20_-_36617313 5.20 ENSDART00000172395
ENSDART00000152856
enah
enabled homolog (Drosophila)
chr14_+_34971554 5.16 ENSDART00000184271
rnf145a
ring finger protein 145a
chr7_-_6604623 4.91 ENSDART00000172874
kcnj10a
potassium inwardly-rectifying channel, subfamily J, member 10a
chr17_-_8268406 4.66 ENSDART00000149873
ENSDART00000064668
ENSDART00000148403
ahi1
Abelson helper integration site 1
chr18_-_2549198 4.49 ENSDART00000186516
CABZ01070631.1

chr1_+_54673846 4.44 ENSDART00000145018
gprc5bb
G protein-coupled receptor, class C, group 5, member Bb
chr21_-_32467799 4.38 ENSDART00000007675
ENSDART00000133099
zgc:123105
zgc:123105
chr21_-_39566854 4.28 ENSDART00000020174
dynll2b
dynein, light chain, LC8-type 2b
chr24_-_39772045 4.04 ENSDART00000087441
GFOD1
si:ch211-276f18.2
chr5_-_69437422 3.79 ENSDART00000073676
isca1
iron-sulfur cluster assembly 1
chr12_+_15002757 3.76 ENSDART00000135036
mylpfb
myosin light chain, phosphorylatable, fast skeletal muscle b
chr1_+_16600690 3.67 ENSDART00000162164
mtus1b
microtubule associated tumor suppressor 1b
chr16_-_35427060 3.55 ENSDART00000172294
ctps1b
CTP synthase 1b
chr25_-_16826219 3.50 ENSDART00000191299
ENSDART00000188504
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr21_-_32467099 3.45 ENSDART00000186354
zgc:123105
zgc:123105
chr9_-_13871935 3.34 ENSDART00000146597
raph1a
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr7_-_40959667 3.30 ENSDART00000084070
rbm33a
RNA binding motif protein 33a
chr25_-_13490744 3.29 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr9_-_9225980 3.04 ENSDART00000180301
cbsb
cystathionine-beta-synthase b
chr15_+_24737599 2.94 ENSDART00000078024
crk
v-crk avian sarcoma virus CT10 oncogene homolog
chr8_-_11324143 2.82 ENSDART00000008215
pip5k1bb
phosphatidylinositol-4-phosphate 5-kinase, type I, beta b
chr8_+_2487883 2.73 ENSDART00000101841
dynll1
dynein, light chain, LC8-type 1
chr5_-_36949476 2.70 ENSDART00000047269
h3f3c
H3 histone, family 3C
chr5_+_15350954 2.68 ENSDART00000140990
ENSDART00000137287
ENSDART00000061653
pebp1
phosphatidylethanolamine binding protein 1
chr19_+_4990320 2.61 ENSDART00000147056
zgc:91968
zgc:91968
chr20_+_23083800 2.53 ENSDART00000132093
usp46
ubiquitin specific peptidase 46
chr7_+_52761841 2.49 ENSDART00000111444
ppip5k1a
diphosphoinositol pentakisphosphate kinase 1a
chr12_-_31484677 2.49 ENSDART00000066578
tectb
tectorin beta
chr4_+_21867522 2.47 ENSDART00000140400
acss3
acyl-CoA synthetase short chain family member 3
chr20_-_44496245 2.47 ENSDART00000012229
fkbp1b
FK506 binding protein 1b
chr23_-_21763598 2.43 ENSDART00000145408
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr17_+_15845765 2.31 ENSDART00000130881
ENSDART00000074936
gabrr2a
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr5_+_69808763 2.25 ENSDART00000143482
fsd1l
fibronectin type III and SPRY domain containing 1-like
chr6_-_14038804 2.20 ENSDART00000184606
ENSDART00000184609
etv5b
ets variant 5b
chr10_-_25591194 2.20 ENSDART00000131640
tiam1a
T cell lymphoma invasion and metastasis 1a
chr17_+_49281597 2.16 ENSDART00000155599
zgc:113176
zgc:113176
chr14_+_23717165 2.14 ENSDART00000006373
ndfip1
Nedd4 family interacting protein 1
chr6_+_16468776 1.82 ENSDART00000109151
ENSDART00000114667
zgc:161969
zgc:161969
chr8_+_21225064 1.80 ENSDART00000129210
cry1ba
cryptochrome circadian clock 1ba
chr5_+_22974019 1.79 ENSDART00000147157
ENSDART00000020434
brwd3
bromodomain and WD repeat domain containing 3
chr24_+_18948665 1.45 ENSDART00000106186
prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr22_-_11438627 1.41 ENSDART00000007649
mid1ip1b
MID1 interacting protein 1b
chr20_-_1151265 1.27 ENSDART00000012376
gabrr1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr8_-_37249813 1.26 ENSDART00000098634
ENSDART00000140233
ENSDART00000061328
rbm39b
RNA binding motif protein 39b
chr23_+_9522781 1.17 ENSDART00000136486
osbpl2b
oxysterol binding protein-like 2b
chr22_-_10605045 1.17 ENSDART00000184812
bap1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr5_-_65153731 1.12 ENSDART00000171024
sh2d3cb
SH2 domain containing 3Cb
chr15_+_21882419 1.06 ENSDART00000157216
si:dkey-103g5.4
si:dkey-103g5.4
chr8_-_29851706 0.97 ENSDART00000149297
slc20a2
solute carrier family 20 (phosphate transporter), member 2
chr23_+_33963619 0.95 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr21_-_32781612 0.83 ENSDART00000031028
cnot6a
CCR4-NOT transcription complex, subunit 6a
chr23_-_18981595 0.77 ENSDART00000147617
bcl2l1
bcl2-like 1
chr1_+_19764995 0.76 ENSDART00000138276
si:ch211-42i9.8
si:ch211-42i9.8
chr24_-_23784701 0.75 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr19_-_45650994 0.60 ENSDART00000163504
trps1
trichorhinophalangeal syndrome I
chr19_-_30811161 0.56 ENSDART00000103524
myclb
MYCL proto-oncogene, bHLH transcription factor b
chr20_-_20270191 0.31 ENSDART00000009356
ppp2r5ea
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr13_+_30035253 0.15 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
dnajb12a
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr17_-_31308658 0.14 ENSDART00000124505
bahd1
bromo adjacent homology domain containing 1
chr5_-_54395488 0.10 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19

Network of associatons between targets according to the STRING database.

First level regulatory network of tefa+tefb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.5 GO:0060074 synapse maturation(GO:0060074)
4.0 16.0 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
2.6 7.7 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
1.7 5.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.2 8.3 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
1.2 7.0 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.1 11.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
1.1 3.3 GO:0006089 lactate metabolic process(GO:0006089)
1.1 24.3 GO:0015701 bicarbonate transport(GO:0015701)
1.0 3.0 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
1.0 9.9 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.9 3.6 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.9 7.0 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.7 7.2 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.7 16.2 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.7 4.9 GO:0036268 swimming(GO:0036268)
0.6 27.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.6 10.5 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.5 3.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.5 7.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.5 11.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.4 27.9 GO:0006414 translational elongation(GO:0006414)
0.4 4.7 GO:0044458 motile cilium assembly(GO:0044458)
0.4 6.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.4 10.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.4 16.1 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.3 2.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 1.3 GO:0070316 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.3 1.2 GO:0035521 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.3 17.9 GO:0015914 phospholipid transport(GO:0015914)
0.3 6.5 GO:0048667 cell morphogenesis involved in neuron differentiation(GO:0048667)
0.2 30.5 GO:0006836 neurotransmitter transport(GO:0006836)
0.2 2.5 GO:0006020 inositol metabolic process(GO:0006020)
0.2 13.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2 10.7 GO:0006096 glycolytic process(GO:0006096)
0.1 2.2 GO:0021979 hypothalamus cell differentiation(GO:0021979) limb morphogenesis(GO:0035108)
0.1 2.9 GO:0007520 myoblast fusion(GO:0007520)
0.1 5.6 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.1 GO:0033135 regulation of peptidyl-serine phosphorylation(GO:0033135) positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 1.6 GO:0090382 phagosome maturation(GO:0090382)
0.1 2.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 8.5 GO:0001933 negative regulation of protein phosphorylation(GO:0001933)
0.1 9.6 GO:0016579 protein deubiquitination(GO:0016579)
0.1 3.5 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 2.1 GO:0031398 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.1 25.1 GO:0050767 regulation of neurogenesis(GO:0050767)
0.1 0.8 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 1.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 21.2 GO:0031175 neuron projection development(GO:0031175)
0.0 2.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.4 GO:0072175 epithelial tube formation(GO:0072175)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.3 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 2.8 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 16.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.9 3.6 GO:0097268 cytoophidium(GO:0097268)
0.7 4.4 GO:0070062 extracellular exosome(GO:0070062)
0.6 11.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.6 10.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.5 43.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 17.3 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.5 7.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 17.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 5.6 GO:0060170 ciliary membrane(GO:0060170)
0.2 14.0 GO:0030427 site of polarized growth(GO:0030427)
0.2 25.8 GO:0014069 postsynaptic density(GO:0014069)
0.2 1.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.2 GO:0035517 PR-DUB complex(GO:0035517)
0.1 15.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 34.2 GO:0030424 axon(GO:0030424)
0.1 4.6 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 39.3 GO:0043005 neuron projection(GO:0043005)
0.1 7.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 16.8 GO:1990904 ribonucleoprotein complex(GO:1990904)
0.0 24.8 GO:0005829 cytosol(GO:0005829)
0.0 2.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.7 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.7 16.0 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
2.6 17.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
2.2 6.5 GO:1990715 mRNA CDS binding(GO:1990715)
1.4 9.9 GO:0098809 nitrite reductase activity(GO:0098809)
1.1 11.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
1.1 24.3 GO:0005452 inorganic anion exchanger activity(GO:0005452)
1.0 13.7 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.9 7.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.9 3.6 GO:0003883 CTP synthase activity(GO:0003883)
0.8 17.5 GO:0019894 kinesin binding(GO:0019894)
0.6 2.5 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.6 27.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 3.0 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.5 7.0 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.5 5.2 GO:0005522 profilin binding(GO:0005522)
0.5 11.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 2.1 GO:0050699 WW domain binding(GO:0050699)
0.4 3.3 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.3 16.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 10.3 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.3 7.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 7.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 3.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 5.2 GO:0004707 MAP kinase activity(GO:0004707)
0.1 4.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 3.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 5.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 50.3 GO:0015631 tubulin binding(GO:0015631)
0.1 13.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 30.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 4.4 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 3.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 6.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 2.8 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.1 1.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 2.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 7.7 GO:0003924 GTPase activity(GO:0003924)
0.0 0.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 24.8 GO:0022857 transmembrane transporter activity(GO:0022857)
0.0 0.9 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 5.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 13.5 GO:0003723 RNA binding(GO:0003723)
0.0 2.1 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 2.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.7 PID AURORA B PATHWAY Aurora B signaling
0.0 1.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 11.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.4 5.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 6.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.3 2.9 REACTOME PROLONGED ERK ACTIVATION EVENTS Genes involved in Prolonged ERK activation events
0.3 2.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 10.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 3.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport